Systems biology of industrial oxytetracycline production in Streptomyces rimosus: the secrets of a mutagenized hyperproducer

Systems metabolic engineering upgrades Corynebacterium glutamicum for selective high-level production of the chiral drug precursor and cell-protective extremolyte L-pipecolic acid

(2023) Sarah Pauli et al.   METABOLIC ENGINEERING

Multi-omics view of recombinant Yarrowia lipolytica: Enhanced ketogenic amino acid catabolism increases polyketide-synthase-driven docosahexaenoic production to high selectivity at the gram scale

(2023) Sofija Jovanovic Gasovic et al.   METABOLIC ENGINEERING

Refactoring the architecture of a polyketide gene cluster enhances docosahexaenoic acid production in Yarrowia lipolytica through improved expression and genetic stability

(2023) Demian Dietrich et al.   Microbial Cell Factories

The past, present, and future of antibiotics

(2022) Michael A. Cook et al.   Science Translational Medicine

Systems metabolic engineering of Corynebacterium glutamicum eliminates all by-products for selective and high-yield production of the platform chemical 5-aminovalerate

(2022) Christina Rohles et al.   METABOLIC ENGINEERING

Systems metabolic engineering upgrades Corynebacterium glutamicum to high-efficiency cis, cis-muconic acid production from lignin-based aromatics

(2022) Fabia Weiland et al.   METABOLIC ENGINEERING

Multiple copies of the oxytetracycline gene cluster in selected Streptomyces rimosus strains can provide significantly increased titers

(2021) Špela Pikl et al.   Microbial Cell Factories

Microparticles enhance the formation of seven major classes of natural products in native and metabolically engineered actinobacteria through accelerated morphological development

(2021) Martin Kuhl et al.   BIOTECHNOLOGY AND BIOENGINEERING

Superior production of heavy pamamycin derivatives using a bkdR deletion mutant of Streptomyces albus J1074/R2

(2021) Lars Gläser et al.   Microbial Cell Factories

The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences

(2021) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Engineering of Streptomyces lividans for heterologous expression of secondary metabolite gene clusters

(2020) Yousra Ahmed et al.   Microbial Cell Factories

Benzanthric Acid, a Novel Metabolite From Streptomyces albus Del14 Expressing the Nybomycin Gene Cluster

(2020) Marta Rodríguez Estévez et al.   Frontiers in Chemistry

Metabolic Engineering Design Strategies for Increasing Acetyl-CoA Flux

(2020) Jason T. Ku et al.   Metabolites

A common approach for absolute quantification of short chain CoA thioesters in prokaryotic and eukaryotic microbes

(2020) Lars Gläser et al.   Microbial Cell Factories

Microparticles globally reprogram Streptomyces albus toward accelerated morphogenesis, streamlined carbon core metabolism, and enhanced production of the antituberculosis polyketide pamamycin

(2020) Martin Kuhl et al.   BIOTECHNOLOGY AND BIOENGINEERING

Streptomyces coelicolor

(2019) Paul A. Hoskisson et al.   TRENDS IN MICROBIOLOGY

Metabolic engineering of Corynebacterium glutamicum for high‐level ectoine production – design, combinatorial assembly and implementation of a transcriptionally balanced heterologous ectoine pathway

(2019) Gideon Gießelmann et al.   Biotechnology Journal

Assembly of long, error-prone reads using repeat graphs

(2019) Mikhail Kolmogorov et al.   NATURE BIOTECHNOLOGY

Combinatorial Effect of ARTP Mutagenesis and Ribosome Engineering on an Industrial Strain of Streptomyces albus S12 for Enhanced Biosynthesis of Salinomycin

(2019) Kuipu Zhang et al.   Frontiers in Bioengineering and Biotechnology

Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces

(2019) Weishan Wang et al.   NATURE BIOTECHNOLOGY

Lysine production from the sugar alcohol mannitol: Design of the cell factory Corynebacterium glutamicum SEA-3 through integrated analysis and engineering of metabolic pathway fluxes

(2018) Sarah Lisa Hoffmann et al.   METABOLIC ENGINEERING

From lignin to nylon: Cascaded chemical and biochemical conversion using metabolically engineered Pseudomonas putida

(2018) Michael Kohlstedt et al.   METABOLIC ENGINEERING

Reverse micelle Extraction of Antibiotics using an Eco-friendly Sophorolipids Biosurfactant

(2018) Sing Chuong Chuo et al.   Scientific Reports

Generation of a cluster-free Streptomyces albus chassis strains for improved heterologous expression of secondary metabolite clusters

(2018) Maksym Myronovskyi et al.   METABOLIC ENGINEERING

Streptomyces as a Prominent Resource of Future Anti-MRSA Drugs

(2018) Hefa Mangzira Kemung et al.   Frontiers in Microbiology

Biosynthesis of Oxytetracycline by Streptomyces rimosus: Past, Present and Future Directions in the Development of Tetracycline Antibiotics

(2017) Hrvoje Petković et al.   FOOD TECHNOLOGY AND BIOTECHNOLOGY

Canu: scalable and accurate long-read assembly via adaptivek-mer weighting and repeat separation

(2017) Sergey Koren et al.   GENOME RESEARCH

Bio-based succinate from sucrose: High-resolution 13 C metabolic flux analysis and metabolic engineering of the rumen bacterium Basfia succiniciproducens

(2017) Anna Lange et al.   METABOLIC ENGINEERING

Improvement of oxytetracycline production mediated via cooperation of resistance genes in Streptomyces rimosus

(2017) Shouliang Yin et al.   Science China-Life Sciences

ReadXplorer 2—detailed read mapping analysis and visualization from one single source

(2016) Rolf Hilker et al.   BIOINFORMATICS

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Regulating malonyl-CoA metabolism via synthetic antisense RNAs for enhanced biosynthesis of natural products

(2015) Yaping Yang et al.   METABOLIC ENGINEERING

Fine-Tuning of the Fatty Acid Pathway by Synthetic Antisense RNA for Enhanced (2S)-Naringenin Production from l-Tyrosine in Escherichia coli

(2014) Junjun Wu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Iterative marker excision system

(2014) Maksym Myronovskyi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Prokka: rapid prokaryotic genome annotation

(2014) T. Seemann   BIOINFORMATICS

Adaptation ofBacillus subtiliscarbon core metabolism to simultaneous nutrient limitation and osmotic challenge: a multi-omics perspective

(2014) Michael Kohlstedt et al.   ENVIRONMENTAL MICROBIOLOGY

Relationship Between Morphology and Itaconic Acid Production by Aspergillus terreus

(2014) Qian Gao et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data

(2014) Thomas P Van Boeckel et al.   LANCET INFECTIOUS DISEASES

Pilon: An Integrated Tool for Comprehensive Microbial Variant Detection and Genome Assembly Improvement

(2014) Bruce J. Walker et al.   PLoS One

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

New bhimamycins from Streptomyces sp. AK 671

(2013) Philipp Jetter et al.   JOURNAL OF ANTIBIOTICS

Increased lysine production by flux coupling of the tricarboxylic acid cycle and the lysine biosynthetic pathway—Metabolic engineering of the availability of succinyl-CoA in Corynebacterium glutamicum

(2012) Stefanie Kind et al.   METABOLIC ENGINEERING

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

The history of the tetracyclines

(2011) Mark L. Nelson et al.   Annals of the New York Academy of Sciences

β-Glucuronidase as a Sensitive and Versatile Reporter in Actinomycetes

(2011) Maksym Myronovskyi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Improved enzyme production by bio-pellets of Aspergillus niger: Targeted morphology engineering using titanate microparticles

(2011) Habib Driouch et al.   BIOTECHNOLOGY AND BIOENGINEERING

From zero to hero—Design-based systems metabolic engineering of Corynebacterium glutamicum for l-lysine production

(2011) Judith Becker et al.   METABOLIC ENGINEERING

Chromosomal instability in Streptomyces avermitilis: major deletion in the central region and stable circularized chromosome

(2010) Wei Chen et al.   BMC MICROBIOLOGY

Assembly algorithms for next-generation sequencing data

(2010) Jason R. Miller et al.   GENOMICS

Oxytetracycline Biosynthesis

(2010) Lauren B. Pickens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Malonyl Coenzyme A Biosynthesis by Tuning the Escherichia coli Metabolic Network and Its Application to Flavanone Production

(2009) Z. L. Fowler et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Metabolic Engineering of the Tricarboxylic Acid Cycle for Improved Lysine Production by Corynebacterium glutamicum

(2009) J. Becker et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY