Combinatorial Effect of ARTP Mutagenesis and Ribosome Engineering on an Industrial Strain of Streptomyces albus S12 for Enhanced Biosynthesis of Salinomycin

Ribosome-Targeting Antibiotics: Modes of Action, Mechanisms of Resistance, and Implications for Drug Design

(2018) Jinzhong Lin et al.   Annual Review of Biochemistry

Regulation of the opposing (p)ppGpp synthetase and hydrolase activities in a bifunctional RelA/SpoT homologue from Staphylococcus aureus

(2018) Fabio Lino Gratani et al.   PLoS Genetics

The SCO4117 ECF Sigma Factor Pleiotropically Controls Secondary Metabolism and Morphogenesis in Streptomyces coelicolor

(2018) María T. López-García et al.   Frontiers in Microbiology

Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition

(2018) Hongzhong Lu et al.   Scientific Reports

SlnR is a positive pathway-specific regulator for salinomycin biosynthesis in Streptomyces albus

(2016) Zhenhong Zhu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Enhanced salinomycin production by adjusting the supply of polyketide extender units in Streptomyces albus

(2016) Chenyang Lu et al.   METABOLIC ENGINEERING

The magic dance of the alarmones (p)ppGpp

(2016) Wieland Steinchen et al.   MOLECULAR MICROBIOLOGY

ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria

(2016) Rebecca M. Corrigan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly improved acarbose production of Actinomyces through the combination of ARTP and penicillin susceptible mutant screening

(2016) Fei Ren et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Formation of the Δ18,19Double Bond and Bis(spiroacetal) in Salinomycin Is Atypically Catalyzed by SlnM, a Methyltransferase-like Enzyme

(2015) Chunyan Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Improved ε-poly-l-lysine production of Streptomyces sp. FEEL-1 by atmospheric and room temperature plasma mutagenesis and streptomycin resistance screening

(2015) Liang Wang et al.   ANNALS OF MICROBIOLOGY

Inside Cover: Site-Specific Modification of the Anticancer and Antituberculosis Polyether Salinomycin by Biosynthetic Engineering (ChemBioChem 14/2014)

(2015) Hanna Luhavaya et al.   CHEMBIOCHEM

Direct Fermentation of Gelatinized Cassava Starch to Acetone, Butanol, and Ethanol Using Clostridium acetobutylicum Mutant Obtained by Atmospheric and Room Temperature Plasma

(2014) Han-guang Li et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Atmospheric and room temperature plasma (ARTP) as a new powerful mutagenesis tool

(2014) Xue Zhang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Combined application of plasma mutagenesis and gene engineering leads to 5-oxomilbemycins A3/A4 as main components from Streptomyces bingchenggensis

(2014) Hai-Yan Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

GlnR-mediated regulation of nitrogen metabolism in the actinomycete Saccharopolyspora erythraea

(2014) Li-Li Yao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

An extracytoplasmic function sigma factor, σ25, differentially regulates avermectin and oligomycin biosynthesis in Streptomyces avermitilis

(2014) Shuai Luo et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Rapid Mutation of Spirulina platensis by a New Mutagenesis System of Atmospheric and Room Temperature Plasmas (ARTP) and Generation of a Mutant Library with Diverse Phenotypes

(2013) Mingyue Fang et al.   PLoS One

Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

(2013) L. Jenner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt

(2012) Selena Z Kuo et al.   BMC CANCER

Identification of two-component system AfsQ1/Q2 regulon and its cross-regulation with GlnR inStreptomyces coelicolor

(2012) Rui Wang et al.   MOLECULAR MICROBIOLOGY

Cloning and Characterization of the Polyether Salinomycin Biosynthesis Gene Cluster of Streptomyces albus XM211

(2011) Chunyan Jiang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The ECF sigma factor SigT regulates actinorhodin production in response to nitrogen stress in Streptomyces coelicolor

(2011) Wei-Hong Feng et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A Late-Stage Intermediate in Salinomycin Biosynthesis Is Revealed by Specific Mutation in the Biosynthetic Gene Cluster

(2011) Marie E. Yurkovich et al.   CHEMBIOCHEM

Direct regulation of Escherichia coli ribosomal protein promoters by the transcription factors ppGpp and DksA

(2011) J. J. Lemke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salinomycin overcomes ABC transporter-mediated multidrug and apoptosis resistance in human leukemia stem cell-like KG-1a cells

(2010) Dominik Fuchs et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Novel mutation breeding method forStreptomyces avermitilisusing an atmospheric pressure glow discharge plasma

(2009) L.-Y. Wang et al.   JOURNAL OF APPLIED MICROBIOLOGY

ppGpp and DksA likely regulate the activity of the extracytoplasmic stress factor σEinEscherichia coliby both direct and indirect mechanisms

(2009) Alessandra Costanzo et al.   MOLECULAR MICROBIOLOGY

The Extracytoplasmic Stress Factor, σE, Is Required to Maintain Cell Envelope Integrity in Escherichia coli

(2008) Jennifer D. Hayden et al.   PLoS One