Novel aloe emodin–hydroxyethyl piperazine hybrid dihydrochloride induces oral cancer CAL-27 cells apoptosis through ROS production, DNA damage and mitochondrial pathways

Discovery of Fluorinated 2-Styryl 4(3H)-quinazolinone as Potential Therapeutic Hit for Oral Cancer

(2023) Dinesh Parshuram Satpute et al.   BIOORGANIC & MEDICINAL CHEMISTRY

In vitro Analytical Techniques as Screening Tools to investigate the Metal chelate‐DNA interactions

(2023) Nikita Varghese et al.   ChemistrySelect

Synthesis and DNA interaction of aloe-emodin α-amino phosphate derivatives

(2023) Qiuping Zhang et al.   JOURNAL OF MOLECULAR STRUCTURE

Trismus surgery and microsurgical reconstruction after oral cancer treatment

(2023) Alba De Pablo et al.   JOURNAL OF SURGICAL ONCOLOGY

A new method for oral cancer biomarkers detection with a non-invasive cyto-salivary sampling and rapid-highly sensitive ELISA immunoassay: a pilot study in humans

(2023) Federico Rebaudi et al.   Frontiers in Immunology

Design, synthesis, cytotoxic, and anti-inflammatory activities of some novel analogues of aloe-emodin isolated from the rhizomes of Rheum emodi

(2022) G. Dileep Kumar et al.   NATURAL PRODUCT RESEARCH

Design, synthesis and anti-inflammatory evaluation of aloe-emodin derivatives as potential modulators of Akt, NF-κB and JNK signaling pathways

(2022) Hai Shang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An evolving role of aqueous piperazine to improve the solubility of non-steroidal anti-inflammatory drugs

(2022) Zhengyu Fang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The promoting effect of neutrophil-derived BAFF molecule on the proliferation and life span of CAL-27 oral squamous carcinoma cells

(2022) Ewa Jablonska et al.   IMMUNOBIOLOGY

The Synthesis and Biological Evaluation of Aloe-Emodin-Coumarin Hybrids as Potential Antitumor Agents

(2022) Hai Shang et al.   MOLECULES

Oral health-related quality of life in oral cancer patients: systematic review and meta-analysis

(2021) Monal Yuwanati et al.   Future Oncology

Generation of Reactive Oxygen Species by Mitochondria

(2021) Pablo Hernansanz-Agustín et al.   Antioxidants

Purpurin, a anthraquinone induces ROS-mediated A549 lung cancer cell apoptosis via inhibition of PI3K/AKT and proliferation

(2021) Su Bo et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Bacterial Antigens Reduced the Inhibition Effect of Capsaicin on Cal 27 Oral Cancer Cell Proliferation

(2021) Rajdeep Chakraborty et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cell cycle control in cancer

(2021) Helen K. Matthews et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Natural Berberine-derived Azolyl Ethanols as New Structural Antibacterial Agents against Drug-Resistant Escherichia coli

(2021) Hang Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Zinc‑finger protein 750 mitigates malignant biological behavior of oral CSC‑like cells enriched from parental CAL‑27 cells

(2021) Cong Xu et al.   Oncology Letters

Postoperative quality of life and therapy-related impairments of oral cancer in relation to time–distance since treatment

(2021) Philipp Jehn et al.   Journal of Cancer Survivorship

Synthesis and structure-activity relationship study of water-soluble carbazole sulfonamide derivatives as new anticancer agents

(2020) Yonghua Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel anthraquinone compounds as anticancer agents and their potential mechanism

(2020) Wei Tian et al.   Future Medicinal Chemistry

Design, synthesis and antitumour evaluation of novel anthraquinone derivatives

(2020) Kai-Wei Lin et al.   BIOORGANIC CHEMISTRY

Design, synthesis and anti‐inflammatory study of novel N‐heterocyclic substituted Aloe‐emodin derivatives

(2020) Xiang Qiu et al.   Chemical Biology & Drug Design

Novel Anthraquinone Compounds Induce Cancer Cell Death through Paraptosis

(2019) Wei Tian et al.   ACS Medicinal Chemistry Letters

Quality of Life After Oral Cancer Resection and Free Flap Reconstruction

(2019) Shuai Wang et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Aloe‐emodin: A review of its pharmacology, toxicity, and pharmacokinetics

(2019) Xiaoxv Dong et al.   PHYTOTHERAPY RESEARCH

Piperazine Derivatives Enhance Epithelial Cell Monolayer Permeability by Increased Cell Force Generation and Loss of Cadherin Structures

(2019) Shiyuan Zheng et al.   ACS Biomaterials-Science & Engineering

Synthesis, crystal structure, DNA binding and in vitro cytotoxicity studies of Zn(II) complexes derived from amino-alcohol Schiff-bases

(2018) Yan Zhao et al.   INORGANICA CHIMICA ACTA

Copper(II) complexes with isoxazole Schiff bases: Synthesis, spectroscopic investigation, DNA binding and nuclease activities, antioxidant and antimicrobial studies

(2018) Nirmala Ganji et al.   JOURNAL OF MOLECULAR STRUCTURE

ROS and the DNA damage response in cancer

(2018) Upadhyayula Sai Srinivas et al.   Redox Biology

The caspase-8/Bid/cytochrome c axis links signals from death receptors to mitochondrial reactive oxygen species production

(2017) Wan-Sung Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Organotin(IV) complexes derived from hydrazone Schiff base: Synthesis, crystal structure, in vitro cytotoxicity and DNA/BSA interactions

(2017) Kai Liu et al.   INORGANICA CHIMICA ACTA

Interaction of anthraquinone anti-cancer drugs with DNA:Experimental and computational quantum chemical study

(2017) Jamelah S. Al-Otaibi et al.   JOURNAL OF MOLECULAR STRUCTURE

The novel anthraquinone derivative IMP1338 induces death of human cancer cells by p53-independent S and G2/M cell cycle arrest

(2016) Hyun Kyung Choi et al.   BIOMEDICINE & PHARMACOTHERAPY

The pH of Piperazine Derivative Solutions Predicts Their Utility as Transepithelial Permeation Enhancers

(2016) Nicholas G. Lamson et al.   MOLECULAR PHARMACEUTICS

Diorganotin (IV) complexes with 4-nitro-N-phthaloyl-glycine: Synthesis, characterization, antitumor activity and DNA-binding studies

(2015) Chaoqun Yan et al.   BIOMEDICINE & PHARMACOTHERAPY

Orthotopic non-metastatic and metastatic oral cancer mouse models

(2015) Manish V. Bais et al.   ORAL ONCOLOGY

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

(2015) Joe Dan Dunn et al.   Redox Biology

Synthesis and Antitumor Activity of Natural Compound Aloe Emodin Derivatives

(2014) Naraganahalli R. Thimmegowda et al.   Chemical Biology & Drug Design

Design, synthesis and molecular modeling of aloe-emodin derivatives as potent xanthine oxidase inhibitors

(2014) Da-Hua Shi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Synthesis and antitumor activities of novel rhein α-aminophosphonates conjugates

(2013) Gui-yang Yao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis

(2013) Matthew Brentnall et al.   BMC CELL BIOLOGY

Spectroscopic study one thiosemicarbazone derivative with ctDNA using ethidium bromide as a fluorescence probe

(2013) Shaoguang Geng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Drug–DNA interactions and their study by UV–Visible, fluorescence spectroscopies and cyclic voltametry

(2013) Muhammad Sirajuddin et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Aloe Emodin Induces G2/M Cell Cycle Arrest and Apoptosis via Activation of Caspase-6 in Human Colon Cancer Cells

(2012) Priya Suboj et al.   PHARMACOLOGY

Anthraquinone derivatives induce G2/M cell cycle arrest and apoptosis in NTUB1 cells

(2011) Huang-Yao Tu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research

(2011) Alesia Ivashkevich et al.   CANCER LETTERS

Aloe-emodin induces apoptosis of human nasopharyngeal carcinoma cells via caspase-8-mediated activation of the mitochondrial death pathway

(2009) Meng-Liang Lin et al.   CANCER LETTERS