Discovery of Fluorinated 2-Styryl 4(3H)-quinazolinone as Potential Therapeutic Hit for Oral Cancer

A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics

(2022) Li Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models

(2022) Martina Menna et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Emerging Impact of Tumor Budding in Oral Squamous Cell Carcinoma: Main Issues and Clinical Relevance of a New Prognostic Marker

(2022) Lucrezia Togni et al.   Cancers

Cell-in-Cell Events in Oral Squamous Cell Carcinoma

(2022) Leonardo de Oliveira Siquara da Rocha et al.   Frontiers in Oncology

Design and synthesis of some new 6-bromo-2-(pyridin-3-yl)-4-substituted quinazolines as multi tyrosine kinase inhibitors

(2022) Ahmed K.B.A.W. Farouk et al.   BIOORGANIC CHEMISTRY

Design, synthesis and bioactivity evaluation of favorable evodiamine derivative scaffold for developing cancer therapy

(2022) Ziyi Liang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of quinazoline derivatives as a novel class of potent and in vivo efficacious LSD1 inhibitors by drug repurposing

(2021) Zhonghua Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel Polycyclic Heterocyclic Derivatives from Evodiamine for the Potential Treatment of Triple-Negative Breast Cancer

(2021) Shengtao Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Overview of oral cavity squamous cell carcinoma: Risk factors, mechanisms, and diagnostics

(2021) Ambika Chamoli et al.   ORAL ONCOLOGY

Contribution of Organofluorine Compounds to Pharmaceuticals

(2020) Munenori Inoue et al.   ACS Omega

Synthetic approaches, anticancer potential, HSP90 inhibition, multitarget evaluation, molecular modeling and apoptosis mechanistic study of thioquinazolinone skeleton: Promising antibreast cancer agent

(2020) Hamed W. El-Shafey et al.   BIOORGANIC CHEMISTRY

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer

(2020) Elena Catanzaro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel quinazoline-based EGFR kinase inhibitors: A review focussing on SAR and molecular docking studies (2015-2019)

(2020) Parth Bhatia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β

(2020) Jose Antonio Ortega et al.   JOURNAL OF MEDICINAL CHEMISTRY

HER2 Kinase-Targeted Breast Cancer Therapy: Design, Synthesis, and In Vitro and In Vivo Evaluation of Novel Lapatinib Congeners as Selective and Potent HER2 Inhibitors with Favorable Metabolic Stability

(2020) Tamer A. Elwaie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic progression of quinazolines as targeted chemotherapeutic agents

(2020) Ranju Bansal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advancements of 4-aminoquinazoline derivatives as kinase inhibitors and their applications in medicinal chemistry

(2019) Debasis Das et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of 4-Methyl Quinazoline Derivatives as Anticancer Agents Simultaneously Targeting Phosphoinositide 3-Kinases and Histone Deacetylases

(2019) Kehui Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of arylamide-5-anilinoquinazoline-8-nitro derivatives as VEGFR-2 kinase inhibitors: Synthesis, in vitro biological evaluation and molecular docking

(2019) Yongqiang Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

An overview of quinazolines: Pharmacological significance and recent developments

(2018) V. Alagarsamy et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Bismuth-catalyzed synthesis of 2-substituted quinazolinones

(2018) Sandeep R. Vemula et al.   TETRAHEDRON LETTERS

The association between anti-tumor potency and structure-activity of protein-kinases inhibitors based on quinazoline molecular skeleton

(2018) Yang Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors

(2017) Chenzhou Hao et al.   JOURNAL OF MEDICINAL CHEMISTRY

An insight into the therapeutic potential of quinazoline derivatives as anticancer agents

(2017) Shagufta Shagufta et al.   MedChemComm

Novel morpholin-3-one fused quinazoline derivatives as EGFR tyrosine kinase inhibitors

(2016) Xuemei Qin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and biological evaluation of N-phenylquinazolin-4-amine hybrids as dual inhibitors of VEGFR-2 and HDAC

(2016) Fan-Wei Peng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Oral cancer: Etiology and risk factors: A review

(2016) Malay Kumar et al.   Journal of Cancer Research and Therapeutics

Merging C–H Bond Functionalization with Amide Alcoholysis: En Route to 2-Aminopyridines

(2016) Dinesh Kumar et al.   ACS Catalysis

Discovery of 1-substituted benzyl-quinazoline-2,4(1H,3H)-dione derivatives as novel poly(ADP-ribose)polymerase-1 inhibitors

(2015) Haiping Yao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The cascade synthesis of quinazolinones and quinazolines using an α-MnO2 catalyst and tert-butyl hydroperoxide (TBHP) as an oxidant

(2015) Zhe Zhang et al.   CHEMICAL COMMUNICATIONS

Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties

(2015) Khurshed Bozorov et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Evaluation of Clinical Candidate AZD3759, a Potent, Oral Active, Central Nervous System-Penetrant, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor

(2015) Qingbei Zeng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents

(2015) Shengzheng Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cancer of the Oral Cavity

(2015) Pablo H. Montero et al.   Surgical Oncology Clinics of North America

The chemistry and pharmacology of privileged pyrroloquinazolines

(2015) Bo Chao et al.   MedChemComm

Discovery of Biarylaminoquinazolines as Novel Tubulin Polymerization Inhibitors

(2014) Giovanni Marzaro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimization of 4-(N-Cycloamino)phenylquinazolines as a Novel Class of Tubulin-Polymerization Inhibitors Targeting the Colchicine Site

(2014) Xiao-Feng Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of quinazolinones from anthranilamides and aldehydes via metal-free aerobic oxidation in DMSO

(2014) Na Yeun Kim et al.   TETRAHEDRON LETTERS

XenoSite: Accurately Predicting CYP-Mediated Sites of Metabolism with Neural Networks

(2013) Jed Zaretzki et al.   Journal of Chemical Information and Modeling

Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines.

(2010) Feng Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacotherapy of head and neck squamous cell carcinoma

(2009) Quintin Pan et al.   EXPERT OPINION ON PHARMACOTHERAPY

Current concepts for the management of head and neck cancer: Chemotherapy

(2008) Pol M. Specenier et al.   ORAL ONCOLOGY

Global epidemiology of oral and oropharyngeal cancer

(2008) Saman Warnakulasuriya   ORAL ONCOLOGY

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS