Novel anthraquinone compounds as anticancer agents and their potential mechanism

Engagement with tNOX (ENOX2) to Inhibit SIRT1 and Activate p53-Dependent and -Independent Apoptotic Pathways by Novel 4,11-Diaminoanthra[2,3-b]furan-5,10-diones in Hepatocellular Carcinoma Cells

(2019) Chia-Yang Lin et al.   Cancers

Novel Anthraquinone Compounds Induce Cancer Cell Death through Paraptosis

(2019) Wei Tian et al.   ACS Medicinal Chemistry Letters

Host−guest complexation-mediated codelivery of anticancer drug and photosensitizer for cancer photochemotherapy

(2019) Guocan Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design and Synthesis of Novel Anti-Proliferative Emodin Derivatives and Studies on their Cell Cycle Arrest, Apoptosis Pathway and Migration

(2019) Kun Yang et al.   MOLECULES

Development of Anthraquinone Analogues as Phosphoglycerate Mutase 1 Inhibitors

(2019) Ke Huang et al.   MOLECULES

Synthesis, FT-IR and NMR Characterization, Antimicrobial Activity, Cytotoxicity and DNA Docking Analysis of a New Anthraquinone Derivate Compound

(2019) Sefa Celik et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

New anthra[2,3-b]furancarboxamides: A role of positioning of the carboxamide moiety in antitumor properties

(2019) Yulia L. Volodina et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of various quinizarin derivatives as potential anticancer agents in acute T lymphoblastic leukemia

(2019) Xiufang Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment

(2019) Ke Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Analysis of interactions between calf thymus DNA and 1,5-di(piperazin-1-yl)anthracene-9,10-dione using spectroscopic and electrochemical methods

(2019) Wioleta Białobrzeska et al.   JOURNAL OF MOLECULAR LIQUIDS

Three‐Component Synthesis of Tetrazolo Anthraquinone as a Representation of a New Heterocyclic System

(2019) Zahra Aelami et al.   ChemistrySelect

An autophagy-dependent cell death of MDA-MB-231 cells triggered by a novel Rhein derivative 4F

(2019) Yunfeng Liu et al.   ANTI-CANCER DRUGS

In situ reactivity of electrochemically generated semiquinone on Emodin and its CuII/MnII complexes with pyrimidine based nucleic acid bases and calf thymus DNA: Insight into free radical induced cytotoxicity of anthracyclines

(2019) Bitapi Mandal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

From DNA Sequencing to Clinical Trials: Finding New Targeted Drugs for Acute Myeloid Leukemia

(2019) Musa Yilmaz et al.   DRUGS

Small-molecule compounds target paraptosis to improve cancer therapy

(2019) Yujia Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Innovative Strategies for Hypoxic-Tumor Photodynamic Therapy

(2018) Xingshu Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modulating autophagy in cancer therapy: Advancements and challenges for cancer cell death sensitization

(2018) Punya Bhat et al.   BIOCHEMICAL PHARMACOLOGY

Development and MPI tracking of novel hypoxia-targeted theranostic exosomes

(2018) Kyung Oh Jung et al.   BIOMATERIALS

Physcion 8-O-β-glucopyranoside inhibits clear-cell renal cell carcinoma bydownregulating hexokinase II and inhibiting glycolysis

(2018) Qiang Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Highly selective anthraquinone-chalcone hybrids as potential antileukemia agents

(2018) Tatjana Stanojković et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyrrolidine dithiocarbamate reverses Bcl-xL-mediated apoptotic resistance to doxorubicin by inducing paraptosis

(2018) Seok Soon Park et al.   CARCINOGENESIS

Nucleus-targeted DNA tetrahedron as a nanocarrier of metal complexes for enhanced glioma therapy

(2018) Yiqiao Tian et al.   CHEMICAL COMMUNICATIONS

Supramolecular photosensitizers rejuvenate photodynamic therapy

(2018) Xingshu Li et al.   CHEMICAL SOCIETY REVIEWS

1-Hydroxy-3-[( E )-4-(piperazine-diium)but-2-enyloxy]-9,10-anthraquinone ditrifluoroactate induced autophagic cell death in human PC3 cells

(2018) A-Mei Huang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Multiply Intercalator-Substituted Cu(II) Cyclen Complexes as DNA Condensers and DNA/RNA Synthesis Inhibitors

(2018) Jan Hormann et al.   INORGANIC CHEMISTRY

Comparative studies on DNA-binding and in vitro antitumor activity of enantiomeric ruthenium(II) complexes

(2018) Wen-Xu Hong et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

IMGN779, a Novel CD33-Targeting Antibody–Drug Conjugate with DNA-Alkylating Activity, Exhibits Potent Antitumor Activity in Models of AML

(2018) Yelena Kovtun et al.   MOLECULAR CANCER THERAPEUTICS

The autophagic network and cancer

(2018) Marissa D. Rybstein et al.   NATURE CELL BIOLOGY

BPIFB1 (LPLUNC1) inhibits radioresistance in nasopharyngeal carcinoma by inhibiting VTN expression

(2018) Fang Wei et al.   Cell Death & Disease

An updated overview on the development of new photosensitizers for anticancer photodynamic therapy

(2018) Juan Zhang et al.   Acta Pharmaceutica Sinica B

Tri-armed ligands of G-quadruplex on heteroarene-fused anthraquinone scaffolds: Design, synthesis and pre-screening of biological properties

(2018) Alexander S. Tikhomirov et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and electrochemical, spectral, and biological evaluation of novel 9,10-anthraquinone derivatives containing piperidine unit as potent antiproliferative agents

(2018) Paweł Niedziałkowski et al.   JOURNAL OF MOLECULAR STRUCTURE

Autophagy maintains tumour growth through circulating arginine

(2018) Laura Poillet-Perez et al.   NATURE

Danthron suppresses autophagy and sensitizes pancreatic cancer cells to doxorubicin

(2018) Hua Chen et al.   TOXICOLOGY IN VITRO

A novel Rhein derivative: Activation of Rac1/NADPH pathway enhances sensitivity of nasopharyngeal carcinoma cells to radiotherapy

(2018) Zhengying Su et al.   CELLULAR SIGNALLING

Synthesis, SAR and pharmacological characterization of novel anthraquinone cation compounds as potential anticancer agents

(2017) Yanyan Zheng et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of emodin derivatives as novel inhibitors of ATP-citrate lyase

(2017) Steffi K. Koerner et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Molecular Modeling of Thermally Stable DNA G-Quadruplexes with Anthraquinone Insertions

(2017) Alaa S. Gouda et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

A ruthenium(II) anthraquinone complex as the theranostic agent combining hypoxia imaging and HIF-1α inhibition

(2017) Jinquan Wang et al.   INORGANICA CHIMICA ACTA

The use of functional epirubicin liposomes to induce programmed death in refractory breast cancer

(2017) Lei Liu et al.   International Journal of Nanomedicine

Model studies on the interactions of a Cu(II)-quinone complex with surfactant micelles and DNA explore its induction of apoptosis in human MDA-MB-231 breast adenocarcinoma cells

(2017) Sanjay Roy et al.   JOURNAL OF COORDINATION CHEMISTRY

Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/Akt signaling pathway in gastric cancer

(2017) Jiahui Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Interaction of anthraquinone anti-cancer drugs with DNA:Experimental and computational quantum chemical study

(2017) Jamelah S. Al-Otaibi et al.   JOURNAL OF MOLECULAR STRUCTURE

Mitoxantrone, etoposide and cytarabine following epigenetic priming with decitabine in adults with relapsed/refractory acute myeloid leukemia or other high-grade myeloid neoplasms: a phase 1/2 study

(2017) A B Halpern et al.   LEUKEMIA

Inhibition of MDM2 by a Rhein-Derived Compound AQ-101 Suppresses Cancer Development in SCID Mice

(2017) Lubing Gu et al.   MOLECULAR CANCER THERAPEUTICS

Dual role of autophagy in hallmarks of cancer

(2017) Shikha Satendra Singh et al.   ONCOGENE

CuII complex of emodin with improved anticancer activity as demonstrated by its performance on HeLa and Hep G2 cells

(2017) Bitapi Mandal et al.   RSC Advances

Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells

(2016) Qi Xu et al.   BIOMEDICINE & PHARMACOTHERAPY

Phosphoglycerate mutase 1 promotes cancer cell migration independent of its metabolic activity

(2016) D Zhang et al.   ONCOGENE

Radiation enhances the therapeutic effect of Banoxantrone in hypoxic tumour cells with elevated levels of nitric oxide synthase

(2016) MANAL MEHIBEL et al.   ONCOLOGY REPORTS

Paraptosis in the anti-cancer arsenal of natural products

(2016) Dongjoo Lee et al.   PHARMACOLOGY & THERAPEUTICS

Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2

(2015) Yan-tao Han et al.   ACTA PHARMACOLOGICA SINICA

Cytotoxicity of anthraquinones from the roots of Pentas schimperi towards multi-factorial drug-resistant cancer cells

(2015) Victor Kuete et al.   INVESTIGATIONAL NEW DRUGS

Review of aerobic glycolysis and its key enzymes - new targets for lung cancer therapy

(2015) Xue-bing Li et al.   Thoracic Cancer

A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathway

(2014) Jui-Ling Hsu et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The role of phosphoglycerate mutase 1 in tumor aerobic glycolysis and its potential therapeutic implications

(2013) Xiangli Jiang et al.   INTERNATIONAL JOURNAL OF CANCER

3-Bromo-1-Hydroxy-9,10-Anthraquinone (BHAQ) Inhibits Growth and Migration of the Human Breast Cancer Cell Lines MCF-7 and MDA-MB231

(2013) Nadiah Abu et al.   MOLECULES

SZ-685C exhibits potent anticancer activity in both radiosensitive and radioresistant NPC cells through the miR-205-PTEN-Akt pathway

(2013) DUJUAN WANG et al.   ONCOLOGY REPORTS

Design, Synthesis, and Initial Biological Evaluation of a Steroidal Anti-Estrogen–Doxorubicin Bioconjugate for Targeting Estrogen Receptor-Positive Breast Cancer Cells

(2012) Kinh-Luan Dao et al.   BIOCONJUGATE CHEMISTRY

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

(2012) Taro Hitosugi et al.   CANCER CELL

Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors

(2012) Xia Ke et al.   CARCINOGENESIS

Targeting glucose metabolism for cancer therapy: Figure 1.

(2012) Robert B. Hamanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glucose metabolism in cancer cells

(2010) Alessandro Annibaldi et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

(2010) M. G. Vander Heiden et al.   SCIENCE

Cancer Cell Metabolism: Warburg and Beyond

(2008) Peggy P. Hsu et al.   CELL