Design, synthesis and anti-inflammatory evaluation of aloe-emodin derivatives as potential modulators of Akt, NF-κB and JNK signaling pathways

Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities

(2022) Wang Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, and tumor drug resistance reversal activity of novel hederagenin derivatives modified by nitrogen-containing heterocycles

(2022) Wentao Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Aloe-emodin-loaded SBA-15 and its in vitro release properties and cytotoxicity to cervical cancer cells

(2020) Suman Jangra et al.   MATERIALS RESEARCH INNOVATIONS

Nitrogen-containing naringenin derivatives for reversing multidrug resistance in cancer

(2020) Ricardo J. Ferreira et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Nitrogen-containing derivatives of O-tetramethylquercetin: Synthesis and biological profiles in prostate cancer cell models

(2019) Pravien Rajaram et al.   BIOORGANIC CHEMISTRY

Synthesis of novel andrographolide beckmann rearrangement derivatives and evaluation of their HK2-related anti-inflammatory activities

(2019) Wang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel resveratrol-based flavonol derivatives: Synthesis and anti-inflammatory activity in vitro and in vivo

(2019) Liu Zeng Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Aloe‐emodin: A review of its pharmacology, toxicity, and pharmacokinetics

(2019) Xiaoxv Dong et al.   PHYTOTHERAPY RESEARCH

Aloe-emodin ameliorates renal fibrosis via inhibiting PI3K/Akt/mTOR signaling pathway in vivo and in vitro

(2018) Fang Dou et al.   REJUVENATION RESEARCH

Design, synthesis and biological evaluation of nitrogen-containing macrocyclic bisbibenzyl derivatives as potent anticancer agents by targeting the lysosome

(2017) Bin Sun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New arylpyrazoline-coumarins: Synthesis and anti-inflammatory activity

(2017) Liu Zeng Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities

(2017) Jawaid Akhtar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of novel sesquistilbene indanone analogues as potent anti-inflammatory agents

(2016) Mei-Lin Tang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Research advances for the extraction, analysis and uses of anthraquinones: A review

(2016) Johanna Duval et al.   INDUSTRIAL CROPS AND PRODUCTS

Synthesis and biological evaluation of bufalin-3-yl nitrogen-containing-carbamate derivatives as anticancer agents

(2016) Min Lei et al.   STEROIDS

Anti-inflammatory activity and molecular mechanism of delphinidin 3-sambubioside, aHibiscusanthocyanin

(2015) Takayuki Sogo et al.   BIOFACTORS

Aloe-emodin exerts a potent anticancer and immunomodulatory activity on BRAF-mutated human melanoma cells

(2015) Claudio Tabolacci et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antiviral activity of aloe-emodin against influenza A virus via galectin-3 up-regulation

(2014) Shih-Wen Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Aloe-emodin from rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages

(2014) Boyang Hu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Isolation of antiplasmodial anthraquinones from Kniphofia ensifolia, and synthesis and structure–activity relationships of related compounds

(2013) Yumin Dai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and structure–activity relationships study of cytotoxic bufalin 3-nitrogen-containing-ester derivatives

(2013) Biao Ma et al.   STEROIDS

Renal safety of Non Steroidal Anti Inflammatory Drugs (NSAIDs) in the pharmacologic treatment of patent ductus arteriosus

(2012) Vassilios Fanos et al.   Journal of Maternal-Fetal & Neonatal Medicine

Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-κB

(2011) Priya Suboj et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evaluation of Aloin and Aloe-Emodin as Anti-Inflammatory Agents in Aloe by Using Murine Macrophages

(2009) Mi-Young PARK et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Obesity, the PI3K/Akt signal pathway and colon cancer

(2009) X-F. Huang et al.   Obesity Reviews

Design, synthesis and characterization of novel 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives as inhibitors of NF-κB and AP-1 mediated transcription activation and as potential anti-inflammatory agents

(2008) Rajan S. Giri et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY