Design, synthesis and anti‐inflammatory study of novel N‐heterocyclic substituted Aloe‐emodin derivatives

Synthesis, anti-inflammatory, cytotoxic, and COX-1/2 inhibitory activities of cyclic imides bearing 3-benzenesulfonamide, oxime, and β-phenylalanine scaffolds: a molecular docking study

(2020) Alaa A.-M. Abdel-Aziz et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Pharmacological Update Properties of Aloe Vera and its Major Active Constituents

(2020) Marta Sánchez et al.   MOLECULES

Design, synthesis and evaluation of novel 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as potent, selective and reversible Bruton's tyrosine kinase (BTK) inhibitors for the treatment of rheumatoid arthritis

(2019) Chufeng Zhang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Anti-tumor effect of aloe-emodin on cervical cancer cells was associated with human papillomavirus E6/E7 and glucose metabolism

(2019) Rui Gao et al.   OncoTargets and Therapy

Antiglycation Activity and HT-29 Cellular Uptake of Aloe-Emodin, Aloin, and Aloe arborescens Leaf Extracts

(2019) Guglielmina Froldi et al.   MOLECULES

A Phase I Trial of Berberine in Chinese with Ulcerative Colitis

(2019) Li Xu et al.   Cancer Prevention Research

NF-κB and Nrf2 pathways contribute to the protective effect of Licochalcone A on dextran sulphate sodium-induced ulcerative colitis in mice

(2018) Dongyu Liu et al.   BIOMEDICINE & PHARMACOTHERAPY

Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate

(2018) Benaïssa Boubia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ulcerative colitis

(2017) Ryan Ungaro et al.   LANCET

Analysis of the pharmacokinetics and metabolism of aloe-emodin following intravenous and oral administrations in rats

(2016) Chung-Ping Yu et al.   BIOMEDICAL CHROMATOGRAPHY

Aloe-Emodin Protects RIN-5F (Pancreatic β-cell) Cell from Glucotoxicity via Regulation of Pro-Inflammatory Cytokine and Downregulation of Bax and Caspase 3

(2016) Ali A Alshatwi et al.   Biomolecules & Therapeutics

Development and mechanism investigation of a new piperlongumine derivative as a potent anti-inflammatory agent

(2015) Lan-Di Sun et al.   BIOCHEMICAL PHARMACOLOGY

Activity-Guided Chemo Toxic Profiling of Cassia occidentalis (CO) Seeds: Detection of Toxic Compounds in Body Fluids of CO-Exposed Patients and Experimental Rats

(2015) Gati Krushna Panigrahi et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Potential Antineoplastic Effects of Aloe-emodin: A Comprehensive Review

(2014) Ruie Chen et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Synthesis and Antitumor Activity of Natural Compound Aloe Emodin Derivatives

(2014) Naraganahalli R. Thimmegowda et al.   Chemical Biology & Drug Design

Effect of the Piperazine Unit and Metal-Binding Site Position on the Solubility and Anti-Proliferative Activity of Ruthenium(II)- and Osmium(II)- Arene Complexes of Isomeric Indolo[3,2-c]quinoline—Piperazine Hybrids

(2014) Lukas K. Filak et al.   INORGANIC CHEMISTRY

Aloe-emodin from rhubarb (Rheum rhabarbarum) inhibits lipopolysaccharide-induced inflammatory responses in RAW264.7 macrophages

(2014) Boyang Hu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Risks of Inflammatory Bowel Disease Treatment with Glucocorticosteroids and Aminosalicylates

(2013) Ivanka Curkovic et al.   DIGESTIVE DISEASES

Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2

(2012) Kangdong Liu et al.   CARCINOGENESIS

Hepatotoxicity or Hepatoprotection? Pattern Recognition for the Paradoxical Effect of the Chinese Herb Rheum palmatum L. in Treating Rat Liver Injury

(2011) Jia-bo Wang et al.   PLoS One

Role of Human Liver Microsomes in In Vitro Metabolism of Drugs—A Review

(2009) Sepuri Asha et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY