A novel brick on the wall of non-alcoholic fatty liver disease (NAFLD): Nuclear receptor coactivator 4 (NCOA4)

JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy

(2023) Kai Sun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Overexpression of Hepcidin Alleviates Steatohepatitis and Fibrosis in a Diet-induced Nonalcoholic Steatohepatitis

(2022) Hui Chen et al.   Journal of Clinical and Translational Hepatology

A critical evaluation of the role of iron overload in fatty liver disease

(2022) Monique Fernandez et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Mineral metabolism and ferroptosis in non-alcoholic fatty liver diseases

(2022) Chenhui Ma et al.   BIOCHEMICAL PHARMACOLOGY

The role of iron metabolism in chronic diseases related to obesity

(2022) Fangyi Qiu et al.   MOLECULAR MEDICINE

Loss of COPZ1 induces NCOA4 mediated autophagy and ferroptosis in glioblastoma cell lines

(2021) Yulin Zhang et al.   ONCOGENE

Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP/NCOA4 in non‐alcoholic fatty liver disease

(2021) Xiaoyu Qi et al.   CELL PROLIFERATION

Iron overload inhibits BMP/SMAD and IL-6/STAT3 signaling to hepcidin in cultured hepatocytes

(2021) Edouard Charlebois et al.   PLoS One

The iron chaperone and nucleic acid–binding activities of poly(rC)-binding protein 1 are separable and independently essential

(2021) Sarju J. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NCOA4 Expression in Hepatic Cells Is Upregulated Under Physiological and Pathophysiological Conditions Associated with Hypoxia

(2020) Xiuqi Li et al.   BLOOD

Dysmetabolic hyperferritinemia and dysmetabolic iron overload syndrome (DIOS): two related conditions or different entities?

(2020) Raffaela Rametta et al.   CURRENT PHARMACEUTICAL DESIGN

H 2 O 2 induces oxidative stress damage through the BMP‐6/SMAD/hepcidin axis

(2020) Li Chen et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Iron metabolism and iron disorders revisited in the hepcidin era

(2020) Clara Camaschella et al.   HAEMATOLOGICA

Iron Metabolism in Obesity and Metabolic Syndrome

(2020) Álvaro González-Domínguez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis

(2020) Dominik C. Fuhrmann et al.   Redox Biology

Cell‐type‐specific insights into iron regulatory processes

(2020) Katarzyna Mleczko‐Sanecka et al.   AMERICAN JOURNAL OF HEMATOLOGY

Extrahepatic hepcidin production: The intriguing outcomes of recent years

(2019) Raêd Daher et al.   World Journal of Clinical Cases

Endothelial Bmp2 knockout exacerbates hemochromatosis in Hfe knockout mice but not Bmp6 knockout mice

(2019) Xia Xiao et al.   HEPATOLOGY

Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3

(2019) Chia-Yu Wang et al.   BLOOD

Erythropoietic regulators of iron metabolism

(2018) Tomas Ganz   FREE RADICAL BIOLOGY AND MEDICINE

Pathways underlying iron accumulation in human nonalcoholic fatty liver disease

(2018) Elmar Aigner et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells

(2018) Zili Zhang et al.   Autophagy

JNK facilitates IL-1β-induced hepcidin transcription via JunB activation

(2018) Yohei Kanamori et al.   CYTOKINE

Transient decrease of serum iron after acute erythropoietin treatment contributes to hepcidin inhibition by ERFE in mice

(2018) Irene Artuso et al.   HAEMATOLOGICA

Interleukin-1β (IL-1β) transcriptionally activates hepcidin by inducing CCAAT enhancer-binding protein δ (C/EBPδ) expression in hepatocytes

(2017) Yohei Kanamori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysmetabolic iron overload syndrome (DIOS)

(2017) Yves Deugnier et al.   PRESSE MEDICALE

Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice

(2016) Susanna Canali et al.   BLOOD

Intracellular labile iron determines H 2 O 2 -induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis

(2016) M.D. Mantzaris et al.   FREE RADICAL BIOLOGY AND MEDICINE

NCOA4 Deficiency Impairs Systemic Iron Homeostasis

(2016) Roberto Bellelli et al.   Cell Reports

Hepcidin and its potential clinical utility

(2015) Attila Miseta et al.   CELL BIOLOGY INTERNATIONAL

Nonalcoholic Fatty Liver Disease Review: Diagnosis, Treatment, and Outcomes

(2015) Aijaz Ahmed et al.   Clinical Gastroenterology and Hepatology

Iron, oxidative stress, and redox signaling in the cardiovascular system

(2014) Aurélie Gudjoncik et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

DNA Methylation Analysis in Nonalcoholic Fatty Liver Disease Suggests Distinct Disease-Specific and Remodeling Signatures after Bariatric Surgery

(2013) Markus Ahrens et al.   Cell Metabolism

Hepcidin Is Directly Regulated by Insulin and Plays an Important Role in Iron Overload in Streptozotocin-Induced Diabetic Rats

(2013) Heyang Wang et al.   DIABETES

Expression and function of nuclear receptor co-activator 4: evidence of a potential role independent of co-activator activity

(2012) Alexandra Kollara et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Genetic Polymorphisms of the Human PNPLA3 Gene Are Strongly Associated with Severity of Non-Alcoholic Fatty Liver Disease in Japanese

(2012) Takahisa Kawaguchi et al.   PLoS One

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats

(2011) I. Theurl et al.   BLOOD

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

(2011) A. U. Steinbicker et al.   BLOOD

Iron in fatty liver and in the metabolic syndrome: A promising therapeutic target

(2011) Paola Dongiovanni et al.   JOURNAL OF HEPATOLOGY

Hepcidin and Disorders of Iron Metabolism

(2010) Tomas Ganz et al.   Annual Review of Medicine

Two to Tango: Regulation of Mammalian Iron Metabolism

(2010) Matthias W. Hentze et al.   CELL

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY

Contribution of STAT3 and SMAD4 pathways to the regulation of hepcidin by opposing stimuli

(2009) H. Huang et al.   BLOOD

Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes

(2009) G. Ramey et al.   HAEMATOLOGICA

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

(2008) L. Kautz et al.   BLOOD

The Transferrin Receptor Modulates Hfe-Dependent Regulation of Hepcidin Expression

(2008) Paul J. Schmidt et al.   Cell Metabolism

Factors accounting for high ferritin levels in obesity

(2008) A Lecube et al.   INTERNATIONAL JOURNAL OF OBESITY