JNK-JUN-NCOA4 axis contributes to chondrocyte ferroptosis and aggravates osteoarthritis via ferritinophagy

Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression

(2022) Yu Miao et al.   EBioMedicine

Intrinsic disorder in proteins associated with oxidative stress-induced JNK signaling

(2022) Bhuvaneshwari R. Gehi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition

(2022) Laura Mahoney-Sanchez et al.   Cell Reports

NCOA4-mediated ferritinophagy is involved in ionizing radiation-induced ferroptosis of intestinal epithelial cells

(2022) Hao Zhou et al.   Redox Biology

Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus

(2021) Longmin Chen et al.   CELL DEATH AND DIFFERENTIATION

Iron Overload Is Associated With Accelerated Progression of Osteoarthritis: The Role of DMT1 Mediated Iron Homeostasis

(2021) Xingzhi Jing et al.   Frontiers in Cell and Developmental Biology

Distinct Effects of Escherichia coli,Pseudomonas aeruginosa and Staphylococcus aureus Cell Wall Component-Induced Inflammation on the Iron Metabolism of THP-1 Cells

(2021) Edina Pandur et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The detrimental effect of iron on OA chondrocytes: Importance of pro‐inflammatory cytokines induced iron influx and oxidative stress

(2021) Xingzhi Jing et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1

(2021) Shuying Shen et al.   ANNALS OF THE RHEUMATIC DISEASES

HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration

(2021) Zhimin Tang et al.   Redox Biology

Iron homeostasis in arthropathies: From pathogenesis to therapeutic potential

(2021) Kai Sun et al.   AGEING RESEARCH REVIEWS

Recent Advances in c-Jun N-terminal Kinase (JNK) Inhibitors

(2020) Gang Li et al.   CURRENT MEDICINAL CHEMISTRY

Molecular Processes in Chondrocyte Biology

(2020) Toshihisa Komori   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Systemic iron overload exacerbates osteoarthritis in the strain 13 guinea pig

(2020) L.H. Burton et al.   OSTEOARTHRITIS AND CARTILAGE

Mitophagy in degenerative joint diseases

(2020) Kai Sun et al.   Autophagy

Ferroptosis: machinery and regulation

(2020) Xin Chen et al.   Autophagy

Involvement of oxidative stress‐induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis

(2020) Run‐Ze Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

Chondrocyte ferroptosis contribute to the progression of osteoarthritis

(2020) Xudong Yao et al.   Journal of Orthopaedic Translation

Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis

(2019) Masahiro Yoshida et al.   Nature Communications

Hyperferritinemia and inflammation

(2017) Kate F Kernan et al.   INTERNATIONAL IMMUNOLOGY

Reduced Osteoarthritis Severity in Aged Mice With Deletion of Macrophage Migration Inhibitory Factor

(2017) Meredith A. Rowe et al.   Arthritis & Rheumatology

Inhibition of BATF/JUN transcriptional activity protects against osteoarthritic cartilage destruction

(2016) Jinseol Rhee et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Using mouse models to investigate the pathophysiology, treatment, and prevention of post-traumatic osteoarthritis

(2016) Carina L. Blaker et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

(2016) Alexander R. Bogdan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Age-dependent ferritin elevations and HFE C282Y mutation as risk factors for symptomatic knee osteoarthritis in males: a longitudinal cohort study

(2014) Lauren Kennish et al.   BMC MUSCULOSKELETAL DISORDERS

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee

(2011) J.S. Lewis et al.   OSTEOARTHRITIS AND CARTILAGE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE