Iron overload inhibits BMP/SMAD and IL-6/STAT3 signaling to hepcidin in cultured hepatocytes

Iron overload induces apoptosis of osteoblast cells via eliciting ER stress-mediated mitochondrial dysfunction and p-eIF2α/ATF4/CHOP pathway in vitro

(2021) Jingmin Che et al.   CELLULAR SIGNALLING

H 2 O 2 induces oxidative stress damage through the BMP‐6/SMAD/hepcidin axis

(2020) Li Chen et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Basics and principles of cellular and systemic iron homeostasis

(2020) Angeliki Katsarou et al.   MOLECULAR ASPECTS OF MEDICINE

Iron homeostasis and oxidative stress: An intimate relationship

(2019) Dimitrios Galaris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3

(2019) Chia-Yu Wang et al.   BLOOD

Hepcidin-mediated hypoferremic response to acute inflammation requires a threshold of Bmp6/Hjv/Smad signaling

(2018) Carine Fillebeen et al.   BLOOD

Liver iron sensing and body iron homeostasis

(2018) Chia-Yu Wang et al.   BLOOD

Iron homeostasis: An anthropocentric perspective

(2017) Richard Coffey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hamp1 but not Hamp2 regulates ferroportin in fish with two functionally distinct hepcidin types

(2017) João V. Neves et al.   Scientific Reports

Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice

(2016) Susanna Canali et al.   BLOOD

Angiocrine Bmp2 signaling in murine liver controls normal iron homeostasis

(2016) Philipp-Sebastian Koch et al.   BLOOD

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

(2016) Agnieszka Loboda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inductively coupled mass spectrometry analysis of biometals in conditional Hamp1 and Hamp1 and Hamp2 transgenic mouse models

(2015) S. Lu et al.   TRANSGENIC RESEARCH

The type I BMP receptor Alk3 is required for the induction of hepatic hepcidin gene expression by interleukin-6

(2014) C. Mayeur et al.   BLOOD

Systemic Iron Homeostasis

(2013) Tomas Ganz   PHYSIOLOGICAL REVIEWS

Interleukin-6 and Lipopolysaccharide Modulate Hepcidin mRNA Expression by Hepg2 Cells

(2012) Pia Villarroel et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

The biology and mechanism of action of suppressor of cytokine signaling 3

(2012) Jeffrey J. Babon et al.   GROWTH FACTORS

Differences in activation of mouse hepcidin by dietary iron and parenterally administered iron dextran: compartmentalization is critical for iron sensing

(2012) Alina Daba et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Regulation of cellular iron metabolism

(2011) Jian Wang et al.   BIOCHEMICAL JOURNAL

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

(2011) Emilio Ramos et al.   HEPATOLOGY

Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice

(2011) Elena Corradini et al.   HEPATOLOGY

Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage

(2010) Paolo Arosio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Rapid Activation of Glutamate Cysteine Ligase following Oxidative Stress

(2010) Cecile M. Krejsa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iron inhibits replication of infectious hepatitis C virus in permissive Huh7.5.1 cells

(2010) Carine Fillebeen et al.   JOURNAL OF HEPATOLOGY

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

(2008) L. Kautz et al.   BLOOD