Extrahepatic hepcidin production: The intriguing outcomes of recent years

Predominant role of microglia in brain iron retention in Sanfilippo syndrome, a pediatric neurodegenerative disease

(2018) Vincent Puy et al.   GLIA

Involvement of hepcidin in iron metabolism dysregulation in Gaucher disease

(2018) Thibaud Lefebvre et al.   HAEMATOLOGICA

Hepcidin, an emerging and important player in brain iron homeostasis

(2018) Driton Vela   Journal of Translational Medicine

Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk

(2018) De-Liang Zhang et al.   SCIENCE

Involvement of hepcidin in iron metabolism dysregulation in Gaucher disease

(2018) Thibaud Lefebvre et al.   HAEMATOLOGICA

Balance of cardiac and systemic hepcidin and its role in heart physiology and pathology

(2017) Driton Vela   LABORATORY INVESTIGATION

Expression of hepcidin and ferroportin in full term placenta of pregnant cows

(2017) Sante Roperto et al.   THERIOGENOLOGY

Quantification of hepcidin-25 in human cerebrospinal fluid using LC–MS/MS

(2017) Constance Delaby et al.   Bioanalysis

Astrocyte hepcidin is a key factor in LPS-induced neuronal apoptosis

(2017) Lin-Hao You et al.   Cell Death & Disease

Pulmonary Iron Homeostasis in Hepcidin Knockout Mice

(2017) Jean-Christophe Deschemin et al.   Frontiers in Physiology

Hepcidin upregulation by inflammation is independent of Smad1/5/8 signaling by activin B

(2016) Céline Besson-Fournier et al.   BLOOD

Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice

(2016) A. Nai et al.   BLOOD

Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice

(2016) Susanna Canali et al.   ENDOCRINOLOGY

Heterozygous BMP6 Variants Coupled With HFE Variants

(2016) Patricia Bignell et al.   GASTROENTEROLOGY

Bone Morphogenetic Protein-6 Mutations Take Their Place in Iron Overload Diseases

(2016) Mark D. Kleven et al.   GASTROENTEROLOGY

The p.Leu96Pro Missense Mutation in the BMP6 Gene Is Repeatedly Associated With Hyperferritinemia in Patients of French Origin

(2016) Gérald Le Gac et al.   GASTROENTEROLOGY

Heterozygous Mutations in BMP6 Pro-peptide Lead to Inappropriate Hepcidin Synthesis and Moderate Iron Overload in Humans

(2016) Raed Daher et al.   GASTROENTEROLOGY

Hepcidin knockout mice spontaneously develop chronic pancreatitis owing to cytoplasmic iron overload in acinar cells

(2016) Mariia Lunova et al.   JOURNAL OF PATHOLOGY

An essential cell-autonomous role for hepcidin in cardiac iron homeostasis

(2016) Samira Lakhal-Littleton et al.   eLife

Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

(2015) Marian Valko et al.   ARCHIVES OF TOXICOLOGY

Expression and cellular localization of hepcidin mRNA and protein in normal rat brain

(2015) Ruma Raha-Chowdhury et al.   BMC NEUROSCIENCE

Hepcidin Regulation in Prostate and Its Disruption in Prostate Cancer

(2015) Lia Tesfay et al.   CANCER RESEARCH

LC-MS/MS method for hepcidin-25 measurement in human and mouse serum: clinical and research implications in iron disorders

(2015) Thibaud Lefebvre et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Hepcidin as a Major Component of Renal Antibacterial Defenses against Uropathogenic Escherichia coli

(2015) D. Houamel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function

(2015) Samira Lakhal-Littleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity Promotes Alterations in Iron Recycling

(2015) Marta Citelli et al.   Nutrients

High Fat Diet Subverts Hepatocellular Iron Uptake Determining Dysmetabolic Iron Overload

(2015) Paola Dongiovanni et al.   PLoS One

Bone Morphogenetic Proteins as Regulators of Iron Metabolism

(2014) Nermi L. Parrow et al.   Annual Review of Nutrition

Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype

(2014) S. Zumerle et al.   BLOOD

Resistance of Ferroportin to Hepcidin Binding causes Exocrine Pancreatic Failure and Fatal Iron Overload

(2014) Sandro Altamura et al.   Cell Metabolism

Mice That Are Fed a High-Fat Diet Display Increased Hepcidin Expression in Adipose Tissue

(2014) ^|^Eacute;rica Martins Ferreira GOTARDO et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Lipopolysaccharides Upregulate Hepcidin in Neuron via Microglia and the IL-6/STAT3 Signaling Pathway

(2014) Zhong-Ming Qian et al.   MOLECULAR NEUROBIOLOGY

The IRP/IRE system in vivo: insights from mouse models

(2014) Nicole Wilkinson et al.   Frontiers in Pharmacology

Iron refractory iron deficiency anemia

(2013) L. De Falco et al.   HAEMATOLOGICA

Hepcidin Induction by Pathogens and Pathogen-Derived Molecules Is Strongly Dependent on Interleukin-6

(2013) Richard Rodriguez et al.   INFECTION AND IMMUNITY

Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells

(2013) Pamela Urrutia et al.   JOURNAL OF NEUROCHEMISTRY

Hepcidin regulates intrarenal iron handling at the distal nephron

(2013) Boualem Moulouel et al.   KIDNEY INTERNATIONAL

Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling

(2012) C. Besson-Fournier et al.   BLOOD

Divalent Metal Transporter 1 Regulates Iron-Mediated ROS and Pancreatic β Cell Fate in Response to Cytokines

(2012) Jakob Bondo Hansen et al.   Cell Metabolism

Inactive matriptase-2 mutants found in IRIDA patients still repress hepcidin in a transfection assay despite having lost their serine protease activity

(2012) Flavia Guillem et al.   HUMAN MUTATION

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

(2012) Flavia D’Alessio et al.   JOURNAL OF HEPATOLOGY

High-fat diet causes iron deficiency via hepcidin-independent reduction of duodenal iron absorption

(2012) Thomas Sonnweber et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Hematological and acute-phase responses to diet-induced obesity in IL-6 KO mice

(2011) Maria Pini et al.   CYTOKINE

Intestinal DMT1 Cotransporter Is Down-regulated by Hepcidin via Proteasome Internalization and Degradation

(2011) Carole Brasse–Lagnel et al.   GASTROENTEROLOGY

Hepcidin is localised in gastric parietal cells, regulates acid secretion and is induced byHelicobacter pyloriinfection

(2011) Peggy Schwarz et al.   GUT

Dietary iron restriction or iron chelation protects from diabetes and loss of β-cell function in the obese (ob/ob lep−/−) mouse

(2010) Robert C. Cooksey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ferroportin 1 is expressed basolaterally in rat kidney proximal tubule cells and iron excess increases its membrane trafficking

(2010) Natascha A. Wolff et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hepcidin and iron species distribution inside the first-trimester human gestational sac

(2010) P. Evans et al.   MOLECULAR HUMAN REPRODUCTION

Presence of hepcidin-25 in biological fluids: Bile, ascitic and pleural fluids

(2010) Jayantha Arnold   WORLD JOURNAL OF GASTROENTEROLOGY

Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia

(2009) L. Silvestri et al.   BLOOD

Hepcidin Decreases Iron Transporter Expression in Vivo in Mouse Duodenum and Spleen and in Vitro in THP-1 Macrophages and Intestinal Caco-2 Cells

(2009) Bomee Chung et al.   JOURNAL OF NUTRITION

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

Iron Sequestration and Anemia of Inflammation

(2009) Tomas Ganz et al.   SEMINARS IN HEMATOLOGY

Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe

(2008) Jaya P. Gnana-Prakasam et al.   BIOCHEMICAL JOURNAL

Immunoassay for human serum hepcidin

(2008) T. Ganz et al.   BLOOD

Emergency Department Management of Meningitis and Encephalitis

(2008) Michael T. Fitch et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Pancreatic β-cells express hepcidin, an iron-uptake regulatory peptide

(2008) Hasan Kulaksiz et al.   JOURNAL OF ENDOCRINOLOGY

The iron regulatory hormone hepcidin reduces ferroportin 1 content and iron release in H9C2 cardiomyocytes

(2008) Xiao Hu Ge et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A Cytosolic Iron Chaperone That Delivers Iron to Ferritin

(2008) H. Shi et al.   SCIENCE

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE

Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells

(2007) T Chaston et al.   GUT