Lung Microbiome as a Treatable Trait in Chronic Respiratory Disorders

Microbiome and Asthma: Microbial Dysbiosis and the Origins, Phenotypes, Persistence, and Severity of Asthma

(2023) José Valverde-Molina et al.   Nutrients

Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary

(2023) Alvar Agustí et al.   EUROPEAN RESPIRATORY JOURNAL

Effectiveness of Proton-Pump Inhibitors in Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Randomized Controlled Trials

(2022) Fei Yu et al.   Frontiers in Medicine

The emerging role of the lung microbiome and its importance in non-small cell lung cancer diagnosis and treatment

(2022) Anna E.B. McLean et al.   LUNG CANCER

Oxylipin profile in saliva from patients with cystic fibrosis reveals a balance between pro-resolving and pro-inflammatory molecules

(2022) Vincenzo Carnovale et al.   Scientific Reports

COPD and Gut–Lung Axis: How Microbiota and Host Inflammasome Influence COPD and Related Therapeutics

(2022) Ling Qu et al.   Frontiers in Microbiology

Pragmatic Expectancy on Microbiota and Non-Small Cell Lung Cancer: A Narrative Review

(2022) Giulia Maria Stella et al.   Cancers

Exploring the Role of Krebs von den Lungen-6 in Severe to Critical COVID-19 Patients

(2022) Vito D’Agnano et al.   Life-Basel

Microbial Dysregulation of the Gut-Lung Axis in Bronchiectasis

(2022) Jayanth Kumar Narayana et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The role of HMGB1/RAGE/TLR4 signaling pathways in cigarette smoke‐induced inflammation in chronic obstructive pulmonary disease

(2022) Ling Lin et al.   Immunity Inflammation and Disease

The dynamic lung microbiome in health and disease

(2022) Jake G. Natalini et al.   NATURE REVIEWS MICROBIOLOGY

Relationship Between COPD and GERD: A Bibliometrics Analysis

(2022) Menglong Zou et al.   International Journal of Chronic Obstructive Pulmonary Disease

Genetic Adaptation and Acquisition of Macrolide Resistance in Haemophilus spp. during Persistent Respiratory Tract Colonization in Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Long-Term Azithromycin Treatment

(2022) Anna Carrera-Salinas et al.   Microbiology Spectrum

Food, Nutrition, Physical Activity and Microbiota: Which Impact on Lung Cancer?

(2021) Ersilia Nigro et al.   International Journal of Environmental Research and Public Health

Lung Microbiome in Cystic Fibrosis

(2021) Filippo Scialo et al.   Life-Basel

Integrative microbiomics in bronchiectasis exacerbations

(2021) Micheál Mac Aogáin et al.   NATURE MEDICINE

Host-Microbiome Interaction in Lung Cancer

(2021) Qiang Dong et al.   Frontiers in Immunology

The Lung Microbiome during Health and Disease

(2021) Kazuma Yagi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pathogenesis of Children’s Allergic Diseases: Refocusing the Role of the Gut Microbiota

(2021) Tingting Hu et al.   Frontiers in Physiology

A systematic review with meta-analysis of gastroesophageal reflux disease and exacerbations of chronic obstructive pulmonary disease

(2020) Chunrong Huang et al.   BMC Pulmonary Medicine

Airway Microbiota as a Modulator of Lung Cancer

(2020) Taichiro Goto   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TAS2R38 is a novel modifier gene in patients with cystic fibrosis

(2020) Alice Castaldo et al.   Scientific Reports

The Microbiome in Cystic Fibrosis Pulmonary Disease

(2020) Alice Françoise et al.   Genes

Salivary Cytokines and Airways Disease Severity in Patients with Cystic Fibrosis

(2020) Alice Castaldo et al.   Diagnostics

Critical Relevance of Stochastic Effects on Low-Bacterial-Biomass 16S rRNA Gene Analysis

(2020) John R. Erb-Downward et al.   mBio

Implications of the Adiponectin System in Non-Small Cell Lung Cancer Patients: A Case-Control Study

(2020) Ersilia Nigro et al.   Biomolecules

Cystic fibrosis: Physiopathology and the latest pharmacological treatments

(2020) Carla Fonseca et al.   PHARMACOLOGICAL RESEARCH

The effects of cycled inhaled aztreonam on the cystic fibrosis (CF) lung microbiome

(2019) Alya A. Heirali et al.   Journal of Cystic Fibrosis

Lung Microbiota Contribute to Pulmonary Inflammation and Disease Progression in Pulmonary Fibrosis

(2019) David N O'Dwyer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cystic Fibrosis and Pseudomonas aeruginosa: the Host-Microbe Interface

(2019) Sankalp Malhotra et al.   CLINICAL MICROBIOLOGY REVIEWS

Immune Checkpoint Blockade for Advanced NSCLC: A New Landscape for Elderly Patients

(2019) Fabio Perrotta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microbes, metabolites, and the gut–lung axis

(2019) Anh Thu Dang et al.   Mucosal Immunology

Functional effects of the microbiota in chronic respiratory disease

(2019) Kurtis F Budden et al.   Lancet Respiratory Medicine

Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8+ T Cells

(2019) Annabell Bachem et al.   IMMUNITY

The microbiome in bronchiectasis

(2019) Hollian Richardson et al.   European Respiratory Review

Profiling of lung microbiota discloses differences in adenocarcinoma and squamous cell carcinoma

(2019) Sílvia Gomes et al.   Scientific Reports

Airway Microbiota Is Associated with Up-Regulation of the PI3K Pathway in Lung Cancer

(2018) Jun-Chieh J Tsay et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Early Origins of Asthma. Role of Microbial Dysbiosis and Metabolic Dysfunction

(2018) Fernando D. Martinez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Heterogeneity and the origins of asthma

(2018) Rebecca Scherzer et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Interplay between the lung microbiome and lung cancer

(2018) Qixing Mao et al.   CANCER LETTERS

Targeting immune checkpoints in non small cell lung cancer

(2018) Andrea Bianco et al.   CURRENT OPINION IN PHARMACOLOGY

Increased Small Intestinal Permeability during Severe Acute Exacerbations of COPD

(2018) Roy T.M. Sprooten et al.   RESPIRATION

Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity

(2018) Patrick A Flume et al.   LANCET

High HMGB1 levels in sputum are related to pneumococcal bacteraemia but not to disease severity in community-acquired pneumonia

(2018) Helena Alpkvist et al.   Scientific Reports

Early-Life Formation of the Microbial and Immunological Environment of the Human Airways

(2018) Céline Pattaroni et al.   Cell Host & Microbe

Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research

(2017) Adam T. Hill et al.   EUROPEAN RESPIRATORY JOURNAL

Long-term effects of inhaled corticosteroids on sputum bacterial and viral loads in COPD

(2017) Marco Contoli et al.   EUROPEAN RESPIRATORY JOURNAL

Anticancer effects of the microbiome and its products

(2017) Laurence Zitvogel et al.   NATURE REVIEWS MICROBIOLOGY

Microbiomes in respiratory health and disease: An Asia-Pacific perspective

(2017) Sanjay H. Chotirmall et al.   RESPIROLOGY

Longitudinal assessment of sputum microbiome by sequencing of the 16S rRNA gene in non-cystic fibrosis bronchiectasis patients

(2017) Michael J. Cox et al.   PLoS One

Differences of lung microbiome in patients with clinically stable and exacerbated bronchiectasis

(2017) Min Kwang Byun et al.   PLoS One

The Early Development of Wheeze. Environmental Determinants and Genetic Susceptibility at 17q21

(2016) Georg J. Loss et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Airway Microbiota and the Implications of Dysbiosis in Asthma

(2016) Juliana Durack et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Corticosteroid therapy and airflow obstruction influence the bronchial microbiome, which is distinct from that of bronchoalveolar lavage in asthmatic airways

(2016) Darcy R. Denner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The respiratory tract microbiome and lung inflammation: a two-way street

(2016) G B Huffnagle et al.   Mucosal Immunology

Analysis of Lung Microbiota in Bronchoalveolar Lavage, Protected Brush and Sputum Samples from Subjects with Mild-To-Moderate Cystic Fibrosis Lung Disease

(2016) Deborah A. Hogan et al.   PLoS One

Airway acidification initiates host defense abnormalities in cystic fibrosis mice

(2016) V. S. Shah et al.   SCIENCE

Management of chronic obstructive pulmonary disease beyond the lungs

(2016) Lowie E G W Vanfleteren et al.   Lancet Respiratory Medicine

Pulmonary epithelial barrier function: some new players and mechanisms

(2015) Kieran Brune et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Infant Nasopharyngeal Microbiome Impacts Severity of Lower Respiratory Infection and Risk of Asthma Development

(2015) Shu Mei Teo et al.   Cell Host & Microbe

Adiponectin in Asthma: Implications for Phenotyping

(2015) Ersilia Nigro et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia

(2015) Tim J Schuijt et al.   GUT

Association between HMGB1 and COPD: A Systematic Review

(2015) Sebastiano Gangemi et al.   MEDIATORS OF INFLAMMATION

Insights into the respiratory tract microbiota of patients with cystic fibrosis during early Pseudomonas aeruginosa colonization

(2015) Marlène Keravec et al.   SpringerPlus

Lung microbiota across age and disease stage in cystic fibrosis

(2015) Bryan Coburn et al.   Scientific Reports

Polymicrobial airway bacterial communities in adult bronchiectasis patients

(2014) Paul Purcell et al.   BMC MICROBIOLOGY

Defining dysbiosis and its influence on host immunity and disease

(2014) Charisse Petersen et al.   CELLULAR MICROBIOLOGY

Current concepts of immune dysregulation in cystic fibrosis

(2014) N. Rieber et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management

(2014) Josep Roca et al.   Journal of Translational Medicine

The role of the microbiome in exacerbations of chronic lung diseases

(2014) Robert P Dickson et al.   LANCET

Lung Microbiota and Bacterial Abundance in Patients with Bronchiectasis when Clinically Stable and during Exacerbation

(2013) Michael M. Tunney et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of Azithromycin Maintenance Treatment on Infectious Exacerbations Among Patients With Non–Cystic Fibrosis Bronchiectasis

(2013) Josje Altenburg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical measures of disease in adult non-CF bronchiectasis correlate with airway microbiota composition

(2013) Geraint B Rogers et al.   THORAX

The role of the bacterial microbiome in lung disease

(2013) Robert P Dickson et al.   Expert Review of Respiratory Medicine

Activity of mannose-binding lectin in centenarians

(2012) Rossella Tomaiuolo et al.   AGING CELL

The Lung Tissue Microbiome in Chronic Obstructive Pulmonary Disease

(2012) Marc A. Sze et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Gut Microbiota Composition and Activity in Relation to Host Metabolic Phenotype and Disease Risk

(2012) Elaine Holmes et al.   Cell Metabolism

Morphology changes in human lung epithelial cells after exposure to diesel exhaust micron sub particles (PM1.0) and pollen allergens

(2012) V. Esposito et al.   ENVIRONMENTAL POLLUTION

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

(2012) Alejandro A. Pezzulo et al.   NATURE

The Lung Microbiome in Moderate and Severe Chronic Obstructive Pulmonary Disease

(2012) Alexa A. Pragman et al.   PLoS One

Direct sampling of cystic fibrosis lungs indicates that DNA-based analyses of upper-airway specimens can misrepresent lung microbiota

(2012) A. F. Goddard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decade-long bacterial community dynamics in cystic fibrosis airways

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bronchial Secretory Immunoglobulin A Deficiency Correlates With Airway Inflammation and Progression of Chronic Obstructive Pulmonary Disease

(2011) Vasiliy V. Polosukhin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Analysis of the Lung Microbiome in the “Healthy” Smoker and in COPD

(2011) John R. Erb-Downward et al.   PLoS One

Commensal Microflora Contribute to Host Defense Against Escherichia Coli Pneumonia Through Toll-Like Receptors

(2011) Lee-Wei Chen et al.   SHOCK

Immunity and bacterial colonisation in bronchiectasis

(2011) Deborah Whitters et al.   THORAX

Novel Synthetic, Salt-Resistant Analogs of Human Beta-Defensins 1 and 3 Endowed with Enhanced Antimicrobial Activity

(2010) O. Scudiero et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Interactions of airway epithelium with protease allergens in the allergic response

(2010) A. Jacquet   CLINICAL AND EXPERIMENTAL ALLERGY

A polymorphism in the 5’ UTR of the DEFB1 gene is associated with the lung phenotype in F508del homozygous Italian cystic fibrosis patients

(2010) Sergio Crovella et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Relationship between cystic fibrosis respiratory tract bacterial communities and age, genotype, antibiotics and Pseudomonas aeruginosa

(2010) Vanja Klepac-Ceraj et al.   ENVIRONMENTAL MICROBIOLOGY

Partitioning core and satellite taxa from within cystic fibrosis lung bacterial communities

(2010) Christopher J van der Gast et al.   ISME Journal

Pathogenesis of bronchiectasis

(2010) Paul King   Paediatric Respiratory Reviews

Disordered Microbial Communities in Asthmatic Airways

(2010) Markus Hilty et al.   PLoS One

Respiratory burst function of ovine neutrophils

(2009) John-Paul Tung et al.   BMC IMMUNOLOGY