肿瘤相关的三级淋巴结构的检测和量化分析

Prognostic value, DNA variation and immunologic features of a tertiary lymphoid structure-related chemokine signature in clear cell renal cell carcinoma

(2022) Wenhao Xu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures

(2022) Ricardo A. Chaurio et al.   IMMUNITY

Tertiary lymphoid structures in cancer

(2022) Ton N. Schumacher et al.   SCIENCE

Tertiary lymphoid structures and their association to immune phenotypes and circulatory IL2 levels in pancreatic ductal adenocarcinoma

(2022) Azaz Ahmed et al.   OncoImmunology

Tertiary Lymphoid Structures and Chemokine Landscape in Virus-Positive and Virus-Negative Merkel Cell Carcinoma

(2022) Motoki Nakamura et al.   Frontiers in Oncology

Spatial omics: Navigating to the golden era of cancer research

(2022) Yingcheng Wu et al.   Clinical and Translational Medicine

Preoperative prediction of intra-tumoral tertiary lymphoid structures based on CT in hepatocellular cancer

(2022) Pinxiong Li et al.   EUROPEAN JOURNAL OF RADIOLOGY

Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer

(2022) Maxime Meylan et al.   IMMUNITY

Relationship and prognostic significance of IL‐33, PD‐1/PD‐L1, and tertiary lymphoid structures in cervical cancer

(2022) Ying Zhang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tertiary lymphoid structures critical for prognosis in endometrial cancer patients

(2022) Nanda Horeweg et al.   Nature Communications

Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer

(2022) James H. A. Clubb et al.   Frontiers in Immunology

Clinical relevance of tertiary lymphoid structures in esophageal squamous cell carcinoma

(2022) Sota Deguchi et al.   BMC CANCER

Tertiary lymphoid structures in lung adenocarcinoma: characteristics and related factors

(2022) Fangping Ren et al.   Cancer Medicine

Tertiary lymphoid structures favor outcome in resected esophageal squamous cell carcinoma

(2022) Rutao Li et al.   Journal of Pathology Clinical Research

Tertiary Lymphoid Structures: Diversity in Their Development, Composition, and Role

(2021) Catarina Gago da Graça et al.   JOURNAL OF IMMUNOLOGY

Artificial intelligence and computational pathology

(2021) Miao Cui et al.   LABORATORY INVESTIGATION

The Role of Anti-angiogenesis in the Treatment Landscape of Non-small Cell Lung Cancer – New Combinational Approaches and Strategies of Neovessel Inhibition

(2021) Sophia Daum et al.   Frontiers in Cell and Developmental Biology

The prognostic and predictive implications of the 12-chemokine score in muscle invasive bladder cancer.

(2021) Logan Zemp et al.   JOURNAL OF CLINICAL ONCOLOGY

Tertiary lymphoid structure score: a promising approach to refine the TNM staging in resected non-small cell lung cancer

(2021) Mehrdad Rakaee et al.   BRITISH JOURNAL OF CANCER

Tertiary lymphoid structures marker CXCL13 is associated with better survival for patients with advanced-stage bladder cancer treated with immunotherapy

(2021) Clarice S. Groeneveld et al.   EUROPEAN JOURNAL OF CANCER

Tertiary lymphoid structures in epithelioid malignant peritoneal mesothelioma are associated with neoadjuvant chemotherapy, but not with prognosis

(2021) Nazim Benzerdjeb et al.   VIRCHOWS ARCHIV

Prognostic value of tertiary lymphoid structures in early clinical stage oral tongue squamous cell carcinoma

(2021) Cheng Wang et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Tertiary lymphoid structures (TLS) identification and density assessment on H&E-stained digital slides of lung cancer

(2021) Panagiotis Barmpoutis et al.   PLoS One

Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

(2021) Luuk van Hooren et al.   Nature Communications

Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts

(2021) Anthony B. Rodriguez et al.   Cell Reports

A Standardized Analysis of Tertiary Lymphoid Structures in Human Melanoma: Disease Progression- and Tumor Site-Associated Changes With Germinal Center Alteration

(2021) Franziska Werner et al.   Frontiers in Immunology

Tertiary Lymphoid Structures in Cancer: The Double-Edged Sword Role in Antitumor Immunity and Potential Therapeutic Induction Strategies

(2021) Wendi Kang et al.   Frontiers in Immunology

The 12-CK Score: Global Measurement of Tertiary Lymphoid Structures

(2021) Roger Li et al.   Frontiers in Immunology

Peritumoral Tertiary Lymphoid Structures Correlate With Protective Immunity and Improved Prognosis in Patients With Hepatocellular Carcinoma

(2021) Hui Li et al.   Frontiers in Immunology

Multiplex Immunofluorescence and Multispectral Imaging: Forming the Basis of a Clinical Test Platform for Immuno-Oncology

(2021) Clifford C. Hoyt   Frontiers in Molecular Biosciences

Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice

(2021) Francesca R. Delvecchio et al.   Cellular and Molecular Gastroenterology and Hepatology

Tertiary lymphoid structures are associated with favorable survival outcomes in patients with endometrial cancer

(2021) Meng Qin et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Distribution and density of tertiary lymphoid structures predict clinical outcome in intrahepatic cholangiocarcinoma

(2021) Guang-Yu Ding et al.   JOURNAL OF HEPATOLOGY

Existence of intratumoral tertiary lymphoid structures is associated with immune cells infiltration and predicts better prognosis in early-stage hepatocellular carcinoma

(2020) Hui Li et al.   Aging-US

B cells are associated with survival and immunotherapy response in sarcoma

(2020) Florent Petitprez et al.   NATURE

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

(2020) Rita Cabrita et al.   NATURE

B cells and tertiary lymphoid structures promote immunotherapy response

(2020) Beth A. Helmink et al.   NATURE

12‐Chemokine signature, a predictor of tumor recurrence in colorectal cancer

(2020) Ryuma Tokunaga et al.   INTERNATIONAL JOURNAL OF CANCER

Digital quantitative assessment of PD-L1 using digital spatial profiling

(2020) Swati Gupta et al.   LABORATORY INVESTIGATION

Immune-related adverse events of checkpoint inhibitors

(2020) Manuel Ramos-Casals et al.   Nature Reviews Disease Primers

Analytical validation of the Immunoscore and its associated prognostic value in patients with colon cancer

(2020) Florence Marliot et al.   Journal for ImmunoTherapy of Cancer

Preoperative ipilimumab plus nivolumab in locoregionally advanced urothelial cancer: the NABUCCO trial

(2020) Nick van Dijk et al.   NATURE MEDICINE

Prognostic value of tertiary lymphoid structure and tumour infiltrating lymphocytes in oral squamous cell carcinoma

(2020) Qunxing Li et al.   International Journal of Oral Science

Novel, non-invasive imaging approach to identify patients with advanced non-small cell lung cancer at risk of hyperprogressive disease with immune checkpoint blockade

(2020) Pranjal Vaidya et al.   Journal for ImmunoTherapy of Cancer

B Cells and Tertiary Lymphoid Structures Influence Survival in Lung Cancer Patients with Resectable Tumors

(2020) Jun Tang et al.   Cancers

HookNet: Multi-resolution convolutional neural networks for semantic segmentation in histopathology whole-slide images

(2020) Mart van Rijthoven et al.   MEDICAL IMAGE ANALYSIS

Grading of hepatocellular carcinoma using 3D SE-DenseNet in dynamic enhanced MR images

(2019) Qing Zhou et al.   COMPUTERS IN BIOLOGY AND MEDICINE

Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials

(2019) Yucai Wang et al.   JAMA Oncology

Computational Pathology Definitions, Best Practices, and Recommendations for Regulatory Guidance: A White Paper from the Digital Pathology Association

(2019) Esther Abels et al.   JOURNAL OF PATHOLOGY

The prognostic significance of peritumoral tertiary lymphoid structures in breast cancer

(2019) Michael Sofopoulos et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study

(2018) Franck Pagès et al.   LANCET

Cellular Composition and Contribution of Tertiary Lymphoid Structures to Tumor Immune Infiltration and Modulation by Radiation Therapy

(2018) Gaël Boivin et al.   Frontiers in Oncology

OUP accepted manuscript

(2018)   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma

(2018) Julien Calderaro et al.   JOURNAL OF HEPATOLOGY

Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning

(2018) Nicolas Coudray et al.   NATURE MEDICINE

Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors

(2018) Daniel Y. Wang et al.   JAMA Oncology

Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma

(2018) Rodabe N. Amaria et al.   NATURE MEDICINE

The immune contexture in cancer prognosis and treatment

(2017) Wolf H. Fridman et al.   Nature Reviews Clinical Oncology

Distinct Tertiary Lymphoid Structure Associations and Their Prognostic Relevance in HER2 Positive and Negative Breast Cancers

(2017) Xia Liu et al.   ONCOLOGIST

Predictive Value of Tertiary Lymphoid Structures Assessed by High Endothelial Venule Counts in the Neoadjuvant Setting of Triple-Negative Breast Cancer

(2017) In Hye Song et al.   Cancer Research and Treatment

Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?

(2017) Emily Jayne Colbeck et al.   Frontiers in Immunology

High Endothelial Venules and Other Blood Vessels: Critical Regulators of Lymphoid Organ Development and Function

(2017) Ann Ager   Frontiers in Immunology

Maturation of tertiary lymphoid structures and recurrence of stage II and III colorectal cancer

(2017) Florian Posch et al.   OncoImmunology

Lymphoid Aggregates Remodel Lymphatic Collecting Vessels that Serve Mesenteric Lymph Nodes in Crohn Disease

(2016) Gwendalyn J. Randolph et al.   AMERICAN JOURNAL OF PATHOLOGY

Computational pathology: Exploring the spatial dimension of tumor ecology

(2016) Sidra Nawaz et al.   CANCER LETTERS

Lung Pattern Classification for Interstitial Lung Diseases Using a Deep Convolutional Neural Network

(2016) Marios Anthimopoulos et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Tertiary lymphoid structures, drivers of the anti-tumor responses in human cancers

(2016) Marie-Caroline Dieu-Nosjean et al.   IMMUNOLOGICAL REVIEWS

Understanding Immune Cells in Tertiary Lymphoid Organ Development: It Is All Starting to Come Together

(2016) Gareth W. Jones et al.   Frontiers in Immunology

Lymphoid Neogenesis and Tertiary Lymphoid Organs in Transplanted Organs

(2016) Alice Koenig et al.   Frontiers in Immunology

Tumor-infiltrating lymphocyte composition, organization and PD-1/ PD-L1 expression are linked in breast cancer

(2016) Laurence Buisseret et al.   OncoImmunology

Inflammation-induced formation of fat-associated lymphoid clusters

(2015) Cécile Bénézech et al.   NATURE IMMUNOLOGY

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

(2015) Shlomi Finkin et al.   NATURE IMMUNOLOGY

Presence of B Cells in Tertiary Lymphoid Structures Is Associated with a Protective Immunity in Patients with Lung Cancer

(2014) Claire Germain et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Occurrence of Tertiary Lymphoid Tissue Is Associated with T-Cell Infiltration and Predicts Better Prognosis in Early-Stage Colorectal Cancers

(2014) G. Di Caro et al.   CLINICAL CANCER RESEARCH

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Tertiary lymphoid structures in cancer and beyond

(2014) Marie-Caroline Dieu-Nosjean et al.   TRENDS IN IMMUNOLOGY

Role of Tertiary Lymphoid Structures (TLS) in Anti-Tumor Immunity: Potential Tumor-Induced Cytokines/Chemokines that Regulate TLS Formation in Epithelial-Derived Cancers

(2014) Erica Pimenta et al.   Cancers

Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

(2013) J. Goc et al.   CANCER RESEARCH

M1 macrophages act as LTβR-independent lymphoid tissue inducer cells during atherosclerosis-related lymphoid neogenesis

(2013) Kevin Guedj et al.   CARDIOVASCULAR RESEARCH

High Endothelial Venule Blood Vessels for Tumor-Infiltrating Lymphocytes Are Associated with Lymphotoxin  -Producing Dendritic Cells in Human Breast Cancer

(2013) L. Martinet et al.   JOURNAL OF IMMUNOLOGY

The role of viruses in autoreactive B cell activation within tertiary lymphoid structures in autoimmune diseases

(2013) Davide Lucchesi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tertiary lymphoid organs in infection and autoimmunity

(2012) Katrijn Neyt et al.   TRENDS IN IMMUNOLOGY

12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy?

(2012) Jane L. Messina et al.   Scientific Reports

Unique Ectopic Lymph Node-Like Structures Present in Human Primary Colorectal Carcinoma Are Identified by Immune Gene Array Profiling

(2011) Domenico Coppola et al.   AMERICAN JOURNAL OF PATHOLOGY

Human Solid Tumors Contain High Endothelial Venules: Association with T- and B-Lymphocyte Infiltration and Favorable Prognosis in Breast Cancer

(2011) L. Martinet et al.   CANCER RESEARCH

Characterization of Chemokines and Adhesion Molecules Associated with T cell Presence in Tertiary Lymphoid Structures in Human Lung Cancer

(2011) L. de Chaisemartin et al.   CANCER RESEARCH

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

(2011) Anneli Peters et al.   IMMUNITY

Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORγt and LTi cells

(2010) Matthias Lochner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intragraft Th17 Infiltrate Promotes Lymphoid Neogenesis and Hastens Clinical Chronic Rejection

(2010) C. Deteix et al.   JOURNAL OF IMMUNOLOGY

Chronic Rejection Triggers the Development of an Aggressive Intragraft Immune Response through Recapitulation of Lymphoid Organogenesis

(2010) O. Thaunat et al.   JOURNAL OF IMMUNOLOGY

Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling

(2009) Antonio Manzo et al.   IMMUNOLOGICAL REVIEWS

LT R Signaling Induces Cytokine Expression and Up-Regulates Lymphangiogenic Factors in Lymph Node Anlagen

(2009) M. F. Vondenhoff et al.   JOURNAL OF IMMUNOLOGY

Long-Term Survival for Patients With Non–Small-Cell Lung Cancer With Intratumoral Lymphoid Structures

(2008) Marie-Caroline Dieu-Nosjean et al.   JOURNAL OF CLINICAL ONCOLOGY