Tertiary Lymphoid Structures: Diversity in Their Development, Composition, and Role

Existence of intratumoral tertiary lymphoid structures is associated with immune cells infiltration and predicts better prognosis in early-stage hepatocellular carcinoma

(2020) Hui Li et al.   Aging-US

Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis

(2020) Helen He et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

B cells are associated with survival and immunotherapy response in sarcoma

(2020) Florent Petitprez et al.   NATURE

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

(2020) Rita Cabrita et al.   NATURE

B cells and tertiary lymphoid structures promote immunotherapy response

(2020) Beth A. Helmink et al.   NATURE

Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors

(2020) Yukun Huang et al.   Nature Communications

The Immunosuppressive Niche of Soft Tissue Sarcomas is Sustained by Tumor Associated Macrophages and Characterized by Intratumoral Tertiary Lymphoid Structures

(2020) Lingling Chen et al.   CLINICAL CANCER RESEARCH

12‐Chemokine signature, a predictor of tumor recurrence in colorectal cancer

(2020) Ryuma Tokunaga et al.   INTERNATIONAL JOURNAL OF CANCER

TNF-α and IL-10 Control CXCL13 Expression in Human Macrophages

(2020) Nessrine Bellamri et al.   JOURNAL OF IMMUNOLOGY

Notch signalling drives synovial fibroblast identity and arthritis pathology

(2020) Kevin Wei et al.   NATURE

Remodeling of light and dark zone follicular dendritic cells governs germinal center responses

(2020) Natalia B. Pikor et al.   NATURE IMMUNOLOGY

Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis

(2020) Tatsuya Tsukui et al.   Nature Communications

Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses

(2020) Reza Nadafi et al.   Cell Reports

Gut-resident CX3CR1hi macrophages induce tertiary lymphoid structures and IgA response in situ

(2020) Balázs Koscsó et al.   Science Immunology

Fibroblast subtypes in tissues affected by autoimmunity: with lessons from lymph node fibroblasts

(2020) William D Shipman et al.   CURRENT OPINION IN IMMUNOLOGY

A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature

(2020) Menglan Xiang et al.   Frontiers in Cardiovascular Medicine

Fibroblasts as a source of self-antigens for central immune tolerance

(2020) Takeshi Nitta et al.   NATURE IMMUNOLOGY

Prognostic role of programmed death ligand 1 (PD-L1) and the immune microenvironment in laryngeal carcinoma

(2020) Lara Alessandrini et al.   ORAL ONCOLOGY

Single-Cell Analysis Reveals Heterogeneity of High Endothelial Venules and Different Regulation of Genes Controlling Lymphocyte Entry to Lymph Nodes

(2019) Krystle Veerman et al.   Cell Reports

Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients

(2019) Frances Humby et al.   ANNALS OF THE RHEUMATIC DISEASES

Defining the Activated Fibroblast Population in Lung Fibrosis Using Single Cell Sequencing

(2019) Rebecca Peyser et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

B cells in the formation of tertiary lymphoid organs in autoimmunity, transplantation and tumorigenesis

(2019) Elisa Corsiero et al.   CURRENT OPINION IN IMMUNOLOGY

Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer

(2019) Matteo Ligorio et al.   CELL

CCL21 Expression in β-Cells Induces Antigen-Expressing Stromal Cell Networks in the Pancreas and Prevents Autoimmune Diabetes in Mice

(2019) Freddy Gonzalez Badillo et al.   DIABETES

Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology

(2019) Saba Nayar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

Single-Cell Survey of Human Lymphatics Unveils Marked Endothelial Cell Heterogeneity and Mechanisms of Homing for Neutrophils

(2019) Akira Takeda et al.   IMMUNITY

Single-cell RNA sequencing reveals stromal evolution into LRRC15+ myofibroblasts as a determinant of patient response to cancer immunotherapy

(2019) Claudia X Dominguez et al.   Cancer Discovery

B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure

(2019) F. Rivellese et al.   Arthritis & Rheumatology

The Role of Endothelial Cells and TNF-Receptor Superfamily Members in Lymphoid Organogenesis and Function During Health and Inflammation

(2019) Kim C. M. Jeucken et al.   Frontiers in Immunology

Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity

(2018) Lauren B. Rodda et al.   IMMUNITY

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

(2018) Daniela S. Thommen et al.   NATURE MEDICINE

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis

(2018) Fumitaka Mizoguchi et al.   Nature Communications

Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis

(2018) Ting Xie et al.   Cell Reports

A Fresh View on Lymph Node Organogenesis

(2018) Lucas Onder et al.   TRENDS IN IMMUNOLOGY

Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes

(2018) Joern Pezoldt et al.   Nature Communications

The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation

(2018) Konstantin Knoblich et al.   PLOS BIOLOGY

Multiple roles of lymphatic vessels in peripheral lymph node development

(2018) Esther Bovay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ectopic lymphoid neogenesis in rheumatic autoimmune diseases

(2017) Michele Bombardieri et al.   Nature Reviews Rheumatology

Treg Depletion Licenses T Cell–Driven HEV Neogenesis and Promotes Tumor Destruction

(2017) Emily J. Colbeck et al.   Cancer Immunology Research

Tbet and IL-36γ cooperate in therapeutic DC-mediated promotion of ectopic lymphoid organogenesis in the tumor microenvironment

(2017) Aliyah M. Weinstein et al.   OncoImmunology

The Role of Lymphoid Neogenesis in Allografts

(2016) H.-M. Hsiao et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Vagal innervation is required for the formation of tertiary lymphoid tissue in colitis

(2016) Brenda J. Olivier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs

(2016) Catherine E. Hughes et al.   Frontiers in Immunology

Stromal Fibroblasts in Tertiary Lymphoid Structures: A Novel Target in Chronic Inflammation

(2016) Francesca Barone et al.   Frontiers in Immunology

Tertiary Lymphoid Organs in Central Nervous System Autoimmunity

(2016) Meike Mitsdoerffer et al.   Frontiers in Immunology

High Endothelial Venules and Lymphatic Vessels in Tertiary Lymphoid Organs: Characteristics, Functions, and Regulation

(2016) Nancy H. Ruddle   Frontiers in Immunology

Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation

(2015) Christopher D. Buckley et al.   Annual Review of Immunology

Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation

(2015) Natalia B. Pikor et al.   IMMUNITY

Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses

(2015) Nikhil S. Joshi et al.   IMMUNITY

IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs

(2015) Francesca Barone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stromal infrastructure of the lymph node and coordination of immunity

(2015) Jonathan E. Chang et al.   TRENDS IN IMMUNOLOGY

Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction

(2015) Sherin J. Rouhani et al.   Nature Communications

Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity

(2015) J. David Peske et al.   Nature Communications

Fate mapping reveals origin and dynamics of lymph node follicular dendritic cells

(2014) Meryem Jarjour et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-17–induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs

(2014) Henrike Fleige et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymph Node Stromal Cells Negatively Regulate Antigen-Specific CD4+T Cell Responses

(2014) Jun Abe et al.   JOURNAL OF IMMUNOLOGY

Tolerogenic Properties of Lymphatic Endothelial Cells Are Controlled by the Lymph Node Microenvironment

(2014) Jarish N. Cohen et al.   PLoS One

Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation

(2014) Antonio P Baptista et al.   eLife

TNFα-dependent development of lymphoid tissue in the absence of RORγt+ lymphoid tissue inducer cells

(2013) G C Furtado et al.   Mucosal Immunology

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

(2012) E. F. Tewalt et al.   BLOOD

Follicular Dendritic Cells Emerge from Ubiquitous Perivascular Precursors

(2012) Nike Julia Krautler et al.   CELL

Colonic patch and colonic SILT development are independent and differentially regulated events

(2012) A P Baptista et al.   Mucosal Immunology

Association of T-Zone Reticular Networks and Conduits with Ectopic Lymphoid Tissues in Mice and Humans

(2011) Alexander Link et al.   AMERICAN JOURNAL OF PATHOLOGY

Stromal Cell–Immune Cell Interactions

(2011) Ramon Roozendaal et al.   Annual Review of Immunology

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

(2011) Anneli Peters et al.   IMMUNITY

IL-23 Is Required for Long-Term Control of Mycobacterium tuberculosis and B Cell Follicle Formation in the Infected Lung

(2011) Shabaana A. Khader et al.   JOURNAL OF IMMUNOLOGY

Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes

(2011) Veronika Lukacs-Kornek et al.   NATURE IMMUNOLOGY

IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium

(2011) Naruhisa Ota et al.   NATURE IMMUNOLOGY

The development of inducible bronchus-associated lymphoid tissue depends on IL-17

(2011) Javier Rangel-Moreno et al.   NATURE IMMUNOLOGY

Induction of BALT in the absence of IL-17

(2011) Henrike Fleige et al.   NATURE IMMUNOLOGY

Dendritic Cells Produce CXCL13 and Participate in the Development of Murine Small Intestine Lymphoid Tissues

(2010) Keely G. McDonald et al.   AMERICAN JOURNAL OF PATHOLOGY

Presence of lymphocyte aggregates in the synovium of patients with early arthritis in relationship to diagnosis and outcome: is it a constant feature over time?

(2010) M. G. H. van de Sande et al.   ANNALS OF THE RHEUMATIC DISEASES

Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORγt and LTi cells

(2010) Matthias Lochner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymph node–resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

(2010) Jarish N. Cohen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions

(2010) Anne L. Fletcher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The relationship between synovial lymphocyte aggregates and the clinical response to infliximab in rheumatoid arthritis: A prospective study

(2009) Ruth Klaasen et al.   ARTHRITIS AND RHEUMATISM

Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus–infected mice

(2009) Corine H. GeurtsvanKessel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphotoxin β receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of agedApoE−/−mice

(2009) Rolf Gräbner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induced bronchus-associated lymphoid tissue serves as a general priming site for T cells and is maintained by dendritic cells

(2009) Stephan Halle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chemokine Receptor CXCR5 Supports Solitary Intestinal Lymphoid Tissue Formation, B Cell Homing, and Induction of Intestinal IgA Responses

(2009) S. Velaga et al.   JOURNAL OF IMMUNOLOGY

Inflammation Recapitulates the Ontogeny of Lymphoid Stromal Cells

(2009) L. Peduto et al.   JOURNAL OF IMMUNOLOGY

Ectopic Germinal Centers Are Rare in Sjogren's Syndrome Salivary Glands and Do Not Exclude Autoreactive B Cells

(2009) L. Le Pottier et al.   JOURNAL OF IMMUNOLOGY

Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation

(2009) Serge A van de Pavert et al.   NATURE IMMUNOLOGY

Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjögren syndrome in salivary glands of non-obese diabetic mice

(2009) Margaret K Gatumu et al.   ARTHRITIS RESEARCH & THERAPY

Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium

(2009) Frances Humby et al.   PLOS MEDICINE

Synovial lymphoid neogenesis does not define a specific clinical rheumatoid arthritis phenotype

(2008) Rogier M. Thurlings et al.   ARTHRITIS AND RHEUMATISM

Mature antigen-experienced T helper cells synthesize and secrete the B cell chemoattractant CXCL13 in the inflammatory environment of the rheumatoid joint

(2008) Antonio Manzo et al.   ARTHRITIS AND RHEUMATISM

Requirement for Lymphoid Tissue-Inducer Cells in Isolated Follicle Formation and T Cell-Independent Immunoglobulin A Generation in the Gut

(2008) Masayuki Tsuji et al.   IMMUNITY

Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis

(2008) Djahida Bouskra et al.   NATURE

Human fetal lymphoid tissue–inducer cells are interleukin 17–producing precursors to RORC+ CD127+ natural killer–like cells

(2008) Tom Cupedo et al.   NATURE IMMUNOLOGY