Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning

Deep Convolutional Neural Networks Enable Discrimination of Heterogeneous Digital Pathology Images

(2018) Pegah Khosravi et al.   EBioMedicine

Systemic Therapy for Stage IV Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update

(2017) Nasser Hanna et al.   JOURNAL OF CLINICAL ONCOLOGY

Comprehensive Computational Pathological Image Analysis Predicts Lung Cancer Prognosis

(2017) Xin Luo et al.   Journal of Thoracic Oncology

Dermatologist-level classification of skin cancer with deep neural networks

(2017) Andre Esteva et al.   NATURE

Oncology Drug Approvals: Evaluating Endpoints and Evidence in an Era of Breakthrough Therapies

(2017) Gideon M. Blumenthal et al.   ONCOLOGIST

Accurate and reproducible invasive breast cancer detection in whole-slide images: A Deep Learning approach for quantifying tumor extent

(2017) Angel Cruz-Roa et al.   Scientific Reports

IDH2Mutations Define a Unique Subtype of Breast Cancer with Altered Nuclear Polarity

(2016) Sarah Chiang et al.   CANCER RESEARCH

An Automatic Learning-Based Framework for Robust Nucleus Segmentation

(2016) Fuyong Xing et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Guest Editorial Deep Learning in Medical Imaging: Overview and Future Promise of an Exciting New Technique

(2016) Hayit Greenspan et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Lung Pattern Classification for Interstitial Lung Diseases Using a Deep Convolutional Neural Network

(2016) Marios Anthimopoulos et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Locality Sensitive Deep Learning for Detection and Classification of Nuclei in Routine Colon Cancer Histology Images

(2016) Korsuk Sirinukunwattana et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs

(2016) Varun Gulshan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Molecular characterization of pulmonary sarcomatoid carcinoma: analysis of 33 cases

(2016) Simone BSP Terra et al.   MODERN PATHOLOGY

Toward a Shared Vision for Cancer Genomic Data

(2016) Robert L. Grossman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Accuracy of classifying poorly differentiated non–small cell lung carcinoma biopsies with commonly used lung carcinoma markers

(2015) Susanna Zachara-Szczakowski et al.   HUMAN PATHOLOGY

Deep learning in neural networks: An overview

(2015) Jürgen Schmidhuber   NEURAL NETWORKS

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

EGFR mutation specific immunohistochemistry is a useful adjunct which helps to identify false negative mutation testing in lung cancer

(2014) Michelle Houang et al.   PATHOLOGY

Prognostic and predictive biomarkers in lung cancer. A review

(2014) Erik Thunnissen et al.   VIRCHOWS ARCHIV

Mutation incidence and coincidence in non small-cell lung cancer: meta-analyses by ethnicity and histology (mutMap)

(2013) S. Dearden et al.   ANNALS OF ONCOLOGY

LKB1 Inactivation Dictates Therapeutic Response of Non-Small Cell Lung Cancer to the Metabolism Drug Phenformin

(2013) David B. Shackelford et al.   CANCER CELL

EGFR, KRAS, BRAF and ALK gene alterations in lung adenocarcinomas: patient outcome, interplay with morphology and immunophenotype

(2013) A. Warth et al.   EUROPEAN RESPIRATORY JOURNAL

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation

(2013) Luc G T Morris et al.   NATURE GENETICS

Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study

(2012) Pasi A Jänne et al.   LANCET ONCOLOGY

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

Standardization of Epidermal Growth Factor Receptor (EGFR) Measurement by Quantitative Immunofluorescence and Impact on Antibody-Based Mutation Detection in Non–Small Cell Lung Cancer

(2011) Anastasios Dimou et al.   AMERICAN JOURNAL OF PATHOLOGY

Comprehensive Histologic Analysis of ALK-Rearranged Lung Carcinomas

(2011) Akihiko Yoshida et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

TP53 Mutations in Nonsmall Cell Lung Cancer

(2011) Akira Mogi et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma

(2011) William D. Travis et al.   Journal of Thoracic Oncology

Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

(2011) L. V. Sequist et al.   Science Translational Medicine

Optimal Immunohistochemical Markers For Distinguishing Lung Adenocarcinomas From Squamous Cell Carcinomas in Small Tumor Samples

(2010) Jefferson Terry et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Mutation-Specific Antibodies for the Detection of EGFR Mutations in Non-Small-Cell Lung Cancer

(2009) J. Yu et al.   CLINICAL CANCER RESEARCH

Unique Clinicopathologic Features Characterize ALK-Rearranged Lung Adenocarcinoma in the Western Population

(2009) S. J. Rodig et al.   CLINICAL CANCER RESEARCH

A systems pathology model for predicting overall survival in patients with refractory, advanced non-small-cell lung cancer treated with gefitinib

(2009) Michael J. Donovan et al.   EUROPEAN JOURNAL OF CANCER

Role of LKB1 in lung cancer development

(2008) L Makowski et al.   BRITISH JOURNAL OF CANCER

Correlation between morphology and EGFR mutations in lung adenocarcinomas

(2008) Hironori Ninomiya et al.   LUNG CANCER