Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts

B cells are associated with survival and immunotherapy response in sarcoma

(2020) Florent Petitprez et al.   NATURE

Tertiary lymphoid structures improve immunotherapy and survival in melanoma

(2020) Rita Cabrita et al.   NATURE

B cells and tertiary lymphoid structures promote immunotherapy response

(2020) Beth A. Helmink et al.   NATURE

Stromal Cells Covering Omental Fat-Associated Lymphoid Clusters Trigger Formation of Neutrophil Aggregates to Capture Peritoneal Contaminants

(2020) Lucy Helen Jackson-Jones et al.   IMMUNITY

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

(2019) Brian C. Miller et al.   NATURE IMMUNOLOGY

Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy

(2019) Elisabeth Perez-Ruiz et al.   NATURE

Immunofibroblasts are pivotal drivers of tertiary lymphoid structure formation and local pathology

(2019) Saba Nayar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNFR1 and TNFR2 in the Control of the Life and Death Balance of Macrophages

(2019) Harald Wajant et al.   Frontiers in Cell and Developmental Biology

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy

(2019) Tongyan Liu et al.   Journal of Hematology & Oncology

RIG-I activation is critical for responsiveness to checkpoint blockade

(2019) Simon Heidegger et al.   Science Immunology

B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma

(2019) Johannes Griss et al.   Nature Communications

TLR9 activation cooperates with T cell checkpoint blockade to regress poorly immunogenic melanoma

(2019) Matthew J. Reilley et al.   Journal for ImmunoTherapy of Cancer

A peek into cancer-associated fibroblasts: origins, functions and translational impact

(2018) Valerie S. LeBleu et al.   Disease Models & Mechanisms

Immune Cell Infiltration and Tertiary Lymphoid Structures as Determinants of Antitumor Immunity

(2018) Victor H. Engelhard et al.   JOURNAL OF IMMUNOLOGY

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

(2018) Daniela S. Thommen et al.   NATURE MEDICINE

A Fresh View on Lymph Node Organogenesis

(2018) Lucas Onder et al.   TRENDS IN IMMUNOLOGY

Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells

(2016) Olivier De Henau et al.   NATURE

Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection

(2016) Lalit Kumar Dubey et al.   Cell Reports

Fat-Associated Lymphoid Clusters in Inflammation and Immunity

(2016) Sara Cruz-Migoni et al.   Frontiers in Immunology

Lymphoid Neogenesis and Tertiary Lymphoid Organs in Transplanted Organs

(2016) Alice Koenig et al.   Frontiers in Immunology

Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation

(2015) Natalia B. Pikor et al.   IMMUNITY

Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses

(2015) Nikhil S. Joshi et al.   IMMUNITY

Inflammation-induced formation of fat-associated lymphoid clusters

(2015) Cécile Bénézech et al.   NATURE IMMUNOLOGY

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

(2015) Shlomi Finkin et al.   NATURE IMMUNOLOGY

IL-22 regulates lymphoid chemokine production and assembly of tertiary lymphoid organs

(2015) Francesca Barone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ectopic lymphoid neogenesis is strongly associated with activation of the IL-23 pathway in rheumatoid synovitis

(2015) Juan D. Cañete et al.   ARTHRITIS RESEARCH & THERAPY

Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity

(2015) J. David Peske et al.   Nature Communications

The Mesothelial Origin of Carcinoma Associated-Fibroblasts in Peritoneal Metastasis

(2015) Angela Rynne-Vidal et al.   Cancers

Presence of B Cells in Tertiary Lymphoid Structures Is Associated with a Protective Immunity in Patients with Lung Cancer

(2014) Claire Germain et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Occurrence of Tertiary Lymphoid Tissue Is Associated with T-Cell Infiltration and Predicts Better Prognosis in Early-Stage Colorectal Cancers

(2014) G. Di Caro et al.   CLINICAL CANCER RESEARCH

IL-17–induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs

(2014) Henrike Fleige et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Intramuscular Therapeutic Vaccination Targeting HPV16 Induces T Cell Responses That Localize in Mucosal Lesions

(2014) L. Maldonado et al.   Science Translational Medicine

Immunotherapy Converts Nonimmunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation

(2014) E. R. Lutz et al.   Cancer Immunology Research

Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells

(2013) J. Goc et al.   CANCER RESEARCH

M1 macrophages act as LTβR-independent lymphoid tissue inducer cells during atherosclerosis-related lymphoid neogenesis

(2013) Kevin Guedj et al.   CARDIOVASCULAR RESEARCH

Significance of podoplanin expression in cancer-associated fibroblasts: A comprehensive review

(2013) BARTOSZ PULA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

TNFα-dependent development of lymphoid tissue in the absence of RORγt+ lymphoid tissue inducer cells

(2013) G C Furtado et al.   Mucosal Immunology

Antigen-Specific Bacterial Vaccine Combined with Anti-PD-L1 Rescues Dysfunctional Endogenous T Cells to Reject Long-Established Cancer

(2013) D. C. Binder et al.   Cancer Immunology Research

Neogenesis of Lymphoid Structures and Antibody Responses Occur in Human Melanoma Metastases

(2012) Arcadi Cipponi et al.   CANCER RESEARCH

Tertiary lymphoid organs in infection and autoimmunity

(2012) Katrijn Neyt et al.   TRENDS IN IMMUNOLOGY

Association of T-Zone Reticular Networks and Conduits with Ectopic Lymphoid Tissues in Mice and Humans

(2011) Alexander Link et al.   AMERICAN JOURNAL OF PATHOLOGY

The prognostic significance of B lymphocytes in invasive carcinoma of the breast

(2011) S. M. A. Mahmoud et al.   BREAST CANCER RESEARCH AND TREATMENT

Prognostic impact of B-cell density in cutaneous melanoma

(2011) Andrea Ladányi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Blocking lymphotoxin signaling abrogates the development of ectopic lymphoid tissue within cardiac allografts and inhibits effector antibody responses

(2011) Reza Motallebzadeh et al.   FASEB JOURNAL

Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation

(2011) Anneli Peters et al.   IMMUNITY

A Critical Role for Dendritic Cells in the Formation of Lymphatic Vessels within Tertiary Lymphoid Structures

(2011) L. R. Muniz et al.   JOURNAL OF IMMUNOLOGY

IL-23 Is Required for Long-Term Control of Mycobacterium tuberculosis and B Cell Follicle Formation in the Infected Lung

(2011) Shabaana A. Khader et al.   JOURNAL OF IMMUNOLOGY

The development of inducible bronchus-associated lymphoid tissue depends on IL-17

(2011) Javier Rangel-Moreno et al.   NATURE IMMUNOLOGY

Mouse Aorta Smooth Muscle Cells Differentiate Into Lymphoid Tissue Organizer-Like Cells on Combined Tumor Necrosis Factor Receptor-1/Lymphotoxin β-Receptor NF-κB Signaling

(2010) Katharina Lötzer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tumor masses support naive T cell infiltration, activation, and differentiation into effectors

(2010) Elizabeth D. Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCL13 Blockade Disrupts B Lymphocyte Organization in Tertiary Lymphoid Structures without Altering B Cell Receptor Bias or Preventing Diabetes in Nonobese Diabetic Mice

(2010) R. A. Henry et al.   JOURNAL OF IMMUNOLOGY

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

(2010) M. A. Curran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein- 

(2010) M. Kraman et al.   SCIENCE

Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus–infected mice

(2009) Corine H. GeurtsvanKessel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphotoxin β receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of agedApoE−/−mice

(2009) Rolf Gräbner et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induced bronchus-associated lymphoid tissue serves as a general priming site for T cells and is maintained by dendritic cells

(2009) Stephan Halle et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammation Recapitulates the Ontogeny of Lymphoid Stromal Cells

(2009) L. Peduto et al.   JOURNAL OF IMMUNOLOGY

Secondary Lymphoid Organs: Responding to Genetic and Environmental Cues in Ontogeny and the Immune Response

(2009) N. H. Ruddle et al.   JOURNAL OF IMMUNOLOGY

Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjögren syndrome in salivary glands of non-obese diabetic mice

(2009) Margaret K Gatumu et al.   ARTHRITIS RESEARCH & THERAPY