RNA binding protein: coordinated expression between the nuclear and mitochondrial genomes in tumors

Stress granules: functions and mechanisms in cancer

(2023) Huan Zhou et al.   Cell and Bioscience

New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer

(2022) Zi‐Ting Yao et al.   Cancer Communications

CircTHBS1 drives gastric cancer progression by increasing INHBA mRNA expression and stability in a ceRNA- and RBP-dependent manner

(2022) Shengkui Qiu et al.   Cell Death & Disease

DELE1 tracks perturbed protein import and processing in human mitochondria

(2022) Evelyn Fessler et al.   Nature Communications

Potential of Mitochondrial Ribosomal Genes as Cancer Biomarkers Demonstrated by Bioinformatics Results

(2022) Shunchao Bao et al.   Frontiers in Oncology

Complement C1q Binding Protein (C1QBP): Physiological Functions, Mutation-Associated Mitochondrial Cardiomyopathy and Current Disease Models

(2022) Jie Wang et al.   Frontiers in Cardiovascular Medicine

Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management

(2022) Ping Jin et al.   Journal of Hematology & Oncology

Mitochondrial RNA modifications shape metabolic plasticity in metastasis

(2022) Sylvain Delaunay et al.   NATURE

Mechanisms of mitochondrial respiratory adaptation

(2022) Christopher F. Bennett et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Translational Regulation in mTOR Pathway

(2022) Miaomiao Yang et al.   Biomolecules

The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1)

(2022) Zeenat Farooq et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR- and LARP1-dependent regulation of TOP mRNA poly(A) tail and ribosome loading

(2022) Koichi Ogami et al.   Cell Reports

Pentatricopeptide Protein PTCD2 Regulates COIII Translation in Mitochondria of the HeLa Cell Line

(2022) Maria V. Baleva et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The RNAome landscape of tomato during arbuscular mycorrhizal symbiosis reveals an evolving RNA layer symbiotic regulatory network

(2022) Zhen Zeng et al.   Plant Communications

Accumulation of Mitochondrial RPPH1 RNA Is Associated with Cellular Senescence

(2021) Ji Won Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RNA-Binding Protein MSI2 Binds to miR-301a-3p and Facilitates Its Distribution in Mitochondria of Endothelial Cells

(2021) Qian Qian Guo et al.   Frontiers in Molecular Biosciences

Aberrant phase separation and cancer

(2021) Kenzui Taniue et al.   FEBS Journal

MRPL13 Promotes Tumor Cell Proliferation, Migration and EMT Process in Breast Cancer Through the PI3K-AKT-mTOR Pathway

(2021) Miaomiao Cai et al.   Cancer Management and Research

Arginine and lysine methylation of MRPS23 promotes breast cancer metastasis through regulating OXPHOS

(2021) Lingxia Liu et al.   ONCOGENE

Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth

(2021) Denise Sighel et al.   Cell Reports

MRPL15 is a novel prognostic biomarker and therapeutic target for epithelial ovarian cancer

(2021) Haoya Xu et al.   Cancer Medicine

Mitochondrial ribosomal small subunit proteins (MRPS) MRPS6 and MRPS23 show dysregulation in breast cancer affecting tumorigenic cellular processes

(2021) Revathi Paramasivam Oviya et al.   GENE

RNA Granules in the Mitochondria and Their Organization under Mitochondrial Stresses

(2021) Vanessa Joanne Xavier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human Mitochondrial RNA Processing and Modifications: Overview

(2021) Marta Jedynak-Slyvka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ribosome Biogenesis and Cancer: Overview on Ribosomal Proteins

(2021) Annalisa Pecoraro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner

(2021) Youngdae Gwon et al.   SCIENCE

The pathogenesis of mesothelioma is driven by a dysregulated translatome

(2021) Stefano Grosso et al.   Nature Communications

Stress granules inhibit fatty acid oxidation by modulating mitochondrial permeability

(2021) Triana Amen et al.   Cell Reports

MRPL13 Act as a Novel Therapeutic Target and Could Promote Cell Proliferation in Non-Small Cell Lung Cancer

(2021) Chuanqing Jing et al.   Cancer Management and Research

Mitochondrial Protein Translation: Emerging Roles and Clinical Significance in Disease

(2021) Fei Wang et al.   Frontiers in Cell and Developmental Biology

Doxycycline sensitizes renal cell carcinoma to chemotherapy by preferentially inhibiting mitochondrial translation

(2021) Bo Wang et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

The 40 S -LARP1 complex reprograms the cellular translatome upon mTOR inhibition to preserve the protein synthetic capacity

(2021) Pedro Fuentes et al.   Science Advances

Mitochondrial calcium exchange in physiology and disease

(2021) Joanne F. Garbincius et al.   PHYSIOLOGICAL REVIEWS

Reprogramming Oxidative Phosphorylation in Cancer: A Role for RNA-Binding Proteins

(2020) Pau B. Esparza-Moltó et al.   ANTIOXIDANTS & REDOX SIGNALING

A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways

(2020) Marte Molenaars et al.   Cell Metabolism

circHIPK3 Promotes Cell Proliferation and Migration of Gastric Cancer by Sponging miR-107 and Regulating BDNF Expression

(2020) Juan Wei et al.   OncoTargets and Therapy

CLUH granules coordinate translation of mitochondrial proteins with mTORC1 signaling and mitophagy

(2020) David Pla‐Martín et al.   EMBO JOURNAL

Mitochondria Targeting as an Effective Strategy for Cancer Therapy

(2020) Poorva Ghosh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Composition-dependent thermodynamics of intracellular phase separation

(2020) Joshua A. Riback et al.   NATURE

Controversies around the function of LARP1

(2020) Andrea J. Berman et al.   RNA Biology

Mitochondrial Metabolism as a Target for Cancer Therapy

(2020) Karthik Vasan et al.   Cell Metabolism

The Significance of Mitochondrial Dysfunction in Cancer

(2020) Yongde Luo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial RNA granules are fluid condensates positioned by membrane dynamics

(2020) Timo Rey et al.   NATURE CELL BIOLOGY

TUFM‑knockdown inhibits the migration and proliferation of gastrointestinal stromal tumor cells

(2020) Xiaoyuan Weng et al.   Oncology Letters

Cancer metabolism and mitochondria: Finding novel mechanisms to fight tumours

(2020) Sonia Missiroli et al.   EBioMedicine

RNA-Binding Proteins in Cancer: Functional and Therapeutic Perspectives

(2020) Donghee Kang et al.   Cancers

Single-Molecule Imaging Reveals Translation of mRNAs Localized to Stress Granules

(2020) Daniel Mateju et al.   CELL

RNA-binding protein RALY reprogrammes mitochondrial metabolism via mediating miRNA processing in colorectal cancer

(2020) Lei Sun et al.   GUT

Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases

(2020) Guomin Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Elongational stalling activates mitoribosome-associated quality control

(2020) Nirupa Desai et al.   SCIENCE

Mitochondrial RNA quality control in trypanosomes

(2020) Inna Aphasizheva et al.   Wiley Interdisciplinary Reviews-RNA

Poly (A) tail length of human mitochondrial mRNAs is tissue-specific and a mutation in LRPPRC results in transcript-specific patterns of deadenylation

(2020) Shamisa Honarmand et al.   Molecular Genetics and Metabolism Reports

The Ribosome Biogenesis—Cancer Connection

(2019) Marianna Penzo et al.   Cells

Mitochondrial RNA granules are critically dependent on mtDNA replication factors Twinkle and mtSSB

(2019) Fenna Hensen et al.   NUCLEIC ACIDS RESEARCH

A novel, liver-specific long noncoding RNA LINC01093 suppresses HCC progression by interaction with IGF2BP1 to facilitate decay of GLI1 mRNA

(2019) Jia He et al.   CANCER LETTERS

LRPPRC: A Multifunctional Protein Involved in Energy Metabolism and Human Disease

(2019) Jie Cui et al.   Frontiers in Physiology

Screening of key genes and prediction of therapeutic agents in Arsenic-induced lung carcinoma

(2019) Liang Zhang et al.   Cancer Biomarkers

The Mitochondrion as an Emerging Therapeutic Target in Cancer

(2019) Katherine G. Roth et al.   TRENDS IN MOLECULAR MEDICINE

Oxidative phosphorylation as a potential therapeutic target for cancer therapy

(2019) Valentina Sica et al.   INTERNATIONAL JOURNAL OF CANCER

C6orf203 is an RNA-binding protein involved in mitochondrial protein synthesis

(2019) Shreekara Gopalakrishna et al.   NUCLEIC ACIDS RESEARCH

MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome–nascent chain complex

(2019) Cong Wang et al.   EMBO REPORTS

LncRNA-HGBC stabilized by HuR promotes gallbladder cancer progression by regulating miR-502-3p/SET/AKT axis

(2019) Yun-ping Hu et al.   Molecular Cancer

Regulation of the poly(A) status of mitochondrial mRNA by poly(A) specific ribonuclease is conserved among land plants

(2019) Mai Kanazawa et al.   PLANT AND CELL PHYSIOLOGY

Mitochondrial dysfunction and oxidative stress in heart disease

(2019) Jessica N. Peoples et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The basic machineries for mitochondrial protein quality control

(2019) Carmela Vazquez-Calvo et al.   MITOCHONDRION

Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome

(2018) Nicole J. Lake et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Human Elongation Factor 4 Regulates Cancer Bioenergetics by Acting as a Mitochondrial Translation Switch

(2018) Ping Zhu et al.   CANCER RESEARCH

Mitochondrial Translation Efficiency Controls Cytoplasmic Protein Homeostasis

(2018) Tamara Suhm et al.   Cell Metabolism

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy

(2018) Thomas M. Ashton et al.   CLINICAL CANCER RESEARCH

Chemical compounds that suppress hypoxia-induced stress granule formation enhance cancer drug sensitivity of human cervical cancer HeLa cells

(2018) Shikshya Timalsina et al.   JOURNAL OF BIOCHEMISTRY

ZFAND1 Recruits p97 and the 26S Proteasome to Promote the Clearance of Arsenite-Induced Stress Granules

(2018) Ankit Turakhiya et al.   MOLECULAR CELL

mRNA-binding protein tristetraprolin is essential for cardiac response to iron deficiency by regulating mitochondrial function

(2018) Tatsuya Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria as oncotarget: a comparison between the tetracycline analogs doxycycline and COL-3

(2018) Margherita Protasoni et al.   Oncotarget

Regulation of mitochondrion-associated cytosolic ribosomes by mammalian mitochondrial ribonuclease T2 (RNASET2)

(2018) Jinliang Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation

(2018) Roberto Vendramin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibition of mitochondrial translation as a therapeutic strategy for human ovarian cancer to overcome chemoresistance

(2018) Bo Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs

(2017) Désirée Schatton et al.   JOURNAL OF CELL BIOLOGY

The role of RNA-binding protein tristetraprolin in cancer and immunity

(2017) Jian Guo et al.   MEDICAL ONCOLOGY

The FASTK family of proteins: emerging regulators of mitochondrial RNA biology

(2017) Alexis A. Jourdain et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial mutations in human cancer: Curation of translation

(2017) Maϊwen Caudron-Herger et al.   RNA Biology

Mitochondrial ribosomes in cancer

(2017) Hyun-Jung Kim et al.   SEMINARS IN CANCER BIOLOGY

Plasticity of Mitochondrial Translation

(2017) Sven Dennerlein et al.   TRENDS IN CELL BIOLOGY

Translational regulation of mitochondrial biogenesis

(2016) Y. Zhang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cost-effectiveness of preventive case management for parents with a mental illness: a randomized controlled trial from three economic perspectives

(2016) Henny J. Wansink et al.   BMC HEALTH SERVICES RESEARCH

Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein

(2016) Ricarda Richter-Dennerlein et al.   CELL

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

(2016) Marina Feric et al.   CELL

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication

(2016) Yi Zhang et al.   EMBO JOURNAL

Malonate induces the assembly of cytoplasmic stress granules

(2016) Xue Fu et al.   FEBS LETTERS

HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNARMRP

(2016) Ji Heon Noh et al.   GENES & DEVELOPMENT

Mitochondrial RNA granules: Compartmentalizing mitochondrial gene expression

(2016) Alexis A. Jourdain et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial unfolded protein response controls matrix pre-RNA processing and translation

(2016) Christian Münch et al.   NATURE

Synchronized mitochondrial and cytosolic translation programs

(2016) Mary T. Couvillion et al.   NATURE

Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis

(2016) Yanyan Gao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SLIRP stabilizes LRPPRC via an RRM–PPR protein interface

(2016) Henrik Spåhr et al.   NUCLEIC ACIDS RESEARCH

Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice

(2016) Tara R. Richman et al.   Nature Communications

Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis

(2016) Yanyan Gao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Stress granules, P-bodies and cancer

(2015) Paul Anderson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mitochondrial DNA: A disposable genome?

(2015) Inna N. Shokolenko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

mTOR coordinates protein synthesis, mitochondrial activity and proliferation

(2015) Masahiro Morita et al.   CELL CYCLE

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

Impaired mitochondrial protein synthesis in head and neck squamous cell carcinoma

(2015) Emine C. Koc et al.   MITOCHONDRION

Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins

(2015) Yuan Lin et al.   MOLECULAR CELL

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

Mitochondrial Retrograde Signaling: Triggers, Pathways, and Outcomes

(2015) Fernanda Marques da Cunha et al.   Oxidative Medicine and Cellular Longevity

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease

(2015) Rebecca Lamb et al.   Oncotarget

The Human Mitochondrial DEAD-Box Protein DDX28 Resides in RNA Granules and Functions in Mitoribosome Assembly

(2015) Ya-Ting Tu et al.   Cell Reports

A Mitochondria-Specific Isoform of FASTK Is Present In Mitochondrial RNA Granules and Regulates Gene Expression and Function

(2015) Alexis A. Jourdain et al.   Cell Reports

Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis

(2015) Hana Antonicka et al.   Cell Reports

Initial Steps in RNA Processing and Ribosome Assembly Occur at Mitochondrial DNA Nucleoids

(2014) Daniel F. Bogenhagen et al.   Cell Metabolism

CLUH regulates mitochondrial biogenesis by binding mRNAs of nuclear-encoded mitochondrial proteins

(2014) Jie Gao et al.   JOURNAL OF CELL BIOLOGY

MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome

(2014) Joanna Rorbach et al.   MOLECULAR BIOLOGY OF THE CELL

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

(2014) Kıvanç Birsoy et al.   NATURE

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

GRSF1 Regulates RNA Processing in Mitochondrial RNA Granules

(2013) Alexis A. Jourdain et al.   Cell Metabolism

The Mitochondrial RNA-Binding Protein GRSF1 Localizes to RNA Granules and Is Required for Posttranscriptional Mitochondrial Gene Expression

(2013) Hana Antonicka et al.   Cell Metabolism

Organelle transcriptomes: products of a deconstructed genome

(2013) Ian D Small et al.   CURRENT OPINION IN MICROBIOLOGY

Mitochondrial Ribosomal RNA (rRNA) Methyltransferase Family Members Are Positioned to Modify Nascent rRNA in Foci near the Mitochondrial DNA Nucleoid

(2013) Ken-Wing Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Protein Synthesis: Efficiency and Accuracy

(2012) Kirsten Kehrein et al.   ANTIOXIDANTS & REDOX SIGNALING

Ribonucleoprotein Y-box-binding protein-1 regulates mitochondrial oxidative phosphorylation (OXPHOS) protein expression after serum stimulation through binding to OXPHOS mRNA

(2012) Shinya Matsumoto et al.   BIOCHEMICAL JOURNAL

MITRAC Links Mitochondrial Protein Translocation to Respiratory-Chain Assembly and Translational Regulation

(2012) David U. Mick et al.   CELL

Mitochondria “fuel” breast cancer metabolism: Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells

(2012) Federica Sotgia et al.   CELL CYCLE

Translation suppression promotes stress granule formation and cell survival in response to cold shock

(2012) Sarah Hofmann et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates

(2012) Liliana Malinovska et al.   MOLECULAR BIOLOGY OF THE CELL

Human C4orf14 interacts with the mitochondrial nucleoid and is involved in the biogenesis of the small mitochondrial ribosomal subunit

(2012) J. He et al.   NUCLEIC ACIDS RESEARCH

Selenite targets eIF4E-binding protein-1 to inhibit translation initiation and induce the assembly of non-canonical stress granules

(2012) Ken Fujimura et al.   NUCLEIC ACIDS RESEARCH

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

LRPPRC mutation suppresses cytochrome oxidase activity by altering mitochondrial RNA transcript stability in a mouse model

(2011) Fenghao Xu et al.   BIOCHEMICAL JOURNAL

Of P and Z: Mitochondrial tRNA processing enzymes

(2011) Walter Rossmanith   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Mitochondrial poly(A) polymerase and polyadenylation

(2011) Jeong Ho Chang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

LRPPRC is necessary for polyadenylation and coordination of translation of mitochondrial mRNAs

(2011) Benedetta Ruzzenente et al.   EMBO JOURNAL

Dynamic association-dissociation and harboring of endogenous mRNAs in stress granules

(2011) J. Zhang et al.   JOURNAL OF CELL SCIENCE

Engrailed protects mouse midbrain dopaminergic neurons against mitochondrial complex I insults

(2011) Daniel Alvarez-Fischer et al.   NATURE NEUROSCIENCE

PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria

(2011) Joanna Rorbach et al.   NUCLEIC ACIDS RESEARCH

Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs

(2011) Lien K. Brzezniak et al.   RNA Biology

Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit

(2010) Sven Dennerlein et al.   BIOCHEMICAL JOURNAL

Mutation in mitochondrial ribosomal protein MRPS22 leads to Cornelia de Lange-like phenotype, brain abnormalities and hypertrophic cardiomyopathy

(2010) Paulien Smits et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

LRPPRC and SLIRP Interact in a Ribonucleoprotein Complex That Regulates Posttranscriptional Gene Expression in Mitochondria

(2010) Florin Sasarman et al.   MOLECULAR BIOLOGY OF THE CELL

RNA-binding protein HuR mediates cytoprotection through stimulation of XIAP translation

(2010) D Durie et al.   ONCOGENE

Nuclear Speckles

(2010) D. L. Spector et al.   Cold Spring Harbor Perspectives in Biology

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

Mammalian Staufen 1 is recruited to stress granules and impairs their assembly

(2009) M. G. Thomas et al.   JOURNAL OF CELL SCIENCE

Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome

(2009) Woranontee Weraarpachai et al.   NATURE GENETICS

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

(2009) C. P. Brangwynne et al.   SCIENCE

The Mitochondrial Proteome: From Inventory to Function

(2008) Chris Meisinger et al.   CELL

The Structure of YqeH

(2008) Jawahar Sudhamsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways

(2008) Kyoko Arimoto et al.   NATURE CELL BIOLOGY