Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases

Long noncoding RNA MRPL23-AS1 Promotes Adenoid Cystic Carcinoma Lung Metastasis

(2020) Chu-Wen Chen et al.   CANCER RESEARCH

LONP1 de novo dominant mutation causes mitochondrial encephalopathy with loss of LONP1 chaperone activity and excessive LONP1 proteolytic activity

(2020) Arnaud Besse et al.   MITOCHONDRION

Integrating transcriptome-wide association study and copy number variation study identifies candidate genes and pathways for diffuse non-Hodgkin's lymphoma

(2020) Di Wu et al.   Cancer Genetics

Long Noncoding RNA TRIM52-AS1 Sponges miR-514a-5p to Facilitate Hepatocellular Carcinoma Progression Through Increasing MRPS18A

(2020) Chunhui Zhou et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Identification of Candidate Genes Associated with Breast Cancer Prognosis

(2020) Yun-Hua Xu et al.   DNA AND CELL BIOLOGY

Chromatin structure regulates cancer-specific alternative splicing events in primary HPV-related oropharyngeal squamous cell carcinoma

(2020) Theresa Guo et al.   Epigenetics

Whole Genome DNA Methylation Analysis of Active Pulmonary Tuberculosis Disease Identifies Novel Epigenotypes: PARP9/miR-505/RASGRP4/GNG12 Gene Methylation and Clinical Phenotypes

(2020) Yung-Che Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural variant in mitochondrial-associated gene (MRPL3) induces adult-onset neurodegeneration with memory impairment in the mouse

(2020) Lindsay S. Cahill et al.   JOURNAL OF NEUROSCIENCE

Selection of Endogenous Control Reference Genes for Studies on Type 1 or Type 2 Endometrial Cancer

(2020) Thangesweran Ayakannu et al.   Scientific Reports

Prediction of breast cancer proteins involved in immunotherapy, metastasis, and RNA-binding using molecular descriptors and artificial neural networks

(2020) Andrés López-Cortés et al.   Scientific Reports

Investigation of the gene co-expression network and hub genes associated with acute mountain sickness

(2020) Yue Chang et al.   HEREDITAS

The effects of environmental stressors on candidate aging associated genes

(2020) Mariana Andrawus et al.   EXPERIMENTAL GERONTOLOGY

A homozygous MRPL24 mutation causes a complex movement disorder and affects the mitoribosome assembly

(2020) Michela Di Nottia et al.   NEUROBIOLOGY OF DISEASE

Identification of differentially expressed metastatic genes and their signatures to predict the overall survival of uveal melanoma patients by bioinformatics analysis

(2020) Dan-Dan Zhao   International Journal of Ophthalmology

The Progression of Acute Myeloid Leukemia from First Diagnosis to Chemoresistant Relapse: A Comparison of Proteomic and Phosphoproteomic Profiles

(2020) Elise Aasebø et al.   Cancers

Identification of potential crucial genes and key pathways in osteosarcoma

(2020) Junwei Liu et al.   HEREDITAS

CRIF1–CDK2 Interface Inhibitors: An Unprecedented Strategy for Modulation of Cell Radiosensitivity

(2019) Qian Ran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mitochondrial ribosomal protein PTCD3 mutations cause oxidative phosphorylation defects with Leigh syndrome

(2019) Nurun Nahar Borna et al.   NEUROGENETICS

Integrated Bioinformatics Analysis the Function of RNA Binding Proteins (RBPs) and Their Prognostic Value in Breast Cancer

(2019) Ke Wang et al.   Frontiers in Pharmacology

Upregulation of Proteolytic Pathways and Altered Protein Biosynthesis Underlie Retinal Pathology in a Mouse Model of Alzheimer’s Disease

(2019) Mehdi Mirzaei et al.   MOLECULAR NEUROBIOLOGY

Isoforms S and L of MRPL33 from alternative splicing have isoform‑specific roles in the chemoresponse to epirubicin in gastric cancer cells via the PI3K/AKT signaling pathway

(2019) Jie Li et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

MRPL35 Is Up-Regulated in Colorectal Cancer and Regulates Colorectal Cancer Cell Growth and Apoptosis

(2019) Litao Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Integrated analysis of the critical region 5p15.3–p15.2 associated with cri-du-chat syndrome

(2019) Thiago Corrêa et al.   GENETICS AND MOLECULAR BIOLOGY

MRPS25 mutations impair mitochondrial translation and cause encephalomyopathy

(2019) Enrico Bugiardini et al.   HUMAN MOLECULAR GENETICS

Gene signature associated with neuro‐endocrine activity predicting prognosis of pancreatic carcinoma

(2019) Ke Chen et al.   Molecular Genetics & Genomic Medicine

Screening of key genes and prediction of therapeutic agents in Arsenic-induced lung carcinoma

(2019) Liang Zhang et al.   Cancer Biomarkers

Weighted gene coexpression network analysis reveals hub genes involved in cholangiocarcinoma progression and prognosis

(2019) Aiping Tian et al.   HEPATOLOGY RESEARCH

A Multi-Trait Approach Identified Genetic Variants Including a Rare Mutation in RGS3 with Impact on Abnormalities of Cardiac Structure/Function

(2019) Akram Yazdani et al.   Scientific Reports

High-throughput assessment of the antibody profile in ovarian cancer ascitic fluids

(2019) Frank Antony et al.   OncoImmunology

Identification of Crucial Candidate Genes and Pathways in Glioblastoma Multiform by Bioinformatics Analysis

(2019) Ali Mohamed Alshabi et al.   Biomolecules

Identification of robust reference genes for studies of gene expression in FFPE melanoma samples and melanoma cell lines

(2019) Julie N. Christensen et al.   MELANOMA RESEARCH

miR‑126a‑5p‑Dbp and miR‑31a‑Crot/Mrpl4 interaction pairs crucial for the development of hypertension and stroke

(2019) Qini Zhao et al.   Molecular Medicine Reports

Potentially Critical Roles of NDUFB5, TIMMDC1, and VDAC3 in the Progression of Septic Cardiomyopathy Through Integrated Bioinformatics Analysis

(2019) Kai Kang et al.   DNA AND CELL BIOLOGY

Mitochondrial oxidative phosphorylation is impaired in TALLYHO mice, a new obesity and type 2 diabetes animal model

(2019) Caroline A. Hunter et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial deficits in human iPSC-derived neurons from patients with 22q11.2 deletion syndrome and schizophrenia

(2019) Jianping Li et al.   Translational Psychiatry

Two Receptors, Two Isoforms, Two Cancers: Comprehensive Analysis of KIT and TrkA Expression in Neuroblastoma and Acute Myeloid Leukemia

(2019) Timofey D. Lebedev et al.   Frontiers in Oncology

MRPS30-DT Knockdown Inhibits Breast Cancer Progression by Targeting Jab1/Cops5

(2019) Balu Wu et al.   Frontiers in Oncology

Analysis of the microarray gene expression for breast cancer progression after the application modified logistic regression

(2019) Francielly Morais-Rodrigues et al.   GENE

A Comprehensive cis -eQTL Analysis Revealed Target Genes in Breast Cancer Susceptibility Loci Identified in Genome-wide Association Studies

(2018) Xingyi Guo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Bi-allelic Mutations in the Mitochondrial Ribosomal Protein MRPS2 Cause Sensorineural Hearing Loss, Hypoglycemia, and Multiple OXPHOS Complex Deficiencies

(2018) Thatjana Gardeitchik et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Knockdown of MRPL42 suppresses glioma cell proliferation by inducing cell cycle arrest and apoptosis

(2018) Chunyan Hao et al.   BIOSCIENCE REPORTS

Integrative Genomic Analysis Predicts CausativeCis-Regulatory Mechanisms of the Breast Cancer–Associated Genetic Variant rs4415084

(2018) Yi Zhang et al.   CANCER RESEARCH

Screening of prognostic risk microRNAs for acute myeloid leukemia

(2018) Hai-Yan Gao et al.   Hematology

Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency

(2018) Anlu Chen et al.   HUMAN MOLECULAR GENETICS

Polymorphisms in PARK2 and MRPL37 are associated with higher risk of recurrent venous thromboembolism in a sex-specific manner

(2018) Kristina Sundquist et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

CR6 interacting factor 1 deficiency promotes endothelial inflammation by SIRT1 downregulation

(2018) Shuyu Piao et al.   PLoS One

Reduced oxidative capacity in macrophages results in systemic insulin resistance

(2018) Saet-Byel Jung et al.   Nature Communications

The MRPS18-2 protein levels correlate with prostate tumor progression and it induces CXCR4-dependent migration of cancer cells

(2018) Muhammad Mushtaq et al.   Scientific Reports

Mutant MRPS5 affects mitoribosomal accuracy and confers stress‐related behavioral alterations

(2018) Rashid Akbergenov et al.   EMBO REPORTS

Exploring rare and low-frequency variants in the Saguenay–Lac-Saint-Jean population identified genes associated with asthma and allergy traits

(2018) Andréanne Morin et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Whole transcriptome sequencing reveals biologically significant RNA markers and related regulating biological pathways in cardiomyocyte hypertrophy induced by high glucose

(2018) Zheying Meng et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Genetic risk factors for VIPN in childhood acute lymphoblastic leukemia patients identified using whole-exome sequencing

(2018) Rachid Abaji et al.   PHARMACOGENOMICS

Long Noncoding RNA MRPL39 Inhibits Gastric Cancer Proliferation and Progression by Directly Targeting miR-130

(2018) Ming Jun Yu et al.   Genetic Testing and Molecular Biomarkers

A variant in MRPS14 (uS14m) causes perinatal hypertrophic cardiomyopathy with neonatal lactic acidosis, growth retardation, dysmorphic features and neurological involvement

(2018) Christopher B Jackson et al.   HUMAN MOLECULAR GENETICS

Mutations in the MRPS28 gene encoding the small mitoribosomal subunit protein bS1m in a patient with intrauterine growth retardation, craniofacial dysmorphism and multisystemic involvement

(2018) Juliette Pulman et al.   HUMAN MOLECULAR GENETICS

CRIF1 controls autoimmune arthritis by regulation of STAT3 pathway and Th17 cells

(2018) Jin-Sil Park et al.   IMMUNOLOGY

Genetic Basis of Severe Childhood-Onset Cardiomyopathies

(2018) Catalina Vasilescu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Differentially expressed mitochondrial genes in breast cancer cells: Potential new targets for anti-cancer therapies

(2017) Qinglin Zhang et al.   GENE

An innovative strategy to clone positive modifier genes of defects caused by mtDNA mutations: MRPS18C as suppressor gene of m.3946G>A mutation in MT-ND1 gene

(2017) María Elena Rodríguez-García et al.   HUMAN GENETICS

Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness

(2017) Young-Kyoung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A patient with mitochondrial disorder due to a novel mutation in MRPS22

(2017) Mustafa Kılıç et al.   METABOLIC BRAIN DISEASE

MRPL33 and its splicing regulator hnRNPK are required for mitochondria function and implicated in tumor progression

(2017) L Liu et al.   ONCOGENE

The miR-608 rs4919510 polymorphism may modify cancer susceptibility based on type

(2017) Shuangshuang Wu et al.   TUMOR BIOLOGY

High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes

(2017) Meng Pu et al.   TUMOR BIOLOGY

CR6-interacting factor 1 inhibits invasiveness by suppressing TGF-β-mediated epithelial-mesenchymal transition in hepatocellular carcinoma

(2017) Runzhou Zhuang et al.   Oncotarget

Genetic variants in lncRNA H19 are associated with the risk of oral squamous cell carcinoma in a Chinese population

(2017) Zhiyao Yuan et al.   Oncotarget

Mitochondrial markers predict recurrence, metastasis and tamoxifen-resistance in breast cancer patients: Early detection of treatment failure with companion diagnostics

(2017) Federica Sotgia et al.   Oncotarget

Mitochondrial biomarkers predict tumor progression and poor overall survival in gastric cancers: Companion diagnostics for personalized medicine

(2017) Federica Sotgia et al.   Oncotarget

Targeted deletion of Crif1 in mouse epidermis impairs skin homeostasis and hair morphogenesis

(2017) Jung-Min Shin et al.   Scientific Reports

Co-Activation of PKC-δ by CRIF1 Modulates Oxidative Stress in Bone Marrow Multipotent Mesenchymal Stromal Cells after Irradiation by Phosphorylating NRF2 Ser40

(2017) Lili Chen et al.   Theranostics

Genetic Analysis of Mitochondrial Ribosomal Proteins and Cognitive Aging in Postmenopausal Women

(2017) Khyobeni Mozhui et al.   Frontiers in Genetics

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation

(2016) Maya Ghoussaini et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A 19-Gene expression signature as a predictor of survival in colorectal cancer

(2016) Nurul Ainin Abdul Aziz et al.   BMC Medical Genomics

Mitochondrial Ribosomal Protein L10 Associates with Cyclin B1/Cdk1 Activity and Mitochondrial Function

(2016) Hai-Bo Li et al.   DNA AND CELL BIOLOGY

Mammalian mitochondrial ribosomal small subunit (MRPS) genes: A putative role in human disease

(2016) Gopal Gopisetty et al.   GENE

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

(2016) Hyo Kyun Chung et al.   JOURNAL OF CELL BIOLOGY

Haploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium

(2016) P Devaraju et al.   MOLECULAR PSYCHIATRY

Benzyl isothiocyanate alters the gene expression with cell cycle regulation and cell death in human brain glioblastoma GBM 8401 cells

(2016) NOU-YING TANG et al.   ONCOLOGY REPORTS

FoxO3a confers cetuximab resistance in RAS wild-type metastatic colorectal cancer through c-Myc

(2016) Yiyi Yu et al.   Oncotarget

S18 family of mitochondrial ribosomal proteins: evolutionary history and Gly132 polymorphism in colon carcinoma

(2016) Muhammad Mushtaq et al.   Oncotarget

Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21

(2016) Yosr Hamdi et al.   Oncotarget

A Comprehensive Genomic Analysis Reveals the Genetic Landscape of Mitochondrial Respiratory Chain Complex Deficiencies

(2016) Masakazu Kohda et al.   PLoS Genetics

Lymphocyte-specific protein tyrosine kinase (Lck) interacts with CR6-interacting factor 1 (CRIF1) in mitochondria to repress oxidative phosphorylation

(2015) Shahrooz Vahedi et al.   BMC CANCER

The role of death-associated protein 3 in apoptosis, anoikis and human cancer

(2015) Umar Wazir et al.   Cancer Cell International

Mutation in mitochondrial ribosomal protein S7 (MRPS7) causes congenital sensorineural deafness, progressive hepatic and renal failure and lactic acidemia

(2015) Minal J. Menezes et al.   HUMAN MOLECULAR GENETICS

Mitochondrial Citrate Transporter-dependent Metabolic Signature in the 22q11.2 Deletion Syndrome

(2015) Eleonora Napoli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Driver Gene and Novel Mutations in Asbestos-Exposed Lung Adenocarcinoma and Malignant Mesothelioma Detected by Exome Sequencing

(2015) Satu Mäki-Nevala et al.   LUNG

Validation of endogenous control reference genes for normalizing gene expression studies in endometrial carcinoma

(2015) Thangesweran Ayakannu et al.   MOLECULAR HUMAN REPRODUCTION

A Pooling Genome-Wide Association Study Combining a Pathway Analysis for Typical Sporadic Parkinson’s Disease in the Han Population of Chinese Mainland

(2015) Yakun Hu et al.   MOLECULAR NEUROBIOLOGY

MRPS22 mutation causes fatal neonatal lactic acidosis with brain and heart abnormalities

(2015) Fabian Baertling et al.   NEUROGENETICS

MRPL44 mutations cause a slowly progressive multisystem disease with childhood-onset hypertrophic cardiomyopathy

(2015) Felix Distelmaier et al.   NEUROGENETICS

The complete structure of the 55S mammalian mitochondrial ribosome

(2015) B. J. Greber et al.   SCIENCE

The structure of the human mitochondrial ribosome

(2015) A. Amunts et al.   SCIENCE

A Role for the Mitochondrial Protein Mrpl44 in Maintaining OXPHOS Capacity

(2015) Janet H. C. Yeo et al.   PLoS One

A new system for naming ribosomal proteins

(2014) Nenad Ban et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The complete structure of the large subunit of the mammalian mitochondrial ribosome

(2014) Basil J. Greber et al.   NATURE

Cryo-EM structure of the small subunit of the mammalian mitochondrial ribosome

(2014) P. S. Kaushal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the large ribosomal subunit from human mitochondria

(2014) A. Brown et al.   SCIENCE

Associations of Candidate Genes to Age-Related Macular Degeneration Among Racial/Ethnic Groups in the Multi-Ethnic Study of Atherosclerosis

(2013) Ronald Klein et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Whole-exome sequencing identifies a mutation in the mitochondrial ribosome protein MRPL44 to underlie mitochondrial infantile cardiomyopathy

(2013) Christopher J Carroll et al.   JOURNAL OF MEDICAL GENETICS

Structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristae

(2012) K. M. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exome sequencing identifies MRPL3 mutation in mitochondrial cardiomyopathy

(2011) Louise Galmiche et al.   HUMAN MUTATION

Deletion mutational analysis of BMRP, a pro-apoptotic protein that binds to Bcl-2

(2011) Srinivas Malladi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Crystal Structure of the Eukaryotic 40S Ribosomal Subunit in Complex with Initiation Factor 1

(2010) J. Rabl et al.   SCIENCE

Pentatricopeptide repeat domain protein 3 associates with the mitochondrial small ribosomal subunit and regulates translation

(2009) Stefan M.K. Davies et al.   FEBS LETTERS