RNA-Binding Proteins in Cancer: Functional and Therapeutic Perspectives

Development and validation of a RNA binding protein-associated prognostic model for lung adenocarcinoma

(2020) Wei Li et al.   Aging-US

RNA-Binding Proteins as Important Regulators of Long Non-Coding RNAs in Cancer

(2020) Katharina Jonas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Small Protein Hidden in lncRNA LOC90024 Promotes “Cancerous” RNA Splicing and Tumorigenesis

(2020) Nan Meng et al.   Advanced Science

CircSMARCA5 Regulates VEGFA mRNA Splicing and Angiogenesis in Glioblastoma Multiforme Through the Binding of SRSF1

(2019) Davide Barbagallo et al.   Cancers

Blockade of miR-3614 maturation by IGF2BP3 increases TRIM25 expression and promotes breast cancer cell proliferation

(2019) Zhenzhen Wang et al.   EBioMedicine

Integrated Bioinformatics Analysis the Function of RNA Binding Proteins (RBPs) and Their Prognostic Value in Breast Cancer

(2019) Ke Wang et al.   Frontiers in Pharmacology

A miR‐194/PTBP1/CCND3 axis regulates tumor growth in human hepatocellular carcinoma

(2019) Hoin Kang et al.   JOURNAL OF PATHOLOGY

Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia

(2019) Gerard Minuesa et al.   Nature Communications

The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells

(2019) Lorenzo Allegri et al.   Scientific Reports

The RNA-binding protein RBM3 promotes cell proliferation in hepatocellular carcinoma by regulating circular RNA SCD-circRNA 2 production

(2019) Wei Dong et al.   EBioMedicine

HnRNPR-CCNB1/CENPF axis contributes to gastric cancer proliferation and metastasis

(2019) Er-Bao Chen et al.   Aging-US

SRSF3-Regulated RNA Alternative Splicing Promotes Glioblastoma Tumorigenicity by Affecting Multiple Cellular Processes

(2019) Xiao Song et al.   CANCER RESEARCH

Tumor angiogenesis: causes, consequences, challenges and opportunities

(2019) Roberta Lugano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

LncRNA-HGBC stabilized by HuR promotes gallbladder cancer progression by regulating miR-502-3p/SET/AKT axis

(2019) Yun-ping Hu et al.   Molecular Cancer

RNA-binding motif protein 10 induces apoptosis and suppresses proliferation by activating p53

(2019) Ji Hoon Jung et al.   ONCOGENE

The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis

(2019) Tuan M Nguyen et al.   NUCLEIC ACIDS RESEARCH

IMP2 and IMP3 cooperate to promote the metastasis of triple-negative breast cancer through destabilization of progesterone receptor

(2018) Hye-Youn Kim et al.   CANCER LETTERS

Expanding horizons: new roles for non-canonical RNA-binding proteins in cancer

(2018) Samantha Moore et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Chemo-biologic combinatorial drug delivery using folate receptor-targeted dendrimer nanoparticles for lung cancer treatment

(2018) Narsireddy Amreddy et al.   Nanomedicine-Nanotechnology Biology and Medicine

Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

(2018) Huilin Huang et al.   NATURE CELL BIOLOGY

A brave new world of RNA-binding proteins

(2018) Matthias W. Hentze et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of RNA-binding protein HuR facilitates cellular senescence through posttranscriptional regulation of TIN2 mRNA

(2018) Ji Hoon Lee et al.   NUCLEIC ACIDS RESEARCH

Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1

(2018) Hamed Kooshapur et al.   Nature Communications

A General Framework for Interrogation of mRNA Stability Programs Identifies RNA-Binding Proteins that Govern Cancer Transcriptomes

(2018) Gabrielle Perron et al.   Cell Reports

Small-Molecule Inhibitors Disrupt let-7 Oligouridylation and Release the Selective Blockade of let-7 Processing by LIN28

(2018) Longfei Wang et al.   Cell Reports

Comprehensive Genomic Characterization of RNA-Binding Proteins across Human Cancers

(2018) Ze-Lin Wang et al.   Cell Reports

Sequences enriched in Alu repeats drive nuclear localization of long RNAs in human cells

(2018) Yoav Lubelsky et al.   NATURE

Environmental risk factors for cancer – review paper

(2018) Anna Lewandowska et al.   ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE

Disruption of the Rbm38-eIF4E complex with a synthetic peptide Pep8 increases p53 expression

(2018) Christopher A Lucchesi et al.   CANCER RESEARCH

Roles of Tristetraprolin in Tumorigenesis

(2018) Jeong-Min Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Knockdown of DNA/RNA‑binding protein KIN17 promotes apoptosis of triple‑negative breast cancer cells

(2018) Xiang Gao et al.   Oncology Letters

Hu antigen R (HuR) multimerization contributes to glioma disease progression

(2017) Natalia Filippova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor-targeted Nanoparticle Delivery of HuR siRNA Inhibits Lung Tumor Growth In Vitro and In Vivo By Disrupting the Oncogenic Activity of the RNA-binding Protein HuR

(2017) Ranganayaki Muralidharan et al.   MOLECULAR CANCER THERAPEUTICS

WIG1 is crucial for AGO2-mediated ACOT7 mRNA silencing via miRNA-dependent and -independent mechanisms

(2017) Hyung Chul Lee et al.   NUCLEIC ACIDS RESEARCH

Regulation of HuR structure and function by dihydrotanshinone-I

(2017) Preet Lal et al.   NUCLEIC ACIDS RESEARCH

Knockdown of MSI1 inhibited the cell proliferation of human osteosarcoma cells by targeting p21 and p27

(2017) Jianbing Niu et al.   Oncology Letters

KH-type splicing regulatory protein is involved in esophageal squamous cell carcinoma progression

(2017) Yuji Fujita et al.   Oncotarget

Advances in the delivery of RNA therapeutics: from concept to clinical reality

(2017) James C. Kaczmarek et al.   Genome Medicine

Comparison of Host Gene Expression Profiles in Spleen Tissues of Genetically Susceptible and Resistant Mice during ECTV Infection

(2017) Wen-Yu Cheng et al.   Biomed Research International

The LIN28/let-7 Pathway in Cancer

(2017) Julien Balzeau et al.   Frontiers in Genetics

The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro

(2017) Kawaljit Kaur et al.   PLoS One

HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells

(2017) Ranganayaki Muralidharan et al.   Scientific Reports

A Small-Molecule Inhibitor of Lin28

(2016) Martina Roos et al.   ACS Chemical Biology

Identification of RNA-Binding Protein LARP4B as a Tumor Suppressor in Glioma

(2016) Hideto Koso et al.   CANCER RESEARCH

Long Noncoding RNA MALAT1 Promotes Hepatocellular Carcinoma Development by SRSF1 Upregulation and mTOR Activation

(2016) Pushkar Malakar et al.   CANCER RESEARCH

IGF2BP2 promotes colorectal cancer cell proliferation and survival through interfering withRAF-1degradation by miR-195

(2016) Song Ye et al.   FEBS LETTERS

Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease

(2016) Vittorio Calderone et al.   GASTROENTEROLOGY

IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer

(2016) Nils Degrauwe et al.   GENES & DEVELOPMENT

Modulation of tumor eIF4E by antisense inhibition: A phase I/II translational clinical trial of ISIS 183750-an antisense oligonucleotide against eIF4E-in combination with irinotecan in solid tumors and irinotecan-refractory colorectal cancer

(2016) A.G. Duffy et al.   INTERNATIONAL JOURNAL OF CANCER

RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation

(2016) Jayanth Kumar Palanichamy et al.   JOURNAL OF CLINICAL INVESTIGATION

KH-type splicing regulatory protein (KHSRP) contributes to tumorigenesis by promoting miR-26a maturation in small cell lung cancer

(2016) Lihua Tong et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Alternative Polyadenylation: Another Foe in Cancer

(2016) A. E. Erson-Bensan et al.   MOLECULAR CANCER RESEARCH

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma

(2016) Raymond G. Fox et al.   NATURE

LncRNAOIP5-AS1/cyranosponges RNA-binding protein HuR

(2016) Jiyoung Kim et al.   NUCLEIC ACIDS RESEARCH

Lineage-specific roles of the cytoplasmic polyadenylation factor CPEB4 in the regulation of melanoma drivers

(2016) Eva Pérez-Guijarro et al.   Nature Communications

Long noncoding RNA Saf and splicing factor 45 increase soluble Fas and resistance to apoptosis

(2016) Olga Villamizar et al.   Oncotarget

miRNA-Mediated KHSRP Silencing Rewires Distinct Post-transcriptional Programs during TGF-β-Induced Epithelial-to-Mesenchymal Transition

(2016) Margherita Puppo et al.   Cell Reports

HuR-regulated lncRNA NEAT1 stability in tumorigenesis and progression of ovarian cancer

(2016) Yiqing Chai et al.   Cancer Medicine

The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase

(2016) Sandhya Sanduja et al.   Aging-US

The RNA Binding Protein Quaking Regulates Formation of circRNAs

(2015) Simon J. Conn et al.   CELL

Musashi2 sustains the mixed-lineage leukemia–driven stem cell regulatory program

(2015) Sun-Mi Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Natural product (−)-gossypol inhibits colon cancer cell growth by targeting RNA-binding protein Musashi-1

(2015) Lan Lan et al.   Molecular Oncology

Translational regulation of inhibin βA by TGFβ via the RNA-binding protein hnRNP E1 enhances the invasiveness of epithelial-to-mesenchymal transitioned cells

(2015) B V Howley et al.   ONCOGENE

CPEB1 mediates epithelial-to-mesenchyme transition and breast cancer metastasis

(2015) K Nagaoka et al.   ONCOGENE

Oncofetal protein IGF2BP3 facilitates the activity of proto-oncogene protein eIF4E through the destabilization of EIF4E-BP2 mRNA

(2015) R Mizutani et al.   ONCOGENE

Nuclear matrix-associated protein SMAR1 regulates alternative splicing via HDAC6-mediated deacetylation of Sam68

(2015) Kiran Kumar Nakka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HNRNPC as a candidate biomarker for chemoresistance in gastric cancer

(2015) Hao Huang et al.   TUMOR BIOLOGY

Exploiting tumor cell senescence in anticancer therapy

(2014) Minyoung Lee et al.   BMB Reports

Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing

(2014) Y. Xu et al.   GENES & DEVELOPMENT

Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation

(2014) J. Tcherkezian et al.   GENES & DEVELOPMENT

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma

(2014) Tony Gutschner et al.   HEPATOLOGY

Deletion of serine/arginine-rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice

(2014) Supriya Sen et al.   HEPATOLOGY

Post-transcriptional Regulation of Programmed Cell Death 4 (PDCD4) mRNA by the RNA-binding Proteins Human Antigen R (HuR) and T-cell Intracellular Antigen 1 (TIA1)

(2014) Callie P. Wigington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance

(2014) Maryam A. Hamdollah Zadeh et al.   Molecular Oncology

A census of human RNA-binding proteins

(2014) Stefanie Gerstberger et al.   NATURE REVIEWS GENETICS

A novel mechanism for the control of translation of specific mRNAs by tumor suppressor protein Pdcd4: inhibition of translation elongation

(2014) A Biyanee et al.   ONCOGENE

The alternative splicing side of cancer

(2014) Giuseppe Biamonti et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity

(2014) Je-Hyun Yoon et al.   Nature Communications

IMP3 RNP Safe Houses Prevent miRNA-Directed HMGA2 mRNA Decay in Cancer and Development

(2014) Lars Jønson et al.   Cell Reports

Physiological networks and disease functions of RNA-binding protein AUF1

(2014) Ashleigh E. Moore et al.   Wiley Interdisciplinary Reviews-RNA

Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite

(2014) Carina C Clingman et al.   eLife

LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis

(2014) Xiaodan Ji et al.   eLife

Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer

(2014) Sakari Vanharanta et al.   eLife

Cap-dependent translation initiation factor, eIF4E, is the target for Ouabain-mediated inhibition of HIF-1α

(2013) Ji Cao et al.   BIOCHEMICAL PHARMACOLOGY

Exo70 Isoform Switching upon Epithelial-Mesenchymal Transition Mediates Cancer Cell Invasion

(2013) Hezhe Lu et al.   DEVELOPMENTAL CELL

Posttranscriptional destabilization of the liver-specific long noncoding RNA HULC by the IGF2 mRNA-binding protein 1 (IGF2BP1)

(2013) Monika Hämmerle et al.   HEPATOLOGY

Insulin-like growth factor II messenger RNA–binding protein-3 is a valuable diagnostic and prognostic marker of intraductal papillary mucinous neoplasm

(2013) Katsuya Morimatsu et al.   HUMAN PATHOLOGY

Multiple Functions of the RNA-Binding Protein HuR in Cancer Progression, Treatment Responses and Prognosis

(2013) Jun Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RBM5, 6, and 10 Differentially Regulate NUMB Alternative Splicing to Control Cancer Cell Proliferation

(2013) Elias G. Bechara et al.   MOLECULAR CELL

Splicing-Factor Oncoprotein SRSF1 Stabilizes p53 via RPL5 and Induces Cellular Senescence

(2013) Oliver I. Fregoso et al.   MOLECULAR CELL

Treatment of Breast and Lung Cancer Cells with a N-7 Benzyl Guanosine Monophosphate Tryptamine Phosphoramidate Pronucleotide (4Ei-1) Results in Chemosensitization to Gemcitabine and Induced eIF4E Proteasomal Degradation

(2013) Shui Li et al.   MOLECULAR PHARMACEUTICS

CPEB1 coordinates alternative 3′-UTR formation with translational regulation

(2013) Felice-Alessio Bava et al.   NATURE

Post-transcriptional regulation of cyclins D1, D3 and G1 and proliferation of human cancer cells depend on IMP-3 nuclear localization

(2013) T Rivera Vargas et al.   ONCOGENE

Downregulation of serine/arginine-rich splicing factor 3 induces G1 cell cycle arrest and apoptosis in colon cancer cells

(2013) K Kurokawa et al.   ONCOGENE

Epithelial splicing regulatory protein 1 is a favorable prognostic factor in pancreatic cancer that attenuates pancreatic metastases

(2013) J Ueda et al.   ONCOGENE

Overexpression of RNA-binding protein CELF1 prevents apoptosis and destabilizes pro-apoptotic mRNAs in oral cancer cells

(2013) Sudha Talwar et al.   RNA Biology

Mammalian DIS3L2 exoribonuclease targets the uridylated precursors of let-7 miRNAs

(2013) D. Ustianenko et al.   RNA

The RNA-Binding Protein Musashi-1 Regulates Proteasome Subunit Expression in Breast Cancer- and Glioma-Initiating Cells

(2013) Chann Lagadec et al.   STEM CELLS

Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination

(2013) Je-Hyun Yoon et al.   Nature Communications

Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function

(2013) Supriya Sen et al.   Nature Communications

The CPEB-family of proteins, translational control in senescence and cancer

(2012) Gonzalo Fernández-Miranda et al.   AGEING RESEARCH REVIEWS

Lin28 regulates HER2 and promotes malignancy through multiple mechanisms

(2012) Chen Feng et al.   CELL CYCLE

Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment

(2012) Bong Cho Kim et al.   EMBO JOURNAL

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

(2012) M. Janiszewska et al.   GENES & DEVELOPMENT

SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance

(2012) Rong Jia et al.   International Journal of Biological Sciences

Overexpression of HnRNP A1 promotes tumor invasion through regulating CD44v6 and indicates poor prognosis for hepatocellular carcinoma

(2012) Zheng-Jun Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

Regulation of local expression of cell adhesion and motility-related mRNAs in breast cancer cells by IMP1/ZBP1

(2012) W. Gu et al.   JOURNAL OF CELL SCIENCE

The splicing factor SRSF6 is amplified and is an oncoprotein in lung and colon cancers

(2012) Michal Cohen-Eliav et al.   JOURNAL OF PATHOLOGY

The Oncogenic RNA-Binding Protein Musashi1 Is Regulated by HuR via mRNA Translation and Stability in Glioblastoma Cells

(2012) D. T. Vo et al.   MOLECULAR CANCER RESEARCH

mRNA Decay Factor AUF1 Maintains Normal Aging, Telomere Maintenance, and Suppression of Senescence by Activation of Telomerase Transcription

(2012) Adam R. Pont et al.   MOLECULAR CELL

LincRNA-p21 Suppresses Target mRNA Translation

(2012) Je-Hyun Yoon et al.   MOLECULAR CELL

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell

(2012) Toshifumi Yae et al.   Nature Communications

CPEB-mediated ZO-1 mRNA localization is required for epithelial tight-junction assembly and cell polarity

(2012) Kentaro Nagaoka et al.   Nature Communications

Splicing Factor hnRNP A2/B1 Regulates Tumor Suppressor Gene Splicing and Is an Oncogenic Driver in Glioblastoma

(2011) R. Golan-Gerstl et al.   CANCER RESEARCH

LIN28B Promotes Colon Cancer Progression and Metastasis

(2011) C. E. King et al.   CANCER RESEARCH

Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases

(2011) B. W. Konicek et al.   CANCER RESEARCH

HuR-dependent loading of miRNA RISC to the mRNA encoding the Ras-related small GTPase RhoB controls its translation during UV-induced apoptosis

(2011) V Glorian et al.   CELL DEATH AND DIFFERENTIATION

A Phase 1 Dose Escalation, Pharmacokinetic, and Pharmacodynamic Evaluation of eIF-4E Antisense Oligonucleotide LY2275796 in Patients with Advanced Cancer

(2011) D. S. Hong et al.   CLINICAL CANCER RESEARCH

Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas

(2011) Clare V LeFave et al.   EMBO JOURNAL

The RNA-binding protein Sam68 is a multifunctional player in human cancer

(2011) P. Bielli et al.   ENDOCRINE-RELATED CANCER

Modulation of neoplastic gene regulatory pathways by the RNA-binding factor AUF1

(2011) Beth et al.   Frontiers in Bioscience-Landmark

The novel lupus antigen related protein acheron enhances the development of human breast cancer

(2011) Rong Shao et al.   INTERNATIONAL JOURNAL OF CANCER

Interleukin-1 Activates Synthesis of Interleukin-6 by Interfering with a KH-type Splicing Regulatory Protein (KSRP)-dependent Translational Silencing Mechanism

(2011) Sonam Dhamija et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptosis in cancer: from pathogenesis to treatment

(2011) Rebecca SY Wong   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Silencing disease genes in the laboratory and the clinic

(2011) Jonathan K Watts et al.   JOURNAL OF PATHOLOGY

The mRNA Stability Factor HuR Inhibits MicroRNA-16 Targeting of COX-2

(2011) L. E. Young et al.   MOLECULAR CANCER RESEARCH

PTBP1-dependent regulation of USP5 alternative RNA splicing plays a role in glioblastoma tumorigenesis

(2011) Daisy I. Izaguirre et al.   MOLECULAR CARCINOGENESIS

Identification of an mRNP Complex Regulating Tumorigenesis at the Translational Elongation Step

(2011) George S. Hussey et al.   MOLECULAR CELL

Key contribution of CPEB4-mediated translational control to cancer progression

(2011) Elena Ortiz-Zapater et al.   NATURE MEDICINE

Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28

(2011) Fionna E Loughlin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin

(2011) Heike Sandler et al.   NUCLEIC ACIDS RESEARCH

La enhances IRES-mediated translation of laminin B1 during malignant epithelial to mesenchymal transition

(2011) Michaela Petz et al.   NUCLEIC ACIDS RESEARCH

PCBP1 Suppresses the Translation of Metastasis-Associated PRL-3 Phosphatase

(2010) Haihe Wang et al.   CANCER CELL

hnRNP A2/B1 Modulates Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines

(2010) J. Tauler et al.   CANCER RESEARCH

An Alternative Splicing Network Links Cell-Cycle Control to Apoptosis

(2010) Michael J. Moore et al.   CELL

Targeting Eukaryotic Translation Initiation Factor 4E (eIF4E) in Cancer

(2010) A. C. Hsieh et al.   CLINICAL CANCER RESEARCH

HuR Uses AUF1 as a Cofactor To Promote p16INK4 mRNA Decay

(2010) N. Chang et al.   MOLECULAR AND CELLULAR BIOLOGY

Smad Proteins Bind a Conserved RNA Sequence to Promote MicroRNA Maturation by Drosha

(2010) Brandi N. Davis et al.   MOLECULAR CELL

The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation

(2010) Vidisha Tripathi et al.   MOLECULAR CELL

Expansion of the eukaryotic proteome by alternative splicing

(2010) Timothy W. Nilsen et al.   NATURE

TGF-β-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI

(2010) Arindam Chaudhury et al.   NATURE CELL BIOLOGY

Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis

(2010) Gracjan Michlewski et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The RNA-binding protein La contributes to cell proliferation and CCND1 expression

(2010) G Sommer et al.   ONCOGENE

RNA-binding protein HuR mediates cytoprotection through stimulation of XIAP translation

(2010) D Durie et al.   ONCOGENE

Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F

(2010) R. Cencic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

(2010) C. V. Clower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events

(2010) Claude C. Warzecha et al.   RNA Biology

Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: Focus on hnRNP E1's multifunctional regulatory roles

(2010) A. Chaudhury et al.   RNA

hnRNP A2 Regulates Alternative mRNA Splicing of TP53INP2 to Control Invasive Cell Migration

(2009) K. Moran-Jones et al.   CANCER RESEARCH

Alternative Splicing of the Cyclin D1 Proto-Oncogene Is Regulated by the RNA-Binding Protein Sam68

(2009) M. P. Paronetto et al.   CANCER RESEARCH

TUT4 in Concert with Lin28 Suppresses MicroRNA Biogenesis through Pre-MicroRNA Uridylation

(2009) Inha Heo et al.   CELL

Inhibition of Ovarian Cancer Growth by a Tumor-Targeting Peptide That Binds Eukaryotic Translation Initiation Factor 4E

(2009) S. Y. Ko et al.   CLINICAL CANCER RESEARCH

The role of AUF1 in thyroid carcinoma progression

(2009) Bogusz Trojanowicz et al.   ENDOCRINE-RELATED CANCER

RNA-Binding Protein Quaking, a Critical Regulator of Colon Epithelial Differentiation and a Suppressor of Colon Cancer

(2009) Guodong Yang et al.   GASTROENTEROLOGY

Tristetraprolin regulates expression of VEGF and tumorigenesis in human colon cancer

(2009) Hyun Hee Lee et al.   INTERNATIONAL JOURNAL OF CANCER

Blocking  -catenin binding to the ZBP1 promoter represses ZBP1 expression, leading to increased proliferation and migration of metastatic breast-cancer cells

(2009) W. Gu et al.   JOURNAL OF CELL SCIENCE

ESRP1 and ESRP2 Are Epithelial Cell-Type-Specific Regulators of FGFR2 Splicing

(2009) Claude C. Warzecha et al.   MOLECULAR CELL

CRD-BP Protects the Coding Region of βTrCP1 mRNA from miR-183-Mediated Degradation

(2009) Irina Elcheva et al.   MOLECULAR CELL

Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping

(2009) Yuanchao Xue et al.   MOLECULAR CELL

The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs

(2009) Michele Trabucchi et al.   NATURE

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

Lin28 promotes transformation and is associated with advanced human malignancies

(2009) Srinivas R Viswanathan et al.   NATURE GENETICS

The p53 target Wig-1 regulates p53 mRNA stability through an AU-rich element

(2009) A. Vilborg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The SR protein family of splicing factors: master regulators of gene expression

(2008) Jennifer C. Long et al.   BIOCHEMICAL JOURNAL

Cytoplasmic polyadenylation-element-binding protein (CPEB)1 and 2 bind to theHIF-1α mRNA 3′-UTR and modulate HIF-1α protein expression

(2008) Sonja Hägele et al.   BIOCHEMICAL JOURNAL

Tumor-specific RNAi targeting eIF4E suppresses tumor growth, induces apoptosis and enhances cisplatin cytotoxicity in human breast carcinoma cells

(2008) Ke Dong et al.   BREAST CANCER RESEARCH AND TREATMENT

The p53 target protein Wig-1 binds hnRNP A2/B1 and RNA Helicase A via RNA

(2008) Magdalena Prahl et al.   FEBS LETTERS

Knockdown of RNA Binding Protein Musashi-1 Leads to Tumor Regression In Vivo

(2008) Sripathi M. Sureban et al.   GASTROENTEROLOGY

Determinants of MicroRNA Processing Inhibition by the Developmentally Regulated RNA-binding Protein Lin28

(2008) Elena Piskounova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA

(2008) Inha Heo et al.   MOLECULAR CELL

Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs

(2008) D. Weidensdorfer et al.   RNA

RNA-binding proteins in human genetic disease

(2008) Kiven E. Lukong et al.   TRENDS IN GENETICS