Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma

(2019) Yufeng Shi et al.   NATURE

Oxidative Phosphorylation as an Emerging Target in Cancer Therapy

(2018) Thomas M. Ashton et al.   CLINICAL CANCER RESEARCH

A multiprotein supercomplex controlling oncogenic signalling in lymphoma

(2018) James D. Phelan et al.   NATURE

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

(2018) Jennifer R. Molina et al.   NATURE MEDICINE

Therapeutic synergy between tigecycline and venetoclax in a preclinical model of MYC / BCL2 double-hit B cell lymphoma

(2018) Micol Ravà et al.   Science Translational Medicine

A metabolic function of FGFR3-TACC3 gene fusions in cancer

(2018) Véronique Frattini et al.   NATURE

Structural Patching Fosters Divergence of Mitochondrial Ribosomes

(2018) Anton S Petrov et al.   MOLECULAR BIOLOGY AND EVOLUTION

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

(2017) Elodie M Kuntz et al.   NATURE MEDICINE

Mitochondrial ribosomes in cancer

(2017) Hyun-Jung Kim et al.   SEMINARS IN CANCER BIOLOGY

Repositioning chlorpromazine for treating chemoresistant glioma through the inhibition of cytochrome c oxidase bearing the COX4-1 regulatory subunit

(2017) Claudia R. Oliva et al.   Oncotarget

Identification of Small Molecule Inhibitors of Human CytochromecOxidase That Target Chemoresistant Glioma Cells

(2016) Claudia R. Oliva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells

(2016) Francesca Angeletti et al.   Frontiers in Molecular Neuroscience

Metabolic/Proteomic Signature Defines Two Glioblastoma Subtypes With Different Clinical Outcome

(2016) G. Marziali et al.   Scientific Reports

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

Targeting mitochondria metabolism for cancer therapy

(2015) Samuel E Weinberg et al.   Nature Chemical Biology

The structure of the human mitochondrial ribosome

(2015) A. Amunts et al.   SCIENCE

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease

(2015) Rebecca Lamb et al.   Oncotarget

Synergy of Streptogramin Antibiotics Occurs Independently of Their Effects on Translation

(2014) Jonas Noeske et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Metabolic differences in breast cancer stem cells and differentiated progeny

(2014) Erina Vlashi et al.   BREAST CANCER RESEARCH AND TREATMENT

Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy

(2014) B Auffinger et al.   CELL DEATH AND DIFFERENTIATION

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

Easy quantitative assessment of genome editing by sequence trace decomposition

(2014) Eva K. Brinkman et al.   NUCLEIC ACIDS RESEARCH

Structure of the large ribosomal subunit from human mitochondria

(2014) A. Brown et al.   SCIENCE

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

(2013) Rizwan Haq et al.   CANCER CELL

Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

(2013) Alexander Roesch et al.   CANCER CELL

Streptogramins – Two are better than one!

(2013) Yvonne Mast et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Prognostic Relevance of Cytochrome c Oxidase in Primary Glioblastoma Multiforme

(2013) Corinne E. Griguer et al.   PLoS One

Mitochondria “fuel” breast cancer metabolism: Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells

(2012) Federica Sotgia et al.   CELL CYCLE

Metformin selectively affects human glioblastoma tumor-initiating cell viability

(2012) Roberto Würth et al.   CELL CYCLE

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

(2012) M. Janiszewska et al.   GENES & DEVELOPMENT

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2011) Marko Škrtić et al.   CANCER CELL

Metabolic state of glioma stem cells and nontumorigenic cells

(2011) E. Vlashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens

(2009) Steven M. Pollard et al.   Cell Stem Cell