Ribosome Biogenesis and Cancer: Overview on Ribosomal Proteins

Integrated Genomics Identifies miR-181/TFAM Pathway as a Critical Driver of Drug Resistance in Melanoma

(2021) Anna Barbato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis

(2020) Richard Y. Ebright et al.   SCIENCE

Long Noncoding RNA TRIM52-AS1 Sponges miR-514a-5p to Facilitate Hepatocellular Carcinoma Progression Through Increasing MRPS18A

(2020) Chunhui Zhou et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Role of uL3 in the Crosstalk between Nucleolar Stress and Autophagy in Colon Cancer Cells

(2020) Annalisa Pecoraro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RPL32 promotes lung cancer progression by facilitating p53 degradation

(2020) Jiansheng Xie et al.   Molecular Therapy-Nucleic Acids

uL3 Mediated Nucleolar Stress Pathway as a New Mechanism of Action of Antiproliferative G-quadruplex TBA Derivatives in Colon Cancer Cells

(2020) Annalisa Pecoraro et al.   Biomolecules

High RPS11 level in hepatocellular carcinoma associates with poor prognosis after curative resection

(2020) Chenhao Zhou et al.   Annals of Translational Medicine

Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis

(2020) Mateusz Jaskolowski et al.   MOLECULAR CELL

Biological effect of ribosomal protein L32 on human breast cancer cell behavior

(2020) Lu Xu et al.   Molecular Medicine Reports

Ribosomal protein S11 influences glioma response to TOP2 poisons

(2020) Chidiebere U. Awah et al.   ONCOGENE

Role of Autophagy in Cancer Cell Response to Nucleolar and Endoplasmic Reticulum Stress

(2020) Annalisa Pecoraro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inactivation of ribosomal protein S27-like impairs DNA interstrand cross-link repair by destabilization of FANCD2 and FANCI

(2020) Siyuan Sun et al.   Cell Death & Disease

Knockdown of ribosomal protein S6 suppresses proliferation, migration, and invasion in epithelial ovarian cancer

(2020) Xueqing Yang et al.   Journal of Ovarian Research

RPL21 siRNA Blocks Proliferation in Pancreatic Cancer Cells by Inhibiting DNA Replication and Inducing G1 Arrest and Apoptosis

(2020) Chaodong Li et al.   Frontiers in Oncology

Abnormal Expression of Mitochondrial Ribosomal Proteins and Their Encoding Genes with Cell Apoptosis and Diseases

(2020) Guomin Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

S-Adenosyl-l-Methionine Overcomes uL3-Mediated Drug Resistance in p53 Deleted Colon Cancer Cells

(2020) Laura Mosca et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural basis for the final steps of human 40S ribosome maturation

(2020) Michael Ameismeier et al.   NATURE

Ribosomal protein L6 (RPL6) is recruited to DNA damage sites in a poly (ADP-ribose) polymerase-dependent manner and regulates the DNA damage response

(2019) Chuanzhen Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ribosome Biogenesis—Cancer Connection

(2019) Marianna Penzo et al.   Cells

MRPL35 Is Up-Regulated in Colorectal Cancer and Regulates Colorectal Cancer Cell Growth and Apoptosis

(2019) Litao Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging

(2019) Zsofia Turi et al.   Aging-US

The X-Linked DDX3X RNA Helicase Dictates Translation Reprogramming and Metastasis in Melanoma

(2019) Bengt Phung et al.   Cell Reports

Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery

(2019) Martin Saurer et al.   SCIENCE

Mitochondria teach ribosome assembly

(2019) Katrin Karbstein   SCIENCE

Therapeutic Approaches Targeting Nucleolus in Cancer

(2019) Pietro Carotenuto et al.   Cells

Ribosomal protein uL3 targets E2F1 and Cyclin D1 in cancer cell response to nucleolar stress

(2019) Annalisa Pecoraro et al.   Scientific Reports

Regulation of RNA Polymerase I TranscriptioninDevelopment, Disease, and Aging

(2018) Samim Sharifi et al.   Annual Review of Biochemistry

Knockdown of MRPL42 suppresses glioma cell proliferation by inducing cell cycle arrest and apoptosis

(2018) Chunyan Hao et al.   BIOSCIENCE REPORTS

Hybrid Lipid/Polymer Nanoparticles for Pulmonary Delivery of siRNA: Development and Fate Upon In Vitro Deposition on the Human Epithelial Airway Barrier

(2018) Ivana d'Angelo et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

The MRPS18-2 protein levels correlate with prostate tumor progression and it induces CXCR4-dependent migration of cancer cells

(2018) Muhammad Mushtaq et al.   Scientific Reports

Knockdown of RPL34 inhibits the proliferation and migration of glioma cells through the inactivation of JAK/STAT3 signaling pathway

(2018) Peigang Ji et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The roles of moonlight ribosomal proteins in the development of human cancers

(2018) Ghader Molavi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ribosomal protein eL24, involved in two intersubunit bridges, stimulates translation initiation and elongation

(2018) Ivan Kisly et al.   NUCLEIC ACIDS RESEARCH

Ribosomal protein S27-like regulates autophagy via the β-TrCP-DEPTOR-mTORC1 axis

(2018) Xiufang Xiong et al.   Cell Death & Disease

Ribosomal Proteins Control or Bypass p53 during Nucleolar Stress

(2017) Annapina Russo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of uL3 in Multidrug Resistance in p53-Mutated Lung Cancer Cells

(2017) Annapina Russo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness

(2017) Young-Kyoung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crosstalk between the nucleolus and the DNA damage response

(2017) L. M. Ogawa et al.   Molecular BioSystems

Mitochondrial ribosomes in cancer

(2017) Hyun-Jung Kim et al.   SEMINARS IN CANCER BIOLOGY

High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes

(2017) Meng Pu et al.   TUMOR BIOLOGY

Ribosomal proteins: a novel class of oncogenic drivers

(2017) Sergey O. Sulima et al.   Oncotarget

Expression of ribosomal proteins in normal and cancerous human prostate tissue

(2017) Callum Arthurs et al.   PLoS One

The importance of ribosome production, and the 5S RNP-MDM2 pathway, in health and disease

(2016) A. Pelava et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Hold on to your friends: Dedicated chaperones of ribosomal proteins

(2016) Benjamin Pillet et al.   BIOESSAYS

Mitochondrial Ribosomal Protein L10 Associates with Cyclin B1/Cdk1 Activity and Mitochondrial Function

(2016) Hai-Bo Li et al.   DNA AND CELL BIOLOGY

Ribosomal protein S15A promotes malignant transformation and predicts poor outcome in colorectal cancer through misregulation of p53 signaling pathway

(2016) JINGWEN CHEN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Biotin-targeted Pluronic ® P123/F127 mixed micelles delivering niclosamide: A repositioning strategy to treat drug-resistant lung cancer cells

(2016) Annapina Russo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Bcp1 Is the Nuclear Chaperone of Rpl23 inSaccharomyces cerevisiae

(2016) Ya-Han Ting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rpl22 Loss Selectively Impairs αβ T Cell Development by Dysregulating Endoplasmic Reticulum Stress Signaling

(2016) Nehal R. Solanki et al.   JOURNAL OF IMMUNOLOGY

Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency

(2016) Justine Mailliot et al.   JOURNAL OF MOLECULAR BIOLOGY

Benzyl isothiocyanate alters the gene expression with cell cycle regulation and cell death in human brain glioblastoma GBM 8401 cells

(2016) NOU-YING TANG et al.   ONCOLOGY REPORTS

Knockdown of ribosomal protein S15A induces human glioblastoma cell apoptosis

(2016) Chen Zhang et al.   World Journal of Surgical Oncology

The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition

(2016) Carmine Onofrillo et al.   Oncotarget

Multi-focal control of mitochondrial gene expression by oncogenic MYC provides potential therapeutic targets in cancer

(2016) Amanda R. Oran et al.   Oncotarget

Ribosomal protein L34 promotes the proliferation, invasion and metastasis of pancreatic cancer cells

(2016) Feng Wei et al.   Oncotarget

5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-β-synthase in colon cancer cells lacking p53

(2016) Valentina Pagliara et al.   Oncotarget

Enhancement of 5-FU sensitivity by the proapoptotic rpL3 gene in p53 null colon cancer cells through combined polymer nanoparticles

(2016) Annapina Russo et al.   Oncotarget

A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins

(2016) Min-Kyung Sung et al.   eLife

rpL3 promotes the apoptosis of p53 mutated lung cancer cells by down-regulating CBS and NFκB upon 5-FU treatment

(2016) Annapina Russo et al.   Scientific Reports

Functions of Ribosomal Proteins in Assembly of Eukaryotic Ribosomes In Vivo

(2015) Jesús de la Cruz et al.   Annual Review of Biochemistry

Disruption of the ribosomal P complex leads to stress-induced autophagy

(2015) Ana Artero-Castro et al.   Autophagy

Regulatory role of rpL3 in cell response to nucleolar stress induced by Act D in tumor cells lacking functional p53

(2015) Annapina Russo et al.   CELL CYCLE

Mitochondrial ribosome assembly in health and disease

(2015) Dasmanthie De Silva et al.   CELL CYCLE

The endoplasmic reticulum: structure, function and response to cellular signaling

(2015) Dianne S. Schwarz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hyperphosphorylation of ribosomal protein S6 predicts unfavorable clinical survival in non-small cell lung cancer

(2015) Bojiang Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Down-regulation of ribosomal protein S15A inhibits proliferation of human glioblastoma cells in vivo and in vitro via AKT pathway

(2015) Yiqun Yao et al.   TUMOR BIOLOGY

Co-translational capturing of nascent ribosomal proteins by their dedicated chaperones

(2015) Patrick Pausch et al.   Nature Communications

Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA-binding site

(2015) Fabiola R. Calviño et al.   Nature Communications

RPS3 regulates melanoma cell growth and apoptosis by targeting Cyto C/Ca2+/MICU1 dependent mitochondrial signaling

(2015) Yun Tian et al.   Oncotarget

Perturbation of Ribosome Biogenesis Drives Cells into Senescence through 5S RNP-Mediated p53 Activation

(2015) Kazuho Nishimura et al.   Cell Reports

Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis

(2015) Hana Antonicka et al.   Cell Reports

The Dedicated Chaperone Acl4 Escorts Ribosomal Protein Rpl4 to Its Nuclear Pre-60S Assembly Site

(2015) Benjamin Pillet et al.   PLoS Genetics

Biodegradable nanoparticles sequentially decorated with Polyethyleneimine and Hyaluronan for the targeted delivery of docetaxel to airway cancer cells

(2015) Sara Maiolino et al.   JOURNAL OF NANOBIOTECHNOLOGY

Human rpL3 plays a crucial role in cell response to nucleolar stress induced by 5-FU and L-OHP

(2015) Davide Esposito et al.   Oncotarget

Ribosomal proteins as unrevealed caretakers for cellular stress and genomic instability

(2015) Tae-Hyung Kim et al.   Oncotarget

Ribosomal protein L19 overexpression activates the unfolded protein response and sensitizes MCF7 breast cancer cells to endoplasmic reticulum stress-induced cell death

(2014) Mina Hong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Palmitoylethanolamide inhibits rMCP-5 expression by regulating MITF activation in rat chronic granulomatous inflammation

(2014) Daniele De Filippis et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling

(2014) B. Dave et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Final Pre-40S Maturation Depends on the Functional Integrity of the 60S Subunit Ribosomal Protein L3

(2014) Juan J. García-Gómez et al.   PLoS Genetics

Eukaryotic ribosome biogenesis at a glance

(2013) E. Thomson et al.   JOURNAL OF CELL SCIENCE

Crystal Structure of the Yeast Ribosomal Protein rpS3 in Complex with Its Chaperone Yar1

(2013) Sandro Holzer et al.   JOURNAL OF MOLECULAR BIOLOGY

The ribosomal protein S26 regulates p53 activity in response to DNA damage

(2013) D Cui et al.   ONCOGENE

Co-transduction of ribosomal protein L23 enhances the therapeutic efficacy of adenoviral-mediated p53 gene transfer in human gastric cancer

(2013) YA-FEI ZHANG et al.   ONCOLOGY REPORTS

Ribosomal Protein S27-Like in Colorectal Cancer: A Candidate for Predicting Prognoses

(2013) Chi-Jung Huang et al.   PLoS One

Small Ribosomal Protein Subunit S7 Suppresses Ovarian Tumorigenesis through Regulation of the PI3K/AKT and MAPK Pathways

(2013) Ziliang Wang et al.   PLoS One

Essential ribosome assembly factor Fap7 regulates a hierarchy of RNA-protein interactions during small ribosomal subunit biogenesis

(2013) U. A. Hellmich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosomal protein S3 interacts with TRADD to induce apoptosis through caspase dependent JNK activation

(2012) Chang-Young Jang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human rpL3 induces G₁/S arrest or apoptosis by modulating p21waf1/cip1levels in a p53-independent manner

(2012) Annapina Russo et al.   CELL CYCLE

Identification of a motif in BMRP required for interaction with Bcl-2 by site-directed mutagenesis studies

(2012) Juan A. Conde et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Prognostic significance and function of phosphorylated ribosomal protein S6 in esophageal squamous cell carcinoma

(2012) Seok-Hyung Kim et al.   MODERN PATHOLOGY

Ribosomal protein RPL41 induces rapid degradation of ATF4, a transcription factor critical for tumour cell survival in stress

(2011) Aiyuan Wang et al.   JOURNAL OF PATHOLOGY

Ribosomal Protein L11 Recruits miR-24/miRISC To Repress c-Myc Expression in Response to Ribosomal Stress

(2011) K. B. Challagundla et al.   MOLECULAR AND CELLULAR BIOLOGY

Autoregulatory circuit of human rpL3 expression requires hnRNP H1, NPM and KHSRP

(2011) Annapina Russo et al.   NUCLEIC ACIDS RESEARCH

The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer

(2010) Denis Drygin et al.   Annual Review of Pharmacology and Toxicology

hnRNP H1 and intronic G runs in the splicing control of the human rpL3 gene

(2010) Annapina Russo et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Regulation of mitochondrial ribosomal protein S29 (MRPS29) expression by a 5′-upstream open reading frame

(2010) Min-Joon Han et al.   MITOCHONDRION

Role of Ribosomal Protein RPS2 in Controlling let-7a Expression in Human Prostate Cancer

(2010) M. Wang et al.   MOLECULAR CANCER RESEARCH

Human ribosomal protein S13 promotes gastric cancer growth through down-regulating p27Kip1

(2009) Xueyan Guo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

cis-acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins

(2008) Annapina Russo et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms