Accessible Mutational Trajectories for the Evolution of Pyrimethamine Resistance in the Malaria Parasite Plasmodium vivax

Resistance to artemisinin-based combination therapy

(2012) Joel G Breman   LANCET INFECTIOUS DISEASES

Genomic Sequencing of Plasmodium falciparum Malaria Parasites from Senegal Reveals the Demographic History of the Population

(2012) Hsiao-Han Chang et al.   MOLECULAR BIOLOGY AND EVOLUTION

The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum

(2012) Daniel E Neafsey et al.   NATURE GENETICS

Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme

(2012) Nobuhiko Tokuriki et al.   Nature Communications

Plasmodium vivax Vaccine Research: Insights from Colombian Studies

(2011) Falgunee K. Parekh et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Reduced Impact of Pyrimethamine Drug Pressure on Plasmodium malariae Dihydrofolate Reductase Gene

(2011) Nimol Khim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Diminishing Returns Epistasis Among Beneficial Mutations Decelerates Adaptation

(2011) H.-H. Chou et al.   SCIENCE

Computational analysis of binding between malarial dihydrofolate reductases and anti-folates

(2010) Kiattawee Choowongkomon et al.   MALARIA JOURNAL

Compensatory Mutations Restore Fitness during the Evolution of Dihydrofolate Reductase

(2010) K. M. Brown et al.   MOLECULAR BIOLOGY AND EVOLUTION

Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance

(2009) Nicholas J White et al.   MALARIA JOURNAL

Stepwise acquisition of pyrimethamine resistance in the malaria parasite

(2009) E. R. Lozovsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase

(2008) Vivian N Hawkins et al.   MALARIA JOURNAL

Adaptive Copy Number Evolution in Malaria Parasites

(2008) Shalini Nair et al.   PLoS Genetics