iMS‐Bmal1−/− mice show evident signs of sarcopenia that are counteracted by exercise and melatonin therapies

Developmental growth plate cartilage formation suppressed by artificial light at night via inhibiting BMAL1-driven collagen hydroxylation

(2023) Guangjin Chen et al.   CELL DEATH AND DIFFERENTIATION

Exercise for sarcopenia in older people: A systematic review and network meta‐analysis

(2023) Yanjiao Shen et al.   Journal of Cachexia Sarcopenia and Muscle

Resistance exercise as a treatment for sarcopenia: prescription and delivery

(2022) Christopher Hurst et al.   AGE AND AGEING

BMAL1 drives muscle repair through control of hypoxic NAD+ regeneration in satellite cells

(2022) Pei Zhu et al.   GENES & DEVELOPMENT

Circadian rhythm and disease: Relationship, new insights, and future perspectives

(2022) Ana R. Neves et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Deciphering clock genes as emerging targets against aging

(2022) Yanli Zhu et al.   AGEING RESEARCH REVIEWS

Importance of Bmal1 in Alzheimer's disease and associated aging‐related diseases: Mechanisms and interventions

(2022) Rongping Fan et al.   AGING CELL

Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers

(2021) Mikael Flockhart et al.   Cell Metabolism

The role of melatonin in sarcopenia: Advances and application prospects

(2021) Hongfu Jin et al.   EXPERIMENTAL GERONTOLOGY

Melatonin reshapes the mitochondrial network and promotes intercellular mitochondrial transfer via tunneling nanotubes after ischemic‐like injury in hippocampal HT22 cells

(2021) Maria Gemma Nasoni et al.   JOURNAL OF PINEAL RESEARCH

Strategies to Prevent Sarcopenia in the Aging Process: Role of Protein Intake and Exercise

(2021) Patricia S. Rogeri et al.   Nutrients

Sex differences in circadian endocrine rhythms: Clinical implications

(2020) Nicolas C. Nicolaides et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Sex-Related Differences in Locomotion and Climbing of C57Bl/6NTac Mice in a Novel Environment

(2020) V. BORBÉLYOVÁ et al.   PHYSIOLOGICAL RESEARCH

Excessive Treadmill Training Enhances Brain-Specific MicroRNA-34a in the Mouse Hippocampus

(2020) Lin Xu et al.   Frontiers in Molecular Neuroscience

Animal models of sarcopenia

(2020) Courtney J. Christian et al.   AGING CELL

Lack of NLRP3 inflammasome activation reduces age-dependent sarcopenia and mitochondrial dysfunction, favoring the prophylactic effect of melatonin

(2019) Ramy K A Sayed et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mechanisms of Sex Differences in Exercise Capacity

(2019) Marko Oydanich et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Sarcopenia

(2019) Alfonso J Cruz-Jentoft et al.   LANCET

Exercise and mitochondrial health

(2019) Jonathan M. Memme et al.   JOURNAL OF PHYSIOLOGY-LONDON

Muscle function decline and mitochondria changes in middle age precede sarcopenia in mice

(2018) Andrea del Campo et al.   Aging-US

The role of Angptl4/Fiaf in exercise-induced skeletal muscle AMPK activation

(2018) Hyukki Chang et al.   JOURNAL OF APPLIED PHYSIOLOGY

Circadian rhythms in mitochondrial respiration

(2018) Paul de Goede et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Melatonin promotes sleep in mice by inhibiting orexin neurons in the perifornical lateral hypothalamus

(2018) Rishi Sharma et al.   JOURNAL OF PINEAL RESEARCH

Frailty Quantified by the “Valencia Score” as a Potential Predictor of Lifespan in Mice

(2018) Irene Martinez de Toda et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Protective Effect of Melatonin Against Age-Associated, Sarcopenia-Dependent Tubular Aggregate Formation, Lactate Depletion, and Mitochondrial Changes

(2018) Ramy K A Sayed et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Deletion of Bmal1 Prevents Diet-Induced Ectopic Fat Accumulation by Controlling Oxidative Capacity in the Skeletal Muscle

(2018) Taira Wada et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sarcopenia: Aging-Related Loss of Muscle Mass and Function

(2018) Lars Larsson et al.   PHYSIOLOGICAL REVIEWS

Sex-related differences in the wheel-running activity of mice decline with increasing age

(2017) Babett Bartling et al.   EXPERIMENTAL GERONTOLOGY

Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis

(2017) Ibtissem Rahim et al.   JOURNAL OF PINEAL RESEARCH

Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases

(2017) Ana López et al.   PLoS One

Dissociation ofPer1andBmal1circadian rhythms in the suprachiasmatic nucleus in parallel with behavioral outputs

(2017) Daisuke Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

(2017) Yalikun Suofu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of morphological markers of sarcopenia at early stage of aging in skeletal muscle of mice

(2016) Ramy K.A. Sayed et al.   EXPERIMENTAL GERONTOLOGY

Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin

(2016) Huayqui Volt et al.   JOURNAL OF PINEAL RESEARCH

Biology of frailty: Modulation of ageing genes and its importance to prevent age-associated loss of function

(2016) Jose Viña et al.   MOLECULAR ASPECTS OF MEDICINE

Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults

(2016) Javier Angulo et al.   MOLECULAR ASPECTS OF MEDICINE

Strenuous exercise induces mitochondrial damage in skeletal muscle of old mice

(2015) Sangho Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness

(2015) David Jacobi et al.   Cell Metabolism

The benefits of four weeks of melatonin treatment on circadian patterns in resistance-trained athletes

(2015) Roberto C. Leonardo-Mendonça et al.   CHRONOBIOLOGY INTERNATIONAL

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

(2015) José A. García et al.   FASEB JOURNAL

Intrinsic muscle clock is necessary for musculoskeletal health

(2015) Elizabeth A. Schroder et al.   JOURNAL OF PHYSIOLOGY-LONDON

The endogenous molecular clock orchestrates the temporal separation of substrate metabolism in skeletal muscle

(2015) Brian A Hodge et al.   Skeletal Muscle

Extrapineal melatonin: sources, regulation, and potential functions

(2014) Darío Acuña-Castroviejo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fiber Typing in Aging Muscle

(2014) Fennigje M. Purves-Smith et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Mitochondrial energetics is impairedin vivoin aged skeletal muscle

(2013) Gilles Gouspillou et al.   AGING CELL

Circadian Rhythms, Skeletal Muscle Molecular Clocks, and Exercise

(2013) Elizabeth A. Schroder et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Chronic phase advance alters circadian physiological rhythms and peripheral molecular clocks

(2013) Gretchen Wolff et al.   JOURNAL OF APPLIED PHYSIOLOGY

Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

(2013) C. B. Peek et al.   SCIENCE

Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock

(2013) Kenneth A. Dyar et al.   Molecular Metabolism

Melatonin-mitochondria Interplay in Health and Disease

(2012) Dario Acuna Castroviejo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Circadian Disruption and Remedial Interventions

(2012) Sarah Forbes-Robertson et al.   SPORTS MEDICINE

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

(2011) Carmen Venegas et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production

(2008) Ana López et al.   JOURNAL OF PINEAL RESEARCH