5-HT4 Receptor is Protective for MPTP-induced Parkinson’s Disease Mice Via Altering Gastrointestinal Motility or Gut Microbiota

Improvement of loperamide-hydrochloride-induced intestinal motility disturbance by Platycodon grandiflorum polysaccharides through effects on gut microbes and colonic serotonin

(2023) Mengqi Hao et al.   Frontiers in Cellular and Infection Microbiology

Tryptophan‐synthesizing bacteria enhance colonic motility

(2023) Theresa B. Legan et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Prucalopride might improve intestinal motility by promoting the regeneration of the enteric nervous system in diabetic rats

(2022) Yun Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Exploring the role and mechanism of gut microbiota in methamphetamine addiction using antibiotic treatment followed by fecal microbiota transplantation

(2022) Qiuting Wang et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

DAla2-GIP-GLU-PAL Protects Against Cognitive Deficits and Pathology in APP/PS1 Mice by Inhibiting Neuroinflammation and Upregulating cAMP/PKA/CREB Signaling Pathways

(2021) Li Yuan et al.   JOURNAL OF ALZHEIMERS DISEASE

Challenges in the diagnosis of Parkinson's disease

(2021) Eduardo Tolosa et al.   LANCET NEUROLOGY

Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson’s disease

(2020) Jian-Fu Liao et al.   BRAIN BEHAVIOR AND IMMUNITY

Meta‐Analysis of Gut Dysbiosis in Parkinson's Disease

(2020) Hiroshi Nishiwaki et al.   MOVEMENT DISORDERS

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Induced Parkinson’s Disease in Mouse: Potential Association between Neurotransmitter Disturbance and Gut Microbiota Dysbiosis

(2020) Yuanhui Zhu et al.   ACS Chemical Neuroscience

ENT1 inhibition attenuates apoptosis by activation of cAMP/pCREB/Bcl2 pathway after MCAO in rats

(2020) Dongyun Zhang et al.   EXPERIMENTAL NEUROLOGY

Probiotics for constipation in Parkinson’s disease: A randomized placebo-controlled study

(2020) Ai Huey Tan et al.   NEUROLOGY

INT-777 prevents cognitive impairment by activating Takeda G protein-coupled receptor 5 (TGR5) and attenuating neuroinflammation via cAMP/ PKA/ CREB signaling axis in a rat model of sepsis

(2020) Peng Jin et al.   EXPERIMENTAL NEUROLOGY

Altered gut microbiota in Parkinson's disease patients/healthy spouses and its association with clinical features

(2020) Fan Zhang et al.   PARKINSONISM & RELATED DISORDERS

Serotonin enhances depolarizing spontaneous fluctuations, excitability, and ongoing activity in isolated rat DRG neurons via 5-HT4 receptors and cAMP-dependent mechanisms

(2020) Elia R. Lopez et al.   NEUROPHARMACOLOGY

Neuroprotection of Fasting Mimicking Diet on MPTP-Induced Parkinson’s Disease Mice via Gut Microbiota and Metabolites

(2019) Zhi-Lan Zhou et al.   Neurotherapeutics

Significant roles of neuroinflammation in Parkinson’s disease: therapeutic targets for PD prevention

(2019) Yujeong Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Pivotal role of cAMP‐PKA‐CREB signaling pathway in manganese‐induced neurotoxicity in PC12 cells

(2019) Yiping Yang et al.   ENVIRONMENTAL TOXICOLOGY

Altered gut microbiota and inflammatory cytokine responses in patients with Parkinson’s disease

(2019) Chin-Hsien Lin et al.   Journal of Neuroinflammation

Fecal microbiota transplantation to treat Parkinsonʼs disease with constipation

(2019) Hongli Huang et al.   MEDICINE

Dysbiosis of gut microbiota in a selected population of Parkinson's patients

(2019) Daniele Pietrucci et al.   PARKINSONISM & RELATED DISORDERS

Distal colonic transit is linked to gut microbiota diversity and microbial fermentation in humans with slow colonic transit

(2019) Mattea Müller et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Total glucosides of paeony (TGP) extracted from Radix Paeoniae Alba exerts neuroprotective effects in MPTP-induced experimental parkinsonism by regulating the cAMP/PKA/CREB signaling pathway

(2019) Meizhu Zheng et al.   JOURNAL OF ETHNOPHARMACOLOGY

Dysbiosis of gut microbiota and microbial metabolites in Parkinson’s Disease

(2018) Meng-Fei Sun et al.   AGEING RESEARCH REVIEWS

Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson’s disease mice: Gut microbiota, glial reaction and TLR4/TNF-α signaling pathway

(2018) Meng-Fei Sun et al.   BRAIN BEHAVIOR AND IMMUNITY

Alteration of the fecal microbiota in Chinese patients with Parkinson’s disease

(2018) Yiwei Qian et al.   BRAIN BEHAVIOR AND IMMUNITY

Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks

(2018) Filipe De Vadder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oral administration of Proteus mirabilis damages dopaminergic neurons and motor functions in mice

(2018) Jin Gyu Choi et al.   Scientific Reports

Intestinal Pathology and Gut Microbiota Alterations in a Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Mouse Model of Parkinson’s Disease

(2018) Feng Lai et al.   NEUROCHEMICAL RESEARCH

Preoperative administration of the 5-HT4 receptor agonist prucalopride reduces intestinal inflammation and shortens postoperative ileus via cholinergic enteric neurons

(2018) Nathalie Stakenborg et al.   GUT

Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome

(2017) Erin M. Hill-Burns et al.   MOVEMENT DISORDERS

The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder

(2017) Anna Heintz-Buschart et al.   MOVEMENT DISORDERS

Progression of Parkinson's disease is associated with gut dysbiosis: Two-year follow-up study

(2017) Tomomi Minato et al.   PLoS One

Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson’s disease patients

(2017) J. R. Bedarf et al.   Genome Medicine

Dysbiosis contributes to chronic constipation development via regulation of serotonin transporter in the intestine

(2017) Hailong Cao et al.   Scientific Reports

Prucalopride exerts neuroprotection in human enteric neurons

(2016) Francesca Bianco et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon

(2016) Stephanie N. Spohn et al.   GASTROENTEROLOGY

Probiotics and prebiotic fiber for constipation associated with Parkinson disease

(2016) Michela Barichella et al.   NEUROLOGY

Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model

(2016) Yanwei Li et al.   NEUROPHARMACOLOGY

Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut

(2016) Henrik M. Roager et al.   Nature Microbiology

Serotonin in Parkinson's disease

(2015) Marios Politis et al.   BEHAVIOURAL BRAIN RESEARCH

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

The 5-HT4Agonist Prucalopride Stimulates L-DOPA-Induced Dopamine Release in Restricted Brain Regions of the Hemiparkinsonian RatIn Vivo

(2015) Sylvia Navailles et al.   CNS Neuroscience & Therapeutics

Discovery of a novel neuroprotectant, BHDPC, that protects against MPP + /MPTP-induced neuronal death in multiple experimental models

(2015) Cheong-Meng Chong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Colitis Induces Enteric Neurogenesis Through a 5-HT4–dependent Mechanism

(2015) Jaime Belkind-Gerson et al.   INFLAMMATORY BOWEL DISEASES

Colonic bacterial composition in Parkinson's disease

(2015) Ali Keshavarzian et al.   MOVEMENT DISORDERS

Pathogenesis of Parkinson disease—the gut–brain axis and environmental factors

(2015) Lisa Klingelhoefer et al.   Nature Reviews Neurology

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Risk of Parkinson's disease following severe constipation: A nationwide population-based cohort study

(2014) Chin-Hsien Lin et al.   PARKINSONISM & RELATED DISORDERS

Complex Interactions Among Diet, Gastrointestinal Transit, and Gut Microbiota in Humanized Mice

(2013) Purna C. Kashyap et al.   GASTROENTEROLOGY

Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress

(2013) Mohit K. Sharma et al.   JOURNAL OF NEUROCHEMISTRY

The enteric nervous system and neurogastroenterology

(2012) John B. Furness   Nature Reviews Gastroenterology & Hepatology

Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: Pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors

(2012) Shinichi Kato et al.   PHARMACOLOGICAL RESEARCH

Transcriptional Control of Adrenal Steroidogenesis

(2011) Anne-Marie Lefrancois-Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MPTP-induced parkinsonism extends to a subclass of TH-positive neurons in the gut

(2010) Gianfranco Natale et al.   BRAIN RESEARCH

Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition

(2010) M. Kverka et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Commensal bacteria can enter colonic epithelial cells and induce proinflammatory cytokine secretion: a possible pathogenic mechanism of ulcerative colitis

(2009) T. Ohkusa et al.   JOURNAL OF MEDICAL MICROBIOLOGY

5-HT4 Receptor-Mediated Neuroprotection and Neurogenesis in the Enteric Nervous System of Adult Mice

(2009) M.-T. Liu et al.   JOURNAL OF NEUROSCIENCE

Medical records documentation of constipation preceding Parkinson disease: A case-control study

(2009) R. Savica et al.   NEUROLOGY

Molecular biology of 5-HT receptors

(2008) Jason Hannon et al.   BEHAVIOURAL BRAIN RESEARCH