Serotonin enhances depolarizing spontaneous fluctuations, excitability, and ongoing activity in isolated rat DRG neurons via 5-HT4 receptors and cAMP-dependent mechanisms

Depolarization-dependent C-Raf signaling promotes hyperexcitability and reduces opioid sensitivity of isolated nociceptors after spinal cord injury

(2020) Anibal Garza Carbajal et al.   JOURNAL OF NEUROSCIENCE

Role of p120 Catenin in Epac1-Induced Chronic Postsurgical Pain in Rats

(2019) Peng Pan et al.   Pain Research & Management

An NPY Y1 receptor antagonist unmasks latent sensitization and reveals the contribution of Protein Kinase A and EPAC to chronic inflammatory pain

(2019) Weisi Fu et al.   PAIN

Electrophysiological and transcriptomic correlates of neuropathic pain in human dorsal root ganglion neurons

(2019) Robert Y North et al.   BRAIN

An ultrafast system for signaling mechanical pain in human skin

(2019) Saad S. Nagi et al.   Science Advances

Adaptive mechanisms driving maladaptive pain: how chronic ongoing activity in primary nociceptors can enhance evolutionary fitness after severe injury

(2019) Edgar T. Walters   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination

(2018) Jörg Isensee et al.   JOURNAL OF CELL BIOLOGY

Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy

(2018) Pooja Singhmar et al.   PAIN

Isolated Nociceptors Reveal Multiple Specializations for Generating Irregular Ongoing Activity Associated with Ongoing Pain

(2018) Max A. Odem et al.   PAIN

Epac and nociceptor sensitization

(2017) Li-Yen M Huang et al.   Molecular Pain

Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice

(2017) Jörg Isensee et al.   Science Signaling

Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice

(2017) Jörg Isensee et al.   Science Signaling

Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Is Associated with Altered Adenylyl Cyclase Regulation

(2016) Alexis Bavencoffe et al.   JOURNAL OF NEUROSCIENCE

Human dorsal-root-ganglion perfusion measured in-vivo by MRI

(2016) Tim Godel et al.   NEUROIMAGE

Control of sensory neuron excitability by serotonin involves 5HT2C receptors and Ca 2+ -activated chloride channels

(2016) Isabella Salzer et al.   NEUROPHARMACOLOGY

Spinal 5-HT7 receptors induce phrenic motor facilitation via EPAC-mTORC1 signaling

(2015) D. P. Fields et al.   JOURNAL OF NEUROPHYSIOLOGY

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Control of somatic membrane potential in nociceptive neurons and its implications for peripheral nociceptive transmission

(2014) Xiaona Du et al.   PAIN

Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons

(2013) J. Isensee et al.   JOURNAL OF CELL SCIENCE

Identification and Characterization of Small Molecules as Potent and Specific EPAC2 Antagonists

(2013) Haijun Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

5-HT4 Receptors Constitutively Promote the Non-Amyloidogenic Pathway of APP Cleavage and Interact with ADAM10

(2012) Maud Cochet et al.   ACS Chemical Neuroscience

Chronic inflammatory pain is associated with increased excitability and hyperpolarization-activated current (Ih) in C- but not Aδ-nociceptors

(2012) Xiechuan Weng et al.   PAIN

Serotonergic neuromodulation of peripheral nociceptors

(2012) Dayna R. Loyd et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Serotonin Receptor 5-HT2B Mediates Serotonin-Induced Mechanical Hyperalgesia

(2011) S.-Y. Lin et al.   JOURNAL OF NEUROSCIENCE

Up-regulation of low-threshold tetrodotoxin-resistant Na+ current via activation of a cyclic AMP/protein kinase A pathway in nociceptor-like rat dorsal root ganglion cells

(2011) R.S. Scroggs   NEUROSCIENCE

Serotonin increases the functional activity of capsaicin-sensitive rat trigeminal nociceptors via peripheral serotonin receptors

(2011) Dayna R. Loyd et al.   PAIN

Microneurographic identification of spontaneous activity in C-nociceptors in neuropathic pain states in humans and rats

(2011) Jordi Serra et al.   PAIN

HCN2 Ion Channels Play a Central Role in Inflammatory and Neuropathic Pain

(2011) E. C. Emery et al.   SCIENCE

Chronic Spontaneous Activity Generated in the Somata of Primary Nociceptors Is Associated with Pain-Related Behavior after Spinal Cord Injury

(2010) S. S. Bedi et al.   JOURNAL OF NEUROSCIENCE

Guarding Pain and Spontaneous Activity of Nociceptors after Skin versus Skin Plus Deep Tissue Incision

(2009) Jun Xu et al.   ANESTHESIOLOGY

Regulation of firing frequency in nociceptive neurons by pro-inflammatory mediators

(2009) Aliakmal Momin et al.   EXPERIMENTAL BRAIN RESEARCH