Pivotal role of cAMP‐PKA‐CREB signaling pathway in manganese‐induced neurotoxicity in PC12 cells

Roflumilast ameliorates cognitive impairment in APP/PS1 mice via cAMP/CREB/BDNF signaling and anti-neuroinflammatory effects

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Effects of CREB1 gene silencing on cognitive dysfunction by mediating PKA-CREB signaling pathway in mice with vascular dementia

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Manganese exposure induces neuroinflammation by impairing mitochondrial dynamics in astrocytes

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Environmental exposure to manganese in air: Tremor, motor and cognitive symptom profiles

(2018) E.S. Kornblith et al.   NEUROTOXICOLOGY

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

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Dexmedetomidine protects rats from postoperative cognitive dysfunction via regulating the GABAB R-mediated cAMP-PKA-CREB signaling pathway

(2018) Yun-Sheng Zhu et al.   NEUROPATHOLOGY

Manganese in Drinking Water and Cognitive Abilities and Behavior at 10 Years of Age: A Prospective Cohort Study

(2017) Syed Moshfiqur Rahman et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

More Insight into BDNF against Neurodegeneration: Anti-Apoptosis, Anti-Oxidation, and Suppression of Autophagy

(2017) Shang-Der Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Downregulation of Mfn2 participates in manganese-induced neuronal apoptosis in rat striatum and PC12 cells

(2017) Xinhang Liu et al.   NEUROCHEMISTRY INTERNATIONAL

FFPM, a PDE4 inhibitor, reverses learning and memory deficits in APP/PS1 transgenic mice via cAMP/PKA/CREB signaling and anti-inflammatory effects

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The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation

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cAMP/PKA-CREB-BDNF signaling pathway in hippocampus mediates cyclooxygenase 2-induced learning/memory deficits of rats subjected to chronic unpredictable mild stress

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The involvement of the mitochondrial pathway in manganese-induced apoptosis of chicken splenic lymphocytes

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Rolipram improves cognition, reduces anxiety- and despair-like behaviors and impacts hippocampal neuroplasticity after transient global cerebral ischemia

(2016) Lígia Mendes Soares et al.   NEUROSCIENCE

Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models

(2016) Catherine H. Choi et al.   Frontiers in Behavioral Neuroscience

cAMP/PKA Signaling Pathway Induces Apoptosis by Inhibited NF-κB in Aluminum Chloride-Treated Lymphocytes In Vitro

(2015) Feibo Xu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Phosphodiesterase-4 inhibitors ameliorates cognitive deficits in deoxycorticosterone acetate induced hypertensive rats via cAMP/CREB signaling system

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Chronic exposure to manganese sulfate leads to adverse dose-dependent effects on the neurobehavioral ability of rats

(2015) Cheng Su et al.   ENVIRONMENTAL TOXICOLOGY

Effects of chronic manganese exposure on the learning and memory of rats by observing the changes in the hippocampal cAMP signaling pathway

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Manganese neurotoxicity: behavioral disorders associated with dysfunctions in the basal ganglia and neurochemical transmission

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Role of transcription factor yin yang 1 in manganese-induced reduction of astrocytic glutamate transporters: Putative mechanism for manganese-induced neurotoxicity

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Cognitive function and plasma BDNF levels among manganese-exposed smelters

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Manganese exposure and cognitive deficits: A growing concern for manganese neurotoxicity

(2012) H.A. Roels et al.   NEUROTOXICOLOGY

Effect of intranasal manganese administration on neurotransmission and spatial learning in rats

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Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger

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Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling

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The Importance of Antioxidant Micronutrients in Pregnancy

(2011) Hiten D. Mistry et al.   Oxidative Medicine and Cellular Longevity

Treadmill exercise prevents aging-induced failure of memory through an increase in neurogenesis and suppression of apoptosis in rat hippocampus

(2010) Sung-Eun Kim et al.   EXPERIMENTAL GERONTOLOGY

Sleep deprivation impairs cAMP signalling in the hippocampus

(2009) Christopher G. Vecsey et al.   NATURE

Manganese Flux Across the Blood–Brain Barrier

(2009) Robert A. Yokel   NEUROMOLECULAR MEDICINE

Inactivation of CREB mediated gene transcription by HDAC8 bound protein phosphatase

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Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Circadian oscillation of hippocampal MAPK activity and cAMP: implications for memory persistence

(2008) Kristin L Eckel-Mahan et al.   NATURE NEUROSCIENCE

Manganese activates the mitochondrial apoptotic pathway in rat astrocytes by modulating the expression of proteins of the Bcl-2 family

(2008) Laura E. Gonzalez et al.   NEUROCHEMISTRY INTERNATIONAL

BDNF is essential to promote persistence of long-term memory storage

(2008) P. Bekinschtein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?

(2007) Yuan Lu et al.   NEUROBIOLOGY OF LEARNING AND MEMORY