Significant roles of neuroinflammation in Parkinson’s disease: therapeutic targets for PD prevention

Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration

(2018) Matthew Neal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Astrocytes as targets for drug discovery

(2018) Kirill Gorshkov et al.   DRUG DISCOVERY TODAY

Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis

(2018) Vittorio Calabrese et al.   FREE RADICAL BIOLOGY AND MEDICINE

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

Recent advances in the mechanisms of neuroinflammation and their roles in neurodegeneration

(2018) Rituraj Niranjan   NEUROCHEMISTRY INTERNATIONAL

Microglial Phagocytosis and Its Regulation: A Therapeutic Target in Parkinson’s Disease?

(2018) Elzbieta Janda et al.   Frontiers in Molecular Neuroscience

Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease

(2018) Géraldine Gelders et al.   Journal of Immunology Research

Neuroprotective effects of MHY908, a PPAR α/γ dual agonist, in a MPTP-induced Parkinson’s disease model

(2018) Yujeong Lee et al.   BRAIN RESEARCH

MFG-E8 reverses microglial-induced neurotoxic astrocyte (A1) via NF-κB and PI3K-Akt pathways

(2018) Xiaotian Xu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of T cells in the pathogenesis of Parkinson’s disease

(2018) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

Epigenetics Control Microglia Plasticity

(2018) Mathilde Cheray et al.   Frontiers in Cellular Neuroscience

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Modulators of microglial activation and polarization after intracerebral haemorrhage

(2017) Xi Lan et al.   Nature Reviews Neurology

Microglial phenotypes in Parkinson’s disease and animal models of the disease

(2017) Valerie Joers et al.   PROGRESS IN NEUROBIOLOGY

Interleukin-4 Protects Dopaminergic Neurons In vitro but Is Dispensable for MPTP-Induced Neurodegeneration In vivo

(2017) Laura Hühner et al.   Frontiers in Molecular Neuroscience

The Role of Astrocytes in Neuroprotection after Brain Stroke: Potential in Cell Therapy

(2017) Andrea Becerra-Calixto et al.   Frontiers in Molecular Neuroscience

Tangeretin inhibits neurodegeneration and attenuates inflammatory responses and behavioural deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease dementia in rats

(2017) Jin-song Yang et al.   INFLAMMOPHARMACOLOGY

Suppression of Map Kinases Inhibits Microglial Activation and Attenuates Neuronal Cell Death Induced by α-Synuclein Protofibrils

(2017) H. Wilms et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Neuroprotective and anti-inflammatory effects of morin in a murine model of Parkinson's disease

(2016) Kyung Moon Lee et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Alpha-Synuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant

(2016) Claire Hoenen et al.   PLoS One

IL-10 Promotes Neurite Outgrowth and Synapse Formation in Cultured Cortical Neurons after the Oxygen-Glucose Deprivation via JAK1/STAT3 Pathway

(2016) Hongbin Chen et al.   Scientific Reports

Silibinin suppresses astroglial activation in a mouse model of acute Parkinson׳s disease by modulating the ERK and JNK signaling pathways

(2015) Yujeong Lee et al.   BRAIN RESEARCH

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

Apoptosis signal-regulating kinase 1 modulates the phenotype of α-synuclein transgenic mice

(2015) Kang-Woo Lee et al.   NEUROBIOLOGY OF AGING

Glial activation is associated with l-DOPA induced dyskinesia and blocked by a nitric oxide synthase inhibitor in a rat model of Parkinson's disease

(2015) Mariza Bortolanza et al.   NEUROBIOLOGY OF DISEASE

Diversity and plasticity of microglial cells in psychiatric and neurological disorders

(2015) Yutaka Nakagawa et al.   PHARMACOLOGY & THERAPEUTICS

Alternatively activated microglia and macrophages in the central nervous system

(2015) Rafael Franco et al.   PROGRESS IN NEUROBIOLOGY

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance

(2014) Ana I. Rojo et al.   ANTIOXIDANTS & REDOX SIGNALING

Activity-Dependent Structural Plasticity of Perisynaptic Astrocytic Domains Promotes Excitatory Synapse Stability

(2014) Yann Bernardinelli et al.   CURRENT BIOLOGY

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease

(2014) Augusta Pisanu et al.   NEUROBIOLOGY OF DISEASE

The dual role of astrocyte activation and reactive gliosis

(2014) Milos Pekny et al.   NEUROSCIENCE LETTERS

Astrocyte Development and Heterogeneity

(2014) Omer Ali Bayraktar et al.   Cold Spring Harbor Perspectives in Biology

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro

(2013) Vibol Chhor et al.   BRAIN BEHAVIOR AND IMMUNITY

Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators

(2013) Hyeon-Sook Suh et al.   Journal of Neuroinflammation

Baicalein attenuates astroglial activation in the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model by downregulating the activations of nuclear factor-κB, ERK, and JNK

(2013) Eunjin Lee et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Role of Inflammatory and Oxidative Stress Mechanisms in the Pathogenesis of Parkinson’s Disease: Focus on Astrocytes

(2013) Rituraj Niranjan   MOLECULAR NEUROBIOLOGY

DJ-1 facilitates the interaction between STAT1 and its phosphatase, SHP-1, in brain microglia and astrocytes: A novel anti-inflammatory function of DJ-1

(2013) Jong-hyeon Kim et al.   NEUROBIOLOGY OF DISEASE

Microglia: Multiple roles in surveillance, circuit shaping, and response to injury

(2013) E. E. Benarroch   NEUROLOGY

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

Physiological Phenotype and Vulnerability in Parkinson's Disease

(2013) D. J. Surmeier et al.   Cold Spring Harbor Perspectives in Medicine

Aspects of Astrocyte Energy Metabolism, Amino Acid Neurotransmitter Homoeostasis and Metabolic Compartmentation

(2012) Marko Kreft et al.   ASN Neuro

Differential distribution and activation of microglia in the brain of male C57BL/6J mice

(2012) Ting-Ting Yang et al.   Brain Structure & Function

Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease

(2012) Paula Agostinho et al.   CURRENT PHARMACEUTICAL DESIGN

PPARδ prevents radiation-induced proinflammatory responses in microglia via transrepression of NF-κB and inhibition of the PKCα/MEK1/2/ERK1/2/AP-1 pathway

(2012) Caroline I. Schnegg et al.   FREE RADICAL BIOLOGY AND MEDICINE

α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

(2012) Isabel Lastres-Becker et al.   HUMAN MOLECULAR GENETICS

Eosinophils in glioblastoma biology

(2012) Colleen S Curran et al.   Journal of Neuroinflammation

Astrocyte-Specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-Synuclein Mutant (A53T) Mouse Model

(2012) L. Gan et al.   JOURNAL OF NEUROSCIENCE

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Naphthazarin has a protective effect on the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model

(2012) Seon Young Choi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

(2012) Louise M. Collins et al.   NEUROPHARMACOLOGY

In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease

(2012) S. Iannaccone et al.   PARKINSONISM & RELATED DISORDERS

ATF6alpha Promotes Astroglial Activation and Neuronal Survival in a Chronic Mouse Model of Parkinson’s Disease

(2012) Koji Hashida et al.   PLoS One

Progenitors in the adult cerebral cortex: Cell cycle properties and regulation by physiological stimuli and injury

(2011) Christiane Simon et al.   GLIA

Interleukin-1 beta and neurotrophin-3 synergistically promote neurite growth in vitro

(2011) Francesco Boato et al.   Journal of Neuroinflammation

Role of Secondary Mediators in Caffeine-Mediated Neuroprotection in Maneb- and Paraquat-Induced Parkinson’s Disease Phenotype in the Mouse

(2011) Sharawan Yadav et al.   NEUROCHEMICAL RESEARCH

α-Synuclein overexpression enhances manganese-induced neurotoxicity through the NF-κB-mediated pathway

(2011) Krishnan Prabhakaran et al.   TOXICOLOGY MECHANISMS AND METHODS

IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease

(2011) C Barcia et al.   Cell Death & Disease

Targeting cyclooxygenases-1 and -2 in neuroinflammation: Therapeutic implications

(2010) Saba Aïd et al.   BIOCHIMIE

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

(2010) He-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delayed Dominant-Negative TNF Gene Therapy Halts Progressive Loss of Nigral Dopaminergic Neurons in a Rat Model of Parkinson's Disease

(2010) Ashley S Harms et al.   MOLECULAR THERAPY

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

Neuroinflammation – An Early Event in Both the History and Pathogenesis of Alzheimer’s Disease

(2010) Piet Eikelenboom et al.   Neurodegenerative Diseases

Role of microglia in neurotrauma

(2010) David J. Loane et al.   Neurotherapeutics

Astrocytes and therapeutics for Parkinson’s disease

(2010) Phillip M. Rappold et al.   Neurotherapeutics

Changing Face of Microglia

(2010) M. B. Graeber   SCIENCE

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

(2010) Xing-Long Gu et al.   Molecular Brain

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Interferon-γ deficiency modifies the motor and co-morbid behavioral pathology and neurochemical changes provoked by the pesticide paraquat

(2009) D. Litteljohn et al.   NEUROSCIENCE

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

(2009) Pei-Chun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

(2009) Stanley H. Appel et al.   TRENDS IN IMMUNOLOGY

Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment

(2008) Gaylia Jean Harry et al.   Expert Opinion on Drug Metabolism & Toxicology

Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease

(2008) James B Koprich et al.   Journal of Neuroinflammation

Intranigral Lentiviral Delivery of Dominant-negative TNF Attenuates Neurodegeneration and Behavioral Deficits in Hemiparkinsonian rats

(2008) Melissa K McCoy et al.   MOLECULAR THERAPY

DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone

(2008) Steven J. Mullett et al.   NEUROBIOLOGY OF DISEASE

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark

α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia

(2006) Andis Klegeris et al.   NEUROBIOLOGY OF AGING