DAla2-GIP-GLU-PAL Protects Against Cognitive Deficits and Pathology in APP/PS1 Mice by Inhibiting Neuroinflammation and Upregulating cAMP/PKA/CREB Signaling Pathways
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
DAla2-GIP-GLU-PAL Protects Against Cognitive Deficits and Pathology in APP/PS1 Mice by Inhibiting Neuroinflammation and Upregulating cAMP/PKA/CREB Signaling Pathways
Authors
Keywords
-
Journal
JOURNAL OF ALZHEIMERS DISEASE
Volume -, Issue -, Pages 1-19
Publisher
IOS Press
Online
2021-02-14
DOI
10.3233/jad-201262
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease
- (2019) Jong-Hyun Park et al. Science Advances
- Indirubin-3′-monoxime prevents aberrant activation of GSK-3β/NF-κB and alleviates high fat-high fructose induced Aβ-aggregation, gliosis and apoptosis in mice brain
- (2019) C. Sathiya Priya et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Cyclooxygenase-2 Induced the β-Amyloid Protein Deposition and Neuronal Apoptosis Via Upregulating the Synthesis of Prostaglandin E2 and 15-Deoxy-Δ12,14-prostaglandin J2
- (2019) Pei-Pei Guan et al. Neurotherapeutics
- Novel dual incretin agonist peptide with antidiabetic and neuroprotective potential
- (2018) N.M. Pathak et al. BIOCHEMICAL PHARMACOLOGY
- Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease
- (2018) Jingjing Tai et al. BRAIN RESEARCH
- A novel GLP-1/GIP/Gcg triagonist reduces cognitive deficits and pathology in the 3xTg mouse model of Alzheimer's disease
- (2018) Tian Li et al. HIPPOCAMPUS
- Inhibition of cyclin-dependent kinase 5 affects early neuroinflammatory signalling in murine model of amyloid beta toxicity
- (2018) Anna Wilkaniec et al. Journal of Neuroinflammation
- Melatonin ameliorates Aβ42 -induced alteration of βAPP-processing secretases via the melatonin receptor through the Pin1/GSK3β/NF-κB pathway in SH-SY5Y cells
- (2018) Vorapin Chinchalongporn et al. JOURNAL OF PINEAL RESEARCH
- Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models
- (2018) Christian Hölscher NEUROPHARMACOLOGY
- D-Ala2GIP Facilitated Synaptic Plasticity and Reduces Plaque Load in Aged Wild Type Mice and in an Alzheimer's Disease Mouse Model
- (2018) Emilie Faivre et al. JOURNAL OF ALZHEIMERS DISEASE
- Apolipoprotein E4 Impairs in vivo Hippocampal Long-Term Synaptic Plasticity by Reducing the Phosphorylation of CaMKIIα and CREB
- (2018) Feng Qiao et al. JOURNAL OF ALZHEIMERS DISEASE
- A novel GLP-1/GIP dual agonist is more effective than liraglutide in reducing inflammation and enhancing GDNF release in the MPTP mouse model of Parkinson's disease
- (2017) Ziyue Yuan et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- D-Ala2-GIP-glu-PAL is neuroprotective in a chronic Parkinson's disease mouse model and increases BNDF expression while reducing neuroinflammation and lipid peroxidation
- (2017) Yanwei Li et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Beneficial effects of liraglutide (GLP1 analog) in the hippocampal inflammation
- (2017) Andre R. C. Barreto-Vianna et al. METABOLIC BRAIN DISEASE
- Molecular genetics of early-onset Alzheimer's disease revisited
- (2016) Rita Cacace et al. Alzheimers & Dementia
- Neuroprotective effects of a GIP analogue in the MPTP Parkinson's disease mouse model
- (2016) Yanwei Li et al. NEUROPHARMACOLOGY
- [Gly14]-Humanin Protects Against Amyloid β Peptide-Induced Impairment of Spatial Learning and Memory in Rats
- (2016) Li Yuan et al. Neuroscience Bulletin
- Leptin attenuates the detrimental effects of β-amyloid on spatial memory and hippocampal later-phase long term potentiation in rats
- (2015) Jia-qing Tong et al. HORMONES AND BEHAVIOR
- Diabetes and Alzheimer Disease, Two Overlapping Pathologies with the Same Background: Oxidative Stress
- (2015) Sergio Rosales-Corral et al. Oxidative Medicine and Cellular Longevity
- Shared Neuropathological Characteristics of Obesity, Type 2 Diabetes and Alzheimer’s Disease: Impacts on Cognitive Decline
- (2015) Jennifer Walker et al. Nutrients
- Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases
- (2014) Christian Hölscher BIOCHEMICAL SOCIETY TRANSACTIONS
- Tumor necrosis factor-alpha mediates activation of NF-κB and JNK signaling cascades in retinal ganglion cells and astrocytes in opposite ways
- (2014) Galina Dvoriantchikova et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
- (2014) Scott J. Webster et al. Frontiers in Genetics
- A novel acylated form of (d-Ala2)GIP with improved antidiabetic potential, lacking effect on body fat stores
- (2013) Christine M.A. Martin et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- The neuroprotection of Rattin against amyloid β peptide in spatial memory and synaptic plasticity of rats
- (2013) Zhao-Jun Wang et al. HIPPOCAMPUS
- Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease
- (2013) Scott J Webster et al. Alzheimers Research & Therapy
- Neuroprotective effects of D-Ala2GIP on Alzheimer's disease biomarkers in an APP/PS1 mouse model
- (2013) Emilie Faivre et al. Alzheimers Research & Therapy
- Plasma Signaling Proteins in Persons at Genetic Risk for Alzheimer Disease
- (2012) John M. Ringman et al. ARCHIVES OF NEUROLOGY
- Regulation of NF-κB activity in astrocytes: effects of flavonoids at dietary-relevant concentrations
- (2012) Alison Spilsbury et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
- (2012) Konrad Talbot et al. JOURNAL OF CLINICAL INVESTIGATION
- Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats
- (2012) Wei-Na Han et al. NEUROBIOLOGY OF AGING
- Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice
- (2011) Emilie Faivre et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease
- (2011) Chia-Hsiung Chen et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Neuropsin—A possible modulator of synaptic plasticity
- (2011) Sadao Shiosaka et al. JOURNAL OF CHEMICAL NEUROANATOMY
- Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis
- (2011) Emilie Faivre et al. JOURNAL OF NEUROPHYSIOLOGY
- Aβ1–42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β
- (2011) Jihoon Jo et al. NATURE NEUROSCIENCE
- Role of the glucose-dependent insulinotropic polypeptide and its receptor in the central nervous system: therapeutic potential in neurological diseases
- (2010) Cláudia P. Figueiredo et al. BEHAVIOURAL PHARMACOLOGY
- Alzheimer's disease: strategies for disease modification
- (2010) Martin Citron NATURE REVIEWS DRUG DISCOVERY
- Protease-Resistant Glucose-Dependent Insulinotropic Polypeptide Agonists Facilitate Hippocampal LTP and Reverse the Impairment of LTP Induced by Beta-Amyloid
- (2008) Victor A. Gault et al. JOURNAL OF NEUROPHYSIOLOGY
- Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
- (2008) Aileen M. Moloney et al. NEUROBIOLOGY OF AGING
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More