INT-777 prevents cognitive impairment by activating Takeda G protein-coupled receptor 5 (TGR5) and attenuating neuroinflammation via cAMP/ PKA/ CREB signaling axis in a rat model of sepsis

Mesenchymal Stromal Cells Protect the Blood-Brain Barrier, Reduce Astrogliosis, and Prevent Cognitive and Behavioral Alterations in Surviving Septic Mice

(2020) Adriano Y. O. Silva et al.   CRITICAL CARE MEDICINE

Enhanced Akt/GSK‐3β/CREB signaling mediates the anti‐inflammatory actions of mGluR5 positive allosteric modulators in microglia and following traumatic brain injury in male mice

(2020) Shahnawaz A. Bhat et al.   JOURNAL OF NEUROCHEMISTRY

Sepsis-associated encephalopathy: a vicious cycle of immunosuppression

(2020) Chao Ren et al.   Journal of Neuroinflammation

Neuroinflammation after Intracerebral Hemorrhage and Potential Therapeutic Targets

(2020) Christine Tschoe et al.   Journal of Stroke

Neuropeptide Y1 receptor antagonist promotes osteoporosis and microdamage repair and enhances osteogenic differentiation of bone marrow stem cells via cAMP/PKA/CREB pathway

(2020) Weixin Xie et al.   Aging-US

Neuroprotective function of a novel hexapeptide QMDDQ from shrimp via activation of PKA/CREB/BNDF signaling pathway and its structure-activity relationship

(2020) Dan Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats

(2020) Tianyi Wang et al.   Journal of Neuroinflammation

Selenium Nanoparticles Pre-Treatment Reverse Behavioral, Oxidative Damage, Neuronal Loss and Neurochemical Alterations in Pentylenetetrazole-Induced Epileptic Seizures in Mice

(2020) Xiaona Yuan et al.   International Journal of Nanomedicine

Propane-2-sulfonic acid octadec-9-enyl-amide, a novel PPARα/γ dual agonist, reverses neuroinflammation in lipopolysaccharide-induced mice

(2020) Huahui Lu et al.   NEUROREPORT

The Biosynthesis, Signaling, and Neurological Functions of Bile Acids

(2019) Yoshimitsu Kiriyama et al.   Biomolecules

Activation of TGR5 with INT-777 attenuates oxidative stress and neuronal apoptosis via cAMP/PKCε/ALDH2 pathway after subarachnoid hemorrhage in rats

(2019) Gang Zuo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sepsis: developing new alternatives to reduce neuroinflammation and attenuate brain injury

(2018) Gabriela Meneses et al.   Annals of the New York Academy of Sciences

Inhibitory effect of INT-777 on lipopolysaccharide-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice

(2018) Xian Wu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Advancing a Third Revolution in Critical Care

(2016) Theodore J. Iwashyna et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hippocampal Sirtuin 1 Signaling Mediates Depression-like Behavior

(2016) Naoko Abe-Higuchi et al.   BIOLOGICAL PSYCHIATRY

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

P2X7 Receptor Signaling Contributes to Sepsis-Associated Brain Dysfunction

(2016) Luiz Eduardo Baggio Savio et al.   MOLECULAR NEUROBIOLOGY

TGR5, Not Only a Metabolic Regulator

(2016) Cong Guo et al.   Frontiers in Physiology

The role of microglia activation in the development of sepsis-induced long-term cognitive impairment

(2015) Monique Michels et al.   BRAIN BEHAVIOR AND IMMUNITY

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

(2015) Evie P.M. Broeders et al.   Cell Metabolism

Stress Disorders Following Prolonged Critical Illness in Survivors of Severe Sepsis

(2015) Gloria-Beatrice Wintermann et al.   CRITICAL CARE MEDICINE

TGR5 signaling reduces neuroinflammation during hepatic encephalopathy

(2015) Matthew McMillin et al.   JOURNAL OF NEUROCHEMISTRY

G Protein-Coupled Bile Acid Receptor TGR5 Activation Inhibits Kidney Disease in Obesity and Diabetes

(2015) X. X. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cognitive decline after sepsis

(2015) Djillali Annane et al.   Lancet Respiratory Medicine

Neuroinflammation: Microglial Activation During Sepsis

(2014) Monique Michels et al.   CURRENT NEUROVASCULAR RESEARCH

The bile acid TGR5 membrane receptor: From basic research to clinical application

(2014) Henri Duboc et al.   DIGESTIVE AND LIVER DISEASE

Contribution of Adenylyl Cyclase Modulation of Pre- and Postsynaptic GABA Neurotransmission to Morphine Antinociception and Tolerance

(2014) Erin N Bobeck et al.   NEUROPSYCHOPHARMACOLOGY

A GPBAR1 (TGR5) Small Molecule Agonist Shows Specific Inhibitory Effects on Myeloid Cell Activation In Vitro and Reduces Experimental Autoimmune Encephalitis (EAE) In Vivo

(2014) Nuruddeen D. Lewis et al.   PLoS One

Septic encephalopathy: does inflammation drive the brain crazy?

(2014) Felipe Dal-Pizzol et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Sepsis-induced brain dysfunction

(2013) Nicolas Adam et al.   Expert Review of Anti-Infective Therapy

Acute Brain Inflammation and Oxidative Damage Are Related to Long-Term Cognitive Deficits and Markers of Neurodegeneration in Sepsis-Survivor Rats

(2013) Mágada T. Schwalm et al.   MOLECULAR NEUROBIOLOGY

Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells

(2012) Divya P. Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sepsis-associated encephalopathy

(2012) Teneille E. Gofton et al.   Nature Reviews Neurology

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

(2011) Thijs W.H. Pols et al.   Cell Metabolism

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

(2010) Jun Gao et al.   NATURE

TGR5: an emerging bile acid G-protein-coupled receptor target for the potential treatment of metabolic disorders

(2009) Atul Tiwari et al.   DRUG DISCOVERY TODAY

Immunodesign of experimental sepsis by cecal ligation and puncture

(2009) Daniel Rittirsch et al.   Nature Protocols