Diverse Functions of C4b-Binding Protein in Health and Disease

Neisseria gonorrhoeae co-opts C4b-binding protein to enhance complement-independent survival from neutrophils

(2023) Lacie M. Werner et al.   PLoS Pathogens

C4b-binding protein inhibits particulate- and crystalline-induced NLRP3 inflammasome activation

(2023) Damien Bierschenk et al.   Frontiers in Immunology

The Hidden Side of Complement Regulator C4BP: Dissection and Evaluation of Its Immunomodulatory Activity

(2022) Inmaculada Serrano et al.   Frontiers in Immunology

Hijacking the human complement inhibitor C4b-binding protein by the sporozoite stage of the Plasmodium falciparum parasite

(2022) Ayman Khattab et al.   Frontiers in Immunology

C4b Binding Protein Acts as an Innate Immune Effector Against Influenza A Virus

(2021) Praveen M. Varghese et al.   Frontiers in Immunology

Complement Proteins as Soluble Pattern Recognition Receptors for Pathogenic Viruses

(2021) Valarmathy Murugaiah et al.   Viruses-Basel

C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer

(2021) Kosuke Sasaki et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Nontypeable Haemophilus influenzae P5 Binds Human C4b-Binding Protein, Promoting Serum Resistance

(2021) Oskar Thofte et al.   JOURNAL OF IMMUNOLOGY

Serum Complement Activation by C4BP-IgM Fusion Protein Can Restore Susceptibility to Antibiotics in Neisseria gonorrhoeae

(2021) Serena Bettoni et al.   Frontiers in Immunology

Toxoplasma gondii Recruits Factor H and C4b-Binding Protein to Mediate Resistance to Serum Killing and Promote Parasite Persistence in vivo

(2020) Patricia M. Sikorski et al.   Frontiers in Immunology

Antibacterial Fusion Proteins Enhance Moraxella catarrhalis Killing

(2020) Maisem Laabei et al.   Frontiers in Immunology

Intracellular C4BPA Levels Regulate NF-κB-Dependent Apoptosis

(2020) Monica M. Olcina et al.   iScience

Noncanonical immunomodulatory activity of complement regulator C4BP(β-) limits the development of lupus nephritis

(2019) Ana Luque et al.   KIDNEY INTERNATIONAL

Enolase From Aspergillus fumigatus Is a Moonlighting Protein That Binds the Human Plasma Complement Proteins Factor H, FHL-1, C4BP, and Plasminogen

(2019) Prasad Dasari et al.   Frontiers in Immunology

The complement system in the airway epithelium: An overlooked host defense mechanism and therapeutic target?

(2018) Hrishikesh S. Kulkarni et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human IgG Increases Virulence ofStreptococcus pyogenesthrough Complement Evasion

(2018) David Ermert et al.   JOURNAL OF IMMUNOLOGY

Complement and Bacterial Infections: From Molecular Mechanisms to Therapeutic Applications

(2018) Dani A.C. Heesterbeek et al.   Journal of Innate Immunity

The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface

(2018) Kashif S. Haleem et al.   INFECTION AND IMMUNITY

Complement Evasion Strategies of Viruses: An Overview

(2017) Palak Agrawal et al.   Frontiers in Microbiology

C4b-binding protein: The good, the bad and the deadly. Novel functions of an old friend

(2016) David Ermert et al.   IMMUNOLOGY LETTERS

C4b-binding Protein Protects β-Cells from Islet Amyloid Polypeptide-induced Cytotoxicity

(2016) Jonatan Sjölander et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatitis B virus X protein up-regulates C4b-binding protein α through activating transcription factor Sp1 in protection of hepatoma cells from complement attack

(2016) Guoxing Feng et al.   Oncotarget

Hijacking Complement Regulatory Proteins for Bacterial Immune Evasion

(2016) Elise S. Hovingh et al.   Frontiers in Microbiology

Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein

(2016) Cosmo Z. Buffalo et al.   Nature Microbiology

Fine Mapping of the Interaction between C4b-Binding Protein and Outer Membrane Proteins LigA and LigB of Pathogenic Leptospira interrogans

(2015) Leandro C. D. Breda et al.   PLoS Neglected Tropical Diseases

Virulence of Group A Streptococci Is Enhanced by Human Complement Inhibitors

(2015) David Ermert et al.   PLoS Pathogens

Complement System Part II: Role in Immunity

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Pleiotropic Effects of Cell Wall Amidase LytA on Streptococcus pneumoniae Sensitivity to the Host Immune Response

(2014) Elisa Ramos-Sevillano et al.   INFECTION AND IMMUNITY

Binding ofStreptococcus pneumoniaeEndopeptidase O (PepO) to Complement Component C1q Modulates the Complement Attack and Promotes Host Cell Adherence

(2014) Vaibhav Agarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of Complement Inhibitor C4b-Binding Protein Contributes to Serum Resistance of Porphyromonas gingivalis

(2014) M. Potempa et al.   JOURNAL OF IMMUNOLOGY

Yersinia pestisAil recruitment of C4b-binding protein leads to factor I-mediated inactivation of covalently and noncovalently bound C4b

(2013) Derek K. Ho et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Binding of Complement Inhibitor C4b-binding Protein to a Highly VirulentStreptococcus pyogenesM1 Strain Is Mediated by Protein H and Enhances Adhesion to and Invasion of Endothelial Cells

(2013) David Ermert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The  7 0 Isoform of the Complement Regulator C4b-Binding Protein Induces a Semimature, Anti-Inflammatory State in Dendritic Cells

(2013) R. Olivar et al.   JOURNAL OF IMMUNOLOGY

Functional Recruitment of the Human Complement Inhibitor C4BP to Yersinia pseudotuberculosis Outer Membrane Protein Ail

(2012) D. K. Ho et al.   JOURNAL OF IMMUNOLOGY

Enolase of Streptococcus pneumoniae Binds Human Complement Inhibitor C4b-Binding Protein and Contributes to Complement Evasion

(2012) V. Agarwal et al.   JOURNAL OF IMMUNOLOGY

Arranged Sevenfold: Structural Insights into the C-Terminal Oligomerization Domain of Human C4b-Binding Protein

(2012) Thomas Hofmeyer et al.   JOURNAL OF MOLECULAR BIOLOGY

The pH-regulated Antigen 1 ofCandida albicansBinds the Human Complement Inhibitor C4b-binding Protein and Mediates Fungal Complement Evasion

(2011) Shanshan Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of Flavivirus Nonstructural Protein NS1 to C4b Binding Protein Modulates Complement Activation

(2011) P. Avirutnan et al.   JOURNAL OF IMMUNOLOGY

Functional Recruitment of Human Complement Inhibitor C4b-Binding Protein to Outer Membrane Protein Rck of Salmonella

(2011) Derek K. Ho et al.   PLoS One

C4b-Binding Protein: A Forgotten Factor in Thrombosis and Hemostasis

(2011) Björn Dahlbäck   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Yersinia enterocolitica Serum Resistance Proteins YadA and Ail Bind the Complement Regulator C4b-Binding Protein

(2011) Vesa Kirjavainen et al.   PLoS Pathogens

Functional Characterization of LcpA, a Surface-Exposed Protein of Leptospira spp. That Binds the Human Complement Regulator C4BP

(2010) A. S. Barbosa et al.   INFECTION AND IMMUNITY

Complement inhibition by gram-positive pathogens: molecular mechanisms and therapeutic implications

(2010) Alexander Laarman et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Human Complement Regulators C4b-Binding Protein and C1 Esterase Inhibitor Interact with a Novel Outer Surface Protein of Borrelia recurrentis

(2010) Sonja Grosskinsky et al.   PLoS Neglected Tropical Diseases

Clinical Isolates of Streptococcus pneumoniae Bind the Complement Inhibitor C4b-Binding Protein in a PspC Allele-Dependent Fashion

(2009) A. Dieudonne-Vatran et al.   JOURNAL OF IMMUNOLOGY

Binding of the complement inhibitor C4b-binding protein to Lyme disease borreliae

(2009) Johanna Pietikäinen et al.   MOLECULAR IMMUNOLOGY

Phenotypic and Genotypic Analyses of Neisseria gonorrhoeae Isolates That Express Frequently Recovered PorB PIA Variable Region Types Suggest that Certain P1a Porin Sequences Confer a Selective Advantage for Urogenital Tract Infection

(2008) L. E. Garvin et al.   INFECTION AND IMMUNITY

Complement evasion by human pathogens

(2008) John D. Lambris et al.   NATURE REVIEWS MICROBIOLOGY