Complement Proteins as Soluble Pattern Recognition Receptors for Pathogenic Viruses

C4b Binding Protein Acts as an Innate Immune Effector Against Influenza A Virus

(2021) Praveen M. Varghese et al.   Frontiers in Immunology

Complement-Independent Modulation of Influenza A Virus Infection by Factor H

(2020) Valarmathy Murugaiah et al.   Frontiers in Immunology

Metabolic Reprogramming in CD8+ T Cells During Acute Viral Infections

(2020) Shubhranshu S. Gupta et al.   Frontiers in Immunology

Full-length human surfactant protein A inhibits influenza A virus infection of A549 lung epithelial cells: A recombinant form containing neck and lectin domains promotes infectivity

(2019) Ahmed A. Al-Qahtani et al.   IMMUNOBIOLOGY

Complement mediated neutralization of a potent neurotropic human pathogen, Chandipura virus, is dependent on C1q.

(2019) Umerali Kunnakkadan et al.   JOURNAL OF VIROLOGY

The Natural Cytotoxicity Receptors in Health and Disease

(2019) Alexander David Barrow et al.   Frontiers in Immunology

Secretion of functionally active complement factor H related protein 5 (FHR5) by primary tumour cells derived from Glioblastoma Multiforme patients

(2019) Syreeta DeCordova et al.   IMMUNOBIOLOGY

Properdin: A multifaceted molecule involved in inflammation and diseases

(2018) Jin Y. Chen et al.   MOLECULAR IMMUNOLOGY

Entry Inhibition and Modulation of Pro-Inflammatory Immune Response Against Influenza A Virus by a Recombinant Truncated Surfactant Protein D

(2018) Mohammed N. Al-Ahdal et al.   Frontiers in Immunology

Structure and activation of C1, the complex initiating the classical pathway of the complement cascade

(2017) Simon A. Mortensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular vesicles from KSHV-infected endothelial cells activate the complement system

(2017) Hyungtaek Jeon et al.   Oncotarget

Complement Evasion Strategies of Viruses: An Overview

(2017) Palak Agrawal et al.   Frontiers in Microbiology

C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions

(2017) Jinhua Lu et al.   Frontiers in Immunology

Enhancement of Ebola Virus Infection via Ficolin-1 Interaction with the Mucin Domain of GP Glycoprotein

(2016) Anne-Laure Favier et al.   JOURNAL OF VIROLOGY

Inhibition of the Membrane Attack Complex by Dengue Virus NS1 through Interaction with Vitronectin and Terminal Complement Proteins

(2016) Jonas Nascimento Conde et al.   JOURNAL OF VIROLOGY

A recombinant two-module form of human properdin is an inhibitor of the complement alternative pathway

(2016) Lubna Kouser et al.   MOLECULAR IMMUNOLOGY

C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation

(2016) Roberta Bulla et al.   Nature Communications

Hepatitis B virus X protein up-regulates C4b-binding protein α through activating transcription factor Sp1 in protection of hepatoma cells from complement attack

(2016) Guoxing Feng et al.   Oncotarget

Complement Protein C1q Interacts with DC-SIGN via Its Globular Domain and Thus May Interfere with HIV-1 Transmission

(2016) Lina Pednekar et al.   Frontiers in Immunology

Human Lectins and Their Roles in Viral Infections

(2015) Christopher Mason et al.   MOLECULES

The lectin pathway of complement: Advantage or disadvantage in HIV pathogenesis?

(2014) V. Ballegaard et al.   CLINICAL IMMUNOLOGY

Properdin Plays a Protective Role in Polymicrobial Septic Peritonitis

(2014) C. M. Stover et al.   JOURNAL OF IMMUNOLOGY

Ficolin-2 Inhibits Hepatitis C Virus Infection, whereas Apolipoprotein E3 Mediates Viral Immune Escape

(2014) Yinglan Zhao et al.   JOURNAL OF IMMUNOLOGY

Recombinant Human L-Ficolin Directly Neutralizes Hepatitis C Virus Entry

(2014) Mohamed R. Hamed et al.   Journal of Innate Immunity

Intracellular mannose binding lectin mediates subcellular trafficking of HIV-1 gp120 in neurons

(2014) C. Teodorof et al.   NEUROBIOLOGY OF DISEASE

Intracellular sensing of complement C3 activates cell autonomous immunity

(2014) J. C. H. Tam et al.   SCIENCE

Shed GP of Ebola Virus Triggers Immune Activation and Increased Vascular Permeability

(2014) Beatriz Escudero-Pérez et al.   PLoS Pathogens

Ficolins and infectious diseases

(2014) Yushan Ren et al.   VIROLOGICA SINICA

Hepatitis B virus X protein protects hepatoma and hepatic cells from complement-dependent cytotoxicity by up-regulation of CD46

(2013) Shuai Zhang et al.   FEBS LETTERS

Identification of a Novel Mode of Complement Activation on Stimulated Platelets Mediated by Properdin and C3(H2O)

(2013) G. Saggu et al.   JOURNAL OF IMMUNOLOGY

Human complement C3 deficiency: Th1 induction requires T cell-derived complement C3a and CD46 activation

(2013) Arije Ghannam et al.   MOLECULAR IMMUNOLOGY

Ficolin-2 Defends against Virulent Mycobacteria Tuberculosis Infection In Vivo, and Its Insufficiency Is Associated with Infection in Humans

(2013) Fengling Luo et al.   PLoS One

Overview of Complement Activation and Regulation

(2013) Marina Noris et al.   SEMINARS IN NEPHROLOGY

Replication Cycle and Molecular Biology of the West Nile Virus

(2013) Margo Brinton   Viruses-Basel

The CD8-Derived Chemokine XCL1/Lymphotactin Is a Conformation-Dependent, Broad-Spectrum Inhibitor of HIV-1

(2013) Christina Guzzo et al.   PLoS Pathogens

Properdin and Factor H: Opposing Players on the Alternative Complement Pathway “See-Saw”

(2013) Lubna Kouser et al.   Frontiers in Immunology

West Nile Virus: Biology, Transmission, and Human Infection

(2012) T. M. Colpitts et al.   CLINICAL MICROBIOLOGY REVIEWS

The complement system in ischemia–reperfusion injuries

(2012) William B. Gorsuch et al.   IMMUNOBIOLOGY

Human H-Ficolin Inhibits Replication of Seasonal and Pandemic Influenza A Viruses

(2012) A. Verma et al.   JOURNAL OF IMMUNOLOGY

L-Ficolin Binds to the Glycoproteins Hemagglutinin and Neuraminidase and Inhibits Influenza A Virus Infection Both in vitro and in vivo

(2012) Qin Pan et al.   Journal of Innate Immunity

Endothelial Cells Elicit Immune-Enhancing Responses to Dengue Virus Infection

(2012) N. A. Dalrymple et al.   JOURNAL OF VIROLOGY

Ficolins in complement activation

(2012) Misao Matsushita   MOLECULAR IMMUNOLOGY

Which pathways trigger the role of complement in ischaemia/reperfusion injury?

(2012) Conrad A. Farrar et al.   Frontiers in Immunology

Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection

(2011) Wei-Chuan Chang et al.   BMC IMMUNOLOGY

Hepatitis B virus X protein activates CD59 involving DNA binding and let-7i in protection of hepatoma and hepatic cells from complement attack

(2011) Changliang Shan et al.   CARCINOGENESIS

New functional ligands for ficolin-3 among lipopolysaccharides of Hafnia alvei

(2011) Anna Swierzko et al.   GLYCOBIOLOGY

Binding of Flavivirus Nonstructural Protein NS1 to C4b Binding Protein Modulates Complement Activation

(2011) P. Avirutnan et al.   JOURNAL OF IMMUNOLOGY

M-Ficolin Interacts with the Long Pentraxin PTX3: A Novel Case of Cross-Talk between Soluble Pattern-Recognition Molecules

(2011) E. Gout et al.   JOURNAL OF IMMUNOLOGY

Mannose-Binding Lectin Contributes to Deleterious Inflammatory Response in Pandemic H1N1 and Avian H9N2 Infection

(2011) Man To Ling et al.   JOURNAL OF INFECTIOUS DISEASES

Inhibiting the C5–C5a receptor axis

(2011) Trent M. Woodruff et al.   MOLECULAR IMMUNOLOGY

The lectin pathway of complement activation contributes to protection from West Nile virus infection

(2011) Anja Fuchs et al.   VIROLOGY

Complement and viral pathogenesis

(2011) Kristina A. Stoermer et al.   VIROLOGY

The pandemic (H1N1) 2009 influenza virus is resistant to mannose-binding lectin

(2011) Hirotoshi Tokunaga et al.   Virology Journal

Neutrophils and interferon-α-producing cells: who produces interferon in lupus?

(2011) Patrice Decker   ARTHRITIS RESEARCH & THERAPY

Complement-Mediated Neutralization of Dengue Virus Requires Mannose-Binding Lectin

(2011) P. Avirutnan et al.   mBio

Direct Complement Restriction of Flavivirus Infection Requires Glycan Recognition by Mannose-Binding Lectin

(2010) Anja Fuchs et al.   Cell Host & Microbe

Specifically Binding of L-ficolin to N-glycans of HCV Envelope Glycoproteins E1 and E2 Leads to Complement Activation

(2010) Jun Liu et al.   Cellular & Molecular Immunology

Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation

(2010) Kazue Takahashi et al.   IMMUNOBIOLOGY

Antagonism of the complement component C4 by flavivirus nonstructural protein NS1

(2010) Panisadee Avirutnan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pandemic H1N1 Influenza A Viruses Are Resistant to the Antiviral Activities of Innate Immune Proteins of the Collectin and Pentraxin Superfamilies

(2010) E. R. Job et al.   JOURNAL OF IMMUNOLOGY

High-Dose Mannose-Binding Lectin Therapy for Ebola Virus Infection

(2010) Ian C. Michelow et al.   JOURNAL OF INFECTIOUS DISEASES

Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain

(2010) Christian Honoré et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Single Asparagine-Linked Glycosylation Site of the Severe Acute Respiratory Syndrome Coronavirus Spike Glycoprotein Facilitates Inhibition by Mannose-Binding Lectin through Multiple Mechanisms

(2010) Y. Zhou et al.   JOURNAL OF VIROLOGY

Potent inhibition of the classical pathway of complement by a novel C1q-binding peptide derived from the human astrovirus coat protein

(2010) Jenny Q. Gronemus et al.   MOLECULAR IMMUNOLOGY

Complement control protein factor H: The good, the bad, and the inadequate

(2010) Viviana P. Ferreira et al.   MOLECULAR IMMUNOLOGY

HIV gp41 Engages gC1qR on CD4+ T Cells to Induce the Expression of an NK Ligand through the PIP3/H2O2 Pathway

(2010) Hugues Fausther-Bovendo et al.   PLoS Pathogens

Specific interaction of hepatitis C virus glycoproteins with mannan binding lectin inhibits virus entry

(2010) Kristelle S. Brown et al.   Protein & Cell

Properdin: Emerging Roles of a Pattern-Recognition Molecule

(2009) Claudia Kemper et al.   Annual Review of Immunology

Recognition of Mannosylated Ligands and Influenza A Virus by Human Surfactant Protein D: Contributions of an Extended Site and Residue 343†,‡

(2009) Erika Crouch et al.   BIOCHEMISTRY

C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells

(2009) Donald J. Weaver et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mannose-binding lectin 2 gene polymorphism in recurrent herpes simplex virus 2 infection

(2009) Mikko Seppänen et al.   HUMAN IMMUNOLOGY

Complement component 5a (C5a)

(2009) Helga D. Manthey et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Influenza A virus M1 blocks the classical complement pathway through interacting with C1qA

(2009) J. Zhang et al.   JOURNAL OF GENERAL VIROLOGY

The role of the anaphylatoxins in health and disease

(2009) Andreas Klos et al.   MOLECULAR IMMUNOLOGY

Human astrovirus coat protein binds C1q and MBL and inhibits the classical and lectin pathways of complement activation

(2009) Pamela S. Hair et al.   MOLECULAR IMMUNOLOGY

Uncoupling CD21 and CD19 of the B-cell coreceptor

(2009) R. A. Barrington et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate and Adaptive Immune Responses to Herpes Simplex Virus

(2009) Tracy Chew et al.   Viruses-Basel

Complement evasion by human pathogens

(2008) John D. Lambris et al.   NATURE REVIEWS MICROBIOLOGY

The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis

(2008) Claudia Kemper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mannose-binding lectin is present in the infected airway: a possible pulmonary defence mechanism

(2008) K J Fidler et al.   THORAX

Porcine plasma ficolin binds and reduces infectivity of porcine reproductive and respiratory syndrome virus (PRRSV) in vitro

(2007) Natalie D. Keirstead et al.   ANTIVIRAL RESEARCH

Activator-specific requirement of properdin in the initiation and amplification of the alternative pathway complement

(2007) Y. Kimura et al.   BLOOD