Stem cell–like reprogramming is required for leukemia-initiating activity in B-ALL

The PAX5‐JAK2 translocation acts as dual‐hit mutation that promotes aggressive B‐cell leukemia via nuclear STAT5 activation

(2022) Sabine Jurado et al.   EMBO JOURNAL

Hyaluronic acid–GPRC5C signalling promotes dormancy in haematopoietic stem cells

(2022) Yu Wei Zhang et al.   NATURE CELL BIOLOGY

EGR1 Haploinsufficiency Confers a Fitness Advantage to Hematopoietic Stem Cells Following Chemotherapy

(2022) Angela Stoddart et al.   EXPERIMENTAL HEMATOLOGY

PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

(2021) James S. Chavez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Advances in the Diagnosis and Treatment of Pediatric Acute Lymphoblastic Leukemia

(2021) Hiroto Inaba et al.   Journal of Clinical Medicine

TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate

(2021) Laura García-Prat et al.   Cell Stem Cell

The Second Oncogenic Hit Determines the Cell Fate of ETV6-RUNX1 Positive Leukemia

(2021) Guillermo Rodríguez-Hernández et al.   Frontiers in Cell and Developmental Biology

Oncogene-Induced Reprogramming in Acute Lymphoblastic Leukemia: Towards Targeted Therapy of Leukemia-Initiating Cells

(2021) Vincent Fregona et al.   Cancers

Relapse fated latent diagnosis subclones in acute B lineage leukaemia are drug tolerant and possess distinct metabolic programs

(2020) Stephanie M. Dobson et al.   Cancer Discovery

ATAC-seq normalization method can significantly affect differential accessibility analysis and interpretation

(2020) Jake J. Reske et al.   Epigenetics & Chromatin

Yap1-Scribble polarization is required for hematopoietic stem cell division and fate

(2020) Mark Althoff et al.   BLOOD

A 9-gene score for risk stratification in B-cell acute lymphoblastic leukemia

(2020) Feng Yan et al.   LEUKEMIA

Signalling input from divergent pathways subverts B cell transformation

(2020) Lai N. Chan et al.   NATURE

Comparison of differential accessibility analysis strategies for ATAC-seq data

(2020) Paul Gontarz et al.   Scientific Reports

EBF1 and Pax5 safeguard leukemic transformation by limiting IL-7 signaling, Myc expression, and folate metabolism

(2020) Senthilkumar Ramamoorthy et al.   GENES & DEVELOPMENT

Pediatric acute lymphoblastic leukemia

(2020) Hiroto Inaba et al.   HAEMATOLOGICA

ATF3 Prevents Stress-Induced Hematopoietic Stem Cell Exhaustion

(2020) Yufeng Liu et al.   Frontiers in Cell and Developmental Biology

How I Diagnose Minimal/Measurable Residual Disease in B Lymphoblastic Leukemia/Lymphoma by Flow Cytometry

(2020) Sindhu Cherian et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia

(2019) Zhaohui Gu et al.   NATURE GENETICS

Leveraging chromatin accessibility for transcriptional regulatory network inference in T Helper 17 Cells

(2019) Emily R. Miraldi et al.   GENOME RESEARCH

Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia

(2019) Emmalee R Adelman et al.   Cancer Discovery

TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration

(2019) Masayuki Yamashita et al.   Cell Stem Cell

Characterization of Transcriptional Regulatory Networks that Promote and Restrict Identities and Functions of Intestinal Innate Lymphoid Cells

(2019) Maria Pokrovskii et al.   IMMUNITY

CytoNorm: A Normalization Algorithm for Cytometry Data

(2019) Sofie Van Gassen et al.   CYTOMETRY PART A

Quantification of Differential Transcription Factor Activity and Multiomics-Based Classification into Activators and Repressors: diffTF

(2019) Ivan Berest et al.   Cell Reports

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

(2018) Tathiane M. Malta et al.   CELL

Single-cell developmental classification of B cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse

(2018) Zinaida Good et al.   NATURE MEDICINE

Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments

(2018) Matthew C Canver et al.   Nature Protocols

Murine Bone Marrow Niches from Hematopoietic Stem Cells to B Cells

(2018) Michel Aurrand-Lions et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The genetic basis and cell of origin of mixed phenotype acute leukaemia

(2018) Thomas B. Alexander et al.   NATURE

PAX5-ELN oncoprotein promotes multistep B-cell acute lymphoblastic leukemia in mice

(2018) Laura Jamrog et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells

(2018) Cedric S. Tremblay et al.   Nature Communications

Dimensionality reduction for visualizing single-cell data using UMAP

(2018) Etienne Becht et al.   NATURE BIOTECHNOLOGY

SCA-1 Expression Level Identifies Quiescent Hematopoietic Stem and Progenitor Cells

(2017) Mina N.F. Morcos et al.   Stem Cell Reports

flowAI: automatic and interactive anomaly discerning tools for flow cytometry data

(2016) Gianni Monaco et al.   BIOINFORMATICS

Characterization of Rare, Dormant, and Therapy-Resistant Cells in Acute Lymphoblastic Leukemia

(2016) Sarah Ebinger et al.   CANCER CELL

High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells

(2016) Bastien Gerby et al.   JOURNAL OF CLINICAL INVESTIGATION

A 17-gene stemness score for rapid determination of risk in acute leukaemia

(2016) Stanley W. K. Ng et al.   NATURE

A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia

(2016) Konstantinos Tzelepis et al.   Cell Reports

The RUNX1–PU.1 axis in the control of hematopoiesis

(2015) Maria Rosaria Imperato et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists

(2015) Stéphane Prost et al.   NATURE

A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling

(2015) Heide Christine Patterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NF-κB signaling in cancer stem cells: a promising therapeutic target?

(2015) K. Vazquez-Santillan et al.   CELLULAR ONCOLOGY

The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells

(2014) P. B. Staber et al.   BLOOD

CDK6 as a key regulator of hematopoietic and leukemic stem cell activation

(2014) Ruth Scheicher et al.   BLOOD

Single-Cell Trajectory Detection Uncovers Progression and Regulatory Coordination in Human B Cell Development

(2014) Sean C. Bendall et al.   CELL

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing

(2014) Dirk Heckl et al.   NATURE BIOTECHNOLOGY

Full-length RNA-seq from single cells using Smart-seq2

(2014) Simone Picelli et al.   Nature Protocols

SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells

(2014) Bastien Gerby et al.   PLoS Genetics

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Contrasting Quiescent G0 Phase with Mitotic Cell Cycling in the Mouse Immune System

(2013) Michio Tomura et al.   PLoS One

The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis

(2012) Roger Revilla-i-Domingo et al.   EMBO JOURNAL

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia

(2011) F. W. van Delft et al.   BLOOD

Interpretation of cellular proliferation data: Avoid the panglossian

(2011) Mario Roederer   CYTOMETRY PART A

Critical role for Gimap5 in the survival of mouse hematopoietic stem and progenitor cells

(2011) Yuhong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study

(2010) E. Coyaud et al.   BLOOD

The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal

(2010) M. P. McCormack et al.   SCIENCE

Distinct Expression Patterns of CD123 and CD34 on Normal Bone Marrow B-Cell Precursors (“Hematogones”) and B Lymphoblastic Leukemia Blasts

(2009) Nagwa M. Hassanein et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

PML–RARα initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors

(2009) S Wojiski et al.   LEUKEMIA

PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study

(2009) J Familiades et al.   LEUKEMIA

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

The Transcription Factor EGR1 Controls Both the Proliferation and Localization of Hematopoietic Stem Cells

(2008) Irene M. Min et al.   Cell Stem Cell

Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

(2008) Adlen Foudi et al.   NATURE BIOTECHNOLOGY

Initiating and Cancer-Propagating Cells in TEL-AML1-Associated Childhood Leukemia

(2008) D. Hong et al.   SCIENCE

Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

(2008) C. G. Mullighan et al.   SCIENCE