SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells

Therapeutic Targeting of c-Myc in T-Cell Acute Lymphoblastic Leukemia (T-ALL)

(2015) Marie Loosveld et al.   Oncotarget

c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

(2014) J. E. Roderick et al.   BLOOD

LIM Domain Only-2 (LMO2) Induces T-Cell Leukemia by Two Distinct Pathways

(2014) Stephen Smith et al.   PLoS One

The establishment of B versus T cell identity

(2014) Kazuko Miyazaki et al.   TRENDS IN IMMUNOLOGY

Genetic interaction between Kit and Scl

(2013) J. Lacombe et al.   BLOOD

Heterogeneity of Neoplastic Stem Cells: Theoretical, Functional, and Clinical Implications

(2013) P. Valent et al.   CANCER RESEARCH

The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability

(2013) Bryan King et al.   CELL

Stem cells living with a Notch

(2013) U. Koch et al.   DEVELOPMENT

Function of oncogenes in cancer development: a changing paradigm

(2013) Carolina Vicente-Dueñas et al.   EMBO JOURNAL

T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1

(2013) Maria Elena De Obaldia et al.   NATURE IMMUNOLOGY

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Direct reprogramming by oncogenic Ras and Myc

(2013) I. Ischenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Analysis of Transcriptome Variation Uncovers Known and Novel Driver Events in T-Cell Acute Lymphoblastic Leukemia

(2013) Zeynep Kalender Atak et al.   PLoS Genetics

Growth factor independent-1 Maintains Notch1-Dependent Transcriptional Programming of Lymphoid Precursors

(2013) James D. Phelan et al.   PLoS Genetics

Hematopoietic stem cells: to be or Notch to be

(2012) A. Bigas et al.   BLOOD

Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T Cell Acute Lymphoblastic Leukemia

(2012) Takaomi Sanda et al.   CANCER CELL

Dynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity

(2012) Jingli A. Zhang et al.   CELL

Gene Sets Identified with Oncogene Cooperativity Analysis Regulate In Vivo Growth and Survival of Leukemia Stem Cells

(2012) John M. Ashton et al.   Cell Stem Cell

Less Is More: Unveiling the Functional Core of Hematopoietic Stem Cells through Knockout Mice

(2012) Lara Rossi et al.   Cell Stem Cell

A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

(2012) C. Simon et al.   GENES & DEVELOPMENT

The molecular basis of T cell acute lymphoblastic leukemia

(2012) Pieter Van Vlierberghe et al.   JOURNAL OF CLINICAL INVESTIGATION

Thymus-autonomous T cell development in the absence of progenitor import

(2012) Vera C. Martins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors

(2012) Fabian Zohren et al.   NATURE IMMUNOLOGY

NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species

(2012) Vincenzo Giambra et al.   NATURE MEDICINE

Angiopoietin-2 Is a Direct Transcriptional Target of TAL1, LYL1 and LMO2 in Endothelial Cells

(2012) Virginie Deleuze et al.   PLoS One

Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL

(2011) J. Tatarek et al.   BLOOD

Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia

(2011) Irene Homminga et al.   CANCER CELL

Hes1 expression and CYLD repression are essential events downstream of Notch1 in T-cell leukemia

(2011) Teresa D’Altri et al.   CELL CYCLE

A compendium of genome-wide hematopoietic transcription factor maps supports the identification of gene regulatory control mechanisms

(2011) Rebecca Hannah et al.   EXPERIMENTAL HEMATOLOGY

Characterization of a pediatric T-cell acute lymphoblastic leukemia patient with simultaneous LYL1 and LMO2 rearrangements

(2011) I. Homminga et al.   HAEMATOLOGICA

Genomic loss of the putative tumor suppressor geneE2Ain human lymphoma

(2011) Anne Steininger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Expression of CD34 and CD7 on human T-cell acute lymphoblastic leukemia discriminates functionally heterogeneous cell populations

(2011) B Gerby et al.   LEUKEMIA

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells

(2011) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functions of Notch Signaling in the Immune System: Consensus and Controversies

(2010) Julie S. Yuan et al.   Annual Review of Immunology

ChEA: transcription factor regulation inferred from integrating genome-wide ChIP-X experiments

(2010) Alexander Lachmann et al.   BIOINFORMATICS

Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance

(2010) P. P. L. Chiu et al.   BLOOD

PeakAnalyzer: Genome-wide annotation of chromatin binding and modification loci

(2010) Mali Salmon-Divon et al.   BMC BIOINFORMATICS

Combinatorial Transcriptional Control In Blood Stem/Progenitor Cells: Genome-wide Analysis of Ten Major Transcriptional Regulators

(2010) Nicola K. Wilson et al.   Cell Stem Cell

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes

(2010) M. Tremblay et al.   GENES & DEVELOPMENT

Hes1 Is a Critical but Context-Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation

(2010) Agnieszka A. Wendorff et al.   IMMUNITY

NKX3.1is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia

(2010) Sophie Kusy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase–substrate complex

(2010) Linsey Reavie et al.   NATURE IMMUNOLOGY

Promotion of direct reprogramming by transformation-deficient Myc

(2010) M. Nakagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal

(2010) M. P. McCormack et al.   SCIENCE

Scl regulates the quiescence and the long-term competence of hematopoietic stem cells

(2009) J. Lacombe et al.   BLOOD

A Functional Screen to Identify Novel Effectors of Hematopoietic Stem Cell Activity

(2009) Eric Deneault et al.   CELL

Cancer Stem Cells: Controversial or Just Misunderstood?

(2009) Craig T. Jordan   Cell Stem Cell

Adult Hematopoietic Stem and Progenitor Cells Require Either Lyl1 or Scl for Survival

(2009) George P. Souroullas et al.   Cell Stem Cell

Multiple mechanisms induce ectopic expression of LYL1 in subsets of T-ALL cell lines

(2009) Stefan Nagel et al.   LEUKEMIA RESEARCH

Hes1 Potentiates T Cell Lymphomagenesis by Up-Regulating a Subset of Notch Target Genes

(2009) Darryll D. Dudley et al.   PLoS One

Notch Signaling in Leukemia

(2008) Jon C. Aster et al.   Annual Review of Pathology-Mechanisms of Disease

NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity

(2008) F. Armstrong et al.   BLOOD

Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells

(2008) Ivan Maillard et al.   Cell Stem Cell

Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity

(2008) Elisa Laurenti et al.   Cell Stem Cell

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras–initiated leukemia

(2008) Mark Y. Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype

(2008) Helene R. McMurray et al.   NATURE

Initiating and Cancer-Propagating Cells in TEL-AML1-Associated Childhood Leukemia

(2008) D. Hong et al.   SCIENCE