The interplay of quaternary ammonium lipid structure and protein corona on lung-specific mRNA delivery by selective organ targeting (SORT) nanoparticles

Passive, active and endogenous organ-targeted lipid and polymer nanoparticles for delivery of genetic drugs

(2023) Sean A. Dilliard et al.   Nature Reviews Materials

Ionizable lipid nanoparticles deliver mRNA to pancreatic β cells via macrophage-mediated gene transfer

(2023) Jilian R. Melamed et al.   Science Advances

Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis

(2022) Min Qiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Supervised learning model predicts protein adsorption to carbon nanotubes

(2022) Nicholas Ouassil et al.   Science Advances

Macrophages Actively Transport Nanoparticles in Tumors After Extravasation

(2022) Zachary Pengju Lin et al.   ACS Nano

Identifying cell receptors for the nanoparticle protein corona using genome screens

(2022) Wayne Ngo et al.   Nature Chemical Biology

Engineering Lipid Nanoparticles for Enhanced Intracellular Delivery of mRNA through Inhalation

(2022) Jeonghwan Kim et al.   ACS Nano

Lipid Nanoparticle (LNP) Chemistry Can Endow Unique In Vivo RNA Delivery Fates within the Liver That Alter Therapeutic Outcomes in a Cancer Model

(2022) Lindsay T. Johnson et al.   MOLECULAR PHARMACEUTICS

Preparation of selective organ-targeting (SORT) lipid nanoparticles (LNPs) using multiple technical methods for tissue-specific mRNA delivery

(2022) Xu Wang et al.   Nature Protocols

Engineered ionizable lipid nanoparticles for targeted delivery of RNA therapeutics into different types of cells in the liver

(2021) M. Kim et al.   Science Advances

In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates

(2021) Kiran Musunuru et al.   NATURE

Lipids and Lipid Derivatives for RNA Delivery

(2021) Yuebao Zhang et al.   CHEMICAL REVIEWS

CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis

(2021) Julian D. Gillmore et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipid nanoparticles for mRNA delivery

(2021) Xucheng Hou et al.   Nature Reviews Materials

Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation

(2021) Jacob W. Myerson et al.   Nature Nanotechnology

On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles

(2021) Sean A. Dilliard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Screening of the binding affinity of serum proteins to lipid nanoparticles in a cell free environment

(2021) Federica Sebastiani et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

The promise and challenge of therapeutic genome editing

(2020) Jennifer A. Doudna   NATURE

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

Machine learning predicts the functional composition of the protein corona and the cellular recognition of nanoparticles

(2020) Zhan Ban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing

(2020) Tuo Wei et al.   Nature Communications

Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia

(2020) Lei Jiang et al.   Nature Communications

A Systematic Study of Unsaturation in Lipid Nanoparticles Leads to Improved mRNA Transfection In Vivo

(2020) Sang Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Supervised Learning and Mass Spectrometry Predicts the in Vivo Fate of Nanomaterials

(2019) James Lazarovits et al.   ACS Nano

Search-and-replace genome editing without double-strand breaks or donor DNA

(2019) Andrew V. Anzalone et al.   NATURE

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells

(2019) Marco Maugeri et al.   Nature Communications

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

(2019) Akin Akinc et al.   Nature Nanotechnology

Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases

(2018) Alice Huertas et al.   EUROPEAN RESPIRATORY JOURNAL

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

(2018) Jonathan D. Finn et al.   Cell Reports

Breast Cancers Activate Stromal Fibroblast-Induced Suppression of Progenitors in Adjacent Normal Tissue

(2018) Sumanta Chatterjee et al.   Stem Cell Reports

Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I

(2018) Qiang Cheng et al.   ADVANCED MATERIALS

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

(2017) Nicole M. Gaudelli et al.   NATURE

Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics

(2017) Nicolas Bertrand et al.   Nature Communications

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model

(2016) Kejin Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid composition: a “key factor” for the rational manipulation of the liposome–protein corona by liposome design

(2015) G. Caracciolo et al.   RSC Advances

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

(2013) Stefan Tenzer et al.   Nature Nanotechnology

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

(2013) Barbara L Mui et al.   Molecular Therapy-Nucleic Acids

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment

(2011) Carl D. Walkey et al.   CHEMICAL SOCIETY REVIEWS

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Hydrophobic Moiety of Cationic Lipids Strongly Modulates Their Transfection Activity

(2009) Rumiana Koynova et al.   MOLECULAR PHARMACEUTICS

Modulation of a membrane lipid lamellar–nonlamellar phase transition by cationic lipids: A measure for transfection efficiency

(2008) Boris G. Tenchov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES