Engineering Lipid Nanoparticles for Enhanced Intracellular Delivery of mRNA through Inhalation

Self-assembled mRNA vaccines

(2021) Jeonghwan Kim et al.   ADVANCED DRUG DELIVERY REVIEWS

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing

(2021) Shuai Liu et al.   NATURE MATERIALS

CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis

(2021) Julian D. Gillmore et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chemistry of Lipid Nanoparticles for RNA Delivery

(2021) Yulia Eygeris et al.   ACCOUNTS OF CHEMICAL RESEARCH

Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation

(2021) Jacob W. Myerson et al.   Nature Nanotechnology

Nanomedicine hitchhikes on neutrophils to the inflamed lung

(2021) Jeonghwan Kim et al.   Nature Nanotechnology

On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles

(2021) Sean A. Dilliard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

(2020) Siddharth Patel et al.   Nature Communications

Naturally Derived Membrane Lipids Impact Nanoparticle-Based Messenger RNA Delivery

(2020) Jeonghwan Kim et al.   Cellular and Molecular Bioengineering

Highly Efficient Gene Editing of Cystic Fibrosis Patient-Derived Airway Basal Cells Results in Functional CFTR Correction

(2020) Shingo Suzuki et al.   MOLECULAR THERAPY

Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery

(2020) Yulia Eygeris et al.   NANO LETTERS

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

Real-time 3D single molecule tracking

(2020) Shangguo Hou et al.   Nature Communications

How cholesterol stiffens unsaturated lipid membranes

(2020) Saptarshi Chakraborty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium

(2019) Asha Kumari Patel et al.   ADVANCED MATERIALS

Nanoparticles Containing Oxidized Cholesterol Deliver mRNA to the Liver Microenvironment at Clinically Relevant Doses

(2019) Kalina Paunovska et al.   ADVANCED MATERIALS

Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis

(2018) Ema Robinson et al.   MOLECULAR THERAPY

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

(2018) Marianna Yanez Arteta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune Modulation by Human Secreted RNases at the Extracellular Space

(2018) Lu Lu et al.   Frontiers in Immunology

Systemic messenger RNA as an etiological treatment for acute intermittent porphyria

(2018) Lei Jiang et al.   NATURE MEDICINE

Chemically modified hCFTR mRNAs recuperate lung function in a mouse model of cystic fibrosis

(2018) A. K. M. Ashiqul Haque et al.   Scientific Reports

Nonhuman Primate Models of Respiratory Disease: Past, Present, and Future

(2017) Lisa A Miller et al.   ILAR JOURNAL

Robust real-time 3D single-particle tracking using a dynamically moving laser spot

(2017) Shangguo Hou et al.   OPTICS LETTERS

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

Emerging Roles of Apolipoprotein E and Apolipoprotein A-I in the Pathogenesis and Treatment of Lung Disease

(2016) Xianglan Yao et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA

(2016) Sam Chen et al.   JOURNAL OF CONTROLLED RELEASE

Progress in therapies for cystic fibrosis

(2016) Kris De Boeck et al.   Lancet Respiratory Medicine

Impact of Surface Polyethylene Glycol (PEG) Density on Biodegradable Nanoparticle Transport in Mucus ex Vivo and Distribution in Vivo

(2015) Qingguo Xu et al.   ACS Nano

Pulmonary monoclonal antibody delivery via a portable microfluidic nebulization platform

(2015) Christina Cortez-Jugo et al.   Biomicrofluidics

Emerging inhalation aerosol devices and strategies: Where are we headed?

(2014) Qi (Tony) Zhou et al.   ADVANCED DRUG DELIVERY REVIEWS

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

(2013) Barbara L Mui et al.   Molecular Therapy-Nucleic Acids

Cationic polymers and their therapeutic potential

(2012) Sangram Keshari Samal et al.   CHEMICAL SOCIETY REVIEWS

Increased Erythropoiesis in Mice Injected With Submicrogram Quantities of Pseudouridine-containing mRNA Encoding Erythropoietin

(2012) Katalin Karikó et al.   MOLECULAR THERAPY

PEGylated PRINT Nanoparticles: The Impact of PEG Density on Protein Binding, Macrophage Association, Biodistribution, and Pharmacokinetics

(2012) Jillian L. Perry et al.   NANO LETTERS

Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs

(2012) C. Ehre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Airway Mucus Function and Dysfunction

(2010) John V. Fahy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nebulizer therapy in cystic fibrosis: An overview

(2009) Nicola Collins   JOURNAL OF THE ROYAL SOCIETY OF MEDICINE

Cystic fibrosis

(2009) Brian P O'Sullivan et al.   LANCET