Lipid Nanoparticle (LNP) Chemistry Can Endow Unique In Vivo RNA Delivery Fates within the Liver That Alter Therapeutic Outcomes in a Cancer Model

Universal Barcoding Predicts In Vivo ApoE-Independent Lipid Nanoparticle Delivery

(2022) Alejandro J. Da Silva Sanchez et al.   NANO LETTERS

The growth of siRNA-based therapeutics: updated clinical studies

(2021) M. May Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing

(2021) Shuai Liu et al.   NATURE MATERIALS

Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets

(2021) Michael P. Vincent et al.   Nature Communications

Infectious disease mRNA vaccines and a review on epitope prediction for vaccine design

(2021) Xinhui Cai et al.   Briefings in Functional Genomics

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

(2021) Namit Chaudhary et al.   NATURE REVIEWS DRUG DISCOVERY

Lipids and the Emerging RNA Medicines

(2021) Yuling Xiao et al.   CHEMICAL REVIEWS

On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles

(2021) Sean A. Dilliard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ionizable lipid toolbox for RNA delivery

(2021) Xuexiang Han et al.   Nature Communications

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver

(2020) Lei Miao et al.   Nature Communications

Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing

(2020) Tuo Wei et al.   ACS Nano

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutics for advanced hepatocellular carcinoma: Recent advances, current dilemma, and future directions

(2019) Jing Zhu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cost-effectiveness analysis of lenvatinib treatment for patients with unresectable hepatocellular carcinoma (uHCC) compared with sorafenib in Japan

(2019) Masahiro Kobayashi et al.   JOURNAL OF GASTROENTEROLOGY

Elimination Pathways of Nanoparticles

(2019) Wilson Poon et al.   ACS Nano

The Potential for microRNA Therapeutics and Clinical Research

(2019) Johora Hanna et al.   Frontiers in Genetics

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

(2019) Akin Akinc et al.   Nature Nanotechnology

Dendrimer-Based Lipid Nanoparticles Deliver Therapeutic FAH mRNA to Normalize Liver Function and Extend Survival in a Mouse Model of Hepatorenal Tyrosinemia Type I

(2018) Qiang Cheng et al.   ADVANCED MATERIALS

Effect of removing Kupffer cells on nanoparticle tumor delivery

(2017) Anthony J. Tavares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic miRNA and siRNA: Moving from Bench to Clinic as Next Generation Medicine

(2017) Chiranjib Chakraborty et al.   Molecular Therapy-Nucleic Acids

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination

(2016) Yi-Nan Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model

(2016) Kejin Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Corona of Nanoparticles: Distinct Proteins Regulate the Cellular Uptake

(2015) Sandra Ritz et al.   BIOMACROMOLECULES

Hepatocytes: a key cell type for innate immunity

(2015) Zhou Zhou et al.   Cellular & Molecular Immunology

Precise let-7 expression levels balance organ regeneration against tumor suppression

(2015) Linwei Wu et al.   eLife

Diagnostic imaging and therapeutic application of nanoparticles targeting the liver

(2015) Haolu Wang et al.   Journal of Materials Chemistry B

siRNA Versus miRNA as Therapeutics for Gene Silencing

(2015) Jenny K W Lam et al.   Molecular Therapy-Nucleic Acids

Lin28b Is Sufficient to Drive Liver Cancer and Necessary for Its Maintenance in Murine Models

(2014) Liem H. Nguyen et al.   CANCER CELL

Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration

(2014) Sam Chen et al.   JOURNAL OF CONTROLLED RELEASE

Quantitative profiling of the protein coronas that form around nanoparticles

(2014) Dominic Docter et al.   Nature Protocols

MicroRNAs in Hepatocellular Carcinoma: Regulation, Function, and Clinical Implications

(2013) Jie Sun et al.   TheScientificWorldJOURNAL

MYC, Metabolism, Cell Growth, and Tumorigenesis

(2013) C. V. Dang   Cold Spring Harbor Perspectives in Medicine

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Therapeutics Based on microRNA: A New Approach for Liver Cancer

(2010) G. Zhang et al.   CURRENT GENOMICS

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Sorafenib in Liver Cancer — Just the Beginning

(2008) Lewis R. Roberts   NEW ENGLAND JOURNAL OF MEDICINE

The let-7 family of microRNAs

(2008) Sarah Roush et al.   TRENDS IN CELL BIOLOGY