Sirtuin 6 ameliorates arthritis through modulating cyclic AMP-responsive element binding protein/CCN1/cyclooxygenase 2 pathway in osteoblasts

SIRT6 mediates multidimensional modulation to maintain organism homeostasis

(2022) Yueying Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer

(2022) Huimin Jiang et al.   Cell Death & Disease

Sirt6 reprograms myofibers to oxidative type through CREB-dependent Sox6 suppression

(2022) Mi-Young Song et al.   Nature Communications

Determination of the physiological range of oxygen tension in bone marrow monocytes using two-photon phosphorescence lifetime imaging microscopy

(2022) Ayako Narazaki et al.   Scientific Reports

SIRT6 Widely Regulates Aging, Immunity, and Cancer

(2022) Yunjia Li et al.   Frontiers in Oncology

Inhibition of cell invasion and migration by targeting matrix metalloproteinase-9 expression via sirtuin 6 silencing in human breast cancer cells

(2022) On-Yu Hong et al.   Scientific Reports

The Sirtuin 2 Inhibitor AK-7 Leads to an Antidepressant-Like Effect in Mice via Upregulation of CREB1, BDNF, and NTRK2 Pathways

(2022) Ebru Guclu et al.   MOLECULAR NEUROBIOLOGY

Phosphodiesterase 4B activation exacerbates pulmonary hypertension induced by intermittent hypoxia by regulating mitochondrial injury and cAMP/PKA/p-CREB/PGC-1α signaling

(2022) Zhou Pan et al.   BIOMEDICINE & PHARMACOTHERAPY

Reactive oxygen species induce HNF-4α expression via the ASK1-CREB pathway, promoting ChREBP expression and lipogenesis in hepatocytes

(2022) Eunhui Seo et al.   LIFE SCIENCES

Metabolic changes in synovial cells in early inflammation: Involvement of CREB phosphorylation in the anti-inflammatory effect of 2-deoxyglucose

(2021) Kenji Kishimoto et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

miR-124-3p targeted SIRT1 to regulate cell apoptosis, inflammatory response, and oxidative stress in acute myocardial infarction in rats via modulation of the FGF21/CREB/PGC1α pathway

(2021) Yun-Jie Wei et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Ginkgo biloba L. Prevents Hypobaric Hypoxia–Induced Spatial Memory Deficit Through Small Conductance Calcium-Activated Potassium Channel Inhibition: The Role of ERK/CaMKII/CREB Signaling

(2021) Neetu Kushwah et al.   Frontiers in Pharmacology

Osteoclasts adapt to physioxia perturbation through DNA demethylation

(2021) Keizo Nishikawa et al.   EMBO REPORTS

A comprehensive review of Sirtuins: With a major focus on redox homeostasis and metabolism

(2021) Shahab Shahgaldi et al.   LIFE SCIENCES

Multiple Mechanisms Converging on Transcription Factor EB Activation by the Natural Phenol Pterostilbene

(2021) Martina La Spina et al.   Oxidative Medicine and Cellular Longevity

SIRT1 regulates O-GlcNAcylation of tau through OGT

(2020) Shu Lu et al.   Aging-US

Osteogenic differentiation of rat bone mesenchymal stem cells modulated by MiR-186 via SIRT6

(2020) Jijie Xiao et al.   LIFE SCIENCES

Loss of Sirtuin 6 in osteoblast lineage cells activates osteoclasts, resulting in osteopenia

(2020) Sung-Jin Kim et al.   BONE

Osteoblasts/Osteocytes sirtuin6 Is Vital to Preventing Ischemic Osteonecrosis Through Targeting VDR‐RANKL Signaling

(2020) Zhongkai Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Emerging roles of SIRT6 in human diseases and its modulators

(2020) Gang Liu et al.   MEDICINAL RESEARCH REVIEWS

Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis

(2019) Xiaojuan He et al.   EBioMedicine

SIRT6 protects against hepatic ischemia/reperfusion injury by inhibiting apoptosis and autophagy related cell death

(2018) Song Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sirtuin6 inhibits c -triggered inflammation through TLR4 abrogation regulated by ROS and TRPV1/CGRP

(2018) Ruohua Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Sirtuin 6 attenuates periapical lesion propagation by modulating hypoxia-induced chemokine (C-C motif) ligand 2 production in osteoblasts

(2017) Y.-L. Lee et al.   INTERNATIONAL ENDODONTIC JOURNAL

Enhancement of CCL2 expression and monocyte migration by CCN1 in osteoblasts through inhibiting miR-518a-5p: implication of rheumatoid arthritis therapy

(2017) Cheng-Yu Chen et al.   Scientific Reports

Sirtuin 6 suppresses hypoxia-induced inflammatory response in human osteoblasts via inhibition of reactive oxygen species production and glycolysis-A therapeutic implication in inflammatory bone resorption

(2016) Kuo-Liang Hou et al.   BIOFACTORS

Therapeutic potential of cysteine-rich protein 61 in rheumatoid arthritis

(2016) Tao Xu et al.   GENE

Sirtuin 6 Modulates Hypoxia-induced Apoptosis in Osteoblasts via Inhibition of Glycolysis: Implication for Pathogenesis of Periapical Lesions

(2015) Sang-Heng Kok et al.   JOURNAL OF ENDODONTICS

Matricellular protein CCN1/CYR61: a new player in inflammation and leukocyte trafficking

(2014) Yalin Emre et al.   Seminars in Immunopathology

Overexpression of Sirtuin 6 Suppresses Inflammatory Responses and Bone Destruction in Mice With Collagen-Induced Arthritis

(2013) Hwa-Suk Lee et al.   ARTHRITIS AND RHEUMATISM

Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation

(2013) Jeffrey R. Erickson et al.   NATURE

Simvastatin inhibits cysteine-rich protein 61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of sirtuin-1/FoxO3a signaling

(2012) Sang-Heng Kok et al.   ARTHRITIS AND RHEUMATISM

Progression of Chronic Liver Inflammation and Fibrosis Driven by Activation of c-JUN Signaling inSirt6Mutant Mice

(2012) Cuiying Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Over Expression of Wild Type or a Catalytically Dead Mutant of SIRTUIN 6 Does Not Influence NFκB Responses

(2012) Rachel Grimley et al.   PLoS One

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: A therapeutic benefit for arthritis

(2010) Sang-Heng Kok et al.   ARTHRITIS AND RHEUMATISM

Asperosaponin VI protects cardiac myocytes from hypoxia-induced apoptosis via activation of the PI3K/Akt and CREB pathways

(2010) Chunmei Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation

(2008) Jeffrey R. Erickson et al.   CELL

A Key Role for Cyclic AMP-Responsive Element Binding Protein in Hypoxia-Mediated Activation of the Angiogenesis Factor CCN1 (CYR61) in Tumor Cells

(2008) R. Meyuhas et al.   MOLECULAR CANCER RESEARCH