Simvastatin inhibits cysteine-rich protein 61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of sirtuin-1/FoxO3a signaling

Cyr61 Induces IL-6 Production by Fibroblast-like Synoviocytes Promoting Th17 Differentiation in Rheumatoid Arthritis

(2012) J. Lin et al.   JOURNAL OF IMMUNOLOGY

Statins accelerate the onset of collagen type II-induced arthritis in mice

(2012) Rob J Vandebriel et al.   ARTHRITIS RESEARCH & THERAPY

SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance

(2011) F. Niederer et al.   ANNALS OF THE RHEUMATIC DISEASES

Resveratrol-mediated SIRT-1 Interactions with p300 Modulate Receptor Activator of NF-κB Ligand (RANKL) Activation of NF-κB Signaling and Inhibit Osteoclastogenesis in Bone-derived Cells

(2011) Mehdi Shakibaei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atorvastatin upregulates regulatory T cells and reduces clinical disease activity in patients with rheumatoid arthritis

(2011) Ting-Ting Tang et al.   JOURNAL OF LIPID RESEARCH

Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: A therapeutic benefit for arthritis

(2010) Sang-Heng Kok et al.   ARTHRITIS AND RHEUMATISM

SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway

(2010) Viktoria Gagarina et al.   ARTHRITIS AND RHEUMATISM

Sirtuins and inflammation: Friends or foes?

(2010) Mara Gallí et al.   BIOCHEMICAL PHARMACOLOGY

The peroxisome proliferator-activated receptor β/δ (PPARβ/δ) agonist GW501516 prevents TNF-α-induced NF-κB activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1

(2010) Emma Barroso et al.   BIOCHEMICAL PHARMACOLOGY

Targeting IL-17 and Th17 Cells in Rheumatoid Arthritis

(2010) Sujata Sarkar et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner

(2010) Hiroshi Nakayama et al.   RHEUMATOLOGY INTERNATIONAL

FoxO3a involved in neutrophil and T cell survival is overexpressed in rheumatoid blood and synovial tissue

(2009) F. Turrel-Davin et al.   ANNALS OF THE RHEUMATIC DISEASES

Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling: An implication for the pathogenesis of arthritis

(2009) Sang-Heng Kok et al.   ARTHRITIS AND RHEUMATISM

A critical role of Cyr61 in interleukin-17–dependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis

(2009) Qiuyu Zhang et al.   ARTHRITIS AND RHEUMATISM

Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis

(2009) Beatrix Bartok et al.   IMMUNOLOGICAL REVIEWS

Th17 cells in rheumatoid arthritis and systemic lupus erythematosus

(2009) A. B. Pernis   JOURNAL OF INTERNAL MEDICINE

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Foxo in the immune system

(2008) S L Peng   ONCOGENE