Catalytic C–H bond functionalisation of purine and pyrimidine nucleosides: a synthetic and mechanistic perspective

Pd-catalyzed oxidative C–H alkenylation for synthesizing arylvinyltriazole nucleosides

(2015) Jingjie Tang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cobalt-Catalyzed C–H Cyanation of (Hetero)arenes and 6-Arylpurines with N-Cyanosuccinimide as a New Cyanating Agent

(2015) Amit B. Pawar et al.   ORGANIC LETTERS

A mild and selective Pd-mediated methodology for the synthesis of highly fluorescent 2-arylated tryptophans and tryptophan-containing peptides: a catalytic role for Pd0 nanoparticles?

(2014) Thomas J. Williams et al.   CHEMICAL COMMUNICATIONS

Transition-Metal-Free Coupling Reactions

(2014) Chang-Liang Sun et al.   CHEMICAL REVIEWS

C-H Trifluoromethylations of 1,3-Dimethyluracil and Reactivity of the Products in C-H Arylations

(2014) Michal Hocek et al.   HETEROCYCLES

Palladium-Catalyzed Intramolecular Oxidative Coupling Involving Double C(sp2)–H Bonds for the Synthesis of Annulated Biaryl Sultams

(2014) Joydev K. Laha et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed Direct Arylation of 5-Halouracils and 5-Halouracil Nucleosides with Arenes and Heteroarenes Promoted by TBAF

(2014) Yong Liang et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Intermolecular C–H Amination of (Hetero)arenes via Transient Unsymmetrical λ3-Iodanes

(2014) Igors Sokolovs et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Versatile Methodology for the Regioselective C8-Metalation of Purine Bases

(2014) Dirk Brackemeyer et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Formation and propagation of well-defined Pd nanoparticles (PdNPs) during C–H bond functionalization of heteroarenes: are nanoparticles a moribund form of Pd or an active catalytic species?

(2014) Christoph G. Baumann et al.   TETRAHEDRON

Pd(II)-catalyzed regioselective direct arylation of uracil via oxidative Heck reaction using arylboronic acids

(2014) Biplab Mondal et al.   TETRAHEDRON LETTERS

Pd-catalyzed dehydrogenative cross-coupling of pyridine-N-oxides with uracils

(2014) Ebrahim Kianmehr et al.   RSC Advances

Direct C–H amination and C–H chloroamination of 7-deazapurines

(2014) Nazarii Sabat et al.   RSC Advances

Palladium-catalyzed Suzuki reaction in aqueous solvents applied to unprotected nucleosides and nucleotides

(2014) Gwénaëlle Hervé et al.   RSC Advances

Carboxylate-Assisted Ruthenium-Catalyzed Alkyne Annulations by C–H/Het–H Bond Functionalizations

(2013) Lutz Ackermann   ACCOUNTS OF CHEMICAL RESEARCH

Dehydrogenative alkenylation of uracils via palladium-catalyzed regioselective C–H activation

(2013) Yi-Yun Yu et al.   CHEMICAL COMMUNICATIONS

Organometallic aspects of transition-metal catalysed regioselective C–H bond functionalisation of arenes and heteroarenes

(2013) Anant R. Kapdi   DALTON TRANSACTIONS

Cu(OTf)2-Catalyzed Dehydrogenative C-H Activation under Atmospheric Oxygen: An Expedient Approach to Pyrrolo[3,2-d]pyrimidine Derivatives

(2013) B. Roy et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Purinyl N1-Directed Aromatic C–H Oxidation in 6-Arylpurines and 6-Arylpurine Nucleosides

(2013) Raghu Ram Chamala et al.   JOURNAL OF ORGANIC CHEMISTRY

Completely Regioselective Direct C–H Functionalization of Benzo[b]thiophenes Using a Simple Heterogeneous Catalyst

(2013) Dan-Tam D. Tang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cupration of C2F5H: Isolation, Structure, and Synthetic Applications of [K(DMF)2][(t-BuO)Cu(C2F5)]. Highly Efficient Pentafluoroethylation of Unactivated Aryl Bromides

(2013) Anton Lishchynskyi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hydrogen-Bond-Assisted Controlled C–H Functionalization via Adaptive Recognition of a Purine Directing Group

(2013) Hyun Jin Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C–H bond activation enables the rapid construction and late-stage diversification of functional molecules

(2013) Joanna Wencel-Delord et al.   Nature Chemistry

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

(2013) Lars Petter Jordheim et al.   NATURE REVIEWS DRUG DISCOVERY

Improved microwave-assisted ligand-free Suzuki–Miyaura cross-coupling of 5-iodo-2′-deoxyuridine in pure water

(2013) Shawn Gallagher-Duval et al.   NEW JOURNAL OF CHEMISTRY

Direct C–H sulfenylation of purines and deazapurines

(2013) Martin Klečka et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of fused N-heterocycles via tandem C–H activation

(2012) Ge Meng et al.   CHEMICAL COMMUNICATIONS

Transition metal-free direct C–H bond thiolation of 1,3,4-oxadiazoles and related heteroarenes

(2012) Liang-Hua Zou et al.   CHEMICAL COMMUNICATIONS

Ruthenium(II)-Catalyzed C–H Bond Activation and Functionalization

(2012) Percia Beatrice Arockiam et al.   CHEMICAL REVIEWS

C–C, C–O and C–N bond formation via rhodium(iii)-catalyzed oxidative C–H activation

(2012) Guoyong Song et al.   CHEMICAL SOCIETY REVIEWS

Recent advances in transition-metal-free carbon–carbon and carbon–heteroatom bond-forming reactions using arynes

(2012) Anup Bhunia et al.   CHEMICAL SOCIETY REVIEWS

Phosphine-Free Palladium-Catalyzed Direct Arylation of Imidazo[1,2-a]pyridines with Aryl Bromides at Low Catalyst Loading

(2012) Hai Yan Fu et al.   JOURNAL OF ORGANIC CHEMISTRY

Lewis Acid-Catalyzed, Copper(II)-Mediated Synthesis of Heteroaryl Thioethers under Base-Free Conditions

(2012) Chao Dai et al.   JOURNAL OF ORGANIC CHEMISTRY

Efficient Synthesis of Unprotected C-5-Aryl/Heteroaryl-2'-deoxyuridine via a Suzuki-Miyaura Reaction in Aqueous Media

(2012) Nathalie Fresneau et al.   MOLECULES

CuI Controlled C–C and C–N Bond Formation of Heteroaromatics through C(sp3)–H Activation

(2012) Ran Xia et al.   ORGANIC LETTERS

Copper-Mediated Multiple C–H Functionalization of Aromatic N-Heterocycles: Bromoamination of Indoles and Pyrroles

(2012) Alex John et al.   ORGANOMETALLICS

Regioselective arylation of uracil and 4-pyridone derivatives via copper(I) bromide mediated C–H bond activation

(2012) Chien Cheng et al.   TETRAHEDRON

Venting-while-Heating Microwave-Assisted Synthesis of 3-Arylthioindoles

(2012) Giuseppe La Regina et al.   ACS Combinatorial Science

Direct Arylation of 6-Phenylpurine and 6-Arylpurine Nucleosides by Ruthenium-Catalyzed CH Bond Activation

(2011) Mahesh K. Lakshman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-catalyzed C–H bond functionalization of C6-arylpurines

(2011) Hai-Ming Guo et al.   CHEMICAL COMMUNICATIONS

Kinetic Isotope Effects in the Study of Organometallic Reaction Mechanisms

(2011) Mar Gómez-Gallego et al.   CHEMICAL REVIEWS

Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope

(2011) Lutz Ackermann   CHEMICAL REVIEWS

C–H Functionalization in organic synthesis

(2011) Huw M. L. Davies et al.   CHEMICAL SOCIETY REVIEWS

C–H functionalization logic in total synthesis

(2011) Will R. Gutekunst et al.   CHEMICAL SOCIETY REVIEWS

Recent advances in the transition metal-catalyzed twofold oxidative C–H bond activation strategy for C–C and C–N bond formation

(2011) Seung Hwan Cho et al.   CHEMICAL SOCIETY REVIEWS

Recent developments in natural product synthesis using metal-catalysed C–H bond functionalisation

(2011) Lindsay McMurray et al.   CHEMICAL SOCIETY REVIEWS

Regioselectivity of the borylation of alkanes and arenes

(2011) John F. Hartwig   CHEMICAL SOCIETY REVIEWS

Greener solvents for ruthenium and palladium-catalysed aromatic C–H bond functionalisation

(2011) Cedric Fischmeister et al.   GREEN CHEMISTRY

Synthesis of 5-fluorovinyl derivatives of pyrimidines via Suzuki–Miyaura coupling and their 1,3-dipolar cycloaddition reactions with nitrones

(2011) Hanna Wójtowicz-Rajchel et al.   JOURNAL OF FLUORINE CHEMISTRY

Regioselective Direct C–H Arylations of Protected Uracils. Synthesis of 5- and 6-Aryluracil Bases

(2011) Miroslava Čerňová et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-Mediated C–H Activation/C–S Cross-Coupling of Heterocycles with Thiols

(2011) Sadananda Ranjit et al.   JOURNAL OF ORGANIC CHEMISTRY

Intramolecular Oxidative C−H Coupling for Medium-Ring Synthesis

(2011) Didier G. Pintori et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Intermolecular Directed C−H Amidation of Aromatic Ketones

(2011) Bin Xiao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-/Copper-Catalyzed Regioselective Amination and Chloroamination of Indoles

(2011) Xue-Yuan Liu et al.   ORGANIC LETTERS

Pd(II)-CatalyzedOrthoArylation of 6-Arylpurines with Aryl Iodides via Purine-Directed C−H Activation: A New Strategy for Modification of 6-Arylpurine Derivatives

(2011) Hai-Ming Guo et al.   ORGANIC LETTERS

Palladium-catalyzed direct 5-arylation of 1,3-dimethyluracil with aryl bromides: an electrophilic metalation–deprotonation with electrophilic arylpalladium intermediate

(2011) Ko Hoon Kim et al.   TETRAHEDRON LETTERS

Palladium-catalyzed synthesis of benzo[c]pyrimido[1,6-a]azepine scaffold from Morita–Baylis–Hillman adducts: intramolecular 6-arylation of uracil nucleus

(2011) Hyun Seung Lee et al.   TETRAHEDRON LETTERS

Direct C–H Arylation of Purine on Solid Phase and Its Use for Chemical Libraries Synthesis

(2011) Barbora Vaňková et al.   ACS Combinatorial Science

Challenge and progress: palladium-catalyzed sp3 C–H activation

(2011) Hu Li et al.   Catalysis Science & Technology

Formal Inverse Sonogashira Reaction: Direct Alkynylation of Arenes and Heterocycles with Alkynyl Halides

(2010) Alexander S. Dudnik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Advances in nucleoside monophosphate prodrugs as anti-HCV agents

(2010) Drew R Bobeck et al.   ANTIVIRAL THERAPY

A sequential direct arylation/Suzuki–Miyaura cross-coupling transformation of unprotected 2′-deoxyadenosine affords a novel class of fluorescent analogues

(2010) Thomas E. Storr et al.   CHEMICAL COMMUNICATIONS

Introduction to Selective Functionalization of C−H Bonds

(2010) Robert H. Crabtree   CHEMICAL REVIEWS

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

(2010) Thomas W. Lyons et al.   CHEMICAL REVIEWS

Direct C−H Transformation via Iron Catalysis

(2010) Chang-Liang Sun et al.   CHEMICAL REVIEWS

Intramolecular Direct C−H Arylation Approach to Fused Purines. Synthesis of Purino[8,9-f]phenanthridines and 5,6-Dihydropurino[8,9-a]isoquinolines§§ Dedicated to the memory of Keith Fagnou.

(2010) Igor Čerňa et al.   JOURNAL OF ORGANIC CHEMISTRY

A New Entry of Amination Reagents for Heteroaromatic C−H Bonds: Copper-Catalyzed Direct Amination of Azoles with Chloroamines at Room Temperature

(2010) Tsuyoshi Kawano et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regioselective syntheses of fully-substituted 1,2,3-triazoles: the CuAAC/C–H bond functionalization nexus

(2010) Lutz Ackermann et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Development of New Fluorescent Xanthines as Kinase Inhibitors

(2010) Donghee Kim et al.   ORGANIC LETTERS

Transition-Metal-Catalyzed Direct Arylation of (Hetero)Arenes by CH Bond Cleavage

(2009) Lutz Ackermann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium-Catalyzed C−C Bond Formation via Heteroatom-Directed C−H Bond Activation

(2009) Denise A. Colby et al.   CHEMICAL REVIEWS

Transition Metal Catalyzed Alkene and Alkyne Hydroacylation

(2009) Michael C. Willis   CHEMICAL REVIEWS

C−H Activation for the Construction of C−B Bonds

(2009) Ibraheem A. I. Mkhalid et al.   CHEMICAL REVIEWS

Switching the Regioselectivity of Direct C-H Arylation of 1,3-Dimethyluracil

(2009) Miroslava Čerňová et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Pd(0)/Cu(I)-Mediated Direct Arylation of 2′-Deoxyadenosines: Mechanistic Role of Cu(I) and Reactivity Comparisons with Related Purine Nucleosides

(2009) Thomas E. Storr et al.   JOURNAL OF ORGANIC CHEMISTRY

A General Synthesis of C8-Arylpurine Phosphoramidites

(2009) Vorasit Vongsutilers et al.   MOLECULES

Direct C–H borylation and C–H arylation of pyrrolo[2,3-d]pyrimidines: synthesis of 6,8-disubstituted 7-deazapurines

(2009) Martin Klečka et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Copper-Mediated Amidation of Heterocyclic and Aromatic C−H Bonds

(2009) Qiu Wang et al.   ORGANIC LETTERS

Direct Functionalization of Nitrogen Heterocycles via Rh-Catalyzed C−H Bond Activation

(2008) Jared C. Lewis et al.   ACCOUNTS OF CHEMICAL RESEARCH

A General and Efficient Method for the Suzuki–Miyaura Coupling of 2-Pyridyl Nucleophiles

(2008) Kelvin L. Billingsley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Liebeskind-Srogl CC Cross-Coupling Reaction

(2008) Hana Prokopcová et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

(Dimethoxy- and Dihalopyridyl)boronic Acids and Highly Functionalized Heteroarylpyridines by Suzuki Cross-Coupling Reactions

(2008) Amy E. Smith et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The 24 Principles of Green Engineering and Green Chemistry: “IMPROVEMENTS PRODUCTIVELY”

(2008) Samantha Y. Tang et al.   GREEN CHEMISTRY

Synthesis of 6,8,9-Tri- and 2,6,8,9-Tetrasubstituted Purines by a Combination of the Suzuki Cross-coupling, N-Arylation, and Direct C−H Arylation Reactions

(2008) Igor Čerňa et al.   JOURNAL OF ORGANIC CHEMISTRY

Site-Selective sp2and Benzylic sp3Palladium-Catalyzed Direct Arylation

(2008) Louis-Charles Campeau et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C2, C5, and C4 AzoleN-Oxide Direct Arylation Including Room-Temperature Reactions

(2008) Louis-Charles Campeau et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analysis of the Concerted Metalation-Deprotonation Mechanism in Palladium-Catalyzed Direct Arylation Across a Broad Range of Aromatic Substrates

(2008) Serge I. Gorelsky et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility

(2008) Nobutaka Kato et al.   Nature Chemical Biology

Transition-Metal-Catalyzed Carbon-Carbon Bond Formation via Carbon-Hydrogen Bond Cleavage

(2008) Fumitoshi Kakiuchi et al.   SYNTHESIS-STUTTGART

Site-selective direct arylation of unprotected adenine nucleosides mediated by palladium and copper: insights into the reaction mechanism

(2008) Thomas E. Storr et al.   TETRAHEDRON

Microwave-assisted Pd(OH)2-catalyzed direct C−H arylation of free-(NH2) adenines with aryl halides

(2008) Sophian Sahnoun et al.   TETRAHEDRON LETTERS