Leishmania PNUTS discriminates between PP1 catalytic subunits through a RVxF-ΦΦ-F motif and polymorphisms in the PP1 C-tail and catalytic domain

Knockout of protein phosphatase 1 in Leishmania major reveals its role during RNA polymerase II transcription termination

(2023) Rudo Kieft et al.   NUCLEIC ACIDS RESEARCH

ColabFold: making protein folding accessible to all

(2022) Milot Mirdita et al.   NATURE METHODS

ZWC complex-mediated SPT5 phosphorylation suppresses divergent antisense RNA transcription at active gene promoters

(2022) Kihyun Park et al.   NUCLEIC ACIDS RESEARCH

TOX4 facilitates promoter-proximal pausing and C-terminal domain dephosphorylation of RNA polymerase II in human cells

(2022) Ziling Liu et al.   Communications Biology

The ribosomal RNA processing 1B:protein phosphatase 1 holoenzyme reveals non-canonical PP1 interaction motifs

(2022) Gautam Srivastava et al.   Cell Reports

Structure-function analysis of fission yeast cleavage and polyadenylation factor (CPF) subunit Ppn1 and its interactions with Dis2 and Swd22

(2021) Bradley Benjamin et al.   PLoS Genetics

Evolutionary crossroads of cell signaling: PP1 and PP2A substrate sites in intrinsically disordered regions

(2021) Bernhard Hoermann et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Genetic Interaction Between Site-Specific Epigenetic Marks and Roles of H4v in Transcription Termination in Trypanosoma brucei

(2021) Hee-Sook Kim   Frontiers in Cell and Developmental Biology

Identification of a novel base J binding protein complex involved in RNA polymerase II transcription termination in trypanosomes

(2020) Rudo Kieft et al.   PLoS Genetics

Turn and Face the Strange: A New View on Phosphatases

(2020) Maja Köhn   ACS Central Science

Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A

(2020) Bernhard Hoermann et al.   Nature Communications

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Protein phosphatase 1 in tumorigenesis: is it worth a closer look?

(2020) Juliana Felgueiras et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail

(2019) M. Teresa Bertran et al.   Nature Communications

Flexible Tethering of ASPP Proteins Facilitates PP-1c Catalysis

(2019) Yeyun Zhou et al.   STRUCTURE

Control of RNA Pol II Speed by PNUTS-PP1 and Spt5 Dephosphorylation Facilitates Termination by a “Sitting Duck Torpedo” Mechanism

(2019) Michael A. Cortazar et al.   MOLECULAR CELL

A substrate-trapping strategy for protein phosphatase PP1 holoenzymes using hypoactive subunit fusions

(2018) Dan Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Cdk9–PP1 switch regulates the elongation–termination transition of RNA polymerase II

(2018) Pabitra K. Parua et al.   NATURE

Elongation/Termination Factor Exchange Mediated by PP1 Phosphatase Orchestrates Transcription Termination

(2018) Tea Kecman et al.   Cell Reports

Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme

(2018) Ganesan Senthil Kumar et al.   Science Advances

Base J and H3.V Regulate Transcriptional Termination in Trypanosoma brucei

(2016) Danae Schulz et al.   PLoS Genetics

Histone H3 Variant Regulates RNA Polymerase II Transcription Termination and Dual Strand Transcription of siRNA Loci in Trypanosoma brucei

(2016) David Reynolds et al.   PLoS Genetics

The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism

(2016) Ganesan Senthil Kumar et al.   eLife

Transcription of Mammalian cis-Regulatory Elements Is Restrained by Actively Enforced Early Termination

(2015) Liv M.I. Austenaa et al.   MOLECULAR CELL

Regulation of transcription termination by glucosylated hydroxymethyluracil, base J, in Leishmania major and Trypanosoma brucei

(2014) D. Reynolds et al.   NUCLEIC ACIDS RESEARCH

Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code

(2014) M. S. Choy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CPF-Associated Phosphatase Activity Opposes Condensin-Mediated Chromosome Condensation

(2014) Vincent Vanoosthuyse et al.   PLoS Genetics

Regulation of protein phosphatase 1 by intrinsically disordered proteins

(2012) Meng S. Choy et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Glucosylated Hydroxymethyluracil, DNA Base J, Prevents Transcriptional Readthrough in Leishmania

(2012) Henri G.A.M. van Luenen et al.   CELL

Structural basis for protein phosphatase 1 regulation and specificity

(2012) Wolfgang Peti et al.   FEBS Journal

The PP1 binding code: a molecular-lego strategy that governs specificity

(2012) Ewald Heroes et al.   FEBS Journal

Inhibitory Member of the Apoptosis-stimulating Proteins of the p53 Family (iASPP) Interacts with Protein Phosphatase 1 via a Noncanonical Binding Motif

(2011) Susana Llanos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The protein phosphatase 1 regulator PNUTS is a new component of the DNA damage response

(2010) Helga B Landsverk et al.   EMBO REPORTS

Identification and Characterization of a Novel Human PP1 Phosphatase Complex

(2010) Jeong-Heon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Signature of the MYPT1−PP1 Interaction

(2010) Anderson S. Pinheiro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites

(2010) Michael J Ragusa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Two thymidine hydroxylases differentially regulate the formation of glucosylated DNA at regions flanking polymerase II polycistronic transcription units throughout the genome of Trypanosoma brucei

(2010) Laura J. Cliffe et al.   NUCLEIC ACIDS RESEARCH

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

The extended PP1 toolkit: designed to create specificity

(2010) Mathieu Bollen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Histone acetylations mark origins of polycistronic transcription in Leishmania major

(2009) Sean Thomas et al.   BMC GENOMICS

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

Docking Motif-Guided Mapping of the Interactome of Protein Phosphatase-1

(2009) Annick Hendrickx et al.   CHEMISTRY & BIOLOGY

Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma brucei

(2009) T. N. Siegel et al.   GENES & DEVELOPMENT

TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs

(2009) Hyeung Kim et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Selective targeting of the γ1 isoform of protein phosphatase 1 to F-actin in intact cells requires multiple domains in spinophilin and neurabin

(2008) Leigh C. Carmody et al.   FASEB JOURNAL

Histone Acetylation and Methylation at Sites Initiating Divergent Polycistronic Transcription inTrypanosoma cruzi

(2008) Patricia Respuela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Glc7 Phosphatase Subunit of the Cleavage and Polyadenylation Factor Is Essential for Transcription Termination on snoRNA Genes

(2008) Eduard Nedea et al.   MOLECULAR CELL