How Three Self-Secreted Biofilm Exopolysaccharides of Pseudomonas aeruginosa, Psl, Pel, and Alginate, Can Each Be Exploited for Antibiotic Adjuvant Effects in Cystic Fibrosis Lung Infection

Regulation of Biofilm Exopolysaccharide Biosynthesis and Degradation in Pseudomonas aeruginosa

(2022) Luyan Z. Ma et al.   Annual Review of Microbiology

Alginate oligosaccharides enhance diffusion and activity of colistin in a mucin-rich environment

(2022) Joana Stokniene et al.   Scientific Reports

The Pel polysaccharide is predominantly composed of a dimeric repeat of α-1,4 linked galactosamine and N-acetylgalactosamine

(2022) François Le Mauff et al.   Communications Biology

Preclinical Evaluation of Recombinant Microbial Glycoside Hydrolases as Antibiofilm Agents in Acute Pulmonary Pseudomonas aeruginosa Infection

(2022) Hanna Ostapska et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The biofilm life cycle: expanding the conceptual model of biofilm formation

(2022) Karin Sauer et al.   NATURE REVIEWS MICROBIOLOGY

Multidrug-Resistant Bacteria in Children and Adolescents with Cystic Fibrosis

(2022) Valentina Fainardi et al.   Children-Basel

Pseudomonas aeruginosa aggregation and Psl expression in sputum is associated with antibiotic eradication failure in children with cystic fibrosis

(2022) Amanda J. Morris et al.   Scientific Reports

Antibiofilm Activity of α-Amylase from Bacillus subtilis and Prediction of the Optimized Conditions for Biofilm Removal by Response Surface Methodology (RSM) and Artificial Neural Network (ANN)

(2021) Dibyajit Lahiri et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Approaches to Targeting Bacterial Biofilms in Cystic Fibrosis Airways

(2021) Isaac Martin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pseudomonas aeruginosa aggregates in cystic fibrosis sputum produce exopolysaccharides that likely impede current therapies

(2021) Laura K. Jennings et al.   Cell Reports

Amylases: Biofilm Inducer or Biofilm Inhibitor?

(2021) Dibyajit Lahiri et al.   Frontiers in Cellular and Infection Microbiology

Protective Liquid Crystal Nanoparticles for Targeted Delivery of PslG: A Biofilm Dispersing Enzyme

(2021) Chelsea R. Thorn et al.   ACS Infectious Diseases

The role of Psl in the failure to eradicate Pseudomonas aeruginosa biofilms in children with cystic fibrosis

(2021) Amanda J. Morris et al.   npj Biofilms and Microbiomes

In vitro activities of cellulase and ceftazidime, alone and in combination against Pseudomonas aeruginosa biofilms

(2021) Esmat Kamali et al.   BMC MICROBIOLOGY

Increasing life expectancy in cystic fibrosis: Advances and challenges

(2021) Kimberly A. McBennett et al.   PEDIATRIC PULMONOLOGY

Combining Ivacaftor and Intensive Antibiotics Achieves Limited Clearance of Cystic Fibrosis Infections

(2021) Samantha L. Durfey et al.   mBio

Disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate lyase enhances pathogen eradication by antibiotics

(2020) Said M. Daboor et al.   Journal of Cystic Fibrosis

A Rational Designed PslG With Normal Biofilm Hydrolysis and Enhanced Resistance to Trypsin-Like Protease Digestion

(2020) Tiantian Su et al.   Frontiers in Microbiology

The versatile Pseudomonas aeruginosa biofilm matrix protein CdrA promotes aggregation through different extracellular EPS interactions

(2020) Courtney Reichhardt et al.   JOURNAL OF BACTERIOLOGY

Protective effects of anti-alginate monoclonal antibody against Pseudomonas aeruginosa infection of HeLa cells

(2020) Fei Gao et al.   MICROBIAL PATHOGENESIS

Glycoside hydrolase (PelAh) immobilization prevents Pseudomonas aeruginosa biofilm formation on cellulose-based wound dressing

(2020) Magdalena Szymańska et al.   CARBOHYDRATE POLYMERS

Real-World Safety of CFTR Modulators in the Treatment of Cystic Fibrosis: A Systematic Review

(2020) Renée V. E. Dagenais et al.   Journal of Clinical Medicine

Alginate Lyase Immobilized Chitosan Nanoparticles of Ciprofloxacin for the improved antimicrobial activity against the Biofilm associated mucoid P. aeruginosa infection in Cystic Fibrosis

(2019) Krishna Kumar Patel et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Treatment with the Pseudomonas aeruginosa Glycoside Hydrolase PslG Combats Wound Infection by Improving Antibiotic Efficacy and Host Innate Immune Activity

(2019) Matthew J. Pestrak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cystic Fibrosis and Pseudomonas aeruginosa: the Host-Microbe Interface

(2019) Sankalp Malhotra et al.   CLINICAL MICROBIOLOGY REVIEWS

Successful adjunctive use of bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa infection in a cystic fibrosis patient

(2019) Nancy Law et al.   INFECTION

Establishment of an induced memory response in Pseudomonas aeruginosa during infection of a eukaryotic host

(2019) Adrian Kordes et al.   ISME Journal

Identification of a lytic Pseudomonas aeruginosa phage depolymerase and its anti-biofilm effect and bactericidal contribution to serum

(2019) Liyuan Mi et al.   VIRUS GENES

Antibiofilm efficacy of nitric oxide-releasing alginates against cystic fibrosis bacterial pathogens

(2019) Mona Jasmine R. Ahonen et al.   ACS Infectious Diseases

Early clinical experience of bacteriophage therapy in 3 lung transplant recipients

(2019) Saima Aslam et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Molecular mechanism of Aspergillus fumigatus biofilm disruption by fungal and bacterial glycoside hydrolases

(2019) François Le Mauff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The efficacy of lyticase and β-glucosidase enzymes on biofilm degradation of Pseudomonas aeruginosa strains with different gene profiles

(2019) Maryam Banar et al.   BMC MICROBIOLOGY

Targeting Pseudomonas aeruginosa in the Sputum of Primary Ciliary Dyskinesia Patients with a Combinatorial Strategy Having Antibacterial and Anti-Virulence Potential

(2019) Giuseppantonio Maisetta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MEDI3902 Correlates of Protection against Severe Pseudomonas aeruginosa Pneumonia in a Rabbit Acute Pneumonia Model

(2018) Hoan N. Le et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Consequences of Biofilm Dispersal on the Host

(2018) Derek Fleming et al.   Scientific Reports

Targeted disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate oligosaccharides

(2018) Lydia C. Powell et al.   npj Biofilms and Microbiomes

Effects of PslG on the Surface Movement of Pseudomonas aeruginosa

(2018) Jingchao Zhang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Phase 1 study of MEDI3902, an investigational anti–Pseudomonas aeruginosa PcrV and Psl bispecific human monoclonal antibody, in healthy adults

(2018) S.O. Ali et al.   CLINICAL MICROBIOLOGY AND INFECTION

High-resolution in situ transcriptomics of Pseudomonas aeruginosa unveils genotype independent patho-phenotypes in cystic fibrosis lungs

(2018) Elio Rossi et al.   Nature Communications

Ivacaftor, a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator, Enhances Ciprofloxacin Activity Against Pseudomonas aeruginosa

(2018) Do-Yeon Cho et al.   American Journal of Rhinology & Allergy

Activity of innate antimicrobial peptides and ivacaftor against clinical cystic fibrosis respiratory pathogens

(2017) Joanna E. Payne et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

PelA and PelB proteins form a modification and secretion complex essential for Pel polysaccharide-dependent biofilm formation inPseudomonas aeruginosa

(2017) Lindsey S. Marmont et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bispecific antibody targets multiple Pseudomonas aeruginosa evasion mechanisms in the lung vasculature

(2017) Ajitha Thanabalasuriar et al.   JOURNAL OF CLINICAL INVESTIGATION

Phenotypic shift in Pseudomonas aeruginosa populations from cystic fibrosis lungs after 2-week antipseudomonal treatment

(2017) Laia Fernández-Barat et al.   Journal of Cystic Fibrosis

Microbial glycoside hydrolases as antibiofilm agents with cross-kingdom activity

(2017) Brendan D. Snarr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudomonas aeruginosa Alginate Overproduction Promotes Coexistence with Staphylococcus aureus in a Model of Cystic Fibrosis Respiratory Infection

(2017) Dominique H. Limoli et al.   mBio

Psl Produced by Mucoid Pseudomonas aeruginosa Contributes to the Establishment of Biofilms and Immune Evasion

(2017) Christopher J. Jones et al.   mBio

Staphylococcus aureus interaction with Pseudomonas aeruginosa biofilm enhances tobramycin resistance

(2017) T. Beaudoin et al.   npj Biofilms and Microbiomes

Anti-Psl Targeting of Pseudomonas aeruginosa Biofilms for Neutrophil-Mediated Disruption

(2017) Valerie A. Ray et al.   Scientific Reports

OligoG CF-5/20 Disruption of Mucoid Pseudomonas aeruginosa Biofilm in a Murine Lung Infection Model

(2016) Wang Hengzhuang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Changing Epidemiology of the Respiratory Bacteriology of Patients With Cystic Fibrosis

(2016) Elizabeth L. Salsgiver et al.   CHEST

A New Class of Safe Oligosaccharide Polymer Therapy To Modify the Mucus Barrier of Chronic Respiratory Disease

(2016) Manon F. Pritchard et al.   MOLECULAR PHARMACEUTICS

Evaluation of Mannosidase and Trypsin Enzymes Effects on Biofilm Production of Pseudomonas aeruginosa Isolated from Burn Wound Infections

(2016) Maryam Banar et al.   PLoS One

Pseudomonas aeruginosainfection in cystic fibrosis: pathophysiological mechanisms and therapeutic approaches

(2016) Helena Lund-Palau et al.   Expert Review of Respiratory Medicine

Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms

(2016) P. Baker et al.   Science Advances

PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix

(2015) Shan Yu et al.   CELL RESEARCH

Characterization of thePseudomonas aeruginosaGlycoside Hydrolase PslG Reveals That Its Levels Are Critical for Psl Polysaccharide Biosynthesis and Biofilm Formation

(2015) Perrin Baker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of alginate-producing Pseudomonas aeruginosa on alveolar macrophage apoptotic cell clearance

(2015) Charles A. McCaslin et al.   Journal of Cystic Fibrosis

Origins of Cystic Fibrosis Lung Disease

(2015) David A. Stoltz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pel is a cationic exopolysaccharide that cross-links extracellular DNA in thePseudomonas aeruginosabiofilm matrix

(2015) Laura K. Jennings et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The exopolysaccharide Psl-eDNA interaction enables the formation of a biofilm skeleton inPseudomonas aeruginosa

(2015) Shiwei Wang et al.   Environmental Microbiology Reports

Pseudomonas aeruginosa PAO1 exopolysaccharides are important for mixed species biofilm community development and stress tolerance

(2015) Saravanan Periasamy et al.   Frontiers in Microbiology

Alginate lyase: Review of major sources and classification, properties, structure-function analysis and applications

(2015) Benwei Zhu et al.   Bioengineered

Genetics and regulation of bacterial alginate production

(2014) Iain D. Hay et al.   ENVIRONMENTAL MICROBIOLOGY

Antibacterial properties of the CFTR potentiator ivacaftor

(2014) Leah R. Reznikov et al.   Journal of Cystic Fibrosis

Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis

(2014) Rasmus Lykke Marvig et al.   NATURE GENETICS

A multifunctional bispecific antibody protects against Pseudomonas aeruginosa

(2014) A. DiGiandomenico et al.   Science Translational Medicine

Dynamic Remodeling of Microbial Biofilms by Functionally Distinct Exopolysaccharides

(2014) S. C. Chew et al.   mBio

A spider web strategy of type IV pili-mediated migration to build a fibre-like Psl polysaccharide matrix inPseudomonas aeruginosabiofilms

(2013) Shiwei Wang et al.   ENVIRONMENTAL MICROBIOLOGY

PelA Deacetylase Activity Is Required for Pel Polysaccharide Synthesis in Pseudomonas aeruginosa

(2013) K. M. Colvin et al.   JOURNAL OF BACTERIOLOGY

Pseudomonas aeruginosa Biofilms in Disease

(2013) Lawrence R. Mulcahy et al.   MICROBIAL ECOLOGY

Psl trails guide exploration and microcolony formation in Pseudomonas aeruginosa biofilms

(2013) Kun Zhao et al.   NATURE

Pseudomonas aeruginosa Enhances Production of a Non-Alginate Exopolysaccharide during Long-Term Colonization of the Cystic Fibrosis Lung

(2013) Holly K. Huse et al.   PLoS One

The Extracellular Matrix Component Psl Provides Fast-Acting Antibiotic Defense in Pseudomonas aeruginosa Biofilms

(2013) Nicole Billings et al.   PLoS Pathogens

Overcoming Drug Resistance with Alginate Oligosaccharides Able To Potentiate the Action of Selected Antibiotics

(2012) Saira Khan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Alginate Lyase Exhibits Catalysis-Independent Biofilm Dispersion and Antibiotic Synergy

(2012) John W. Lamppa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibiofilm Activity of α-Amylase from Bacillus subtilis S8-18 Against Biofilm Forming Human Bacterial Pathogens

(2012) Balu Jancy Kalpana et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

The roles of biofilm matrix polysaccharide Psl in mucoidPseudomonas aeruginosabiofilms

(2012) Luyan Ma et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Identification of broadly protective human antibodies toPseudomonas aeruginosaexopolysaccharide Psl by phenotypic screening

(2012) Antonio DiGiandomenico et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clearance of initial mucoidPseudomonas aeruginosain patients with cystic fibrosis

(2012) Robert Bradley Troxler et al.   PEDIATRIC PULMONOLOGY

Self-produced exopolysaccharide is a signal that stimulates biofilm formation in Pseudomonas aeruginosa

(2012) Y. Irie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacteriophages  MR299-2 and  NH-4 Can Eliminate Pseudomonas aeruginosa in the Murine Lung and on Cystic Fibrosis Lung Airway Cells

(2012) D. Alemayehu et al.   mBio

Pseudomonas aeruginosaPopulation Diversity and Turnover in Cystic Fibrosis Chronic Infections

(2011) Eilidh Mowat et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pseudomonas aeruginosa Psl polysaccharide reduces neutrophil phagocytosis and the oxidative response by limiting complement-mediated opsonization

(2011) Meenu Mishra et al.   CELLULAR MICROBIOLOGY

Distinct roles of extracellular polymeric substances in Pseudomonas aeruginosa biofilm development

(2011) Liang Yang et al.   ENVIRONMENTAL MICROBIOLOGY

The Pel and Psl polysaccharides provide Pseudomonas aeruginosa structural redundancy within the biofilm matrix

(2011) Kelly M. Colvin et al.   ENVIRONMENTAL MICROBIOLOGY

Genetically Engineered Alginate Lyase-PEG Conjugates Exhibit Enhanced Catalytic Function and Reduced Immunoreactivity

(2011) John W. Lamppa et al.   PLoS One

The Pel Polysaccharide Can Serve a Structural and Protective Role in the Biofilm Matrix of Pseudomonas aeruginosa

(2011) Kelly M. Colvin et al.   PLoS Pathogens

Pseudomonas aeruginosa Alginate Promotes Burkholderia cenocepacia Persistence in Cystic Fibrosis Transmembrane Conductance Regulator Knockout Mice

(2010) S. S. Chattoraj et al.   INFECTION AND IMMUNITY

Pseudomonas aeruginosauses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix

(2010) Bradley R. Borlee et al.   MOLECULAR MICROBIOLOGY

Hospital-Acquired Infections Due to Gram-Negative Bacteria

(2010) Anton Y. Peleg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Importance of DNase and alginate lyase for enhancing free and liposome encapsulated aminoglycoside activity against Pseudomonas aeruginosa

(2009) M. Alipour et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Bacteriophage-derived enzyme that depolymerizes the alginic acid capsule associated with cystic fibrosis isolates ofPseudomonas aeruginosa

(2009) T. Glonti et al.   JOURNAL OF APPLIED MICROBIOLOGY

Genetic and biochemical analyses of thePseudomonas aeruginosaPsl exopolysaccharide reveal overlapping roles for polysaccharide synthesis enzymes in Psl and LPS production

(2009) Matthew S. Byrd et al.   MOLECULAR MICROBIOLOGY

Assembly and Development of the Pseudomonas aeruginosa Biofilm Matrix

(2009) Luyan Ma et al.   PLoS Pathogens