Pseudomonas aeruginosa aggregates in cystic fibrosis sputum produce exopolysaccharides that likely impede current therapies

Antimicrobial susceptibility testing (AST) and associated clinical outcomes in individuals with cystic fibrosis: A systematic review

(2019) Ranjani Somayaji et al.   Journal of Cystic Fibrosis

CdrA Interactions within the Pseudomonas aeruginosa Biofilm Matrix Safeguard It from Proteolysis and Promote Cellular Packing

(2018) Courtney Reichhardt et al.   mBio

Entropically driven aggregation of bacteria by host polymers promotes antibiotic tolerance in Pseudomonas aeruginosa

(2018) Patrick R. Secor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular DNA Acidifies Biofilms and Induces Aminoglycoside Resistance in Pseudomonas aeruginosa

(2015) Mike Wilton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Filamentous Bacteriophage Promote Biofilm Assembly and Function

(2015) Patrick R. Secor et al.   Cell Host & Microbe

Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy

(2015) André M. Cantin et al.   Journal of Cystic Fibrosis

Origins of Cystic Fibrosis Lung Disease

(2015) David A. Stoltz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pel is a cationic exopolysaccharide that cross-links extracellular DNA in thePseudomonas aeruginosabiofilm matrix

(2015) Laura K. Jennings et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conditions Associated with the Cystic Fibrosis Defect Promote ChronicPseudomonas aeruginosaInfection

(2014) Benjamin J. Staudinger et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Modification and periplasmic translocation of the biofilm exopolysaccharide poly- -1,6-N-acetyl-D-glucosamine

(2014) D. J. Little et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular DNA Shields against Aminoglycosides in Pseudomonas aeruginosa Biofilms

(2013) Wen-Chi Chiang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

PelA Deacetylase Activity Is Required for Pel Polysaccharide Synthesis in Pseudomonas aeruginosa

(2013) K. M. Colvin et al.   JOURNAL OF BACTERIOLOGY

The in vivo biofilm

(2013) Thomas Bjarnsholt et al.   TRENDS IN MICROBIOLOGY

Aggregation by depletion attraction in cultures of bacteria producing exopolysaccharide

(2012) G. Dorken et al.   Journal of the Royal Society Interface

Self-produced exopolysaccharide is a signal that stimulates biofilm formation in Pseudomonas aeruginosa

(2012) Y. Irie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia

(2012) B. Button et al.   SCIENCE

Pseudomonas aeruginosa Psl polysaccharide reduces neutrophil phagocytosis and the oxidative response by limiting complement-mediated opsonization

(2011) Meenu Mishra et al.   CELLULAR MICROBIOLOGY

The Pel and Psl polysaccharides provide Pseudomonas aeruginosa structural redundancy within the biofilm matrix

(2011) Kelly M. Colvin et al.   ENVIRONMENTAL MICROBIOLOGY

Phenotypes of Non-Attached Pseudomonas aeruginosa Aggregates Resemble Surface Attached Biofilm

(2011) Morten Alhede et al.   PLoS One

The Pel Polysaccharide Can Serve a Structural and Protective Role in the Biofilm Matrix of Pseudomonas aeruginosa

(2011) Kelly M. Colvin et al.   PLoS Pathogens

Biosynthesis of the Pseudomonas aeruginosa Extracellular Polysaccharides, Alginate, Pel, and Psl

(2011) Michael J. Franklin et al.   Frontiers in Microbiology

Polymer-induced phase separation in suspensions of bacteria

(2010) J. Schwarz-Linek et al.   EPL

Pseudomonas aeruginosauses a cyclic-di-GMP-regulated adhesin to reinforce the biofilm extracellular matrix

(2010) Bradley R. Borlee et al.   MOLECULAR MICROBIOLOGY

The biofilm matrix

(2010) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

The Pseudomonas aeruginosa Exopolysaccharide Psl Facilitates Surface Adherence and NF- B Activation in A549 Cells

(2010) M. S. Byrd et al.   mBio

Genetic and biochemical analyses of thePseudomonas aeruginosaPsl exopolysaccharide reveal overlapping roles for polysaccharide synthesis enzymes in Psl and LPS production

(2009) Matthew S. Byrd et al.   MOLECULAR MICROBIOLOGY

Pseudomonas aeruginosabiofilms in the respiratory tract of cystic fibrosis patients

(2009) Thomas Bjarnsholt et al.   PEDIATRIC PULMONOLOGY

Pseudomonas aeruginosa biofilm formation in the cystic fibrosis airway

(2007) Sophie Moreau-Marquis et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS