Targeted disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate oligosaccharides

The fate of inhaled antibiotics after deposition in cystic fibrosis: How to get drug to the bug?

(2017) Aukje C. Bos et al.   Journal of Cystic Fibrosis

The antimicrobial effects of the alginate oligomer OligoG CF-5/20 are independent of direct bacterial cell membrane disruption

(2017) Manon F. Pritchard et al.   Scientific Reports

OligoG CF-5/20 Disruption of Mucoid Pseudomonas aeruginosa Biofilm in a Murine Lung Infection Model

(2016) Wang Hengzhuang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The effect of alginate lyase on the gentamicin resistance ofPseudomonas aeruginosain mucoid biofilms

(2016) L.A.P. Germoni et al.   JOURNAL OF APPLIED MICROBIOLOGY

A novel guluronate oligomer improves intestinal transit and survival in cystic fibrosis mice

(2016) Megan Vitko et al.   Journal of Cystic Fibrosis

Antimicrobial Action of Compounds from Marine Seaweed

(2016) María Pérez et al.   Marine Drugs

The phenotypic evolution of Pseudomonas aeruginosa populations changes in the presence of subinhibitory concentrations of ciprofloxacin

(2016) Tina Wassermann et al.   MICROBIOLOGY-SGM

A New Class of Safe Oligosaccharide Polymer Therapy To Modify the Mucus Barrier of Chronic Respiratory Disease

(2016) Manon F. Pritchard et al.   MOLECULAR PHARMACEUTICS

Mechanical properties of the superficial biofilm layer determine the architecture of biofilms

(2016) Binu Kundukad et al.   Soft Matter

LadS is a calcium-responsive kinase that induces acute-to-chronic virulence switch in Pseudomonas aeruginosa

(2016) Ursula N. Broder et al.   Nature Microbiology

Exopolysaccharide biosynthetic glycoside hydrolases can be utilized to disrupt and prevent Pseudomonas aeruginosa biofilms

(2016) P. Baker et al.   Science Advances

Antimicrobial resistance, respiratory tract infections and role of biofilms in lung infections in cystic fibrosis patients

(2015) Oana Ciofu et al.   ADVANCED DRUG DELIVERY REVIEWS

Contribution of Stress Responses to Antibiotic Tolerance in Pseudomonas aeruginosa Biofilms

(2015) Philip S. Stewart et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Methods to determine the interactions of micro- and nanoparticles with mucus

(2015) Julia Grießinger et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Pel is a cationic exopolysaccharide that cross-links extracellular DNA in thePseudomonas aeruginosabiofilm matrix

(2015) Laura K. Jennings et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic Interactions of Pseudomonas aeruginosa and Staphylococcus aureus in anIn VitroWound Model

(2014) Stephanie DeLeon et al.   INFECTION AND IMMUNITY

Evaluation of fluorescent stains for visualizing extracellular DNA in biofilms

(2014) Mira Okshevsky et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis

(2014) Rasmus Lykke Marvig et al.   NATURE GENETICS

Iron-Regulated Expression of Alginate Production, Mucoid Phenotype, and Biofilm Formation by Pseudomonas aeruginosa

(2014) J. R. Wiens et al.   mBio

A Nanoscale Characterization of the Interaction of a Novel Alginate Oligomer with the Cell Surface and Motility ofPseudomonas aeruginosa

(2013) Lydia C. Powell et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The effect of alginate oligosaccharides on the mechanical properties of Gram-negative biofilms

(2013) Lydia C. Powell et al.   BIOFOULING

Elevated metal concentrations in the CF airway correlate with cellular injury and disease severity

(2013) Daniel J. Smith et al.   Journal of Cystic Fibrosis

An in vitro study of alginate oligomer therapies on oral biofilms

(2013) J.L. Roberts et al.   JOURNAL OF DENTISTRY

On the Initial Binding of Alginate by Calcium Ions. The Tilted Egg-Box Hypothesis

(2013) Massimiliano Borgogna et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Purification and Characterization of Biofilm-Associated EPS Exopolysaccharides from ESKAPE Organisms and Other Pathogens

(2013) Patrick M. Bales et al.   PLoS One

The Extracellular Matrix Component Psl Provides Fast-Acting Antibiotic Defense in Pseudomonas aeruginosa Biofilms

(2013) Nicole Billings et al.   PLoS Pathogens

Overcoming Drug Resistance with Alginate Oligosaccharides Able To Potentiate the Action of Selected Antibiotics

(2012) Saira Khan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The roles of biofilm matrix polysaccharide Psl in mucoidPseudomonas aeruginosabiofilms

(2012) Luyan Ma et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Gentamicin and leucine inhalable powder: What about antipseudomonal activity and permeation through cystic fibrosis mucus?

(2012) Paola Russo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Treatment of lung infection in patients with cystic fibrosis: Current and future strategies

(2012) Gerd Döring et al.   Journal of Cystic Fibrosis

Oligoguluronate induced competitive displacement of mucin–alginate interactions: relevance for mucolytic function

(2012) Marit Sletmoen et al.   Soft Matter

The clinical impact of bacterial biofilms

(2011) Niels Høiby et al.   International Journal of Oral Science

The Pel Polysaccharide Can Serve a Structural and Protective Role in the Biofilm Matrix of Pseudomonas aeruginosa

(2011) Kelly M. Colvin et al.   PLoS Pathogens

Pseudomonas aeruginosabiofilms in cystic fibrosis

(2010) Niels Høiby et al.   Future Microbiology

The biofilm matrix

(2010) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

Pseudomonas aeruginosa Rugose Small-Colony Variants Have Adaptations That Likely Promote Persistence in the Cystic Fibrosis Lung

(2009) M. Starkey et al.   JOURNAL OF BACTERIOLOGY

Effect of DNase and Antibiotics on Biofilm Characteristics

(2008) G. V. Tetz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitro interaction between calf thymus DNA andEscherichia coli LPS in the presence of divalent cation Ca2+

(2008) Subrata Panja et al.   BIOPOLYMERS

Calcium and Magnesium Cations Enhance the Adhesion of Motile and NonmotilePseudomonasaeruginosaon Alginate Films

(2008) Alexis J. de Kerchove et al.   LANGMUIR

Rhenium complexes of chromophore-appended dipicolylamine ligands: syntheses, spectroscopic properties, DNA binding and X-ray crystal structure

(2008) Lucy A. Mullice et al.   NEW JOURNAL OF CHEMISTRY

Extracellular DNA Chelates Cations and Induces Antibiotic Resistance in Pseudomonas aeruginosa Biofilms

(2008) Heidi Mulcahy et al.   PLoS Pathogens