Specialized pro‐resolving mediators enhance the clearance of dead cells

The role of efferocytosis‐fueled macrophage metabolism in the resolution of inflammation

(2023) Maaike Schilperoort et al.   IMMUNOLOGICAL REVIEWS

Resolvin D1 reprograms energy metabolism to promote microglia to phagocytize neutrophils after ischemic stroke

(2023) Lei Li et al.   Cell Reports

Resolution Pharmacology: Focus on Pro-Resolving Annexin A1 and Lipid Mediators for Therapeutic Innovation in Inflammation

(2022) Mauro Perretti et al.   Annual Review of Pharmacology and Toxicology

CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis

(2022) Hongxue Shi et al.   Science Translational Medicine

Exercise-induced specialized proresolving mediators stimulate AMPK phosphorylation to promote mitochondrial respiration in macrophages

(2022) Ernesto Pena Calderin et al.   Molecular Metabolism

ODC (Ornithine Decarboxylase)-Dependent Putrescine Synthesis Maintains MerTK (MER Tyrosine-Protein Kinase) Expression to Drive Resolution

(2021) Arif Yurdagul et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Resolvin D1 Enhances Necroptotic Cell Clearance Through Promoting Macrophage Fatty Acid Oxidation and Oxidative Phosphorylation

(2021) Zeinab Hosseini et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effect of CD47 Blockade on Vascular Inflammation

(2021) Kai-Uwe Jarr et al.   NEW ENGLAND JOURNAL OF MEDICINE

A New E-Series Resolvin: RvE4 Stereochemistry and Function in Efferocytosis of Inflammation-Resolution

(2021) Stephania Libreros et al.   Frontiers in Immunology

Resolvin T-series Reduce Neutrophil Extracellular Traps

(2021) Nan Chiang et al.   BLOOD

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury

(2020) Arif Yurdagul et al.   Cell Metabolism

Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis

(2020) Alyssa M. Flores et al.   Nature Nanotechnology

Transcriptomic Analysis of Monocyte-Derived Non-Phagocytic Macrophages Favors a Role in Limiting Tissue Repair and Fibrosis

(2020) Sergei Butenko et al.   Frontiers in Immunology

Specialized pro-resolving mediator network: an update on production and actions

(2020) Nan Chiang et al.   Essays in Biochemistry

Aspirin-triggered proresolving mediators stimulate resolution in cancer

(2019) Molly M. Gilligan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin D1 promotes the targeting and clearance of necroptotic cells

(2019) Brennan D. Gerlach et al.   CELL DEATH AND DIFFERENTIATION

Resolvin D1 promotes efferocytosis in aging by limiting senescent cell‐induced MerTK cleavage

(2019) Nicholas Rymut et al.   FASEB JOURNAL

Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions

(2019) Nan Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolution metabolomes activated by hypoxic environment

(2019) Paul C. Norris et al.   Science Advances

GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections

(2019) Magdalena B. Flak et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification and Complete Stereochemical Assignments of the New Resolvin Conjugates in Tissue Regeneration in Human Tissues that Stimulate Proresolving Phagocyte Functions and Tissue Regeneration

(2018) Xavier de la Rosa et al.   AMERICAN JOURNAL OF PATHOLOGY

New maresin conjugates in tissue regeneration pathway counters leukotriene D4–stimulated vascular responses

(2018) Nan Chiang et al.   FASEB JOURNAL

GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain

(2018) Sangsu Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

Frontline Science: Structural insights into Resolvin D4 actions and further metabolites via a new total organic synthesis and validation

(2018) Jeremy W. Winkler et al.   JOURNAL OF LEUKOCYTE BIOLOGY

1α,25-Dihydroxyvitamin D3 and Resolvin D1 Retune the Balance between Amyloid-β Phagocytosis and Inflammation in Alzheimer's Disease Patients

(2018) Mathew T. Mizwicki et al.   JOURNAL OF ALZHEIMERS DISEASE

MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity

(2018) Bishuang Cai et al.   Science Signaling

Resolution of sickle cell disease–associated inflammation and tissue damage with 17R-resolvin D1

(2018) Alessandro Matte et al.   BLOOD

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

(2018) Shuang Zhang et al.   Cell Metabolism

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release

(2018) Sho Morioka et al.   NATURE

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

(2017) Nan Chiang et al.   MOLECULAR ASPECTS OF MEDICINE

Resolvin D1 enhances the resolution of lung inflammation caused by long-term Pseudomonas aeruginosa infection

(2017) M Codagnone et al.   Mucosal Immunology

A cluster of immunoresolvents links coagulation to innate host defense in human blood

(2017) Paul C. Norris et al.   Science Signaling

A cluster of immunoresolvents links coagulation to innate host defense in human blood

(2017) Paul C. Norris et al.   Science Signaling

The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation

(2016) Sesquile Ramon et al.   AMERICAN JOURNAL OF PATHOLOGY

The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation

(2016) Balázs Enyedi et al.   CELL

Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling

(2016) Tarec K. Elajami et al.   FASEB JOURNAL

Resolvin D1, resolvin D2 and maresin 1 activate the GSK3β anti-inflammatory axis in TLR4-engaged human monocytes

(2016) Zhen Gu et al.   Innate Immunity

Novel Resolvin D2 Receptor Axis in Infectious Inflammation

(2016) Nan Chiang et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of NontypeableHaemophilus influenzae

(2016) Amanda Croasdell et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 Polarizes Primary Human Macrophages toward a Proresolution Phenotype through GPR32

(2016) Mattia Schmid et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 Programs Inflammation Resolution by Increasing TGF-  Expression Induced by Dying Cell Clearance in Experimental Autoimmune Neuritis

(2016) B. Luo et al.   JOURNAL OF NEUROSCIENCE

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

(2016) Yoko Kojima et al.   NATURE

MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation

(2016) Bishuang Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programmed necrosis in inflammation: Toward identification of the effector molecules

(2016) D. Wallach et al.   SCIENCE

Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance

(2016) Jeremy W. Winkler et al.   Scientific Reports

Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis

(2016) D. Karunakaran et al.   Science Advances

Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3

(2016) Jesmond Dalli et al.   PLoS One

Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

(2015) Jesmond Dalli et al.   FASEB JOURNAL

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation

(2015) R E Abdulnour et al.   Mucosal Immunology

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections

(2015) Jesmond Dalli et al.   NATURE MEDICINE

Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice

(2015) Gabrielle Fredman et al.   Science Translational Medicine

Immunoresolving actions of oral resolvin D1 include selective regulation of the transcription machinery in resolution-phase mouse macrophages

(2014) Antonio Recchiuti et al.   FASEB JOURNAL

Cutting Edge: Parathyroid Hormone Facilitates Macrophage Efferocytosis in Bone Marrow via Proresolving Mediators Resolvin D1 and Resolvin D2

(2014) L. K. McCauley et al.   JOURNAL OF IMMUNOLOGY

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Maresin Biosynthesis and Identification of Maresin 2, a New Anti-Inflammatory and Pro-Resolving Mediator from Human Macrophages

(2014) Bin Deng et al.   PLoS One

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4synthesis by inhibiting a calcium-activated kinase pathway

(2014) Gabrielle Fredman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection

(2014) J. Dalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin D1-mediated NOX2 inactivation rescues macrophages undertaking efferocytosis from oxidative stress-induced apoptosis

(2013) Ha-Na Lee et al.   BIOCHEMICAL PHARMACOLOGY

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents

(2013) Jesmond Dalli et al.   CHEMISTRY & BIOLOGY

Resolvin D1 stimulates efferocytosis through p50/p50-mediated suppression of tumor necrosis factor-  expression

(2013) H.-N. Lee et al.   JOURNAL OF CELL SCIENCE

Novel n-3 Immunoresolvents: Structures and Actions

(2013) Jesmond Dalli et al.   Scientific Reports

Resolvin D1 Receptor Stereoselectivity and Regulation of Inflammation and Proresolving MicroRNAs

(2012) Sriram Krishnamoorthy et al.   AMERICAN JOURNAL OF PATHOLOGY

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

(2012) Charles N. Serhan et al.   FASEB JOURNAL

Resolvin E2 Formation and Impact in Inflammation Resolution

(2012) S. F. Oh et al.   JOURNAL OF IMMUNOLOGY

Resolvin D1 and Aspirin-Triggered Resolvin D1 Promote Resolution of Allergic Airways Responses

(2012) A. P. Rogerio et al.   JOURNAL OF IMMUNOLOGY

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

Aspirin-triggered lipoxin enhances macrophage phagocytosis of bacteria while inhibiting inflammatory cytokine production

(2011) David Prescott et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Novel Proresolving Aspirin-Triggered DHA Pathway

(2011) Charles N. Serhan et al.   CHEMISTRY & BIOLOGY

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

(2011) Sungwhan F. Oh et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired Phagocytosis in Localized Aggressive Periodontitis: Rescue by Resolvin E1

(2011) Gabrielle Fredman et al.   PLoS One

Saturated-efferocytosis generates pro-resolving CD11blow macrophages: Modulation by resolvins and glucocorticoids

(2010) Sagie Schif-Zuck et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin E1 Receptor Activation Signals Phosphorylation and Phagocytosis

(2009) Taisuke Ohira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis

(2009) Matthew Spite et al.   NATURE

Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets

(2008) M. Dona et al.   BLOOD

Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators

(2008) Aksam J. Merched et al.   FASEB JOURNAL

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

(2008) Charles N. Serhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE