Article
Biochemistry & Molecular Biology
Yu Zou, Bote Qi, Jingwang Tan, Lulu Guan, Qingwen Zhang, Yunxiang Sun, Fengjuan Huang
Summary: Naphthoquinone-dopamine (NQDA) effectively inhibits the aggregation of PHF6* and PHF6 and disrupts fibrillar aggregates. Molecular dynamics simulations show that NQDA prevents hydrogen bond formation, reduces self-assembly of peptides into β-strands and β-sheets, and induces the formation of loosely packed, coil-rich oligomers. The binding interactions between NQDA and PHF6* involve hydrophobic interactions and hydrogen bonding, while for PHF6 peptides, NQDA displays strong π-π stacking interactions.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Jian Chen, Rendi Yang, Yongzheng Wang, Shigenobu Koseki, Linglin Fu, Yanbo
Summary: In this study, the inhibitory effect of D-Tryptophan (D-Trp) on bacterial growth and spoilage potential was investigated. It was found that higher levels of salt and D-Trp were required for optimal growth inhibition. The combination of D-Trp and salt also showed a reduced growth of psychrotrophic bacteria at low temperature.
Article
Biochemical Research Methods
Ling Li, Chuang Li, Li Jia
Summary: Enzyme-based biological method using polydopamine modified magnetic particles for chiral discrimination of D/L-tryptophan demonstrated excellent performance, avoiding the purification of enzymes and unlocking the potential of bacteria modified magnetic particles in chiral discrimination.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Biochemistry & Molecular Biology
A. Antosova, M. Gancar, Z. Bednarikova, J. Marek, D. Zahn, S. Dutz, Z. Gazova
Summary: The surface modifications of nanoparticles have significant impact on the aggregation of proteins, specifically on the amyloid fibrillization process. COAT-MNPs were found to inhibit HEWL fibrillization and destroy mature fibrils, with TC-MNPs demonstrating the highest efficacy among the nanoparticles studied.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Chemistry, Applied
Selma Toumi, Madiha Melha Yahoum, Sonia Lefnaoui, Abdelkader Hadjsadok
Summary: New amphiphilic derivatives of kappa-carrageenan were synthesized by hydrophobic modification using octyl chloride, with microwave-assisted synthesis leading to higher degree of substitution, greater amphiphilic character, and improved emulsifying power compared to conventional heating method. These derivatives show potential applications in food, cosmetics, and pharmaceutics as stabilizers for oil/water emulsions.
CARBOHYDRATE POLYMERS
(2021)
Article
Medicine, Research & Experimental
Lokesh Narsineni, Praveen P. N. Rao, Amy Trinh Pham, Marianna Foldvari
Summary: This study explores the potential of using cell adhesion peptide-gemini surfactants as building blocks for gene carrier nanoparticles for glaucoma treatment. The surfactants showed inhibitory effects on the aggregation of Afi40 peptide and could protect retinal ganglion cells (RGCs) from neurodegeneration in glaucoma.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Dieter Janzen, Benedikt Slavik, Markus Zehe, Christoph Sotriffer, Helene M. Loos, Andrea Buettner, Carmen Villmann
Summary: This study analyzed the modulatory potential of 11 SQTs at GABA(A) receptors to characterize their potential neurotropic activity. The research found differences in receptor modulation by SQTs in HEK293 cells and neurons, with the presence of gamma(2) and delta subunits being important for SQT modulation. Additionally, the study provided insight into how nutritional digestion can affect the neurotropic potential of natural compounds.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Food Science & Technology
Ludovit Cagan, Peter Bokor, Oxana Skokova Habustova
Summary: This study aimed to investigate the impact of genetically modified maize MON810 on thrips communities on maize plants. The results showed that MON810 maize had no effect on the occurrence or composition of thrips, and their presence was influenced by other factors.
Review
Medicine, General & Internal
Adrian Eugen Rosca, Ana-Maria Vladareanu, Radu Mirica, Cristina-Mihaela Anghel-Timaru, Alina Mititelu, Bogdan Ovidiu Popescu, Constantin Caruntu, Suzana Elena Voiculescu, Serban Gologan, Minodora Onisai, Iuliana Iordan, Leon Zagrean
Summary: Taurine, the most abundant free amino acid in the human body, has beneficial therapeutic actions and is approved for heart failure treatment in Japan. It has been shown to inhibit platelet activation and aggregation and has effectiveness in pathologies involving thrombotic diathesis. Chloramine derivatives of taurine may have potential as antithrombotic agents.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Pharmacology & Pharmacy
Hao Zhu, Mehul Mehta, Shiew-Mei Huang, Yaning Wang
Summary: This article discusses the potential use of reducing beta-amyloid (A beta) plaque as a tool for new drug development and improving access to therapies for Alzheimer's disease. By summarizing literature on seven anti-A beta antibodies, the article demonstrates a relationship between the extent of A beta plaque reduction and clinical improvements.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Agricultural Economics & Policy
Yexin Zhou, Siwei Chen, Tianyu Wang, Qi Cui
Summary: This study investigates the causal effects of education level and content on consumers' cognition and attitude towards genetically modified (GM) foods using national representative data. The findings show that formal biology education has a significant influence on consumers' willingness to accept GM foods.
CHINA AGRICULTURAL ECONOMIC REVIEW
(2022)
Article
Biochemical Research Methods
Yen-Pang Hsu, Omar Nourzaie, Ariel E. Tocher, Kavitha Nerella, Grigori Ermakov, Jiwon Jung, Alexandra Fowler, Peidong Wu, Umme Ayesa, Aarron Willingham, Maribel Beaumont, Sampat Ingale
Summary: Antibody-drug conjugates (ADCs) are attracting global attention for disease treatment due to their target specificity, long half-life, and potent ability to modulate targets. This article presents a bisecting glycan-bridged conjugation strategy that enables site-specific conjugation without the need for oligosaccharide synthesis and genetic engineering. The application of this strategy is demonstrated by conjugating anti-HER2 human and mouse IgGs with a cytotoxic drug, monomethyl auristatin E, resulting in stable ADCs that effectively eliminate HER2-expressing cancer cells. Furthermore, this strategy allows for glycan structure remodeling to fine-tune the immunogenicity and pharmacokinetic properties of ADCs through glycoengineering.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Biology
Hussein maitham Qassim, Bagher Seyedalipour, Payam Baziyar, Salman Ahamady-Asbchin
Summary: Protein aggregation caused by misfolded proteins is a biological phenomenon that contributes to neurological diseases like ALS. Genetic point mutations in the SOD1 gene, particularly the D101G mutant, are the main factors contributing to ALS. This study suggests that natural polyphenolic flavonoids, particularly Epigallocatechin-gallate and Hesperidin, show promise in inhibiting the pathogenic behavior of the D101G mutant and reducing the fatal and irreversible effects of ALS.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2023)
Article
Neurosciences
Guido Domingo, Luisa Benussi, Claudia Saraceno, Michela Bertuzzi, Roland Nicsanu, Antonio Longobardi, Sonia Bellini, Alfredo Cagnotto, Mario Salmona, Giuliano Binetti, Roberta Ghidoni
Summary: A newly developed antibody-free method was used to identify and quantify Aβ isoforms in human CSF, revealing the presence of novel Aβ species. Among these, five Aβ isoforms found in CSF of elderly individuals may serve as potential markers for Alzheimer's disease progression.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Chemistry, Physical
Arpan Bera, Md Nur Hasan, Uttam Pal, Damayanti Bagchi, Tuhin Kumar Maji, Tanusri Saha-Dasgupta, Ranjan Das, Samir Kumar Pal
Summary: The application of NIR active drugs like ICG in PDT shows potential, but limitations in ROS generation exist due to aggregation. A solution is the fabrication of ICG-ZnO nanohybrid, which enhances ROS production and prevents aggregation, showing remarkable antimicrobial activity.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Om Shanker Tiwari, Sigal Rencus-Lazar, Ehud Gazit
Summary: Metabolite self-assembly has implications in both pathology and material science, making it a topic of great importance.
Article
Chemistry, Multidisciplinary
Yan Zhang, Qi Li, Haoran Wu, Yancheng Wang, Yan Wang, Sigal Rencus-Lazar, Yurong Zhao, Jiqian Wang, Deqing Mei, Hai Xu, Ehud Gazit, Kai Tao
Summary: Amino acids are bio-building blocks that play various roles in metabolic activities. Supramolecular structures formed by amino acids exhibit amyloid-like characteristics, which are driven by hydrogen bonds and play critical roles in the properties and applications of amino acid assemblies. Tyrosine-based superstructures have diverse properties and functions, making them promising next-generation biomaterials for biomedical applications. However, modulating the energetically stable supramolecular structures of tyrosine-based organizations is challenging. By assembling L-Y and D-Y, the secondary structures of the supramolecular assemblies can be modulated, leading to distinct organization kinetics and modulation of physicochemical properties.
Review
Chemistry, Multidisciplinary
Nikhil Bajpayee, Thangavel Vijayakanth, Sigal Rencus-Lazar, Sneha Dasgupta, Aamod V. Desai, Rahul Jain, Ehud Gazit, Rajkumar Misra
Summary: Flexible and biocompatible metal peptide frameworks (MPFs) have been developed from short and ultra-short peptides for various applications such as greenhouse gas storage, molecular recognition, and chiral transformations. Recently, specifically folded peptides have been utilized to fabricate metal helix frameworks (MHFs) that control the formation of three-dimensional (3D)-MHFs. This article describes the recent progress of metal-driven folded peptide assembly for constructing 3D porous structures with potential applications in energy storage, chiral recognition, and biomedical fields, serving as an alternative to conventional metal-organic frameworks (MOFs).
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Geriatrics & Gerontology
Rony M. Sayig-Keren, Moria Dagan, Pablo Cornejo Thumm, Marina Brozgol, Eran Gazit, Brad Manor, Jeffrey M. Hausdorff
Summary: This study examines the effects of theta-tACS on dual-task walking and cognitive function in older adults. The results show that theta-tACS and tDCS have similar effects in reducing dual-task costs, suggesting that theta-tACS may influence the fronto-parietal network and improve dual-tasking.
Review
Chemistry, Multidisciplinary
Vijay Bhooshan Kumar, Ifat Sher, Sigal Rencus-Lazar, Ygal Rotenstreich, Ehud Gazit
Summary: Carbon quantum dots (CDs) are emerging carbonaceous nanomaterials with excellent fluorescent properties, small size, cell and tissue penetration ability, ease of synthesis, surface modification, low cytotoxicity, and superior water dispersion. They have great potential as bioimaging probes, drug carriers, and disease diagnostics. Functionalized CDs show promise in the diagnosis and treatment of ocular diseases, including macular and anterior segment diseases, as well as targeting A beta amyloids in the retina.
Article
Multidisciplinary Sciences
Luca Palmerini, Luca Reggi, Tecla Bonci, Silvia Del Din, M. Encarna Mico-Amigo, Francesca Salis, Stefano Bertuletti, Marco Caruso, Andrea Cereatti, Eran Gazit, Anisoara Paraschiv-Ionescu, Abolfazl Soltani, Felix Kluge, Arne Kuederle, Martin Ullrich, Cameron Kirk, Hugo Hiden, Ilaria D'Ascanio, Clint Hansen, Lynn Rochester, Claudia Mazza, Lorenzo Chiari
Summary: This study provides an example of organizing, integrating, and storing movement data recorded from different wearables and gold standard technologies. The guidelines derived from the experience of a large multi-centric study offer support for accessing, understanding, and reusing available data, promoting standardization and integration in other studies, and facilitating comparison of recorded data in the scientific community.
Review
Pharmacology & Pharmacy
Vijay Bhooshan Kumar, Om Shanker Tiwari, Gal Finkelstein-Zuta, Sigal Rencus-Lazar, Ehud Gazit
Summary: Tissue engineering is focused on restoring or replacing damaged tissues, and peptide self-assembly, particularly RGD peptides, is an effective method for developing tissue structures and functionalities. This review summarizes the progress of RGD application in tissue and organ development, examines its impact on TE efficacy in clinical and preclinical studies, and outlines recent advancements in the use of RGD functionalized biomaterials for tissue regeneration.
Article
Chemistry, Multidisciplinary
Ruth Aizen, Zohar A. Arnon, Or Berger, Antonella Ruggiero, Dor Zaguri, Noam Brown, Evgeny Shirshin, Inna Slutsky, Ehud Gazit
Summary: Nucleobase crystals have unique fluorescence properties in the visible spectrum, unlike their monomeric counterparts. Additionally, some nucleobases exhibit a red edge excitation shift, which is uncommon in the field of organic supramolecular materials and may have implications in therapeutic and materials science.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
Om Shanker Tiwari, Ruth Aizen, Massimiliano Meli, Giorgio Colombo, Linda J. W. Shimon, Noam Tal, Ehud Gazit
Summary: Molecular self- and co-assembly have the ability to form diverse and well-defined supramolecular structures with notable physical properties. By exploring the co-assembly of L-His with different aromatic amino acids, including Phe, Tyr, and Trp, we expanded the structural space of amino acid nanomaterials. The best seamless co-assembly was observed between L-His and L-Phe, resulting in the formation of single crystals.
Article
Chemistry, Physical
Yunxiao Wang, Qiang Geng, Yan Zhang, Lihi Adler-Abramovich, Xinyuan Fan, Deqing Mei, Ehud Gazit, Kai Tao
Summary: In this article, the mechanisms underlying the self-assembly of 9-fluorenylmethoxycarbonyl-diphenylalanine (Fmoc-FF), the preparation methodologies of Fmoc-FF hydrogels, and the properties and applications of Fmoc-FF self-assemblies are systematically summarized. The contemporary shortcomings that limit the development of Fmoc-FF self-assembly are raised, and alternative solutions and future research perspectives are proposed.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Vijay Bhooshan Kumar, Busra Ozguney, Anastasia Vlachou, Yu Chen, Ehud Gazit, Phanourios Tamamis
Summary: The design of novel cancer drug nanocarriers is crucial in cancer therapeutics. Nanomaterials, especially self-assembling peptides, show great potential in drug delivery by promoting drug release and stability while reducing side effects. This review highlights the importance of metal coordination, structure stabilization, cyclization, and minimalism in the design of peptide self-assembled nanocarriers for cancer drug delivery. Future perspectives suggest that incorporating these materials into single or multicomponent systems could lead to novel classes of cancer drug delivery systems.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Computer Science, Interdisciplinary Applications
Gaelle Prigent, Kamiar Aminian, Andrea Cereatti, Francesca Salis, Tecla Bonci, Kirsty Scott, Claudia Mazza, Lisa Alcock, Silvia Del Din, Eran Gazit, Clint Hansen, Anisoara Paraschiv-Ionescu
Summary: This study aims to validate a robust walking detection algorithm using a single foot-worn inertial measurement unit (IMU) in real-life settings. Accurate walking detection was obtained, with sensitivity and specificity of 98% and 91% respectively. A validated algorithm would pave the way for assessing patient performance and gait quality in real-world conditions.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2023)
Article
Biotechnology & Applied Microbiology
Francesca Salis, Stefano Bertuletti, Tecla Bonci, Marco Caruso, Kirsty Scott, Lisa Alcock, Ellen Buckley, Eran Gazit, Clint Hansen, Lars Schwickert, Kamiar Aminian, Clemens Becker, Philip Brown, Anne-Elie Carsin, Brian Caulfield, Lorenzo Chiari, Ilaria D'Ascanio, Silvia Del Din, Bjoern M. Eskofier, Judith Garcia-Aymerich, Jeffrey M. Hausdorff, Emily C. Hume, Cameron Kirk, Felix Kluge, Sarah Koch, Arne Kuederle, Walter Maetzler, Encarna M. Mico-Amigo, Arne Mueller, Isabel Neatrour, Anisoara Paraschiv-Ionescu, Luca Palmerini, Alison J. Yarnall, Lynn Rochester, Basil Sharrack, David Singleton, Beatrix Vereijken, Ioannis Vogiatzis, Ugo Della Croce, Claudia Mazza, Andrea Cereatti
Summary: This study presents a wearable multi-sensor system (INDIP) that accurately assesses people's gait in real-world conditions. The system performed well in different cohorts and gait patterns, and was easy to use. Therefore, it can be considered a valid and feasible solution for analyzing gait in real-world conditions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yuehui Wang, Yuanyuan Yin, Sigal Rencus-Lazar, Kaiyong Cai, Ehud Gazit, Wei Ji
Summary: Metabolites are substances that perform various physiological functions in living organisms. They can self-assemble into materials for biomedical and nanotechnology applications. Excessive accumulation of metabolites can lead to diseases.
Article
Materials Science, Biomaterials
Jiajie Sui, Jun Li, Long Gu, Connor A. Schmidt, Ziyi Zhang, Yan Shao, Ehud Gazit, Pupa U. P. A. Gilbert, Xudong Wang
Summary: This study demonstrates a kinetic approach to control the crystal orientation of glycine films, resulting in enhanced piezoelectric properties.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
