Drosophila tweety facilitates autophagy to regulate mitochondrial homeostasis and bioenergetics in Glia

Glycolytically impaired Drosophila glial cells fuel neural metabolism via β-oxidation

(2023) Ellen McMullen et al.   Nature Communications

Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration

(2023) Yashi Mi et al.   Nature Metabolism

Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons

(2022) Juliet Goldsmith et al.   NEURON

Citrin mediated metabolic rewiring in response to altered basal subcellular Ca2+ homeostasis

(2022) Zhanat Koshenov et al.   Communications Biology

Role of mitochondrial reactive oxygen species in homeostasis regulation

(2022) Baoyi Zhang et al.   REDOX REPORT

Loss of Activity-Induced Mitochondrial ATP Production Underlies the Synaptic Defects in a Drosophila Model of ALS

(2022) Nicholas E. Karagas et al.   JOURNAL OF NEUROSCIENCE

Atg1 modulates mitochondrial dynamics to promote germline stem cell maintenance in Drosophila

(2022) Minal S. Ayachit et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pharos 2023: an integrated resource for the understudied human proteome

(2022) Keith J Kelleher et al.   NUCLEIC ACIDS RESEARCH

Regulation of longevity by depolarization-induced activation of PLC-β–IP3R signaling in neurons

(2021) Ching-On Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial biogenesis in developing astrocytes regulates astrocyte maturation and synapse formation

(2021) Tamara Zehnder et al.   Cell Reports

Astrocyte-neuron metabolic cooperation shapes brain activity

(2021) Gilles Bonvento et al.   Cell Metabolism

Cryo-EM structures of the TTYH family reveal a novel architecture for lipid interactions

(2021) Anastasiia Sukalskaia et al.   Nature Communications

Glial glucose fuels the neuronal pentose phosphate pathway for long-term memory

(2021) Eloïse de Tredern et al.   Cell Reports

The tweety Gene Family: From Embryo to Disease

(2021) Rithvik R. Nalamalapu et al.   Frontiers in Molecular Neuroscience

Astrocytic Changes in Mitochondrial Oxidative Phosphorylation Protein Levels in Parkinson's Disease

(2021) Chun Chen et al.   MOVEMENT DISORDERS

Structures of tweety homolog proteins TTYH2 and TTYH3 reveal a Ca2+-dependent switch from intra- to intermembrane dimerization

(2021) Baobin Li et al.   Nature Communications

Neuron–glia interaction in the Drosophila nervous system

(2020) Jonas Bittern et al.   Developmental Neurobiology

A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPC

(2020) Robinson Arce-Molina et al.   eLife

Modeling Neurodegenerative Disorders in Drosophila melanogaster

(2020) Harris Bolus et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management

(2020) Tulasi Yadati et al.   Cells

N-acetylcysteine amide ameliorates mitochondrial dysfunction and reduces oxidative stress in hiPSC-derived dopaminergic neurons with POLG mutation

(2020) Kristina Xiao Liang et al.   EXPERIMENTAL NEUROLOGY

N-Acetylcysteine extends lifespan of Drosophila via modulating ROS scavenger gene expression

(2019) Prakshit Niraula et al.   BIOGERONTOLOGY

Deficiency of Ttyh1 downstream to Notch signaling results in precocious differentiation of neural stem cells

(2019) Hai-Ning Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TTYH1 and TTYH2 Serve as LRRC8A-Independent Volume-Regulated Anion Channels in Cancer Cells

(2019) Yeonju Bae et al.   Cells

Upregulated TTYH2 expression is critical for the invasion and migration of U2OS human osteosarcoma cell lines

(2019) Dong Kyu Moon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mitochondria–Lysosome Crosstalk: From Physiology to Neurodegeneration

(2019) Cláudia M. Deus et al.   TRENDS IN MOLECULAR MEDICINE

High Expression of TTYH3 is Related to Poor Clinical Outcomes in Human Gastric Cancer

(2019) Saha et al.   Journal of Clinical Medicine

Live imaging using a FRET glucose sensor reveals glucose delivery to all cell types in the Drosophila brain

(2018) Anne Volkenhoff et al.   JOURNAL OF INSECT PHYSIOLOGY

Lactate in the brain: from metabolic end-product to signalling molecule

(2018) Pierre J. Magistretti et al.   NATURE REVIEWS NEUROSCIENCE

A gene-specific T2A-GAL4 library for Drosophila

(2018) Pei-Tseng Lee et al.   eLife

Effects of N-acetyl-L-cysteine on lifespan, locomotor activity and stress-resistance of 3 Drosophila species with different lifespans

(2018) Mikhail V. Shaposhnikov et al.   Aging-US

Ttyh1 regulates embryonic neural stem cell properties by enhancing the Notch signaling pathway

(2018) Juwan Kim et al.   EMBO REPORTS

The Endolysosomal System and Proteostasis: From Development to Degeneration

(2018) Bettina Winckler et al.   JOURNAL OF NEUROSCIENCE

Atg1-mediated autophagy suppresses tissue degeneration in pink1/parkin mutants by promoting mitochondrial fission in Drosophila

(2018) Peng Ma et al.   MOLECULAR BIOLOGY OF THE CELL

Tweety-Homolog 1 Drives Brain Colonization of Gliomas

(2017) Erik Jung et al.   JOURNAL OF NEUROSCIENCE

Respiration-Deficient Astrocytes Survive As Glycolytic Cells In Vivo

(2017) Lotti M. Supplie et al.   JOURNAL OF NEUROSCIENCE

High lumenal chloride in the lysosome is critical for lysosome function

(2017) Kasturi Chakraborty et al.   eLife

Endolysosomes Are the Principal Intracellular Sites of Acid Hydrolase Activity

(2016) Nicholas A. Bright et al.   CURRENT BIOLOGY

Lipids, lysosomes, and autophagy

(2016) Bharat Jaishy et al.   JOURNAL OF LIPID RESEARCH

The Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative Diseases

(2016) Matthew Redmann et al.   Aging and Disease

The role of TRPMLs in endolysosomal trafficking and function

(2015) Kartik Venkatachalam et al.   CELL CALCIUM

Glial Glycolysis Is Essential for Neuronal Survival in Drosophila

(2015) Anne Volkenhoff et al.   Cell Metabolism

Characterization of tweety gene (ttyh1-3) expression in Xenopus laevis during embryonic development

(2015) Andrew D. Halleran et al.   GENE EXPRESSION PATTERNS

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

The Astrocyte: Powerhouse and Recycling Center

(2015) Bruno Weber et al.   Cold Spring Harbor Perspectives in Biology

A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila

(2015) Sonal Nagarkar-Jaiswal et al.   eLife

ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

(2014) W. Wu et al.   EMBO REPORTS

N-acetylcysteine amide preserves mitochondrial bioenergetics and improves functional recovery following spinal trauma

(2014) Samir P. Patel et al.   EXPERIMENTAL NEUROLOGY

A NovelMitoTimerReporter Gene for Mitochondrial Content, Structure, Stress, and Damagein Vivo

(2014) Rhianna C. Laker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ttyh1 Protein is Expressed in Glia In Vitro and Shows Elevated Expression in Activated Astrocytes Following Status Epilepticus

(2014) Elzbieta Wiernasz et al.   NEUROCHEMICAL RESEARCH

ACUTE EXPOSURE OFDrosophila melanogasterTO PARAQUAT CAUSES OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTION

(2013) Ravikumar Hosamani et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

MitoTimer

(2013) Genaro Hernandez et al.   Autophagy

Regulation of pyruvate metabolism and human disease

(2013) Lawrence R. Gray et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Imaging energy status in live cells with a fluorescent biosensor of the intracellular ATP-to-ADP ratio

(2013) Mathew Tantama et al.   Nature Communications

Role of Autophagy in Glycogen Breakdown and Its Relevance to Chloroquine Myopathy

(2013) Jonathan Zirin et al.   PLOS BIOLOGY

Drosophila TRPML Is Required for TORC1 Activation

(2012) Ching-On Wong et al.   CURRENT BIOLOGY

A mutation in Drosophila Aldolase Causes Temperature-Sensitive Paralysis, Shortened Lifespan, and Neurodegeneration

(2012) Daniel Miller et al.   JOURNAL OF NEUROGENETICS

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

(2012) S. Herzig et al.   SCIENCE

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans

(2012) D. K. Bricker et al.   SCIENCE

The Proteome of the Locus Ceruleus in Parkinson's Disease: Relevance to Pathogenesis

(2011) Karin D. van Dijk et al.   BRAIN PATHOLOGY

In Vivo Mapping of Hydrogen Peroxide and Oxidized Glutathione Reveals Chemical and Regional Specificity of Redox Homeostasis

(2011) Simone C. Albrecht et al.   Cell Metabolism

Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation

(2011) Mireille Bélanger et al.   Cell Metabolism

Ttyh1, a Ca2+-binding protein localized to the endoplasmic reticulum, is required for early embryonic development

(2010) Tomohiro Kumada et al.   DEVELOPMENTAL DYNAMICS

A Molecularly Defined Duplication Set for the X Chromosome of Drosophila melanogaster

(2010) K. J. T. Venken et al.   GENETICS

Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during lateDrosophila melanogasteroogenesis

(2010) Ioannis P. Nezis et al.   JOURNAL OF CELL BIOLOGY

Expression of Ttyh1, a member of the Tweety family in neurons in vitro and in vivo and its potential role in brain pathology

(2010) Marzena Stefaniuk et al.   JOURNAL OF NEUROCHEMISTRY

Attenuation of Rotenone-Induced Mitochondrial Oxidative Damage and Neurotoxicty in Drosophila melanogaster Supplemented with Creatine

(2010) Ravikumar Hosamani et al.   NEUROCHEMICAL RESEARCH

Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE

(2010) et al.   SCIENCE

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Real-time imaging of the intracellular glutathione redox potential

(2008) Marcus Gutscher et al.   NATURE METHODS