Glial glucose fuels the neuronal pentose phosphate pathway for long-term memory

In vivo glucose imaging in multiple model organisms with an engineered single-wavelength sensor

(2021) Jacob P. Keller et al.   Cell Reports

Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila

(2020) Esther van Dam et al.   Cell Metabolism

Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior

(2019) Marion Soto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative in vivo imaging of neuronal glucose concentrations with a genetically encoded fluorescence lifetime sensor

(2019) Carlos Manlio Díaz‐García et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Glial Ca2+signaling links endocytosis to K+ buffering around neuronal somas to regulate excitability

(2019) Shirley Weiss et al.   eLife

Insulin modulates hippocampally-mediated spatial working memory via glucose transporter-4

(2018) J. Pearson-Leary et al.   BEHAVIOURAL BRAIN RESEARCH

A Single-Cell Transcriptome Atlas of the Aging Drosophila Brain

(2018) Kristofer Davie et al.   CELL

Do the right thing: neural network mechanisms of memory formation, expression and update in Drosophila

(2018) Paola Cognigni et al.   CURRENT OPINION IN NEUROBIOLOGY

Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism

(2018) Gary Yellen   JOURNAL OF CELL BIOLOGY

Live imaging using a FRET glucose sensor reveals glucose delivery to all cell types in the Drosophila brain

(2018) Anne Volkenhoff et al.   JOURNAL OF INSECT PHYSIOLOGY

CrossTalk opposing view: lack of evidence supporting an astrocyte-to-neuron lactate shuttle coupling neuronal activity to glucose utilisation in the brain

(2018) Lasse K. Bak et al.   JOURNAL OF PHYSIOLOGY-LONDON

CrossTalk proposal: an important astrocyte-to-neuron lactate shuttle couples neuronal activity to glucose utilisation in the brain

(2018) L. F. Barros et al.   JOURNAL OF PHYSIOLOGY-LONDON

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Calcium in Kenyon Cell Somata as a Substrate for an Olfactory Sensory Memory in Drosophila

(2018) Alja Lüdke et al.   Frontiers in Cellular Neuroscience

Defective cortex glia plasma membrane structure underlies light-induced epilepsy in cpes mutants

(2018) Govind Kunduri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endocytosis at the Drosophila blood–brain barrier as a function for sleep

(2018) Gregory Artiushin et al.   eLife

Broadening the definition of brain insulin resistance in aging and Alzheimer's disease

(2018) Hilaree N. Frazier et al.   EXPERIMENTAL NEUROLOGY

The secreted neurotrophin Spätzle 3 promotes glial morphogenesis and supports neuronal survival and function

(2017) Jaeda C. Coutinho-Budd et al.   GENES & DEVELOPMENT

The glia of the adult Drosophila nervous system

(2017) Malte C. Kremer et al.   GLIA

Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness

(2017) Thomas Papouin et al.   NEURON

GLUT4 Mobilization Supports Energetic Demands of Active Synapses

(2017) Ghazaleh Ashrafi et al.   NEURON

Upregulated energy metabolism in the Drosophila mushroom body is the trigger for long-term memory

(2017) Pierre-Yves Plaçais et al.   Nature Communications

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

(2016) Cristina García-Cáceres et al.   CELL

Novel Roles for the Insulin-Regulated Glucose Transporter-4 in Hippocampally Dependent Memory

(2016) Jiah Pearson-Leary et al.   JOURNAL OF NEUROSCIENCE

Neuromodulators signal through astrocytes to alter neural circuit activity and behaviour

(2016) Zhiguo Ma et al.   NATURE

Memory-Relevant Mushroom Body Output Synapses Are Cholinergic

(2016) Oliver Barnstedt et al.   NEURON

Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation

(2016) Virginia Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glial Glycolysis Is Essential for Neuronal Survival in Drosophila

(2015) Anne Volkenhoff et al.   Cell Metabolism

Long-Term Memory Formation in Drosophila Requires Training-Dependent Glial Transcription

(2015) M. Matsuno et al.   JOURNAL OF NEUROSCIENCE

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

(2015) Pierre J. Magistretti et al.   NEURON

Activation of α7 nicotinic acetylcholine receptors protects astrocytes against oxidative stress-induced apoptosis: Implications for Parkinson's disease

(2015) Yuan Liu et al.   NEUROPHARMACOLOGY

Specialized Cortex Glial Cells Accumulate Lipid Droplets in Drosophila melanogaster

(2015) Viktor Kis et al.   PLoS One

Insulin signaling is acutely required for long-term memory in Drosophila

(2015) Daniel B. Chambers et al.   Frontiers in Neural Circuits

DrosophilaCentral Nervous System Glia

(2015) Marc R. Freeman   Cold Spring Harbor Perspectives in Biology

Aerobic Glycolysis in the Human Brain Is Associated with Development and Neotenous Gene Expression

(2014) Manu S. Goyal et al.   Cell Metabolism

Glial Dysfunction Causes Age-Related Memory Impairment in Drosophila

(2014) Daisuke Yamazaki et al.   NEURON

Imaging Mitochondrial Flux in Single Cells with a FRET Sensor for Pyruvate

(2014) Alejandro San Martín et al.   PLoS One

Suppression of Conditioned Odor Approach by Feeding Is Independent of Taste and Nutritional Value in Drosophila

(2013) Franz Gruber et al.   CURRENT BIOLOGY

Mutation of a NCKX Eliminates Glial Microdomain Calcium Oscillations and Enhances Seizure Susceptibility

(2013) J. E. Melom et al.   JOURNAL OF NEUROSCIENCE

Insulin Stimulates Translocation of Human GLUT4 to the Membrane in Fat Bodies of Transgenic Drosophila melanogaster

(2013) Georgeta Crivat et al.   PLoS One

To Favor Survival Under Food Shortage, the Brain Disables Costly Memory

(2013) P.-Y. Placais et al.   SCIENCE

Requirement for Nuclear Calcium Signaling in Drosophila Long-Term Memory

(2013) J.-M. Weislogel et al.   Science Signaling

Functional α7 Nicotinic ACh Receptors on Astrocytes in Rat Hippocampal CA1 Slices

(2012) Jian-xin Shen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The mechanisms and possible sites of acetylcholine release during chick primary sensory neuron differentiation

(2012) V. Corsetti et al.   LIFE SCIENCES

Slow oscillations in two pairs of dopaminergic neurons gate long-term memory formation in Drosophila

(2012) Pierre-Yves Plaçais et al.   NATURE NEUROSCIENCE

Synaptic Energy Use and Supply

(2012) Julia J. Harris et al.   NEURON

Mutations in the Drosophila insulin receptor substrate, CHICO, impair olfactory associative learning

(2012) Shintaro Naganos et al.   NEUROSCIENCE RESEARCH

Secreted Peptide Dilp8 Coordinates Drosophila Tissue Growth with Developmental Timing

(2012) J. Colombani et al.   SCIENCE

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical Plasticity In Vivo

(2011) N. Takata et al.   JOURNAL OF NEUROSCIENCE

A critical role for IGF-II in memory consolidation and enhancement

(2011) Dillon Y. Chen et al.   NATURE

Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila

(2011) Rita Sousa-Nunes et al.   NATURE

Lactate Produced by Glycogenolysis in Astrocytes Regulates Memory Processing

(2011) Lori A. Newman et al.   PLoS One

MAPK/ERK Signaling Regulates Insulin Sensitivity to Control Glucose Metabolism in Drosophila

(2011) Wei Zhang et al.   PLoS Genetics

Nutrition-Responsive Glia Control Exit of Neural Stem Cells from Quiescence

(2010) James M. Chell et al.   CELL

Cytochemical and cytological properties of perineuronal oligodendrocytes in the mouse cortex

(2010) Chihiro Takasaki et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Refinement of Tools for Targeted Gene Expression in Drosophila

(2010) B. D. Pfeiffer et al.   GENETICS

Do astrocytes really exocytose neurotransmitters?

(2010) Nicola B. Hamilton et al.   NATURE REVIEWS NEUROSCIENCE

Hippocampal memory processes are modulated by insulin and high-fat-induced insulin resistance

(2010) Ewan C. McNay et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Molecular Evolution and Functional Characterization of Drosophila Insulin-Like Peptides

(2010) Sebastian Grönke et al.   PLoS Genetics

Functional α7-containing nicotinic receptors of NG2-expressing cells in the hippocampus

(2009) Mateo Vélez-Fort et al.   GLIA

Neuronal glucose but not lactate utilization is positively correlated with NMDA-induced neurotransmission and fluctuations in cytosolic Ca2+levels

(2009) Lasse K. Bak et al.   JOURNAL OF NEUROCHEMISTRY

Ensheathing Glia Function as Phagocytes in the Adult Drosophila Brain

(2009) J. Doherty et al.   JOURNAL OF NEUROSCIENCE

Neuroscience: Glia — more than just brain glue

(2009) Nicola J. Allen et al.   NATURE

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

Energy-Efficient Action Potentials in Hippocampal Mossy Fibers

(2009) H. Alle et al.   SCIENCE

GLUT1 and GLUT9 as major contributors to glucose influx in HepG2 cells identified by a high sensitivity intramolecular FRET glucose sensor

(2008) Hitomi Takanaga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Organization and Postembryonic Development of Glial Cells in the Adult Central Brain of Drosophila

(2008) T. Awasaki et al.   JOURNAL OF NEUROSCIENCE