Regulation of longevity by depolarization-induced activation of PLC-β–IP3R signaling in neurons

High neural activity accelerates the decline of cognitive plasticity with age in Caenorhabditis elegans

(2020) Qiaochu Li et al.   eLife

GPN does not release lysosomal Ca2+, but evokes ER Ca2+ release by increasing cytosolic pH independent of cathepsin C

(2019) Peace Atakpa et al.   JOURNAL OF CELL SCIENCE

Genetic and pharmacological interventions in the aging motor nervous system slow motor aging and extend life span in C. elegans

(2019) Guang Li et al.   Science Advances

Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis

(2019) Peter Dongmin Sohn et al.   NEURON

Regulation of lifespan by neural excitation and REST

(2019) Joseph M. Zullo et al.   NATURE

Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism

(2018) Gary Yellen   JOURNAL OF CELL BIOLOGY

IP3 Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca2+ to Lysosomes

(2018) Peace Atakpa et al.   Cell Reports

Mitochondrial calcium uniporter in Drosophila transfers calcium between the endoplasmic reticulum and mitochondria in oxidative stress-induced cell death

(2017) Sekyu Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-Dependent Exocytosis of Lysosomes Regulates the Structural Plasticity of Dendritic Spines

(2017) Zahid Padamsey et al.   NEURON

A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation

(2016) Xinran Li et al.   NATURE CELL BIOLOGY

The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes

(2016) Abigail G Garrity et al.   eLife

The A- and B-type muscarinic acetylcholine receptors from Drosophila melanogaster couple to different second messenger pathways

(2015) Guilin R. Ren et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glial Glycolysis Is Essential for Neuronal Survival in Drosophila

(2015) Anne Volkenhoff et al.   Cell Metabolism

Tau-Dependent Kv4.2 Depletion and Dendritic Hyperexcitability in a Mouse Model of Alzheimer's Disease

(2015) Alicia M. Hall et al.   JOURNAL OF NEUROSCIENCE

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling

(2015) Y. Zhou et al.   SCIENCE

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

(2015) Ju-Hyun Lee et al.   Cell Reports

Analyzing and Quantifying the Gain-of-Function Enhancement of IP3 Receptor Gating by Familial Alzheimer’s Disease-Causing Mutants in Presenilins

(2015) Don-On Daniel Mak et al.   PLoS Computational Biology

Activity-Driven Local ATP Synthesis Is Required for Synaptic Function

(2014) Vidhya Rangaraju et al.   CELL

A Computational Model of Motor Neuron Degeneration

(2014) Gwendal Le Masson et al.   NEURON

A TRPV Channel in Drosophila Motor Neurons Regulates Presynaptic Resting Ca2+ Levels, Synapse Growth, and Synaptic Transmission

(2014) Ching-On Wong et al.   NEURON

Rapid Recycling of Ca2+ between IP3-Sensitive Stores and Lysosomes

(2014) Cristina I. López Sanjurjo et al.   PLoS One

Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence

(2014) Clotilde Wiel et al.   Nature Communications

Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons

(2014) Brian J. Wainger et al.   Cell Reports

Mitochondrial Free Ca2+ Levels and Their Effects on Energy Metabolism in Drosophila Motor Nerve Terminals

(2013) Maxim V. Ivannikov et al.   BIOPHYSICAL JOURNAL

DrosophilaTRPML Forms PI(3,5)P2-activated Cation Channels in Both Endolysosomes and Plasma Membrane

(2013) Xinghua Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy

(2013) S Quraishe et al.   MOLECULAR PSYCHIATRY

Imaging energy status in live cells with a fluorescent biosensor of the intracellular ATP-to-ADP ratio

(2013) Mathew Tantama et al.   Nature Communications

Drosophila Ryanodine Receptors Mediate General Anesthesia by Halothane

(2012) Shuying Gao et al.   ANESTHESIOLOGY

Drosophila TRPML Is Required for TORC1 Activation

(2012) Ching-On Wong et al.   CURRENT BIOLOGY

High-content RNAi screening identifies the Type 1 inositol triphosphate receptor as a modifier of TDP-43 localization and neurotoxicity

(2012) Sang Hwa Kim et al.   HUMAN MOLECULAR GENETICS

Cytosolic Calcium Coordinates Mitochondrial Energy Metabolism with Presynaptic Activity

(2012) A. K. Chouhan et al.   JOURNAL OF NEUROSCIENCE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

(2010) César Cárdenas et al.   CELL

Inositol trisphosphate and calcium signalling mechanisms

(2008) Michael J. Berridge   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Motor Deficit in a Drosophila Model of Mucolipidosis Type IV due to Defective Clearance of Apoptotic Cells

(2008) Kartik Venkatachalam et al.   CELL

The Amyotrophic Lateral Sclerosis 8 Protein VAPB Is Cleaved, Secreted, and Acts as a Ligand for Eph Receptors

(2008) Hiroshi Tsuda et al.   CELL

PDF Cells Are a GABA-Responsive Wake-Promoting Component of the Drosophila Sleep Circuit

(2008) Katherine M. Parisky et al.   NEURON