Hepatocyte reprogramming in liver regeneration: Biological mechanisms and applications

Hepatocyte-to-cholangiocyte conversion occurs through transdifferentiation independently of proliferation in zebrafish

(2023) Seung-Hoon Lee et al.   HEPATOLOGY

Kupffer-cell-derived IL-6 is repurposed for hepatocyte dedifferentiation via activating progenitor genes from injury-specific enhancers

(2023) Lu Li et al.   Cell Stem Cell

Reversal of liver failure using a bioartificial liver device implanted with clinical-grade human-induced hepatocytes

(2023) Yifan Wang et al.   Cell Stem Cell

Bipotent transitional liver progenitor cells contribute to liver regeneration

(2023) Wenjuan Pu et al.   NATURE GENETICS

Small molecule drugs promote repopulation of transplanted hepatocytes by stimulating cell dedifferentiation

(2023) Mengmeng Jiang et al.   JHEP Reports

A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes

(2023) Shanshan Yang et al.   Protein & Cell

The spatiotemporal program of zonal liver regeneration following acute injury

(2022) Shani Ben-Moshe et al.   Cell Stem Cell

NOTCH-YAP1/TEAD-DNMT1 Axis Drives Hepatocyte Reprogramming into Intrahepatic Cholangiocarcinoma

(2022) Shikai Hu et al.   GASTROENTEROLOGY

Successful induction of human chemically induced liver progenitors with small molecules from damaged liver

(2022) Takayuki Miyoshi et al.   JOURNAL OF GASTROENTEROLOGY

Chemical reprogramming of human somatic cells to pluripotent stem cells

(2022) Jingyang Guan et al.   NATURE

In vivo partial cellular reprogramming enhances liver plasticity and regeneration

(2022) Tomoaki Hishida et al.   Cell Reports

NETISCE: a network-based tool for cell fate reprogramming

(2022) Lauren Marazzi et al.   npj Systems Biology and Applications

IL6 supports long-term expansion of hepatocytes in vitro

(2022) Ren Guo et al.   Nature Communications

Dynamic transcriptional and epigenetic changes drive cellular plasticity in the liver

(2021) Allyson J Merrell et al.   HEPATOLOGY

A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence

(2021) Wei Wang et al.   Science Translational Medicine

Direct cell reprogramming: approaches, mechanisms and progress

(2021) Haofei Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair

(2021) Lingjuan He et al.   SCIENCE

Liver homeostasis is maintained by midlobular zone 2 hepatocytes

(2021) Yonglong Wei et al.   SCIENCE

Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice

(2021) Yanpu Chen et al.   SCIENCE

Reversing aging for heart repair

(2021) Yu Xin Wang et al.   SCIENCE

In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche

(2021) Chao Wang et al.   Nature Communications

Large-scale chemical screen identifies Gallic acid as a geroprotector for human stem cells

(2021) Hezhen Shan et al.   Protein & Cell

Single-nucleus transcriptomic landscape of primate hippocampal aging

(2021) Hui Zhang et al.   Protein & Cell

Yap-Sox9 signaling determines hepatocyte plasticity and lineage-specific hepatocarcinogenesis

(2021) Yuchen Liu et al.   JOURNAL OF HEPATOLOGY

Cell Plasticity in Liver Regeneration

(2020) Weiping Li et al.   TRENDS IN CELL BIOLOGY

Myofibroblast induces hepatocyte-to-ductal metaplasia via laminin–ɑvβ6 integrin in liver fibrosis

(2020) Ting Xu et al.   Cell Death & Disease

Attenuating the EGFR‐ERK‐SOX9 axis promotes liver progenitor cell‐mediated liver regeneration in zebrafish

(2020) Juhoon So et al.   HEPATOLOGY

Liver regeneration: biological and pathological mechanisms and implications

(2020) George K. Michalopoulos et al.   Nature Reviews Gastroenterology & Hepatology

Epithelial Plasticity during Liver Injury and Regeneration

(2020) Victoria L. Gadd et al.   Cell Stem Cell

Cell Therapy for Advanced Liver Diseases: Repair or Rebuild

(2020) Benjamin J. Dwyer et al.   JOURNAL OF HEPATOLOGY

Farnesoid X receptor activation impairs liver progenitor cell‐mediated liver regeneration via the PTEN‐PI3K‐AKT‐mTOR axis in zebrafish

(2020) Kyounghwa Jung et al.   HEPATOLOGY

Single-cell omics analysis reveals functional diversification of hepatocytes during liver regeneration

(2020) Tianyi Chen et al.   JCI Insight

Liver Regeneration after Acetaminophen Hepatotoxicity: Mechanisms and Therapeutic Opportunities

(2019) Bharat Bhushan et al.   AMERICAN JOURNAL OF PATHOLOGY

Notch Inhibition Promotes Differentiation of Liver Progenitor Cells into Hepatocytes via sox9b Repression in Zebrafish

(2019) Jacquelyn O. Russell et al.   Stem Cells International

Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration

(2019) Brian J. Pepe-Mooney et al.   Cell Stem Cell

Spatial heterogeneity in the mammalian liver

(2019) Shani Ben-Moshe et al.   Nature Reviews Gastroenterology & Hepatology

A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling

(2019) Weiping Li et al.   Cell Stem Cell

Liver Progenitors and Adult Cell Plasticity in Hepatic Injury and Repair: Knowns and Unknowns

(2019) Sungjin Ko et al.   Annual Review of Pathology-Mechanisms of Disease

Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis

(2019) Ross Dobie et al.   Cell Reports

Broad Distribution of Hepatocyte Proliferation in Liver Homeostasis and Regeneration

(2019) Feng Chen et al.   Cell Stem Cell

AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration

(2019) Tianliang Sun et al.   Cell Stem Cell

Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes

(2018) Xing Deng et al.   Cell Stem Cell

Stat3 regulates liver progenitor cell-driven liver regeneration in zebrafish

(2018) Mehwish Khaliq et al.   GENE EXPRESSION

Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice

(2018) Jingxiao Wang et al.   ONCOGENE

Small molecule-mediated reprogramming of human hepatocytes into bipotent progenitor cells

(2018) Yohan Kim et al.   JOURNAL OF HEPATOLOGY

Burden of Liver Diseases in the World

(2018) Sumeet K. Asrani et al.   JOURNAL OF HEPATOLOGY

De novo formation of the biliary system by TGFβ-mediated hepatocyte transdifferentiation

(2018) Johanna R. Schaub et al.   NATURE

Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens

(2018) Gong-Bo Fu et al.   CELL RESEARCH

In Vitro Expansion of Primary Human Hepatocytes with Efficient Liver Repopulation Capacity

(2018) Kun Zhang et al.   Cell Stem Cell

Hdac1 Regulates Differentiation of Bipotent Liver Progenitor Cells During Regeneration via Sox9b and Cdk8

(2018) Sungjin Ko et al.   GASTROENTEROLOGY

Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation

(2018) Tomohito Izumi et al.   Nature Communications

Bone morphogenetic protein signaling governs biliary-driven liver regeneration in zebrafish through tbx2b and id2a

(2017) Tae-Young Choi et al.   HEPATOLOGY

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

(2017) Alexander Raven et al.   NATURE

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

(2017) Keren Bahar Halpern et al.   NATURE

Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells

(2017) Krishna S. Tummala et al.   Cell Reports

Progressive induction of hepatocyte progenitor cells in chronically injured liver

(2017) Naoki Tanimizu et al.   Scientific Reports

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

(2016) Alejandro Ocampo et al.   CELL

In Vivo Hepatic Reprogramming of Myofibroblasts with AAV Vectors as a Therapeutic Strategy for Liver Fibrosis

(2016) Milad Rezvani et al.   Cell Stem Cell

Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis

(2016) Wantae Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver regeneration — mechanisms and models to clinical application

(2016) Stuart J. Forbes et al.   Nature Reviews Gastroenterology & Hepatology

Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer

(2015) Joan Font-Burgada et al.   CELL

Hepatocellular carcinoma originates from hepatocytes and not from the progenitor/biliary compartment

(2015) Xueru Mu et al.   JOURNAL OF CLINICAL INVESTIGATION

Acetaminophen-induced acute liver injury in mice

(2015) JC Mossanen et al.   LABORATORY ANIMALS

Contribution of Mature Hepatocytes to Biliary Regeneration in Rats with Acute and Chronic Biliary Injury

(2015) Ya-Hui Chen et al.   PLoS One

YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression

(2015) Julien Fitamant et al.   Cell Reports

Contributions of Hepatocytes and Bile Ductular Cells in Ductular Reactions and Remodeling of the Biliary System after Chronic Liver Injury

(2014) Yasuharu Nagahama et al.   AMERICAN JOURNAL OF PATHOLOGY

Hepatocytes, Rather than Cholangiocytes, Can Be the Major Source of Primitive Ductules in the Chronically Injured Mouse Liver

(2014) Sayaka Sekiya et al.   AMERICAN JOURNAL OF PATHOLOGY

Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation

(2014) Kilangsungla Yanger et al.   Cell Stem Cell

Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes

(2014) Branden D. Tarlow et al.   Cell Stem Cell

The biliary epithelium gives rise to liver progenitor cells

(2014) Daniel Rodrigo-Torres et al.   HEPATOLOGY

Sry HMG Box Protein 9-positive (Sox9+) Epithelial Cell Adhesion Molecule-negative (EpCAM−) Biphenotypic Cells Derived from Hepatocytes Are Involved in Mouse Liver Regeneration

(2014) Naoki Tanimizu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenome rejuvenation: HP1β mobility as a measure of pluripotent and senescent chromatin ground states

(2014) Maria Manukyan et al.   Scientific Reports

Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury

(2014) Johanna R. Schaub et al.   Cell Reports

Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling

(2013) Guobin He et al.   CELL

Extensive Conversion of Hepatic Biliary Epithelial Cells to Hepatocytes After Near Total Loss of Hepatocytes in Zebrafish

(2013) Tae–Young Choi et al.   GASTROENTEROLOGY

Links Between Hepatic Fibrosis, Ductular Reaction, and Progenitor Cell Expansion

(2013) Michael J. Williams et al.   GASTROENTEROLOGY

Robust cellular reprogramming occurs spontaneously during liver regeneration

(2013) K. Yanger et al.   GENES & DEVELOPMENT

Rejuvenating liver and pancreas through cell transdifferentiation

(2012) Fei Yi et al.   CELL RESEARCH

Establishment of hepatic and neural differentiation platforms of Wilson’s disease specific induced pluripotent stem cells

(2012) Fei Yi et al.   Protein & Cell

Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy

(2012) Fei Yi et al.   Protein & Cell

Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors

(2011) Pengyu Huang et al.   NATURE

Switching cell fate: the remarkable rise of induced pluripotent stem cells and lineage reprogramming technologies

(2010) Vimal Selvaraj et al.   TRENDS IN BIOTECHNOLOGY

Biliary differentiation and bile duct morphogenesis in development and disease

(2009) Peggy Raynaud et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

EpCAM-Positive Hepatocellular Carcinoma Cells Are Tumor-Initiating Cells With Stem/Progenitor Cell Features

(2008) Taro Yamashita et al.   GASTROENTEROLOGY