The spatiotemporal program of zonal liver regeneration following acute injury

Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair

(2021) Lingjuan He et al.   SCIENCE

Liver homeostasis is maintained by midlobular zone 2 hepatocytes

(2021) Yonglong Wei et al.   SCIENCE

ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation

(2021) Tianliang Sun et al.   Cell Stem Cell

A spatial vascular transcriptomic, proteomic, and phosphoproteomic atlas unveils an angiocrine Tie–Wnt signaling axis in the liver

(2021) Donato Inverso et al.   DEVELOPMENTAL CELL

XCR1+ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis

(2021) Aleksandra Deczkowska et al.   NATURE MEDICINE

Spatial transcriptome profiling by MERFISH reveals fetal liver hematopoietic stem cell niche architecture

(2021) Yanfang Lu et al.   Cell Discovery

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

Identification of Lineage-specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution

(2020) Xiao Liu et al.   GASTROENTEROLOGY

A scalable SCENIC workflow for single-cell gene regulatory network analysis

(2020) Bram Van de Sande et al.   Nature Protocols

Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma

(2020) Ankur Sharma et al.   CELL

Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver

(2020) Anneleen Remmerie et al.   IMMUNITY

Acute liver failure is regulated by MYC- and microbiome-dependent programs

(2020) Aleksandra A. Kolodziejczyk et al.   NATURE MEDICINE

Liver Regeneration after Acetaminophen Hepatotoxicity: Mechanisms and Therapeutic Opportunities

(2019) Bharat Bhushan et al.   AMERICAN JOURNAL OF PATHOLOGY

Determining cell type abundance and expression from bulk tissues with digital cytometry

(2019) Aaron M. Newman et al.   NATURE BIOTECHNOLOGY

Spatial heterogeneity in the mammalian liver

(2019) Shani Ben-Moshe et al.   Nature Reviews Gastroenterology & Hepatology

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

Changes in alpha‐foetoprotein and Gc‐globulin in relation to outcomes in non‐acetaminophen acute liver failure

(2019) Sundeep Singh et al.   LIVER INTERNATIONAL

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis

(2019) Xuelian Xiong et al.   MOLECULAR CELL

The Hepatic Central Vein: Structure, Fibrosis, and Role in Liver Biology

(2019) Ki M. Mak et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Single-Cell Transcriptomics Uncovers Zonation of Function in the Mesenchyme during Liver Fibrosis

(2019) Ross Dobie et al.   Cell Reports

AXIN2+ Pericentral Hepatocytes Have Limited Contributions to Liver Homeostasis and Regeneration

(2019) Tianliang Sun et al.   Cell Stem Cell

NicheNet: modeling intercellular communication by linking ligands to target genes

(2019) Robin Browaeys et al.   NATURE METHODS

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Sensitive and powerful single-cell RNA sequencing using mcSCRB-seq

(2018) Johannes W. Bagnoli et al.   Nature Communications

zUMIs - A fast and flexible pipeline to process RNA sequencing data with UMIs

(2018) Swati Parekh et al.   GigaScience

Spatial Reconstruction of Single Enterocytes Uncovers Broad Zonation along the Intestinal Villus Axis

(2018) Andreas E. Moor et al.   CELL

Paired-cell sequencing enables spatial gene expression mapping of liver endothelial cells

(2018) Keren Bahar Halpern et al.   NATURE BIOTECHNOLOGY

Plau and Tgfbr3 are YAP-regulated genes that promote keratinocyte proliferation

(2018) Susan M. Corley et al.   Cell Death & Disease

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

(2017) Johanne Poisson et al.   JOURNAL OF HEPATOLOGY

Multilineage communication regulates human liver bud development from pluripotency

(2017) J. Gray Camp et al.   NATURE

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

(2017) Keren Bahar Halpern et al.   NATURE

SCENIC: single-cell regulatory network inference and clustering

(2017) Sara Aibar et al.   NATURE METHODS

Dynamic zonation of liver polyploidy

(2016) Sivan Tanami et al.   CELL AND TISSUE RESEARCH

Gene expression profiles predict the possible regulatory role of OPN-mediated signaling pathways in rat liver regeneration

(2016) Gaiping Wang et al.   GENE

Tissue-Resident Macrophage Ontogeny and Homeostasis

(2016) Florent Ginhoux et al.   IMMUNITY

The extracellular matrix: Tools and insights for the “omics” era

(2016) Alexandra Naba et al.   MATRIX BIOLOGY

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

(2016) Lara Planas-Paz et al.   NATURE CELL BIOLOGY

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis

(2015) Satdarshan Pal Monga   GASTROENTEROLOGY

Acetaminophen-induced acute liver injury in mice

(2015) JC Mossanen et al.   LABORATORY ANIMALS

Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

(2015) Bruce Wang et al.   NATURE

High-throughput spatial mapping of single-cell RNA-seq data to tissue of origin

(2015) Kaia Achim et al.   NATURE BIOTECHNOLOGY

High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers

(2015) Ingmar Mederacke et al.   Nature Protocols

A draft network of ligand–receptor-mediated multicellular signalling in human

(2015) Jordan A. Ramilowski et al.   Nature Communications

Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation

(2014) Kilangsungla Yanger et al.   Cell Stem Cell

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

Infiltrating Monocyte-Derived Macrophages and Resident Kupffer Cells Display Different Ontogeny and Functions in Acute Liver Injury

(2014) E. Zigmond et al.   JOURNAL OF IMMUNOLOGY

The quantified cell

(2014) Avi Flamholz et al.   MOLECULAR BIOLOGY OF THE CELL

Single-molecule mRNA detection and counting in mammalian tissue

(2013) Anna Lyubimova et al.   Nature Protocols

Cadherin-17 interacts with α2β1 integrin to regulate cell proliferation and adhesion in colorectal cancer cells causing liver metastasis

(2013) R A Bartolomé et al.   ONCOGENE

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

(2012) Juliane S. Troeger et al.   GASTROENTEROLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

Beta-Catenin Activation Promotes Liver Regeneration after Acetaminophen-Induced Injury

(2009) Udayan Apte et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma

(2009) Ling Xiao Liu et al.   HEPATOLOGY

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS